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ITMI20060621A1 - Nuova classe di inibitori delle istone deacetilasi - Google Patents

Nuova classe di inibitori delle istone deacetilasi

Info

Publication number
ITMI20060621A1
ITMI20060621A1 IT000621A ITMI20060621A ITMI20060621A1 IT MI20060621 A1 ITMI20060621 A1 IT MI20060621A1 IT 000621 A IT000621 A IT 000621A IT MI20060621 A ITMI20060621 A IT MI20060621A IT MI20060621 A1 ITMI20060621 A1 IT MI20060621A1
Authority
IT
Italy
Prior art keywords
histons
deacetilase
inhibitors
new class
bond
Prior art date
Application number
IT000621A
Other languages
English (en)
Inventor
Andrea Colombo
Stefania Gagliardi
Antonello Mai
Saverio Minucci
Giles Pain
Florian Thaler
Original Assignee
Dac Srl
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dac Srl filed Critical Dac Srl
Priority to IT000621A priority Critical patent/ITMI20060621A1/it
Priority to US12/295,498 priority patent/US20100113438A1/en
Priority to AT07727569T priority patent/ATE470663T1/de
Priority to CN200780018172XA priority patent/CN101448802B/zh
Priority to BRPI0709283-0A priority patent/BRPI0709283A2/pt
Priority to JP2009502111A priority patent/JP5167241B2/ja
Priority to MX2008012466A priority patent/MX2008012466A/es
Priority to KR1020087025469A priority patent/KR20090018883A/ko
Priority to ES07727569T priority patent/ES2347183T3/es
Priority to CA2647445A priority patent/CA2647445C/en
Priority to EP07727569A priority patent/EP2049508B1/en
Priority to AU2007233732A priority patent/AU2007233732B2/en
Priority to NZ572147A priority patent/NZ572147A/en
Priority to PCT/EP2007/053097 priority patent/WO2007113249A2/en
Priority to RU2008143232/04A priority patent/RU2420522C2/ru
Priority to DE602007007092T priority patent/DE602007007092D1/de
Publication of ITMI20060621A1 publication Critical patent/ITMI20060621A1/it
Priority to IL194422A priority patent/IL194422A0/en
Priority to ZA200809025A priority patent/ZA200809025B/xx
Priority to HK09104436.5A priority patent/HK1126755A1/xx
Priority to US12/962,209 priority patent/US8242175B2/en
Priority to US13/100,670 priority patent/US20120115867A1/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/40—Oxygen atoms
    • C07D211/44—Oxygen atoms attached in position 4
    • C07D211/46—Oxygen atoms attached in position 4 having a hydrogen atom as the second substituent in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4468—Non condensed piperidines, e.g. piperocaine having a nitrogen directly attached in position 4, e.g. clebopride, fentanyl
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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/34—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
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    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
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    • C07D295/22—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with hetero atoms directly attached to ring nitrogen atoms
    • C07D295/26—Sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings

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IT000621A 2004-10-01 2006-03-31 Nuova classe di inibitori delle istone deacetilasi ITMI20060621A1 (it)

Priority Applications (21)

