SI2658844T1 - Novi derivati pirimidina, njihova priprava in njihova farmacevtska uporaba kot inhibitorje AKT(PKB) fosforilacije - Google Patents
Novi derivati pirimidina, njihova priprava in njihova farmacevtska uporaba kot inhibitorje AKT(PKB) fosforilacijeInfo
- Publication number
- SI2658844T1 SI2658844T1 SI201131075A SI201131075A SI2658844T1 SI 2658844 T1 SI2658844 T1 SI 2658844T1 SI 201131075 A SI201131075 A SI 201131075A SI 201131075 A SI201131075 A SI 201131075A SI 2658844 T1 SI2658844 T1 SI 2658844T1
- Authority
- SI
- Slovenia
- Prior art keywords
- pkb
- akt
- preparation
- pharmaceutical use
- pyrimidine derivatives
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/10—Spiro-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (11)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR1061300A FR2969610B1 (fr) | 2010-12-28 | 2010-12-28 | Nouveaux derives de (6-oxo-1,6-dihydro-pyrimidin-2-yl)-indolinamide, leur preparation et leur utilisation pharmaceutique comme inhibiteurs de phosphorylation d'akt(pkb) |
| FR1061298A FR2969609B1 (fr) | 2010-12-28 | 2010-12-28 | Nouveaux derives de 6-oxo-dihydro-pyrimidine, leur preparation et leur utilisation pharmaceutique comme inhibiteurs de phosphorylation d'akt(pkb) |
| FR1061303A FR2969607B1 (fr) | 2010-12-28 | 2010-12-28 | Nouveaux derives de thiopyrimidinones, leur preparation et leur utilisation pharmaceutique comme inhibiteurs de phosphorylation d'akt(pkb) |
| FR1061301A FR2969614A1 (fr) | 2010-12-28 | 2010-12-28 | Nouveaux derives de pyrimidinones, leur preparation et leur utilisation pharmaceutique comme inhibiteurs de phosphorylation d'akt(pkb) |
| FR1061297A FR2969608B1 (fr) | 2010-12-28 | 2010-12-28 | Nouveaux derives de (5-halo-6-oxo-1,6-dihydro-pyrimidin-2-yl)-amide, leur preparation et leur utilisation pharmaceutique comme inhibiteurs de phosphorylation d'akt(pkb) |
| FR1159316 | 2011-10-14 | ||
| FR1159315 | 2011-10-14 | ||
| FR1159313 | 2011-10-14 | ||
| FR1159317 | 2011-10-14 | ||
| PCT/EP2011/073875 WO2012089633A1 (fr) | 2010-12-28 | 2011-12-22 | Nouveaux derives de pyrimidines, leur preparation et leur utilisation pharmaceutique comme inhibiteurs de phosphorylation d'akt(pkb) |
| EP11805849.4A EP2658844B1 (fr) | 2010-12-28 | 2011-12-22 | Nouveaux derives de pyrimidines, leur preparation et leur utilisation pharmaceutique comme inhibiteurs de phosphorylation d'akt(pkb) |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SI2658844T1 true SI2658844T1 (sl) | 2017-02-28 |
Family
ID=45464546
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SI201131075A SI2658844T1 (sl) | 2010-12-28 | 2011-12-22 | Novi derivati pirimidina, njihova priprava in njihova farmacevtska uporaba kot inhibitorje AKT(PKB) fosforilacije |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US9133168B2 (sl) |
| EP (1) | EP2658844B1 (sl) |
| CY (1) | CY1118858T1 (sl) |
| DK (1) | DK2658844T3 (sl) |
| ES (1) | ES2612492T3 (sl) |
| HR (1) | HRP20170119T1 (sl) |
| HU (1) | HUE030393T2 (sl) |
| LT (1) | LT2658844T (sl) |
| PL (1) | PL2658844T3 (sl) |
| PT (1) | PT2658844T (sl) |
