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HK1054237A1 - 3-氨基喹唑啉-2，4-二酮抗菌劑 - Google Patents

3-氨基喹唑啉-2，4-二酮抗菌劑

Info

Publication number
HK1054237A1
HK1054237A1 HK03106519.6A HK03106519A HK1054237A1 HK 1054237 A1 HK1054237 A1 HK 1054237A1 HK 03106519 A HK03106519 A HK 03106519A HK 1054237 A1 HK1054237 A1 HK 1054237A1
Authority
HK
Hong Kong
Prior art keywords
aminoquinazolin
antibacterial agents
dione
dione antibacterial
agents
Prior art date
Application number
HK03106519.6A
Other languages
English (en)
Inventor
P‧伯德
E‧L‧艾爾斯沃斯
D‧Q‧恩吉安
J‧P‧桑切茲
H‧D‧H‧舒沃爾特
R‧辛格
M‧A‧斯蒂爾
T‧P‧特蘭
B‧M‧沃特森
J‧伊普
Original Assignee
沃尼爾‧朗伯公司
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 沃尼爾‧朗伯公司 filed Critical 沃尼爾‧朗伯公司
Publication of HK1054237A1 publication Critical patent/HK1054237A1/zh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/95—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in positions 2 and 4
    • C07D239/96—Two oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/10—Spiro-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Virology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Paper (AREA)
HK03106519.6A 2000-01-24 2003-09-11 3-氨基喹唑啉-2，4-二酮抗菌劑 HK1054237A1 (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US17825200P 2000-01-24 2000-01-24
US24126700P 2000-10-18 2000-10-18
PCT/US2000/033656 WO2001053273A1 (en) 2000-01-24 2000-12-12 3-aminoquinazolin-2,4-dione antibacterial agents

Publications (1)

Publication Number Publication Date
HK1054237A1 true HK1054237A1 (zh) 2003-11-21

Family

ID=26874138

Family Applications (1)

Application Number Title Priority Date Filing Date
HK03106519.6A HK1054237A1 (zh) 2000-01-24 2003-09-11 3-氨基喹唑啉-2，4-二酮抗菌劑

Country Status (38)

Country Link
US (2) US7094780B1 (zh)
EP (1) EP1255739B1 (zh)
JP (1) JP4811978B2 (zh)
KR (1) KR20020067701A (zh)
CN (1) CN1425008A (zh)
AP (1) AP2002002603A0 (zh)
AR (1) AR030186A1 (zh)
AT (1) ATE398110T1 (zh)
AU (1) AU783078B2 (zh)
BG (1) BG107023A (zh)
BR (1) BR0017010A (zh)
CA (1) CA2393802C (zh)
CO (1) CO5320600A1 (zh)
CR (1) CR6709A (zh)
DE (1) DE60039194D1 (zh)
EA (1) EA005585B1 (zh)
EE (1) EE200200412A (zh)
ES (1) ES2304992T3 (zh)
GE (1) GEP20053429B (zh)
HK (1) HK1054237A1 (zh)
HN (1) HN2001000009A (zh)
HR (1) HRP20020696A2 (zh)
HU (1) HUP0204101A3 (zh)
IL (1) IL150393A0 (zh)
IS (1) IS6448A (zh)
MA (1) MA26866A1 (zh)
MX (1) MXPA02005989A (zh)
NO (1) NO20023516L (zh)
OA (1) OA12316A (zh)
PA (1) PA8510101A1 (zh)
PE (1) PE20011060A1 (zh)
PL (1) PL356837A1 (zh)
SK (1) SK10572002A3 (zh)
SV (1) SV2001000288A (zh)
TN (1) TNSN01011A1 (zh)
UY (1) UY26551A1 (zh)
WO (1) WO2001053273A1 (zh)
YU (1) YU55902A (zh)