Application Number Priority Date Filing Date Title
IT000621A ITMI20060621A1 (it) 2006-03-31 2006-03-31 Nuova classe di inibitori delle istone deacetilasi
CA2647445A CA2647445C (en) 2006-03-31 2007-03-30 N-hydroxy-3-(4-{3-phenyl-s-oxo-propenyl}-phenyl)-acrylamide derivatives and related compounds as histone deacetylase inhibitors for the treatment of cancer
NZ572147A NZ572147A (en) 2006-03-31 2007-03-30 N-hydroxy-3-(4-{3-phenyl-s-oxo-propenyl}-phenyl)-acrylamide derivatives and related compounds as histone deacetylase inhibitors for the treatment of cancer
CN200780018172XA CN101448802B (zh) 2006-03-31 2007-03-30 作为组蛋白去乙酰化酶抑制剂用于癌症治疗的丙烯酰胺衍生物
BRPI0709283-0A BRPI0709283A2 (pt) 2006-03-31 2007-03-30 derivados de n-hidroxi-3- (4-{3-fenil-s-oxo-propenil} -fenil) - acrilamida e compostos relacionados a estes, tais como inibidores de histona desacetilase para o tratamento de cáncer
JP2009502111A JP5167241B2 (ja) 2006-03-31 2007-03-30 癌の処置用のヒストンデアセチラーゼ阻害剤としての、ｎ−ヒドロキシ−３−（４−｛３−フェニル−ｓ−オキソ−プロペニル｝−フェニル）−アクリルアミド誘導体及びその関連化合物
MX2008012466A MX2008012466A (es) 2006-03-31 2007-03-30 Derivados de n-hidroxi-3-(4-{3-fenil-s-oxo-propenil}-fenil)-acrila mida y compuestos relacionados como inhibidores de histona desacetilasa para el tratamiento del cancer.
KR1020087025469A KR20090018883A (ko) 2006-03-31 2007-03-30 암치료용 히스톤 탈아세틸화 효소 저해제로서 엔-히드록시-3-(4-[3-페닐-에스-옥소-프로페닐]-페닐)-아크릴아미드 유도체 및 그 관련 화합물
ES07727569T ES2347183T3 (es) 2006-03-31 2007-03-30 Derivados de la n-hidroxi-3-(4-(3-penil-3-oxopropenil)-penil)-acrilamida y compuestos relacionados como inhibidores de la histona desacetilasa para el tratamiento del cancer.
US12/295,498 US20100113438A1 (en) 2006-03-31 2007-03-30 Class of histone deacetylase inhibitors
EP07727569A EP2049508B1 (en) 2006-03-31 2007-03-30 N-hydroxy-3-(4-{3-phenyl-3-oxo-propenyl}-phenyl)-acrylamide derivatives and related compounds as histone deacetylase inhibitors for the treatment of cancer
AU2007233732A AU2007233732B2 (en) 2006-03-31 2007-03-30 N-hydroxy-3-(4-{3-phenyl-s-oxo-propenyl}-phenyl)-acrylamide derivatives and related compounds as histone deacetylase inhibitors for the treatment of cancer
AT07727569T ATE470663T1 (de) 2006-03-31 2007-03-30 N-hydroxy-3-(4-ä3-phenyl-3- oxopropenylüphenyl)acrylamidderivate und verwandte verbindungen als histondeacetylaseinhibitoren zur behandlung von krebs
PCT/EP2007/053097 WO2007113249A2 (en) 2006-03-31 2007-03-30 N-hydroxy-3-(4-{3-phenyl-s-oxo-propenyl}-phenyl)-acrylamide derivatives and related compounds as histone deacetylase inhibitors for the treatment of cancer
RU2008143232/04A RU2420522C2 (ru) 2006-03-31 2007-03-30 Новый класс ингибиторов гистондеацетилаз
DE602007007092T DE602007007092D1 (de) 2006-03-31 2007-03-30 N-HYDROXY-3-(4-ä3-PHENYL-3-OXOPROPENYLüPHENYL)ACRYLAMIDDERIVATE UND VERWANDTE VERBINDUNGEN ALS HISTONDEACETYLASEINHIBITOREN ZUR BEHANDLUNG VON KREBS
IL194422A IL194422A0 (en) 2006-03-31 2008-09-28 N-hydroxy-3-(4-[3-phenyl-s-oxo-propenyl}-phenyl)-acrylamide derivatives and related compounds as histone deacetylase inhibitors for the treatment of cancer
ZA200809025A ZA200809025B (en) 2006-03-31 2008-10-21 N-hydroxy-3-(4-{3-phenyl-s-oxo-propenyl}-phenyl)-acry-lamide derivatives and related compounds as histone deacetylase inhibitors for the treatment of cancer
HK09104436.5A HK1126755A1 (en) 2006-03-31 2009-05-15 N-hydroxy-3-(4-{3-phenyl-3-oxo-propenyl}-phenyl)-acrylamide derivatives and related compounds as histone deacetylase inhibitors for the treatment of cancer
US12/962,209 US8242175B2 (en) 2004-10-01 2010-12-07 Class of histone deacetylase inhibitors
US13/100,670 US20120115867A1 (en) 2004-10-01 2011-05-04 New class of histone deacetylase inhibitors

