DE60215652D1 - Aromatische hydroxamsäurederivate, die sich als hdac inhibitoren eignen - Google Patents

Aromatische hydroxamsäurederivate, die sich als hdac inhibitoren eignen

Info

Publication number: DE60215652D1
Authority: DE; Germany
Prior art keywords: acid derivatives; hydroxamic acid; hdac inhibitors; aromatic hydroxamic; suited
Prior art date: 2001-06-15
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired - Fee Related

Application number

DE60215652T

Other languages

English (en)

Other versions

DE60215652T2 (de

Inventor

Ulrike Leser-Reiff

Tim Sattelkau

Gerd Zimmermann

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

F Hoffmann La Roche AG

Original Assignee

F Hoffmann La Roche AG

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2001-06-15

Filing date

2002-06-13

Publication date

2006-12-07

2002-06-13 Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG

2006-12-07 Publication of DE60215652D1 publication Critical patent/DE60215652D1/de

2007-08-23 Application granted granted Critical

2007-08-23 Publication of DE60215652T2 publication Critical patent/DE60215652T2/de

2022-06-14 Anticipated expiration legal-status Critical

Status Expired - Fee Related legal-status Critical Current

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/36—Radicals substituted by singly-bound nitrogen atoms
- C07D213/40—Acylated substituent nitrogen atom
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C259/00—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups
- C07C259/04—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids
- C07C259/10—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids having carbon atoms of hydroxamic groups bound to carbon atoms of six-membered aromatic rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
- C07D207/09—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/10—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms
- C07D211/16—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms with acylated ring nitrogen atom
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/04—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D307/10—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D307/14—Radicals substituted by nitrogen atoms not forming part of a nitro radical
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
- C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
- C07D317/50—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to atoms of the carbocyclic ring
- C07D317/58—Radicals substituted by nitrogen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/02—Systems containing only non-condensed rings with a three-membered ring
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/14—The ring being saturated
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2602/00—Systems containing two condensed rings
- C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
- C07C2602/04—One of the condensed rings being a six-membered aromatic ring
- C07C2602/08—One of the condensed rings being a six-membered aromatic ring the other ring being five-membered, e.g. indane
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2602/00—Systems containing two condensed rings
- C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
- C07C2602/04—One of the condensed rings being a six-membered aromatic ring
- C07C2602/10—One of the condensed rings being a six-membered aromatic ring the other ring being six-membered, e.g. tetraline

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Public Health (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Heterocyclic Compounds Containing Sulfur Atoms (AREA)
Plural Heterocyclic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Pyridine Compounds (AREA)

DE60215652T 2001-06-15 2002-06-13 Aromatische hydroxamsäurederivate, die sich als hdac inhibitoren eignen Expired - Fee Related DE60215652T2 (de)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
EP01114496		2001-06-15
EP01114496		2001-06-15
PCT/EP2002/006488 WO2003011851A2 (en)	2001-06-15	2002-06-13	Aromatic hydroxamic acid derivatives useful as hdac inhibitors

Publications (2)

Publication Number	Publication Date
DE60215652D1 true DE60215652D1 (de)	2006-12-07
DE60215652T2 DE60215652T2 (de)	2007-08-23

Family

ID=8177731

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DE60215652T Expired - Fee Related DE60215652T2 (de)	2001-06-15	2002-06-13	Aromatische hydroxamsäurederivate, die sich als hdac inhibitoren eignen

Country Status (33)

Country	Link
US (2)	US6784173B2 (de)
EP (1)	EP1401824B1 (de)
JP (1)	JP4195377B2 (de)
KR (2)	KR20090059172A (de)
CN (1)	CN1271066C (de)
AR (1)	AR036055A1 (de)
AT (1)	ATE343569T1 (de)
AU (1)	AU2002355626B2 (de)
BG (1)	BG108450A (de)
BR (1)	BR0210424A (de)
CA (1)	CA2449804A1 (de)
CO (1)	CO5540280A2 (de)
CZ (1)	CZ200425A3 (de)
DE (1)	DE60215652T2 (de)
EC (1)	ECSP034896A (de)
ES (1)	ES2272800T3 (de)
GT (1)	GT200200121A (de)
HK (1)	HK1065787A1 (de)
HR (1)	HRP20031019A2 (de)
HU (1)	HUP0401233A3 (de)
IL (1)	IL159097A0 (de)
MA (1)	MA27041A1 (de)
MX (1)	MXPA03011501A (de)
NO (1)	NO20035555D0 (de)
NZ (1)	NZ529874A (de)
PA (1)	PA8548001A1 (de)
PE (1)	PE20030086A1 (de)
PL (1)	PL366729A1 (de)
RS (1)	RS98203A (de)
RU (1)	RU2289580C2 (de)
SK (1)	SK172004A3 (de)
WO (1)	WO2003011851A2 (de)
ZA (1)	ZA200309260B (de)

