SK172004A3 - Aromatic hydroxamic acid derivatives useful as HDAC inhibitors - Google Patents

Aromatic hydroxamic acid derivatives useful as HDAC inhibitors Download PDF

Info

Publication number: SK172004A3
Authority: SK; Slovakia
Prior art keywords: thiophene; dicarboxylic acid; hydroxyamide; amide; group
Prior art date: 2001-06-15

Application number

SK17-2004A

Other languages

English (en)

Slovak (sk)

Inventor

Ulrike Leser-Reiff

Tim Sattelkau

Gerd Zimmermann

Original Assignee

Hoffmann La Roche

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2001-06-15

Filing date

2002-06-13

Publication date

2004-07-07

2002-06-13 Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche

2004-07-07 Publication of SK172004A3 publication Critical patent/SK172004A3/sk

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/36—Radicals substituted by singly-bound nitrogen atoms
- C07D213/40—Acylated substituent nitrogen atom
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C259/00—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups
- C07C259/04—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids
- C07C259/10—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids having carbon atoms of hydroxamic groups bound to carbon atoms of six-membered aromatic rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
- C07D207/09—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/10—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms
- C07D211/16—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms with acylated ring nitrogen atom
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/04—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D307/10—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D307/14—Radicals substituted by nitrogen atoms not forming part of a nitro radical
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
- C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
- C07D317/50—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to atoms of the carbocyclic ring
- C07D317/58—Radicals substituted by nitrogen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/02—Systems containing only non-condensed rings with a three-membered ring
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/14—The ring being saturated
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2602/00—Systems containing two condensed rings
- C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
- C07C2602/04—One of the condensed rings being a six-membered aromatic ring
- C07C2602/08—One of the condensed rings being a six-membered aromatic ring the other ring being five-membered, e.g. indane
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2602/00—Systems containing two condensed rings
- C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
- C07C2602/04—One of the condensed rings being a six-membered aromatic ring
- C07C2602/10—One of the condensed rings being a six-membered aromatic ring the other ring being six-membered, e.g. tetraline

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
Public Health (AREA)
General Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Heterocyclic Compounds Containing Sulfur Atoms (AREA)
Plural Heterocyclic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Pyridine Compounds (AREA)

SK17-2004A 2001-06-15 2002-06-13 Aromatic hydroxamic acid derivatives useful as HDAC inhibitors SK172004A3 (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
EP01114496		2001-06-15
PCT/EP2002/006488 WO2003011851A2 (en)	2001-06-15	2002-06-13	Aromatic hydroxamic acid derivatives useful as hdac inhibitors

Publications (1)

Publication Number	Publication Date
SK172004A3 true SK172004A3 (en)	2004-07-07

Family

ID=8177731

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
SK17-2004A SK172004A3 (en)	2001-06-15	2002-06-13	Aromatic hydroxamic acid derivatives useful as HDAC inhibitors

Country Status (33)

Country	Link
US (2)	US6784173B2 (ru)
EP (1)	EP1401824B1 (ru)
JP (1)	JP4195377B2 (ru)
KR (2)	KR100910958B1 (ru)
CN (1)	CN1271066C (ru)
AR (1)	AR036055A1 (ru)
AT (1)	ATE343569T1 (ru)
AU (1)	AU2002355626B2 (ru)
BG (1)	BG108450A (ru)
BR (1)	BR0210424A (ru)
CA (1)	CA2449804A1 (ru)
CO (1)	CO5540280A2 (ru)
CZ (1)	CZ200425A3 (ru)
DE (1)	DE60215652T2 (ru)
EC (1)	ECSP034896A (ru)
ES (1)	ES2272800T3 (ru)
GT (1)	GT200200121A (ru)
HK (1)	HK1065787A1 (ru)
HR (1)	HRP20031019A2 (ru)
HU (1)	HUP0401233A3 (ru)
IL (1)	IL159097A0 (ru)
MA (1)	MA27041A1 (ru)
MX (1)	MXPA03011501A (ru)
NO (1)	NO20035555D0 (ru)
NZ (1)	NZ529874A (ru)
PA (1)	PA8548001A1 (ru)
PE (1)	PE20030086A1 (ru)
PL (1)	PL366729A1 (ru)
RS (1)	RS98203A (ru)
RU (1)	RU2289580C2 (ru)
SK (1)	SK172004A3 (ru)
WO (1)	WO2003011851A2 (ru)
ZA (1)	ZA200309260B (ru)