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EP (1) EP2049508B1 (it)
JP (1) JP5167241B2 (it)
KR (1) KR20090018883A (it)
CN (1) CN101448802B (it)
AT (1) ATE470663T1 (it)
AU (1) AU2007233732B2 (it)
BR (1) BRPI0709283A2 (it)
CA (1) CA2647445C (it)
DE (1) DE602007007092D1 (it)
ES (1) ES2347183T3 (it)
HK (1) HK1126755A1 (it)
IL (1) IL194422A0 (it)
IT (1) ITMI20060621A1 (it)
MX (1) MX2008012466A (it)
NZ (1) NZ572147A (it)
RU (1) RU2420522C2 (it)
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US8242175B2 (en) 2004-10-01 2012-08-14 Dac S.R.L. Class of histone deacetylase inhibitors
US8980877B2 (en) 2008-04-15 2015-03-17 Dac S.R.L. Spirocyclic derivatives as histone deacetylase inhibitors
EP2110377A1 (en) * 2008-04-15 2009-10-21 DAC S.r.l. Spirocyclic derivatives as histone deacetylase inhibitors
EP2311840A1 (en) * 2009-10-13 2011-04-20 DAC S.r.l. Spirocyclic derivatives as histone deacetylase inhibitors
EP2133334A1 (en) * 2008-06-09 2009-12-16 DAC S.r.l. Heterocyclic derivatives as HDAC inhibitors
SI2658844T1 (sl) 2010-12-28 2017-02-28 Sanofi Novi derivati pirimidina, njihova priprava in njihova farmacevtska uporaba kot inhibitorje AKT(PKB) fosforilacije
GB201114448D0 (en) 2011-08-22 2011-10-05 Takeda Pharmaceutical Compounds and their use
CN103102331B (zh) * 2013-01-17 2015-05-27 浙江大学 含哌嗪环的查尔酮类化合物的药物用途
CN103102332B (zh) * 2013-01-17 2015-05-27 浙江大学 含哌嗪环的查尔酮类化合物及其制备和应用
CN108164476B (zh) * 2016-12-08 2021-01-26 沈阳化工研究院有限公司 间苯二腈类化合物、其应用以及包含该化合物的药物

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WO1995013264A1 (fr) * 1993-11-08 1995-05-18 Terumo Kabushiki Kaisha Derive d'acide hydroxamique et preparation medicamenteuse contenant ledit derive
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FR2796951A1 (fr) * 1999-07-26 2001-02-02 Centre Nat Rech Scient Complexes de phosphine/palladium, utiles comme catalyseurs notamment pour l'arylation d'olefines
AU783504C (en) * 1999-11-23 2006-08-03 Methylgene Inc. Inhibitors of histone deacetylase
US20070167499A1 (en) * 2003-10-27 2007-07-19 A*Bio Pte Ltd. Biaryl linked hydroxamates: preparation and pharmaceutical applications
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IL194422A0 (en) 2009-08-03
CA2647445A1 (en) 2007-10-11
CN101448802A (zh) 2009-06-03
JP2009531393A (ja) 2009-09-03
CN101448802B (zh) 2012-11-07
AU2007233732B2 (en) 2012-02-02
JP5167241B2 (ja) 2013-03-21
CA2647445C (en) 2014-08-19
MX2008012466A (es) 2008-10-10
EP2049508A2 (en) 2009-04-22
ZA200809025B (en) 2009-07-29
WO2007113249A3 (en) 2007-11-29
AU2007233732A1 (en) 2007-10-11
RU2420522C2 (ru) 2011-06-10
DE602007007092D1 (de) 2010-07-22
ES2347183T3 (es) 2010-10-26
NZ572147A (en) 2010-11-26
KR20090018883A (ko) 2009-02-24
BRPI0709283A2 (pt) 2011-07-05
RU2008143232A (ru) 2010-05-10
US20100113438A1 (en) 2010-05-06
EP2049508B1 (en) 2010-06-09
ATE470663T1 (de) 2010-06-15
WO2007113249A2 (en) 2007-10-11

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