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ATE399012T1 (de) *	2002-04-03	2008-07-15	Topotarget Uk Ltd	Carbaminsäurederivate enthaltend eine piperazin verknüpfung als hdac-inhibitoren
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US20100087328A1 (en) *	2005-03-01	2010-04-08	The Regents Of The University Of Michigan	Brm expression and related diagnostics
US7772238B2 (en)	2005-04-20	2010-08-10	Merck Sharp & Dohme Corp.	Benzothiophene hydroxamic acid derivatives
GB0509223D0 (en)	2005-05-05	2005-06-15	Chroma Therapeutics Ltd	Enzyme inhibitors
GB0509225D0 (en)	2005-05-05	2005-06-15	Chroma Therapeutics Ltd	Inhibitors of enzymatic activity
JP2008540574A (ja) *	2005-05-11	2008-11-20	タケダサンディエゴインコーポレイテッド	ヒストンデアセチラーゼ阻害剤
CN101263121A (zh) *	2005-07-14	2008-09-10	塔克达圣地亚哥公司	组蛋白脱乙酰基酶抑制剂
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GB0619753D0 (en)	2006-10-06	2006-11-15	Chroma Therapeutics Ltd	Enzyme inhibitors
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KR101536050B1 (ko) *	2013-07-30	2015-07-13	충북대학교 산학협력단	신규 이사틴 기반 히드록삼산 및 이를 유효성분으로 포함하는 항암용 조성물
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2002
- 2002-06-11 US US10/167,677 patent/US6784173B2/en not_active Expired - Fee Related
- 2002-06-12 PA PA20028548001A patent/PA8548001A1/es unknown
- 2002-06-13 AT AT02791436T patent/ATE343569T1/de not_active IP Right Cessation
- 2002-06-13 KR KR1020097010546A patent/KR20090059172A/ko not_active Application Discontinuation
- 2002-06-13 AU AU2002355626A patent/AU2002355626B2/en not_active Ceased
- 2002-06-13 IL IL15909702A patent/IL159097A0/xx unknown
- 2002-06-13 RS YUP-982/03A patent/RS98203A/sr unknown
- 2002-06-13 CN CNB028120108A patent/CN1271066C/zh not_active Expired - Fee Related
- 2002-06-13 DE DE60215652T patent/DE60215652T2/de not_active Expired - Fee Related
- 2002-06-13 HU HU0401233A patent/HUP0401233A3/hu unknown
- 2002-06-13 ES ES02791436T patent/ES2272800T3/es not_active Expired - Lifetime
- 2002-06-13 PE PE2002000510A patent/PE20030086A1/es not_active Application Discontinuation
- 2002-06-13 PL PL02366729A patent/PL366729A1/xx not_active Application Discontinuation
- 2002-06-13 AR ARP020102231A patent/AR036055A1/es unknown
- 2002-06-13 BR BR0210424-5A patent/BR0210424A/pt not_active IP Right Cessation
- 2002-06-13 CA CA002449804A patent/CA2449804A1/en not_active Abandoned
- 2002-06-13 WO PCT/EP2002/006488 patent/WO2003011851A2/en active Application Filing
- 2002-06-13 EP EP02791436A patent/EP1401824B1/de not_active Expired - Lifetime
- 2002-06-13 SK SK17-2004A patent/SK172004A3/sk unknown
- 2002-06-13 JP JP2003517043A patent/JP4195377B2/ja not_active Expired - Fee Related
- 2002-06-13 KR KR1020037016358A patent/KR100910958B1/ko not_active IP Right Cessation
- 2002-06-13 RU RU2003137578/04A patent/RU2289580C2/ru not_active IP Right Cessation
- 2002-06-13 MX MXPA03011501A patent/MXPA03011501A/es active IP Right Grant
- 2002-06-13 NZ NZ529874A patent/NZ529874A/xx unknown
- 2002-06-13 CZ CZ200425A patent/CZ200425A3/cs unknown
- 2002-06-14 GT GT200200121A patent/GT200200121A/es unknown
2003
- 2003-11-27 ZA ZA200309260A patent/ZA200309260B/en unknown
- 2003-12-09 HR HR20031019A patent/HRP20031019A2/xx not_active Application Discontinuation
- 2003-12-10 CO CO03108279A patent/CO5540280A2/es not_active Application Discontinuation
- 2003-12-11 EC EC2003004896A patent/ECSP034896A/es unknown
- 2003-12-12 NO NO20035555A patent/NO20035555D0/no not_active Application Discontinuation
- 2003-12-12 MA MA27440A patent/MA27041A1/fr unknown
- 2003-12-15 BG BG108450A patent/BG108450A/xx unknown
2004
- 2004-05-17 US US10/847,166 patent/US20040214862A1/en not_active Abandoned
- 2004-10-29 HK HK04108497A patent/HK1065787A1/xx not_active IP Right Cessation