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EP1015445B1 (en) 1997-09-15 2009-02-25 The Procter & Gamble Company Antimicrobial quinolones, their compositions and uses
ATE315038T1 (de) 2001-05-30 2006-02-15 Warner Lambert Co Antibakterielle mittel
CA2446963A1 (en) * 2001-06-19 2002-12-27 Warner-Lambert Company Llc Quinazolinediones as antibacterial agents
US6900224B2 (en) * 2002-07-31 2005-05-31 The Procter & Gamble Company Antimicrobial quinolones, their compositions and uses
WO2005026153A1 (en) * 2003-09-12 2005-03-24 Warner-Lambert Company Llc Quinazoline-2, 4-diones as antibacterial agents
JP2007505096A (ja) * 2003-09-12 2007-03-08 ワーナー−ランバート カンパニー リミティド ライアビリティー カンパニー キノロン抗菌剤
CA2546339A1 (en) * 2003-11-18 2005-06-02 Warner-Lambert Company Llc Antibacterial aminoquinazolidinedione derivatives
WO2006019965A2 (en) * 2004-07-16 2006-02-23 Takeda San Diego, Inc. Dipeptidyl peptidase inhibitors
GB0416730D0 (en) 2004-07-27 2004-09-01 Novartis Ag Organic compounds
BRPI0607241A2 (pt) * 2005-01-26 2009-08-25 Hoffmann La Roche derivados de fenil metanona e o uso dos mesmos como inibidores do transportador de glicina 1
GB0507298D0 (en) * 2005-04-11 2005-05-18 Novartis Ag Organic compounds
US7977346B2 (en) 2006-01-17 2011-07-12 Guoqing Paul Chen Spiro compounds and methods of use
CA2647454A1 (en) 2006-03-28 2007-10-04 The Procter & Gamble Company A coupling process for preparing quinolone intermediates
WO2007110834A2 (en) 2006-03-28 2007-10-04 The Procter & Gamble Company Malate salts, and polymorphs of (3s,5s)-7-[3-amino-5-methyl-piperidinyl]-1-cyclopropyl-1,4-dihydro-8-methoxy-4-oxo-3-quinolinecarboxylic acid
US20080139574A1 (en) 2006-11-30 2008-06-12 Cadila Healthcare Limited Novel quinoline derivatives
US8404696B2 (en) * 2008-01-30 2013-03-26 Shin Poong Pharmaceutical Co., Ltd. Quinazoline-2,4-dione derivative, and medical compositions for the prophylaxis and treatment of cranial nerve disease containing the same
WO2011031745A1 (en) 2009-09-09 2011-03-17 Achaogen, Inc. Antibacterial fluoroquinolone analogs
US8754114B2 (en) 2010-12-22 2014-06-17 Incyte Corporation Substituted imidazopyridazines and benzimidazoles as inhibitors of FGFR3
BR112013023266B8 (pt) 2011-03-15 2021-04-06 L Livermore Nat Security Llc inibidores da girase tricíclicos
MX358679B (es) * 2011-12-21 2018-08-31 Jiangsu Hengrui Medicine Co Derivado de anillo de heteroarilo de seis miembros de pirrol, método de preparación del mismo y usos médicos del mismo.
MX359293B (es) 2012-06-13 2018-09-24 Incyte Holdings Corp Compuestos triciclicos sustituidos como inhibidores del receptor del factor de crecimiento de fibroblastos (fgfr).
US9388185B2 (en) 2012-08-10 2016-07-12 Incyte Holdings Corporation Substituted pyrrolo[2,3-b]pyrazines as FGFR inhibitors
US10865216B2 (en) 2012-09-12 2020-12-15 Merck Sharp & Dohme Corp. Tricyclic Gyrase inhibitors
US9266892B2 (en) 2012-12-19 2016-02-23 Incyte Holdings Corporation Fused pyrazoles as FGFR inhibitors
SG11201508328PA (en) 2013-04-19 2015-11-27 Incyte Corp Bicyclic heterocycles as fgfr inhibitors
US10851105B2 (en) 2014-10-22 2020-12-01 Incyte Corporation Bicyclic heterocycles as FGFR4 inhibitors
US9580423B2 (en) 2015-02-20 2017-02-28 Incyte Corporation Bicyclic heterocycles as FGFR4 inhibitors
MA41551A (fr) 2015-02-20 2017-12-26 Incyte Corp Hétérocycles bicycliques utilisés en tant qu'inhibiteurs de fgfr4
EP3617205B1 (en) 2015-02-20 2021-08-04 Incyte Corporation Bicyclic heterocycles as fgfr inhibitors
CN108530448A (zh) * 2017-03-02 2018-09-14 浙江司太立制药股份有限公司 含有碱性氮杂螺环片段的苯并噻嗪-4-酮类化合物及其制备方法
AR111960A1 (es) 2017-05-26 2019-09-04 Incyte Corp Formas cristalinas de un inhibidor de fgfr y procesos para su preparación
BR112020022373A2 (pt) 2018-05-04 2021-02-02 Incyte Corporation sais de um inibidor de fgfr
MX2020011718A (es) 2018-05-04 2021-02-15 Incyte Corp Formas solidas de un inhibidor de receptores del factor de crecimiento de fibroblastos (fgfr) y procesos para prepararlas.
CN111620866A (zh) * 2019-02-27 2020-09-04 南京药石科技股份有限公司 一种顺式-7,7-二氟-六氢-1H 吡咯并[3,4-c]吡啶衍生物及其制备方法
US11628162B2 (en) 2019-03-08 2023-04-18 Incyte Corporation Methods of treating cancer with an FGFR inhibitor
US11591329B2 (en) 2019-07-09 2023-02-28 Incyte Corporation Bicyclic heterocycles as FGFR inhibitors
US12122767B2 (en) 2019-10-01 2024-10-22 Incyte Corporation Bicyclic heterocycles as FGFR inhibitors
JOP20220083A1 (ar) 2019-10-14 2023-01-30 Incyte Corp حلقات غير متجانسة ثنائية الحلقة كمثبطات لـ fgfr
WO2021076728A1 (en) 2019-10-16 2021-04-22 Incyte Corporation Bicyclic heterocycles as fgfr inhibitors
CR20220285A (es) 2019-12-04 2022-10-27 Incyte Corp Derivados de un inhibidor de fgfr
US11897891B2 (en) 2019-12-04 2024-02-13 Incyte Corporation Tricyclic heterocycles as FGFR inhibitors
WO2021146424A1 (en) 2020-01-15 2021-07-22 Incyte Corporation Bicyclic heterocycles as fgfr inhibitors
CN111499513B (zh) * 2020-04-24 2023-03-14 上海毕得医药科技股份有限公司 一种2,3,4,5-四溴苯甲酸酯的合成方法
JP2024513575A (ja) 2021-04-12 2024-03-26 インサイト・コーポレイション Ｆｇｆｒ阻害剤及びネクチン－４標的化剤を含む併用療法
JP2024522189A (ja) 2021-06-09 2024-06-11 インサイト・コーポレイション Ｆｇｆｒ阻害剤としての三環式ヘテロ環

