SG10201402867TA - Novel (6-oxo-1, 6-dihydro-pyrimidin-2-yl)-amide derivatives, preparation thereof, and pharmaceutical use thereof as akt(pkb) phosphorylation inhibitors - Google Patents

Novel (6-oxo-1, 6-dihydro-pyrimidin-2-yl)-amide derivatives, preparation thereof, and pharmaceutical use thereof as akt(pkb) phosphorylation inhibitors

Info

Publication number: SG10201402867TA
Authority: SG; Singapore
Prior art keywords: pkb; akt; pyrimidin; dihydro; oxo
Prior art date: 2009-07-02

Application number

SG10201402867TA

Original Assignee

Sanofi Sa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2009-07-02

Filing date

2010-07-01

Publication date

2014-08-28

2009-07-02 Priority claimed from FR0903239A external-priority patent/FR2947547B1/en

2009-10-09 Priority claimed from FR0957070A external-priority patent/FR2951169B1/en

2010-07-01 Application filed by Sanofi Sa filed Critical Sanofi Sa

2014-08-28 Publication of SG10201402867TA publication Critical patent/SG10201402867TA/en

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/20—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D239/22—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms directly attached to ring carbon atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/47—One nitrogen atom and one oxygen or sulfur atom, e.g. cytosine
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

SG10201402867TA 2009-07-02 2010-07-01 Novel (6-oxo-1, 6-dihydro-pyrimidin-2-yl)-amide derivatives, preparation thereof, and pharmaceutical use thereof as akt(pkb) phosphorylation inhibitors SG10201402867TA (en)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
FR0903239A FR2947547B1 (en)	2009-07-02	2009-07-02	NOVEL (6-OXO-1,6-DIHYDRO-PYRIMIDIN-2-YL) -AMIDE DERIVATIVES, THEIR PREPARATION AND THEIR PHARMACEUTICAL USE AS AKT PHOSPHORYLATION INHIBITORS (PKB)
US24110009P	2009-09-10	2009-09-10
FR0957070A FR2951169B1 (en)	2009-10-09	2009-10-09	NOVEL (6-OXO-1,6-DIHYDRO-PYRIMIDIN-2-YL) -AMIDE DERIVATIVES, THEIR PREPARATION AND THEIR PHARMACEUTICAL USE AS AKT PHOSPHORYLATION INHIBITORS (PKB)

Publications (1)

Publication Number	Publication Date
SG10201402867TA true SG10201402867TA (en)	2014-08-28

Family

ID=42635553

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
SG10201402867TA SG10201402867TA (en)	2009-07-02	2010-07-01	Novel (6-oxo-1, 6-dihydro-pyrimidin-2-yl)-amide derivatives, preparation thereof, and pharmaceutical use thereof as akt(pkb) phosphorylation inhibitors
SG2011097938A SG177469A1 (en)	2009-07-02	2010-07-01	Novel (6-oxo-1, 6-dihydro-pyrimidin-2-yl)-amide derivatives, preparation thereof, and pharmaceutical use thereof as akt(pkb) phosphorylation inhibitors

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
SG2011097938A SG177469A1 (en)	2009-07-02	2010-07-01	Novel (6-oxo-1, 6-dihydro-pyrimidin-2-yl)-amide derivatives, preparation thereof, and pharmaceutical use thereof as akt(pkb) phosphorylation inhibitors

Country Status (37)

