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RS49675B - 4"supstituisani-9-deokso-9a-aza-9a- homoeritromicin a derivati - Google Patents

4"supstituisani-9-deokso-9a-aza-9a- homoeritromicin a derivati

Info

Publication number
RS49675B
RS49675B YUP-586/99A YU58699A RS49675B RS 49675 B RS49675 B RS 49675B YU 58699 A YU58699 A YU 58699A RS 49675 B RS49675 B RS 49675B
Authority
RS
Serbia
Prior art keywords
groups
integer
membered heteroaryl
carbon
optionally substituted
Prior art date
Application number
YUP-586/99A
Other languages
English (en)
Inventor
Brian Scott Bronk
Michael Anthony Levatic
Takushi Kaneko
Bingwei Vera Yang
Edward Alan Glazer
Hengmiao Cheng
Original Assignee
Pfizer Products Inc.,
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=21959336&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=RS49675(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Pfizer Products Inc., filed Critical Pfizer Products Inc.,
Publication of YU58699A publication Critical patent/YU58699A/xx
Publication of RS49675B publication Critical patent/RS49675B/sr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biotechnology (AREA)
  • Veterinary Medicine (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Communicable Diseases (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
YUP-586/99A 1997-06-11 1998-05-29 4"supstituisani-9-deokso-9a-aza-9a- homoeritromicin a derivati RS49675B (sr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US4934897P 1997-06-11 1997-06-11
PCT/IB1998/000839 WO1998056802A1 (en) 1997-06-11 1998-05-29 4'-substituted-9-deoxo-9a-aza-9a-homoerythromycin a derivatives

Publications (2)

Publication Number Publication Date
YU58699A YU58699A (sr) 2002-08-12
RS49675B true RS49675B (sr) 2007-11-15

Family

ID=21959336

Family Applications (1)

Application Number Title Priority Date Filing Date
YUP-586/99A RS49675B (sr) 1997-06-11 1998-05-29 4"supstituisani-9-deokso-9a-aza-9a- homoeritromicin a derivati

Country Status (50)

Country Link
US (4) US6420536B1 (sr)
EP (1) EP0988310B9 (sr)
JP (2) JP3315704B2 (sr)
KR (1) KR100396168B1 (sr)
CN (4) CN1793155B (sr)
AP (1) AP1231A (sr)
AR (1) AR013086A1 (sr)
AT (1) ATE251173T1 (sr)
AU (1) AU749816B2 (sr)
BG (1) BG64391B1 (sr)
BR (1) BRPI9810519B8 (sr)
CA (1) CA2293823C (sr)
CO (1) CO4950611A1 (sr)
CZ (1) CZ298556B6 (sr)
DE (2) DE69818665T2 (sr)
DK (1) DK0988310T3 (sr)
DZ (1) DZ2514A1 (sr)
EA (1) EA002441B1 (sr)
EG (1) EG24081A (sr)
ES (1) ES2205487T3 (sr)
FR (1) FR04C0013I2 (sr)
GT (1) GT199800077A (sr)
HK (3) HK1028048A1 (sr)
HN (1) HN1998000086A (sr)
HR (1) HRP980314B1 (sr)
HU (2) HU228005B1 (sr)
ID (1) ID22992A (sr)
IL (1) IL132809A0 (sr)
IS (1) IS1998B (sr)
LU (1) LU91076I9 (sr)
MA (1) MA24564A1 (sr)
ME (1) ME00876B (sr)
MY (1) MY123354A (sr)
NL (1) NL300150I2 (sr)
NO (1) NO316911B1 (sr)
NZ (2) NZ514871A (sr)
OA (1) OA11224A (sr)
PA (1) PA8452201A1 (sr)
PE (1) PE79699A1 (sr)
PL (1) PL191601B1 (sr)
PT (1) PT988310E (sr)
RS (1) RS49675B (sr)
SI (1) SI0988310T1 (sr)
SK (1) SK284171B6 (sr)
TN (1) TNSN98082A1 (sr)
TW (1) TW472060B (sr)
UA (1) UA67744C2 (sr)
UY (1) UY25040A1 (sr)
WO (1) WO1998056802A1 (sr)
ZA (1) ZA985017B (sr)