Also Published As

Publication number	Publication date
CO5540280A2 (es)	2005-07-29
JP4195377B2 (ja)	2008-12-10
RS98203A (en)	2007-02-05
AU2002355626B2 (en)	2008-09-25
KR20040018270A (ko)	2004-03-02
DE60215652T2 (de)	2007-08-23
WO2003011851A2 (en)	2003-02-13
CN1271066C (zh)	2006-08-23
PL366729A1 (en)	2005-02-07
ATE343569T1 (de)	2006-11-15
PA8548001A1 (es)	2003-01-24
NZ529874A (en)	2004-12-24
KR100910958B1 (ko)	2009-08-05
KR20090059172A (ko)	2009-06-10
HRP20031019A2 (en)	2005-08-31
WO2003011851A3 (en)	2003-09-18
RU2289580C2 (ru)	2006-12-20
MA27041A1 (fr)	2004-12-20
US20040214862A1 (en)	2004-10-28
HUP0401233A2 (hu)	2004-10-28
NO20035555D0 (no)	2003-12-12
HUP0401233A3 (en)	2007-05-29
CZ200425A3 (cs)	2004-04-14
CA2449804A1 (en)	2003-02-13
US6784173B2 (en)	2004-08-31
EP1401824B1 (de)	2006-10-25
SK172004A3 (en)	2004-07-07
IL159097A0 (en)	2004-05-12
ECSP034896A (es)	2004-01-28
HK1065787A1 (en)	2005-03-04
JP2005502641A (ja)	2005-01-27
AR036055A1 (es)	2004-08-04
EP1401824A2 (de)	2004-03-31
US20030013757A1 (en)	2003-01-16
BG108450A (en)	2005-01-31
BR0210424A (pt)	2004-08-17
PE20030086A1 (es)	2003-02-08
CN1516697A (zh)	2004-07-28
MXPA03011501A (es)	2004-03-09
ES2272800T3 (es)	2007-05-01
RU2003137578A (ru)	2005-05-20
ZA200309260B (en)	2005-02-28
GT200200121A (es)	2003-06-19

Publication	Publication Date	Title
DE60215652D1 (de)	2006-12-07	Aromatische hydroxamsäurederivate, die sich als hdac inhibitoren eignen
DE60234264D1 (de)	2009-12-17	Spiro-hydantoin-verbindungen, die sich als entzündungshemmende mittel eignen
NO20040933L (no)	2004-03-03	Nye gamma-sekretaseinhibitorer.
ATE308544T1 (de)	2005-11-15	N-substituiete heteroaryloxy-aryl-spiro- pyrimidine-2,4,6-trion metalloproteinase inhibitoren
NO20034042L (no)	2003-11-10	Metallproteinase-inhibitorer
NO20034308L (no)	2003-11-26	Nye tyrokinase-inhibitorer
CY2015028I2 (el)	2016-07-27	Ενας αναστολεας ν-ακυλοσφιγγοσινο γλυκοζυλοτρανσφερασης
IS7138A (is)	2004-01-30	Alkýn-arýl fosfódíesterasa-4 hindrar
DE60234125D1 (de)	2009-12-03	E inhibitoren
ATE304015T1 (de)	2005-09-15	Triaryl-oxy-aryl-spiro-pyrimidin-2, 4, 6-trion metalloproteinase inhibitoren
PT1370553E (pt)	2006-09-29	Inibidores de rhoquinase
NO20035428D0 (no)	2003-12-05	Nye anti-ineffektiver
NO20034992D0 (no)	2003-11-10	Nye 4-aninlinokinolin-3-karboksamider
NO20034032D0 (no)	2003-09-11	Metallproteinase-inhibitorer
DE60124296D1 (de)	2006-12-14	Biphenylcarbonsäureamide, die sich als lipidsenker eignen
NO20034695D0 (no)	2003-10-20	Nye sammensetninger
DE60218213D1 (de)	2007-03-29	Pyridyloxyalkancarbonsäureamid-derivate verwendbar als fungizide
ATE308325T1 (de)	2005-11-15	Triaryl-oxy-aryloxy-pyrimidine-2,4,6-trion derivate als metalloproteinase inhibitoren
ATE287405T1 (de)	2005-02-15	5-halogen-6-phenyl-7-fluoroalkylamino- triazolopyrimidine als fungizide
NO20042942L (no)	2004-07-12	Mousse
SE0301854L (sv)	2003-08-26	Antiigensättningsbehandling
DE60324703D1 (de)	2008-12-24	Barbitursäure derivaten.
NO20033921D0 (no)	2003-09-04	Inhibitor av monoaminopptak
DK1532111T3 (da)	2007-10-22	2,5-disubstitueret 3-mercaptopentansyre
DE50206876D1 (de)	2006-06-29	Titan-Zirkonium-Legierung

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