[go: up one dir, main page]
More Web Proxy on the site http://driver.im/

SK10572002A3 - 3-Aminochinazolín-2,4-diónové antibakteriálne činidlá - Google Patents

3-Aminochinazolín-2,4-diónové antibakteriálne činidlá Download PDF

Info

Publication number
SK10572002A3
SK10572002A3 SK1057-2002A SK10572002A SK10572002A3 SK 10572002 A3 SK10572002 A3 SK 10572002A3 SK 10572002 A SK10572002 A SK 10572002A SK 10572002 A3 SK10572002 A3 SK 10572002A3
Authority
SK
Slovakia
Prior art keywords
amino
cyclopropyl
dione
quinazoline
fluoro
Prior art date
Application number
SK1057-2002A
Other languages
English (en)
Slovak (sk)
Inventor
Paul Bird
Edmund Lee Ellsworth
Dai Quoc Nguyen
Joseph Peter Sanchez
Howard Daniel Hollis Showalter
Rajeshwar Singh
Michael Andrew Stier
Tuan Phong Tran
Brian Morgan Watson
Judy Yip
Original Assignee
Warner-Lambert Company
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Warner-Lambert Company filed Critical Warner-Lambert Company
Publication of SK10572002A3 publication Critical patent/SK10572002A3/sk

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/95—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in positions 2 and 4
    • C07D239/96—Two oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/10—Spiro-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Communicable Diseases (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Virology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Paper (AREA)
SK1057-2002A 2000-01-24 2000-12-12 3-Aminochinazolín-2,4-diónové antibakteriálne činidlá SK10572002A3 (sk)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US17825200P 2000-01-24 2000-01-24
US24126700P 2000-10-18 2000-10-18
PCT/US2000/033656 WO2001053273A1 (en) 2000-01-24 2000-12-12 3-aminoquinazolin-2,4-dione antibacterial agents

Publications (1)

Publication Number Publication Date
SK10572002A3 true SK10572002A3 (sk) 2003-10-07

Family

ID=26874138

Family Applications (1)

Application Number Title Priority Date Filing Date
SK1057-2002A SK10572002A3 (sk) 2000-01-24 2000-12-12 3-Aminochinazolín-2,4-diónové antibakteriálne činidlá

Country Status (38)

Country Link
US (2) US7094780B1 (no)
EP (1) EP1255739B1 (no)
JP (1) JP4811978B2 (no)
KR (1) KR20020067701A (no)
CN (1) CN1425008A (no)
AP (1) AP2002002603A0 (no)
AR (1) AR030186A1 (no)
AT (1) ATE398110T1 (no)
AU (1) AU783078B2 (no)
BG (1) BG107023A (no)
BR (1) BR0017010A (no)
CA (1) CA2393802C (no)
CO (1) CO5320600A1 (no)
CR (1) CR6709A (no)
DE (1) DE60039194D1 (no)
EA (1) EA005585B1 (no)
EE (1) EE200200412A (no)
ES (1) ES2304992T3 (no)
GE (1) GEP20053429B (no)
HK (1) HK1054237A1 (no)
HN (1) HN2001000009A (no)
HR (1) HRP20020696A2 (no)
HU (1) HUP0204101A3 (no)
IL (1) IL150393A0 (no)
IS (1) IS6448A (no)
MA (1) MA26866A1 (no)
MX (1) MXPA02005989A (no)
NO (1) NO20023516L (no)
OA (1) OA12316A (no)
PA (1) PA8510101A1 (no)
PE (1) PE20011060A1 (no)
PL (1) PL356837A1 (no)
SK (1) SK10572002A3 (no)
SV (1) SV2001000288A (no)
TN (1) TNSN01011A1 (no)
UY (1) UY26551A1 (no)
WO (1) WO2001053273A1 (no)
YU (1) YU55902A (no)