Families Citing this family (52)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6822267B1 (en) *	1997-08-20	2004-11-23	Advantest Corporation	Signal transmission circuit, CMOS semiconductor device, and circuit board
CA2475764C (en) *	2002-03-13	2011-05-31	Janssen Pharmaceutica N.V.	New inhibitors of histone deacetylase
NZ534831A (en)	2002-03-13	2007-01-26	Janssen Pharmaceutica Nv	Carbonylamino-derivatives having histone deacetylase (HDAC) inhibiting enzymatic activity
MXPA04009490A (es) *	2002-04-03	2005-06-08	Topo Target Uk Ltd	Compuesto de acido carbamico que comprenden un enlace de piperazina como inhibidores de histona desacetilasa.
US7154002B1 (en)	2002-10-08	2006-12-26	Takeda San Diego, Inc.	Histone deacetylase inhibitors
US7250514B1 (en)	2002-10-21	2007-07-31	Takeda San Diego, Inc.	Histone deacetylase inhibitors
US7098241B2 (en) *	2002-12-16	2006-08-29	Hoffmann-La Roche Inc.	Thiophene hydroxamic acid derivatives
TW200424174A (en)	2003-02-06	2004-11-16	Hoffmann La Roche	New TP diamide
US7208491B2 (en)	2003-02-07	2007-04-24	Hoffmann-La Roche Inc.	N-monoacylated o-phenylenediamines
JP2006520796A (ja)	2003-03-17	2006-09-14	タケダサンディエゴインコーポレイテッド	ヒストンデアセチラーゼインヒビター
TW200424187A (en) *	2003-04-04	2004-11-16	Hoffmann La Roche	New oxime derivatives and their use as pharmaceutically active agents
WO2005034880A2 (en) *	2003-10-09	2005-04-21	Aton Pharma, Inc.	Thiophene and benzothiophene hydroxamic acid derivatives
US20050137234A1 (en) *	2003-12-19	2005-06-23	Syrrx, Inc.	Histone deacetylase inhibitors
WO2005065681A1 (en) *	2003-12-19	2005-07-21	Takeda San Diego, Inc.	N- hydroxy-3-(3-(1h-imidazol-2-yl)-phenyl)-acrylamide derivatives and related compounds as histone deacetylase (hdac) inhibitors for the treatment of cancer
US7217723B2 (en)	2004-02-02	2007-05-15	Eisai Co., Ltd.	Heterocyclic compound having oxime group
WO2005081954A2 (en) *	2004-02-25	2005-09-09	Wyeth	Inhibitors of protein tyrosine phosphatase 1b
US20050203081A1 (en) *	2004-02-25	2005-09-15	Jinbo Lee	Inhibitors of protein tyrosine phosphatase 1B
EP1758881A1 (en) *	2004-06-14	2007-03-07	F.Hoffmann-La Roche Ag	Thiophene hydroxamic acid derivatives and their use as hdac inhibitors
JP2008502627A (ja) *	2004-06-14	2008-01-31	エフ．ホフマン−ラ　ロシュ　アーゲー	ヒドロキサム酸塩、その製造、および薬剤としての使用
CA2566525A1 (en) *	2004-06-14	2005-12-22	F. Hoffmann-La Roche Ag	Thiophene derivatives, their manufacture and use as pharmaceutical agents
PL1781639T3 (pl)	2004-07-28	2012-07-31	Janssen Pharmaceutica Nv	Podstawione pochodne indolilo-alkiloaminowe jako nowe inhibitory deacetylazy histonowej
KR100620488B1 (ko)	2004-08-13	2006-09-08	연세대학교 산학협력단	신규한 히스톤 디아세틸라아제 억제제 및 이의 제조방법
US7642275B2 (en)	2004-12-16	2010-01-05	Takeda San Diego, Inc.	Histone deacetylase inhibitors
US20100087328A1 (en) *	2005-03-01	2010-04-08	The Regents Of The University Of Michigan	Brm expression and related diagnostics
WO2006094068A2 (en) *	2005-03-01	2006-09-08	The Regents Of The University Of Michigan	Hdac inhibitors that promote brm expression and brm related diagnostics