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CA2546195A1 (en) * 2003-11-21 2005-06-02 Pfizer Products Inc. The use of anti biotics as vaccine adjuvants
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US20060116336A1 (en) * 2004-03-17 2006-06-01 American Pharmaceutical Partners, Inc. Lyophilized azithromycin formulation
US7402568B2 (en) 2004-09-29 2008-07-22 Enanta Pharmaceuticals, Inc. Bicyclic 9a-azalide derivatives
US7767797B1 (en) * 2004-09-30 2010-08-03 Synovo Gmbh Macrocyclic compounds and methods of use thereof
US7271155B2 (en) 2005-01-07 2007-09-18 Enanta Pharmaceuticals, Inc. 9A, 11-2C-bicyclic 9a-azalide derivatives
JP2008526948A (ja) * 2005-01-14 2008-07-24 グラクソスミスクライン・イストラジヴァッキ・センタル・ザグレブ・ドルズバ・ゼー・オメイェノ・オドゴヴォルノスティオ 抗マラリア活性を有する９ａ−カルバモイルおよびチオカルバモイルアザライド
WO2009055557A1 (en) 2007-10-25 2009-04-30 Cempra Pharmaceuticals, Inc. Process for the preparation of macrolide antibacterial agents
EP3031460A1 (en) 2008-10-24 2016-06-15 Cempra Pharmaceuticals Inc. Biodefenses using triazole-containing macrolides
US9937194B1 (en) * 2009-06-12 2018-04-10 Cempra Pharmaceuticals, Inc. Compounds and methods for treating inflammatory diseases
EP2475253B1 (en) 2009-09-10 2016-10-26 Cempra Pharmaceuticals, Inc. Methods for treating malaria, tuberculosis and mac diseases
DK2550286T3 (en) 2010-03-22 2016-02-29 Cempra Pharmaceuticals Inc CRYSTALLINE FORMS OF A MACROLID AND APPLICATIONS THEREOF
US9051346B2 (en) 2010-05-20 2015-06-09 Cempra Pharmaceuticals, Inc. Process for preparing triazole-containing ketolide antibiotics
KR20180110181A (ko) 2010-09-10 2018-10-08 셈프라 파마슈티컬스, 인크. 질환을 치료하기 위한 수소결합 형성 플루오로 케토라이드
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US9145436B2 (en) * 2010-10-10 2015-09-29 Michael W. Burnet Anti-inflammatory macrolides
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CN102260306B (zh) * 2011-07-22 2012-07-18 山东鲁抗舍里乐药业有限公司 一种制备泰拉霉素的方法
EP2736915A1 (en) 2011-07-27 2014-06-04 Farma GRS, d.o.o. New crystalline forms of tulathromycin
MX2014011537A (es) 2012-03-27 2015-02-10 Cempra Pharmaceuticals Inc Formulaciones parenterales para la administracion de antibioticos macrolidos.
CN102786569B (zh) * 2012-09-07 2016-12-07 安徽中升药业有限公司 泰拉霉素中间体及其制备方法与泰拉霉素的制备方法
RU2015138796A (ru) 2013-03-14 2017-04-19 Семпра Фармасьютикалс, Инк. Способы и составы для лечения респираторных заболеваний
EP2968384A4 (en) 2013-03-15 2017-02-15 Cempra Pharmaceuticals, Inc. Convergent processes for preparing macrolide antibacterial agents
WO2015014907A1 (en) * 2013-07-31 2015-02-05 Farma Grs, D.O.O. Process for preparation of tulathromycin
CN103497227B (zh) * 2013-09-13 2015-09-30 青岛科技大学 一种泰拉菌素中间体的制备方法
CN104725446B (zh) * 2015-03-26 2017-10-27 宁夏泰瑞制药股份有限公司 一种从泰拉霉素粗品中分离泰拉霉素a和泰拉霉素b的方法
CN104861018A (zh) * 2015-06-17 2015-08-26 瑞普（天津）生物药业有限公司 一种泰拉菌素的制备方法
CN105646617A (zh) * 2016-01-21 2016-06-08 杭州海尔希畜牧科技有限公司 一种制备泰拉霉素的方法
FR3048612B1 (fr) * 2016-03-14 2020-10-02 Septeos Tulathromycine potentialisee
CN106046077B (zh) * 2016-08-04 2019-07-26 湖北美天生物科技股份有限公司 一种泰拉霉素a的合成方法
CN108003207B (zh) 2017-12-19 2019-05-10 海门慧聚药业有限公司 制备泰拉霉素的方法
CN111087433B (zh) * 2018-10-23 2023-03-21 湖北美天生物科技股份有限公司 一种泰拉霉素中间体的制备方法