Country	Link
US (2)	US8791255B2 (en)
EP (1)	EP2448927B1 (en)
JP (1)	JP5680638B2 (en)
KR (1)	KR20120106714A (en)
CN (1)	CN102548970B (en)
AR (1)	AR077364A1 (en)
AU (1)	AU2010267816B2 (en)
CA (1)	CA2767064C (en)
CL (1)	CL2012000003A1 (en)
CO (1)	CO6480974A2 (en)
CR (1)	CR20110703A (en)
DK (1)	DK2448927T3 (en)
DO (1)	DOP2011000407A (en)
EA (1)	EA021088B1 (en)
EC (1)	ECSP12011570A (en)
ES (1)	ES2464125T3 (en)
HK (1)	HK1169110A1 (en)
HN (1)	HN2011003482A (en)
HR (1)	HRP20140478T1 (en)
IL (2)	IL217295A (en)
MA (1)	MA33501B1 (en)
ME (1)	ME01885B (en)
MX (1)	MX2012000094A (en)
MY (1)	MY153042A (en)
NI (1)	NI201200002A (en)
NZ (1)	NZ597579A (en)
PE (1)	PE20120640A1 (en)
PL (1)	PL2448927T3 (en)
PT (1)	PT2448927E (en)
RS (1)	RS53317B (en)
SG (2)	SG10201402867TA (en)
SI (1)	SI2448927T1 (en)
SM (1)	SMT201400084B (en)
TW (1)	TWI466883B (en)
UY (1)	UY32755A (en)
WO (1)	WO2011001114A1 (en)
ZA (1)	ZA201200026B (en)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR2969609B1 (en) *	2010-12-28	2013-02-08	Sanofi Aventis	NOVEL 6-OXO-DIHYDRO-PYRIMIDINE DERIVATIVES, THEIR PREPARATION AND THEIR PHARMACEUTICAL USE AS AKT PHOSPHORYLATION INHIBITORS (PKB)
FR2969610B1 (en) *	2010-12-28	2013-04-05	Sanofi Aventis	NOVEL (6-OXO-1,6-DIHYDRO-PYRIMIDIN-2-YL) -INDOLINAMIDE DERIVATIVES, THEIR PREPARATION AND THEIR PHARMACEUTICAL USE AS AKT PHOSPHORYLATION INHIBITORS (PKB)
FR2969614A1 (en) *	2010-12-28	2012-06-29	Sanofi Aventis	New pyrimidinone compounds are akt phosphorylation inhibitors useful for treating e.g. gastric cancer, glioblastomas, thyroid cancer, bladder cancer, breast cancer, melanoma, lymphoid or myeloid hematopoietic tumors, and sarcomas
SI2658844T1 (en) *	2010-12-28	2017-02-28	Sanofi	Novel pyrimidine derivatives, preparation thereof, and pharmaceutical use thereof as akt(pkb) phosphorylation inhibitors
JP2014505107A (en) *	2011-02-11	2014-02-27	デイナファーバーキャンサーインスティチュート，インコーポレイテッド	Methods for inhibiting hamartoma tumor cells
EP2570127A1 (en) *	2011-09-16	2013-03-20	Sanofi	Compositions and methods for treating cancer using PI3KB beta inhibitor and MAPK pathway inhibitor, including MEK and RAF inhibitors
EP2968350A1 (en)	2013-03-15	2016-01-20	Sanofi	Anti-tumoral composition comprising a pi3kbeta inhibitor and a raf inhibitor, to overcome cancer cells resistance
US20160030440A1 (en)	2013-04-05	2016-02-04	Sanofi	Anti-tumoral composition comprising a pi3kbeta-selective inhibitor and a pi3kalpha-selective inhibitor
US10544902B2 (en)	2014-12-02	2020-01-28	Halliburton Energy Services, Inc.	Liquefied natural gas vaporizer for downhole oil or gas applications