| SI (1) | SI2658844T1 (sl) |
| WO (1) | WO2012089633A1 (sl) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103819422A (zh) * | 2014-03-18 | 2014-05-28 | 南通佰华生物医药研究有限公司 | 一种制备手性n-取代-2-吗啉甲醇类化合物的方法 |
| BR112016028876A2 (pt) | 2014-06-13 | 2017-08-22 | Gilead Sciences Inc | composto, composição farmacêutica, método para tratar uma doença ou condição em um ser humano, kit, e, uso de um composto, um sal, isômero ou uma mistura farmaceuticamente aceitável dos mesmos. |
| WO2015191745A1 (en) | 2014-06-13 | 2015-12-17 | Gilead Sciences, Inc. | Phosphatidylinositol 3-kinase inhibitors |
| JP6455995B2 (ja) | 2014-06-13 | 2019-01-23 | ギリアード サイエンシーズ， インコーポレイテッド | ホスファチジルイノシトール３−キナーゼ阻害剤 |
| AU2015274635B2 (en) | 2014-06-13 | 2018-04-19 | Gilead Sciences, Inc. | Phosphatidylinositol 3-kinase inhibitors |
| EA201692265A1 (ru) | 2014-06-13 | 2017-05-31 | Джилид Сайэнс, Инк. | Ингибиторы фосфатидилинозитол-3-киназы |
| TW201813963A (zh) | 2016-09-23 | 2018-04-16 | 美商基利科學股份有限公司 | 磷脂醯肌醇3-激酶抑制劑 |
| TW201825465A (zh) | 2016-09-23 | 2018-07-16 | 美商基利科學股份有限公司 | 磷脂醯肌醇3-激酶抑制劑 |
| WO2018057808A1 (en) | 2016-09-23 | 2018-03-29 | Gilead Sciences, Inc. | Benzimidazole derivatives and their use as phosphatidylinositol 3-kinase inhibitors |
| CN106966951B (zh) * | 2017-04-21 | 2020-01-31 | 常州佳德医药科技有限公司 | 4-氟-2-甲基吲哚及其制备方法和应用 |
| KR20240131463A (ko) | 2020-05-05 | 2024-08-30 | 뉴베일런트, 아이엔씨. | 헤테로방향족 거대환식 에터 화학치료제 |
| KR102699528B1 (ko) | 2020-05-05 | 2024-08-30 | 뉴베일런트, 아이엔씨. | 헤테로방향족 거대환식 에터 화학치료제 |
| CN115707685A (zh) * | 2021-08-20 | 2023-02-21 | 中国石油化工股份有限公司 | 一种制备胺-环氧卤丙烷聚合单体的方法及产物和系统 |
| EP4408844A1 (en) | 2021-10-01 | 2024-08-07 | Nuvalent, Inc. | Solid forms, pharmaceutical compositions and preparation of heteroaromatic macrocyclic ether compounds |
Family Cites Families (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4416884A (en) | 1978-04-12 | 1983-11-22 | Otsuka Pharmaceutical Co., Ltd. | Piperazinylbenzoheterocyclic compounds |
| AU3042601A (en) | 2000-01-24 | 2001-07-31 | Thrombogenix Pty Ltd | Therapeutic morpholino-substituted compounds |
| GB0119865D0 (en) | 2001-08-14 | 2001-10-10 | Cancer Res Campaign Tech | DNA-PK inhibitors |
| CA2495661C (en) | 2002-08-16 | 2011-06-14 | Kinacia Pty Ltd. | Inhibition of phosphoinositide 3-kinase beta |
| BRPI0410237A (pt) | 2003-05-09 | 2006-05-09 | Hoffmann La Roche | metil indóis e metil pirrolopiridinas como agonistas adrenérgicos alfa-1 |
| WO2005000812A1 (ja) * | 2003-06-27 | 2005-01-06 | Nissan Chemical Industries, Ltd. | インドール化合物の製造方法 |
| KR20070083484A (ko) | 2004-07-14 | 2007-08-24 | 피티씨 테라퓨틱스, 인크. | Ｃ형 간염 치료 방법 |
| ITMI20060621A1 (it) | 2006-03-31 | 2007-10-01 | Dac Srl | Nuova classe di inibitori delle istone deacetilasi |
| AR053358A1 (es) | 2005-04-15 | 2007-05-02 | Cancer Rec Tech Ltd | Inhibidores de adn - pk |
| US20090035394A1 (en) | 2005-05-26 | 2009-02-05 | Graeme Cameron Murray Smith | Use of dna-pk inhibition to sensitise atm deficient cancers to dna-damaging cancer therapies |
| US20070072897A1 (en) | 2005-09-29 | 2007-03-29 | Wyeth | Phenylaminopropanol derivatives and methods of their use |
