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UA96113C2 - Inhibitors of caspases - Google Patents

Inhibitors of caspases

Info

Publication number
UA96113C2
UA96113C2 UA20041210341A UA20041210341A UA96113C2 UA 96113 C2 UA96113 C2 UA 96113C2 UA 20041210341 A UA20041210341 A UA 20041210341A UA 20041210341 A UA20041210341 A UA 20041210341A UA 96113 C2 UA96113 C2 UA 96113C2
Authority
UA
Ukraine
Prior art keywords
compounds
relates
diseases
interferon
methods
Prior art date
Application number
UA20041210341A
Other languages
English (en)
Ukrainian (uk)
Inventor
Марион В. Ваннамейкер
Гай В. Бемис
Пол С. Чарифсон
Девид Дж. Лауффер
Майкл Д. Малликен
Марк А. Мурко
Кейт П. Вилсон
Джеймс В. Янетка
Роберт Дж. Девис
Анна-Лаура Грилло
Жан Ши
Корнелия Дж. Форстер
Original Assignee
Вертекс Фармасьютикалс Инкорпорейтед
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Вертекс Фармасьютикалс Инкорпорейтед filed Critical Вертекс Фармасьютикалс Инкорпорейтед
Publication of UA96113C2 publication Critical patent/UA96113C2/ru

Links

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    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0202—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-X-X-C(=0)-, X being an optionally substituted carbon atom or a heteroatom, e.g. beta-amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
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  • Health & Medical Sciences (AREA)
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Abstract

Это изобретение касается новых классов соединений, которые представляют собой ингибиторы каспаз, в частности ингибиторы интерлейкин-1-преобразующего фермента (ICE).Это изобретение касается также фармацевтических композиций, которые содержат эти соединения.Соединения и фармацевтические композиции этого изобретения, в частности, хорошо применимы для торможения активности каспазы и, итак, могут быть успешно применены как агенты, направлены против заболеваний, опосредованных интерлейкином-1 (IL-1), апоптозом, фактором, индуцирующим интерферон-(IGIF), или интерфероном-(IFN-), включая воспалительные заболевания, аутоиммунные заболевания, деструктивные заболевания костей, н
UA20041210341A 1998-03-19 2004-12-15 Inhibitors of caspases UA96113C2 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US7877098P 1998-03-19 1998-03-19

Publications (1)

Publication Number Publication Date
UA96113C2 true UA96113C2 (en) 2011-10-10

Family

ID=22146109

Family Applications (2)

Application Number Title Priority Date Filing Date
UA2000105920A UA74133C2 (ru) 1998-03-19 1999-03-19 Ингибиторы каспаз
UA20041210341A UA96113C2 (en) 1998-03-19 2004-12-15 Inhibitors of caspases

Family Applications Before (1)

Application Number Title Priority Date Filing Date
UA2000105920A UA74133C2 (ru) 1998-03-19 1999-03-19 Ингибиторы каспаз

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US (3) US6531474B1 (ru)
EP (6) EP2011800A3 (ru)
JP (3) JP4594520B2 (ru)
KR (2) KR100928878B1 (ru)
CN (1) CN1321129C (ru)
AP (1) AP2000001919A0 (ru)
AR (1) AR019011A1 (ru)
AT (1) ATE410439T1 (ru)
AU (1) AU769033B2 (ru)
BG (1) BG104863A (ru)
BR (2) BR9909660A (ru)
CA (1) CA2324226C (ru)
CZ (1) CZ302281B6 (ru)
DE (1) DE69939689D1 (ru)
DK (1) DK1064298T3 (ru)
ES (1) ES2315010T3 (ru)
GE (1) GEP20043163B (ru)
HK (1) HK1035733A1 (ru)
HU (1) HU227920B1 (ru)
ID (1) ID27002A (ru)
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AR019011A1 (es) 2001-12-26
ID27002A (id) 2001-02-22
CA2324226C (en) 2012-06-05
HUP0103575A3 (en) 2002-10-28
RU2274642C2 (ru) 2006-04-20
SK13822000A3 (sk) 2001-04-09
EP2261233A3 (en) 2011-04-20
US7358273B2 (en) 2008-04-15
PT1064298E (pt) 2009-01-02
JP2002506878A (ja) 2002-03-05
BRPI9909660B8 (pt) 2021-05-25
HU227920B1 (en) 2012-06-28
EP2261232A2 (en) 2010-12-15
US20030232986A1 (en) 2003-12-18
NO331829B1 (no) 2012-04-16
JP4594520B2 (ja) 2010-12-08
EP2261235A2 (en) 2010-12-15
KR20010042038A (ko) 2001-05-25
GEP20043163B (en) 2004-01-26
AU769033B2 (en) 2004-01-15
CZ302281B6 (cs) 2011-01-26
EP1064298A2 (en) 2001-01-03
PL204619B1 (pl) 2010-01-29
TR200103406T2 (tr) 2002-06-21
CN1321129C (zh) 2007-06-13
AP2000001919A0 (en) 2000-09-30
EP2261234A2 (en) 2010-12-15
AU3098699A (en) 1999-10-11
DE69939689D1 (de) 2008-11-20
TWI243828B (en) 2005-11-21
EP2261233A2 (en) 2010-12-15
NO20004546D0 (no) 2000-09-12
WO1999047545A2 (en) 1999-09-23
ATE410439T1 (de) 2008-10-15
IL206621A0 (en) 2010-12-30
WO1999047545A3 (en) 1999-11-25
EP2261234A3 (en) 2011-04-20
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DK1064298T3 (da) 2009-01-19
US20090048226A1 (en) 2009-02-19

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