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AR023052A1 (en) *	1998-09-25	2002-09-04	Mitsuharu Yoshimura Milton	DERIVATIVES OF PIRIMIDONA
CA2386218A1 (en)	1999-10-07	2001-04-12	Amgen Inc.	Triazine kinase inhibitors
AU3042601A (en)	2000-01-24	2001-07-31	Thrombogenix Pty Ltd	Therapeutic morpholino-substituted compounds
GB0119865D0 (en)	2001-08-14	2001-10-10	Cancer Res Campaign Tech	DNA-PK inhibitors
US7365069B2 (en) *	2002-04-10	2008-04-29	Bexel Pharmaceuticals Inc.	Pyrimidone derivatives
CA2495661C (en)	2002-08-16	2011-06-14	Kinacia Pty Ltd.	Inhibition of phosphoinositide 3-kinase beta
ES2285517T3 (en) *	2003-10-31	2007-11-16	Warner-Lambert Company Llc	PYRIMIDINS AS PHOSFOINOSITIDA-3-KINASES INHIBITORS (PI3K).
GB0415365D0 (en)	2004-07-09	2004-08-11	Astrazeneca Ab	Pyrimidine derivatives
AR053358A1 (en)	2005-04-15	2007-05-02	Cancer Rec Tech Ltd	DNA INHIBITORS - PK
US20090035394A1 (en)	2005-05-26	2009-02-05	Graeme Cameron Murray Smith	Use of dna-pk inhibition to sensitise atm deficient cancers to dna-damaging cancer therapies
US7700592B2 (en)	2005-08-25	2010-04-20	Schering Corporation	α2C adrenoreceptor agonists
GB0520657D0 (en)	2005-10-11	2005-11-16	Ludwig Inst Cancer Res	Pharmaceutical compounds
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WO2008064244A2 (en)	2006-11-20	2008-05-29	The Trustees Of Columbia University In The City Of New York	Phosphoinositide modulation for the treatment of neurodegenerative diseases
WO2008148074A2 (en)	2007-05-24	2008-12-04	Research Foundation Of State University Of New York	Inhibitors of mtor and methods of treatment using same
KR20100031639A (en)	2007-07-09	2010-03-23	아스트라제네카 아베	Trisubstituted pyrimidine derivatives for the treatment of proliferative diseases
US20100227858A1 (en)	2007-07-09	2010-09-09	Astrazeneca Ab	Trisubstituted pyrimidine derivatives for the treatment of proliferative diseases
ES2385692T3 (en)	2007-07-09	2012-07-30	Astrazeneca Ab	Morpholino pyrimidine derivatives used in diseases related to mTOR kinase and / or PI3K
JP2010533159A (en) *	2007-07-09	2010-10-21	アストラゼネカアクチボラグ	Compound 947
AR074072A1 (en)	2008-11-11	2010-12-22	Lilly Co Eli	COMPOSITE OF IMIDAZOL -PIPERIDIN -PIRROL-PIRIMIDIN-6-ONA, PHARMACEUTICAL COMPOSITION THAT INCLUDES IT AND ITS USE TO PREPARE A USEFUL MEDICINAL PRODUCT TO TREAT MULTIFORM GLIOBLASTOMA
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2010
- 2010-07-01 SG SG10201402867TA patent/SG10201402867TA/en unknown
- 2010-07-01 PE PE2012000004A patent/PE20120640A1/en not_active Application Discontinuation
- 2010-07-01 EP EP10742014.3A patent/EP2448927B1/en active Active
- 2010-07-01 PL PL10742014T patent/PL2448927T3/en unknown
- 2010-07-01 ES ES10742014.3T patent/ES2464125T3/en active Active
- 2010-07-01 MY MYPI2011006377 patent/MY153042A/en unknown
- 2010-07-01 MX MX2012000094A patent/MX2012000094A/en active IP Right Grant
- 2010-07-01 CN CN201080039214.XA patent/CN102548970B/en not_active Expired - Fee Related
- 2010-07-01 AR ARP100102350A patent/AR077364A1/en unknown
- 2010-07-01 NZ NZ597579A patent/NZ597579A/en not_active IP Right Cessation
- 2010-07-01 DK DK10742014.3T patent/DK2448927T3/en active
- 2010-07-01 EA EA201270111A patent/EA021088B1/en not_active IP Right Cessation
- 2010-07-01 MA MA34593A patent/MA33501B1/en unknown
- 2010-07-01 JP JP2012518120A patent/JP5680638B2/en not_active Expired - Fee Related
- 2010-07-01 RS RS20140306A patent/RS53317B/en unknown
- 2010-07-01 KR KR1020127002839A patent/KR20120106714A/en active IP Right Grant
- 2010-07-01 ME MEP-2014-62A patent/ME01885B/en unknown
- 2010-07-01 SI SI201030607T patent/SI2448927T1/en unknown
- 2010-07-01 CA CA2767064A patent/CA2767064C/en not_active Expired - Fee Related
- 2010-07-01 AU AU2010267816A patent/AU2010267816B2/en not_active Ceased
- 2010-07-01 PT PT107420143T patent/PT2448927E/en unknown
- 2010-07-01 SG SG2011097938A patent/SG177469A1/en unknown
- 2010-07-01 WO PCT/FR2010/051375 patent/WO2011001114A1/en active Application Filing
- 2010-07-02 TW TW99121906A patent/TWI466883B/en not_active IP Right Cessation
- 2010-07-02 UY UY0001032755A patent/UY32755A/en not_active Application Discontinuation
2011
- 2011-12-21 CR CR20110703A patent/CR20110703A/en unknown
- 2011-12-26 DO DO2011000407A patent/DOP2011000407A/en unknown
- 2011-12-27 US US13/338,011 patent/US8791255B2/en not_active Expired - Fee Related
- 2011-12-29 IL IL217295A patent/IL217295A/en not_active IP Right Cessation
- 2011-12-29 CO CO11180700A patent/CO6480974A2/en active IP Right Grant
- 2011-12-30 HN HN2011003482A patent/HN2011003482A/en unknown
2012
- 2012-01-01 IL IL217321A patent/IL217321A0/en unknown
- 2012-01-02 CL CL2012000003A patent/CL2012000003A1/en unknown
- 2012-01-03 EC EC2012011570A patent/ECSP12011570A/en unknown
- 2012-01-03 ZA ZA2012/00026A patent/ZA201200026B/en unknown
- 2012-01-05 NI NI201200002A patent/NI201200002A/en unknown
- 2012-10-05 HK HK12109790.9A patent/HK1169110A1/en not_active IP Right Cessation
2014
- 2014-05-28 HR HRP20140478AT patent/HRP20140478T1/en unknown
- 2014-06-23 US US14/312,124 patent/US8993565B2/en not_active Expired - Fee Related
- 2014-06-26 SM SM201400084T patent/SMT201400084B/en unknown