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DE1068263B (zh) * 1959-11-05
FR1203542A (fr) * 1958-02-25 1960-01-19 Rhone Poulenc Sa Nouveaux dérivés de la phénothiazine comportant en position 10 une chaîne pipérazinique et leurs procédés de préparation
ATE8626T1 (de) 1980-03-10 1984-08-15 Berri-Balzac Societe Dite: 3-amino-(1h,3h)-2,4-chinazolindionderivate.
GB2097784A (en) 1981-04-28 1982-11-10 Davidson Dr John Stirton Dihydrobenzotriazepine diones; aminoquinazoline diones
AU5813394A (en) 1992-12-23 1994-07-19 Byk Gulden Lomberg Chemische Fabrik Gmbh Anellated uracil derivates
WO1998018781A2 (en) 1996-10-28 1998-05-07 Versicor, Inc. Fused 2,4-pyrimidinedione combinatorial libraries, their preparation and the use of fused 2,4-pyrimidinediones derivatives as antimicrobial agents
EP1028950B1 (en) 1997-10-28 2003-05-02 Warner-Lambert Company LLC 7-substituted quinazolin-2,4-diones useful as antibacterial agents
BR9911590A (pt) * 1998-05-26 2001-02-13 Warner Lambert Co Pirimidinas bicìclicas e 3,4-diidropirimidinas bicìclicas como inibidores da proliferação celular
BR9916005A (pt) * 1998-12-11 2001-09-04 Hoffmann La Roche Derivados de hidrazina cìclicos como inibidores do tnf-alfa

Also Published As

Publication number Publication date
AU783078B2 (en) 2005-09-22
JP2003520277A (ja) 2003-07-02
SK10572002A3 (sk) 2003-10-07
EA200200661A1 (ru) 2003-02-27
DE60039194D1 (de) 2008-07-24
CO5320600A1 (es) 2003-09-30
CR6709A (es) 2003-11-25
ES2304992T3 (es) 2008-11-01
PL356837A1 (en) 2004-07-12
TNSN01011A1 (en) 2005-11-10
MXPA02005989A (es) 2002-10-23
HUP0204101A3 (en) 2004-05-28
WO2001053273A1 (en) 2001-07-26
EP1255739B1 (en) 2008-06-11
KR20020067701A (ko) 2002-08-23
EE200200412A (et) 2003-10-15
AR030186A1 (es) 2003-08-13
CN1425008A (zh) 2003-06-18
PA8510101A1 (es) 2003-06-30
BG107023A (en) 2003-04-30
US20060287308A1 (en) 2006-12-21
OA12316A (en) 2006-05-15
AU2089901A (en) 2001-07-31
NO20023516D0 (no) 2002-07-23
IS6448A (is) 2002-06-27
JP4811978B2 (ja) 2011-11-09
US7582627B2 (en) 2009-09-01
YU55902A (sh) 2006-01-16
NO20023516L (no) 2002-07-23
IL150393A0 (en) 2002-12-01
HUP0204101A2 (hu) 2003-04-28
PE20011060A1 (es) 2001-10-12
EP1255739A1 (en) 2002-11-13
AP2002002603A0 (en) 2002-09-30
CA2393802C (en) 2011-04-19
US7094780B1 (en) 2006-08-22
US20060183762A1 (en) 2006-08-17
HRP20020696A2 (en) 2003-12-31
EA005585B1 (ru) 2005-04-28
MA26866A1 (fr) 2004-12-20
GEP20053429B (en) 2005-01-25
UY26551A1 (es) 2001-04-30
HN2001000009A (es) 2001-06-13
ATE398110T1 (de) 2008-07-15
BR0017010A (pt) 2002-11-05
CA2393802A1 (en) 2001-07-26
SV2001000288A (es) 2001-11-30

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