CN101163690A (zh)	2005-04-20	2008-04-16	默克公司	苯并噻吩异羟肟酸衍生物
GB0509223D0 (en)	2005-05-05	2005-06-15	Chroma Therapeutics Ltd	Enzyme inhibitors
GB0509225D0 (en)	2005-05-05	2005-06-15	Chroma Therapeutics Ltd	Inhibitors of enzymatic activity
WO2006122319A2 (en)	2005-05-11	2006-11-16	Takeda San Diego, Inc.	Histone deacetylase inhibitors
BRPI0613429A2 (pt)	2005-07-14	2009-02-10	Takeda San Diego Inc	inibidores de histona desacetilase
GB0518237D0 (en) *	2005-09-07	2005-10-19	Angeletti P Ist Richerche Bio	Therapeutic compounds
AR057579A1 (es) *	2005-11-23	2007-12-05	Merck & Co Inc	Compuestos espirociclicos como inhibidores de histona de acetilasa (hdac)
US8088804B2 (en) *	2005-12-15	2012-01-03	Pfizer Inc.	N-hydroxyamide derivatives possessing antibacterial activity
JP2009525955A (ja) *	2006-01-13	2009-07-16	タケダサンディエゴインコーポレイテッド	ヒストンデアセチラーゼ阻害剤
US8114876B2 (en)	2006-01-19	2012-02-14	Janssen Pharmaceutica N.V.	Pyridine and pyrimidine derivatives as inhibitors of histone deacetylase
GB0603041D0 (en) *	2006-02-15	2006-03-29	Angeletti P Ist Richerche Bio	Therapeutic compounds
GB0619753D0 (en)	2006-10-06	2006-11-15	Chroma Therapeutics Ltd	Enzyme inhibitors
ES2509342T3 (es)	2006-10-30	2014-10-17	Chroma Therapeutics Limited	Hidroxamatos como inhibidores de histona desacetilasa
GB0713686D0 (en) *	2007-07-13	2007-08-22	Addex Pharmaceuticals Sa	New compounds 2
AU2008307575A1 (en) *	2007-10-04	2009-04-09	Merck Sharp & Dohme Corp.	N-hydroxy-naphthalene dicarboxamide and N-hydroxy-biphenyl-dicarboxamide compounds as histone deacetylase inhibitors
CA2735593C (en)	2008-09-03	2017-08-15	Repligen Corporation	Compositions including 6-aminohexanoic acid derivatives as hdac inhibitors
GB0903480D0 (en)	2009-02-27	2009-04-08	Chroma Therapeutics Ltd	Enzyme Inhibitors
CA3061239A1 (en)	2011-02-28	2012-09-07	Biomarin Pharmaceutical Inc.	Histone deacetylase inhibitors
US8957066B2 (en)	2011-02-28	2015-02-17	Biomarin Pharmaceutical Inc.	Histone deacetylase inhibitors
US10059723B2 (en)	2011-02-28	2018-08-28	Biomarin Pharmaceutical Inc.	Histone deacetylase inhibitors
RU2665554C2 (ru)	2013-03-15	2018-08-31	Байомарин Фармасьютикал Инк.	Ингибиторы hdac
EP2826769A1 (en)	2013-07-18	2015-01-21	Institut de Recherche pour le Développement ( IRD)	Compounds for the treatment and/or prevention of parasitic diseases and method of production thereof
KR101536050B1 (ko) *	2013-07-30	2015-07-13	충북대학교 산학협력단	신규 이사틴 기반 히드록삼산 및 이를 유효성분으로 포함하는 항암용 조성물
WO2015058106A1 (en) *	2013-10-18	2015-04-23	The General Hospital Corporation	Imaging histone deacetylases with a radiotracer using positron emission tomography
ES2694053T3 (es) *	2014-03-12	2018-12-17	Chong Kun Dang Pharmaceutical Corp.	Compuestos novedosos como inhibidores de histona desacetilasa 6 y composiciones farmacéuticas que comprenden los mismos
WO2019185413A1 (en)	2018-03-27	2019-10-03	Basf Se	Pesticidal substituted cyclopropyl derivatives
WO2024123700A1 (en) *	2022-12-05	2024-06-13	The General Hospital Corporation	Histone deacetylase inhibitors