Families Citing this family (45)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TR200505120T2 (tr) 1997-09-15 2006-08-21 The Procter & Gamble Company Antimikrobiyal kuinolonlar, bunların bileşimleri ve kullanımları.
EP1395585B1 (en) 2001-05-30 2006-01-04 Warner-Lambert Company LLC Antibacterial agents
CA2446963A1 (en) * 2001-06-19 2002-12-27 Warner-Lambert Company Llc Quinazolinediones as antibacterial agents
US6900224B2 (en) * 2002-07-31 2005-05-31 The Procter & Gamble Company Antimicrobial quinolones, their compositions and uses
CA2538420A1 (en) * 2003-09-12 2005-03-24 Warner-Lambert Company Llc Quinolone antibacterial agents
WO2005026153A1 (en) * 2003-09-12 2005-03-24 Warner-Lambert Company Llc Quinazoline-2, 4-diones as antibacterial agents
MXPA06005550A (es) * 2003-11-18 2006-08-17 Warner Lambert Co Agentes antibacterianos.
WO2006019965A2 (en) * 2004-07-16 2006-02-23 Takeda San Diego, Inc. Dipeptidyl peptidase inhibitors
GB0416730D0 (en) 2004-07-27 2004-09-01 Novartis Ag Organic compounds
ES2332529T3 (es) * 2005-01-26 2010-02-08 F. Hoffmann-La Roche Ag Derivados de fenil-metanona y su empleo como inhibidores del transportador 1 de glicina.
GB0507298D0 (en) * 2005-04-11 2005-05-18 Novartis Ag Organic compounds
US7977346B2 (en) 2006-01-17 2011-07-12 Guoqing Paul Chen Spiro compounds and methods of use
MY148393A (en) 2006-03-28 2013-04-15 Taigen Biotechnology Co Ltd Malate salts, and polymorphs of (3s, 5s)-7-[3-amino-5-methyl-piperidinyl]-1-cyclopropyl-1,4-dihydro-8-methoxy-4-oxo-3-quinolinecarboxylic acid
WO2007110835A2 (en) 2006-03-28 2007-10-04 The Procter & Gamble Company A coupling process for preparing quinolone intermediates
US20080139574A1 (en) 2006-11-30 2008-06-12 Cadila Healthcare Limited Novel quinoline derivatives
WO2009096667A2 (ko) * 2008-01-30 2009-08-06 Shin Poong Pharmaceutical Co., Ltd. 신규한 퀴나졸린-2,4-디온 유도체 및 이를 함유하는 뇌신경질환 예방 및 치료용 의약 조성물
WO2011031745A1 (en) 2009-09-09 2011-03-17 Achaogen, Inc. Antibacterial fluoroquinolone analogs
WO2012088266A2 (en) 2010-12-22 2012-06-28 Incyte Corporation Substituted imidazopyridazines and benzimidazoles as inhibitors of fgfr3
AR085806A1 (es) 2011-03-15 2013-10-30 Trius Therapeutics Inc Inhibidores triciclicos de girasa
WO2013091539A1 (zh) * 2011-12-21 2013-06-27 江苏恒瑞医药股份有限公司 吡咯并六元杂芳环类衍生物、其制备方法及其在医药上的应用
PT3176170T (pt) 2012-06-13 2019-02-05 Incyte Holdings Corp Compostos tricíclicos substituídos como inibidores de fgfr
WO2014026125A1 (en) 2012-08-10 2014-02-13 Incyte Corporation Pyrazine derivatives as fgfr inhibitors
US10865216B2 (en) 2012-09-12 2020-12-15 Merck Sharp & Dohme Corp. Tricyclic Gyrase inhibitors
US9266892B2 (en) 2012-12-19 2016-02-23 Incyte Holdings Corporation Fused pyrazoles as FGFR inhibitors
KR102469849B1 (ko) 2013-04-19 2022-11-23 인사이트 홀딩스 코포레이션 Fgfr 저해제로서 이환식 헤테로사이클
US10851105B2 (en) 2014-10-22 2020-12-01 Incyte Corporation Bicyclic heterocycles as FGFR4 inhibitors
US9580423B2 (en) 2015-02-20 2017-02-28 Incyte Corporation Bicyclic heterocycles as FGFR4 inhibitors
MA41551A (fr) 2015-02-20 2017-12-26 Incyte Corp Hétérocycles bicycliques utilisés en tant qu'inhibiteurs de fgfr4
SG11201706287PA (en) 2015-02-20 2017-09-28 Incyte Corp Bicyclic heterocycles as fgfr inhibitors
CN108530448A (zh) * 2017-03-02 2018-09-14 浙江司太立制药股份有限公司 含有碱性氮杂螺环片段的苯并噻嗪-4-酮类化合物及其制备方法
AR111960A1 (es) 2017-05-26 2019-09-04 Incyte Corp Formas cristalinas de un inhibidor de fgfr y procesos para su preparación
PE20210920A1 (es) 2018-05-04 2021-05-19 Incyte Corp Formas solidas de un inhibidor de fgfr y procesos para prepararlas
CN112566912A (zh) 2018-05-04 2021-03-26 因赛特公司 Fgfr抑制剂的盐
CN111620866A (zh) * 2019-02-27 2020-09-04 南京药石科技股份有限公司 一种顺式-7,7-二氟-六氢-1H 吡咯并[3,4-c]吡啶衍生物及其制备方法
WO2020185532A1 (en) 2019-03-08 2020-09-17 Incyte Corporation Methods of treating cancer with an fgfr inhibitor
US11591329B2 (en) 2019-07-09 2023-02-28 Incyte Corporation Bicyclic heterocycles as FGFR inhibitors
US12122767B2 (en) 2019-10-01 2024-10-22 Incyte Corporation Bicyclic heterocycles as FGFR inhibitors
TW202128685A (zh) 2019-10-14 2021-08-01 美商英塞特公司 作為ｆｇｆｒ抑制劑之雙環雜環
US11566028B2 (en) 2019-10-16 2023-01-31 Incyte Corporation Bicyclic heterocycles as FGFR inhibitors
EP4069696A1 (en) 2019-12-04 2022-10-12 Incyte Corporation Tricyclic heterocycles as fgfr inhibitors
MX2022006691A (es) 2019-12-04 2022-09-19 Incyte Corp Derivados de un inhibidor de receptores del factor de crecimiento de fibroblastos (fgfr).
WO2021146424A1 (en) 2020-01-15 2021-07-22 Incyte Corporation Bicyclic heterocycles as fgfr inhibitors
CN111499513B (zh) * 2020-04-24 2023-03-14 上海毕得医药科技股份有限公司 一种2,3,4,5-四溴苯甲酸酯的合成方法
JP2024513575A (ja) 2021-04-12 2024-03-26 インサイト・コーポレイション Ｆｇｆｒ阻害剤及びネクチン－４標的化剤を含む併用療法
TW202313611A (zh) 2021-06-09 2023-04-01 美商英塞特公司 作為ｆｇｆｒ抑制劑之三環雜環