| TWI418556B (zh) * | 2006-07-27 | 2013-12-11 | Mitsubishi Tanabe Pharma Corp | 吲哚衍生物 |
| WO2008064244A2 (en) | 2006-11-20 | 2008-05-29 | The Trustees Of Columbia University In The City Of New York | Phosphoinositide modulation for the treatment of neurodegenerative diseases |
| WO2008148074A2 (en) | 2007-05-24 | 2008-12-04 | Research Foundation Of State University Of New York | Inhibitors of mtor and methods of treatment using same |
| KR20100031639A (ko) | 2007-07-09 | 2010-03-23 | 아스트라제네카 아베 | 증식성 질환의 치료용 삼중 치환된 피리미딘 유도체 |
| JP2010533159A (ja) | 2007-07-09 | 2010-10-21 | アストラゼネカ アクチボラグ | 化合物９４７ |
| US20100227858A1 (en) | 2007-07-09 | 2010-09-09 | Astrazeneca Ab | Trisubstituted pyrimidine derivatives for the treatment of proliferative diseases |
| ES2385692T3 (es) | 2007-07-09 | 2012-07-30 | Astrazeneca Ab | Derivados de morfolino pirimidina usados en enfermedades relacionadas con mTOR quinasa y/o PI3K |
| JP5389028B2 (ja) | 2007-08-14 | 2014-01-15 | コンサート ファーマシューティカルズ インコーポレイテッド | 置換オキサゾリジノン誘導体 |
| EP2062889A1 (de) | 2007-11-22 | 2009-05-27 | Boehringer Ingelheim Pharma GmbH & Co. KG | Verbindungen |
| EP2231632A2 (en) | 2008-01-25 | 2010-09-29 | Syngenta Participations AG | 2-cyanophenyl sulfonamide derivatives useful as pesticides |
| JP2012508692A (ja) * | 2008-11-12 | 2012-04-12 | シェーリング コーポレイション | 脂肪酸結合タンパク質（ｆａｂｐ）の阻害薬 |
| TWI469965B (zh) | 2008-12-22 | 2015-01-21 | Ono Pharmaceutical Co | 乙炔基吲哚化合物 |
| SG10201402867TA (en) * | 2009-07-02 | 2014-08-28 | Sanofi Sa | Novel (6-oxo-1, 6-dihydro-pyrimidin-2-yl)-amide derivatives, preparation thereof, and pharmaceutical use thereof as akt(pkb) phosphorylation inhibitors |
-
2011
- 2011-12-22 SI SI201131075A patent/SI2658844T1/sl unknown
- 2011-12-22 PL PL11805849T patent/PL2658844T3/pl unknown
- 2011-12-22 HU HUE11805849A patent/HUE030393T2/en unknown
- 2011-12-22 LT LTEP11805849.4T patent/LT2658844T/lt unknown
- 2011-12-22 PT PT118058494T patent/PT2658844T/pt unknown
- 2011-12-22 ES ES11805849.4T patent/ES2612492T3/es active Active
- 2011-12-22 WO PCT/EP2011/073875 patent/WO2012089633A1/fr active Application Filing
- 2011-12-22 DK DK11805849.4T patent/DK2658844T3/en active
- 2011-12-22 US US13/977,396 patent/US9133168B2/en active Active
- 2011-12-22 EP EP11805849.4A patent/EP2658844B1/fr active Active
-
2017
- 2017-01-25 HR HRP20170119TT patent/HRP20170119T1/hr unknown
- 2017-01-26 CY CY20171100117T patent/CY1118858T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| PT2658844T (pt) | 2017-01-24 |
| ES2612492T3 (es) | 2017-05-17 |
| CY1118858T1 (el) | 2018-01-10 |
| WO2012089633A9 (fr) | 2012-08-23 |
| US9133168B2 (en) | 2015-09-15 |
| DK2658844T3 (en) | 2017-02-06 |
| US20130274253A1 (en) | 2013-10-17 |
| EP2658844B1 (fr) | 2016-10-26 |
| HRP20170119T1 (hr) | 2017-03-24 |
| HUE030393T2 (en) | 2017-05-29 |
| WO2012089633A1 (fr) | 2012-07-05 |
| PL2658844T3 (pl) | 2017-04-28 |
| LT2658844T (lt) | 2017-02-10 |
| EP2658844A1 (fr) | 2013-11-06 |
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