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3825554A (en) *	1969-06-13	1974-07-23	Atlantic Richfield Co	Method for preparing cyclic nitrile carbonates
JPS54148743A (en)	1978-05-12	1979-11-21	Asahi Chem Ind Co Ltd	Production of methoclopramide
US5700811A (en)	1991-10-04	1997-12-23	Sloan-Kettering Institute For Cancer Research	Potent inducers of terminal differentiation and method of use thereof
US5369108A (en)	1991-10-04	1994-11-29	Sloan-Kettering Institute For Cancer Research	Potent inducers of terminal differentiation and methods of use thereof
US6174905B1 (en)	1996-09-30	2001-01-16	Mitsui Chemicals, Inc.	Cell differentiation inducer
AUPO721997A0 (en)	1997-06-06	1997-07-03	Queensland Institute Of Medical Research, The	Anticancer compounds
AU783504C (en)	1999-11-23	2006-08-03	Methylgene Inc.	Inhibitors of histone deacetylase

2002
- 2002-06-11 US US10/167,677 patent/US6784173B2/en not_active Expired - Fee Related
- 2002-06-12 PA PA20028548001A patent/PA8548001A1/es unknown
- 2002-06-13 WO PCT/EP2002/006488 patent/WO2003011851A2/en active Application Filing
- 2002-06-13 PE PE2002000510A patent/PE20030086A1/es not_active Application Discontinuation
- 2002-06-13 AR ARP020102231A patent/AR036055A1/es unknown
- 2002-06-13 BR BR0210424-5A patent/BR0210424A/pt not_active IP Right Cessation
- 2002-06-13 IL IL15909702A patent/IL159097A0/xx unknown
- 2002-06-13 HU HU0401233A patent/HUP0401233A3/hu unknown
- 2002-06-13 PL PL02366729A patent/PL366729A1/xx not_active Application Discontinuation
- 2002-06-13 AT AT02791436T patent/ATE343569T1/de not_active IP Right Cessation
- 2002-06-13 CN CNB028120108A patent/CN1271066C/zh not_active Expired - Fee Related
- 2002-06-13 DE DE60215652T patent/DE60215652T2/de not_active Expired - Fee Related
- 2002-06-13 NZ NZ529874A patent/NZ529874A/xx unknown
- 2002-06-13 KR KR1020037016358A patent/KR100910958B1/ko not_active IP Right Cessation
- 2002-06-13 CA CA002449804A patent/CA2449804A1/en not_active Abandoned
- 2002-06-13 KR KR1020097010546A patent/KR20090059172A/ko not_active Application Discontinuation
- 2002-06-13 MX MXPA03011501A patent/MXPA03011501A/es active IP Right Grant
- 2002-06-13 ES ES02791436T patent/ES2272800T3/es not_active Expired - Lifetime
- 2002-06-13 EP EP02791436A patent/EP1401824B1/en not_active Expired - Lifetime
- 2002-06-13 RS YUP-982/03A patent/RS98203A/sr unknown
- 2002-06-13 AU AU2002355626A patent/AU2002355626B2/en not_active Ceased
- 2002-06-13 RU RU2003137578/04A patent/RU2289580C2/ru not_active IP Right Cessation
- 2002-06-13 JP JP2003517043A patent/JP4195377B2/ja not_active Expired - Fee Related
- 2002-06-13 CZ CZ200425A patent/CZ200425A3/cs unknown
- 2002-06-13 SK SK17-2004A patent/SK172004A3/sk unknown
- 2002-06-14 GT GT200200121A patent/GT200200121A/es unknown
2003
- 2003-11-27 ZA ZA200309260A patent/ZA200309260B/en unknown
- 2003-12-09 HR HR20031019A patent/HRP20031019A2/xx not_active Application Discontinuation
- 2003-12-10 CO CO03108279A patent/CO5540280A2/es not_active Application Discontinuation
- 2003-12-11 EC EC2003004896A patent/ECSP034896A/es unknown
- 2003-12-12 MA MA27440A patent/MA27041A1/fr unknown
- 2003-12-12 NO NO20035555A patent/NO20035555D0/no not_active Application Discontinuation
- 2003-12-15 BG BG108450A patent/BG108450A/xx unknown
2004
- 2004-05-17 US US10/847,166 patent/US20040214862A1/en not_active Abandoned
- 2004-10-29 HK HK04108497A patent/HK1065787A1/xx not_active IP Right Cessation

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Publication number	Publication date
US6784173B2 (en)	2004-08-31
JP2005502641A (ja)	2005-01-27
KR100910958B1 (ko)	2009-08-05
CA2449804A1 (en)	2003-02-13
EP1401824B1 (en)	2006-10-25
WO2003011851A3 (en)	2003-09-18
AU2002355626B2 (en)	2008-09-25
BR0210424A (pt)	2004-08-17
ATE343569T1 (de)	2006-11-15
GT200200121A (es)	2003-06-19
PA8548001A1 (es)	2003-01-24
ES2272800T3 (es)	2007-05-01
HUP0401233A3 (en)	2007-05-29
PL366729A1 (en)	2005-02-07
KR20090059172A (ko)	2009-06-10
DE60215652T2 (de)	2007-08-23
BG108450A (en)	2005-01-31
NZ529874A (en)	2004-12-24
EP1401824A2 (en)	2004-03-31
ECSP034896A (es)	2004-01-28
US20040214862A1 (en)	2004-10-28
KR20040018270A (ko)	2004-03-02
HRP20031019A2 (en)	2005-08-31
WO2003011851A2 (en)	2003-02-13
CO5540280A2 (es)	2005-07-29
AR036055A1 (es)	2004-08-04
JP4195377B2 (ja)	2008-12-10
CN1516697A (zh)	2004-07-28
HK1065787A1 (en)	2005-03-04
RU2003137578A (ru)	2005-05-20
MA27041A1 (fr)	2004-12-20
ZA200309260B (en)	2005-02-28
PE20030086A1 (es)	2003-02-08
DE60215652D1 (de)	2006-12-07
CZ200425A3 (cs)	2004-04-14
RU2289580C2 (ru)	2006-12-20
NO20035555D0 (no)	2003-12-12
US20030013757A1 (en)	2003-01-16
RS98203A (en)	2007-02-05
HUP0401233A2 (hu)	2004-10-28
CN1271066C (zh)	2006-08-23
IL159097A0 (en)	2004-05-12
MXPA03011501A (es)	2004-03-09

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