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1068263B (no) * 1959-11-05
FR1203542A (fr) * 1958-02-25 1960-01-19 Rhone Poulenc Sa Nouveaux dérivés de la phénothiazine comportant en position 10 une chaîne pipérazinique et leurs procédés de préparation
ATE8626T1 (de) 1980-03-10 1984-08-15 Berri-Balzac Societe Dite: 3-amino-(1h,3h)-2,4-chinazolindionderivate.
GB2097784A (en) * 1981-04-28 1982-11-10 Davidson Dr John Stirton Dihydrobenzotriazepine diones; aminoquinazoline diones
WO1994014809A1 (de) 1992-12-23 1994-07-07 Byk Gulden Lomberg Chemische Fabrik Gmbh Anellierte uracilderivate
AU6908398A (en) 1996-10-28 1998-05-22 Versicor Inc Fused 2,4-pyrimidinedione combinatorial libraries and biologically active fused 2,4-pyramidinediones
WO1999021840A1 (en) * 1997-10-28 1999-05-06 Warner-Lambert Company Novel 7-substituted quinazolin-2,4-diones useful as antibacterial agents
EA003640B1 (ru) 1998-05-26 2003-08-28 Варнер-Ламберт Компани Бициклические пиримидины и бициклические 3,4-дигидропиримидины как ингибиторы клеточной пролиферации
ATE305003T1 (de) * 1998-12-11 2005-10-15 Hoffmann La Roche Zyklische hydrazinderivate als tnf-alpha inhibitoren