Also Published As

Publication number	Publication date
KR20120106714A (en)	2012-09-26
MA33501B1 (en)	2012-08-01
HK1169110A1 (en)	2013-01-18
IL217321A0 (en)	2012-02-29
HN2011003482A (en)	2014-11-10
CN102548970B (en)	2015-11-25
US8791255B2 (en)	2014-07-29
ME01885B (en)	2014-12-20
ES2464125T3 (en)	2014-05-30
TW201103924A (en)	2011-02-01
DOP2011000407A (en)	2012-06-15
HRP20140478T1 (en)	2014-07-04
ECSP12011570A (en)	2012-02-29
MY153042A (en)	2014-12-31
RS53317B (en)	2014-10-31
IL217295A (en)	2015-10-29
NZ597579A (en)	2013-06-28
EP2448927A1 (en)	2012-05-09
WO2011001114A1 (en)	2011-01-06
CR20110703A (en)	2012-03-06
SG177469A1 (en)	2012-02-28
US20140303156A1 (en)	2014-10-09
AR077364A1 (en)	2011-08-24
EA201270111A1 (en)	2012-07-30
NI201200002A (en)	2012-03-30
PT2448927E (en)	2014-06-12
CA2767064C (en)	2017-11-07
SMT201400084B (en)	2014-09-08
JP5680638B2 (en)	2015-03-04
IL217295A0 (en)	2012-02-29
US20120270867A1 (en)	2012-10-25
CN102548970A (en)	2012-07-04
PE20120640A1 (en)	2012-06-09
CA2767064A1 (en)	2011-01-06
DK2448927T3 (en)	2014-06-16
UY32755A (en)	2011-01-31
AU2010267816B2 (en)	2015-11-12
AU2010267816A1 (en)	2012-02-16
EA021088B1 (en)	2015-04-30
EP2448927B1 (en)	2014-03-12
TWI466883B (en)	2015-01-01
SI2448927T1 (en)	2014-06-30
CO6480974A2 (en)	2012-07-16
US8993565B2 (en)	2015-03-31
MX2012000094A (en)	2012-05-22
JP2012531464A (en)	2012-12-10
PL2448927T3 (en)	2014-09-30
CL2012000003A1 (en)	2012-08-03
ZA201200026B (en)	2013-03-27

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