Also Published As

Publication number Publication date
EA005585B1 (ru) 2005-04-28
NO20023516D0 (no) 2002-07-23
CO5320600A1 (es) 2003-09-30
ES2304992T3 (es) 2008-11-01
BG107023A (en) 2003-04-30
CN1425008A (zh) 2003-06-18
DE60039194D1 (de) 2008-07-24
IL150393A0 (en) 2002-12-01
ATE398110T1 (de) 2008-07-15
KR20020067701A (ko) 2002-08-23
HRP20020696A2 (en) 2003-12-31
WO2001053273A1 (en) 2001-07-26
EE200200412A (et) 2003-10-15
HN2001000009A (es) 2001-06-13
YU55902A (sh) 2006-01-16
MA26866A1 (fr) 2004-12-20
CA2393802C (en) 2011-04-19
HUP0204101A3 (en) 2004-05-28
AU2089901A (en) 2001-07-31
PA8510101A1 (es) 2003-06-30
SV2001000288A (es) 2001-11-30
JP4811978B2 (ja) 2011-11-09
MXPA02005989A (es) 2002-10-23
EP1255739A1 (en) 2002-11-13
US20060183762A1 (en) 2006-08-17
IS6448A (is) 2002-06-27
TNSN01011A1 (en) 2005-11-10
NO20023516L (no) 2002-07-23
PE20011060A1 (es) 2001-10-12
UY26551A1 (es) 2001-04-30
CA2393802A1 (en) 2001-07-26
BR0017010A (pt) 2002-11-05
US20060287308A1 (en) 2006-12-21
US7582627B2 (en) 2009-09-01
OA12316A (en) 2006-05-15
EA200200661A1 (ru) 2003-02-27
AP2002002603A0 (en) 2002-09-30
AR030186A1 (es) 2003-08-13
AU783078B2 (en) 2005-09-22
CR6709A (es) 2003-11-25
US7094780B1 (en) 2006-08-22
EP1255739B1 (en) 2008-06-11
HUP0204101A2 (hu) 2003-04-28
GEP20053429B (en) 2005-01-25
PL356837A1 (en) 2004-07-12
JP2003520277A (ja) 2003-07-02
HK1054237A1 (zh) 2003-11-21

Similar Documents

Publication Publication Date Title
SK10572002A3 (sk) 3-Aminochinazolín-2,4-diónové antibakteriálne činidlá
EP3429994B1 (en) 2-cyanoisoindoline derivatives for treating cancer
EP3414234B1 (en) Bruton's tyrosine kinase inhibitors
US6413980B1 (en) Nitrogen containing heterobicycles as factor Xa inhibitors
US6936619B2 (en) Quinazolinone compounds useful in therapy
EP2789614B1 (en) Azaindazoles as Btk kinase modulators and use thereof
EP3080131A1 (en) Imidazopyridazine compounds useful as modulators of il-12, il-23 and/or ifn alpha responses
HU196986B (en) Process for producing new naphtiridine- and quinoline-carboxylic acids of antibacterial activity and pharmaceutical compositions containing them
CA2669686A1 (en) 7-substituted purine derivatives for immunosuppression
JPH06508366A (ja) イミダゾ〔１，５−ａ〕キノキサリン
US6825199B2 (en) 7-Substituted quinazolin-2,4-diones useful as antibacterial agents
EP3475283B1 (en) Novel[1,2,3]triazolo[4,5-d]pyrimidine derivatives
US6858616B2 (en) Nitrogen containing heterobicycles as factor Xa inhibitors
US20030114666A1 (en) Antibacterial agents