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Also Published As

Publication number Publication date
CN1259136A (zh) 2000-07-05
US6936592B2 (en) 2005-08-30
US6420536B1 (en) 2002-07-16
NO996106L (no) 2000-02-10
PL337505A1 (en) 2000-08-28
KR100396168B1 (ko) 2003-08-27
SK168399A3 (en) 2000-11-07
CN101691390A (zh) 2010-04-07
PL191601B1 (pl) 2006-06-30
US20040023896A1 (en) 2004-02-05
SK284171B6 (sk) 2004-10-05
BRPI9810519A (pt) 2000-09-19
BG64391B1 (bg) 2004-12-30
NZ500660A (en) 2002-03-01
CN1172947C (zh) 2004-10-27
DZ2514A1 (fr) 2003-02-01
CN1243766C (zh) 2006-03-01
PE79699A1 (es) 1999-08-25
DE69818665D1 (de) 2003-11-06
JP2000514098A (ja) 2000-10-24
UA67744C2 (uk) 2004-07-15
NZ514871A (en) 2003-08-29
FR04C0013I1 (sr) 2004-06-11
LU91076I9 (en) 2018-07-02
US6777393B2 (en) 2004-08-17
EP0988310A1 (en) 2000-03-29
HU228005B1 (en) 2012-08-28
CA2293823C (en) 2004-02-17
HRP980314A2 (en) 1999-04-30
NL300150I2 (nl) 2004-09-01
DE122004000018I1 (de) 2004-09-30
YU58699A (sr) 2002-08-12
IL132809A0 (en) 2001-03-19
HUS1200028I1 (hu) 2016-08-29
EA199901015A1 (ru) 2000-06-26
LU91076I2 (fr) 2004-07-05
UY25040A1 (es) 2000-09-29
AU749816B2 (en) 2002-07-04
SI0988310T1 (en) 2004-02-29
ATE251173T1 (de) 2003-10-15
MY123354A (en) 2006-05-31
ID22992A (id) 1999-12-23
DE122004000018I2 (de) 2011-01-13
JP2002316933A (ja) 2002-10-31
PT988310E (pt) 2003-12-31
CO4950611A1 (es) 2000-09-01
HK1068893A1 (en) 2005-07-29
IS1998B (is) 2005-03-15
ME00876B (me) 2012-06-20
HRP980314B1 (en) 2004-04-30
EG24081A (en) 2008-05-11
HUP0002209A2 (hu) 2000-12-28
EA002441B1 (ru) 2002-04-25
HUP0002209A3 (en) 2003-05-28
NO316911B1 (no) 2004-06-21
BRPI9810519B8 (pt) 2022-11-16
JP3315704B2 (ja) 2002-08-19
CN1793155B (zh) 2010-05-12
ZA985017B (en) 1999-12-17
GT199800077A (es) 1999-12-02
HK1088014A1 (en) 2006-10-27
CN1566129A (zh) 2005-01-19
BRPI9810519B1 (pt) 2012-02-22
CZ298556B6 (cs) 2007-11-07
CA2293823A1 (en) 1998-12-17
AP9801255A0 (en) 1998-06-30
BG103945A (en) 2000-07-31
IS5252A (is) 1999-11-16
PA8452201A1 (es) 2000-05-24
US20040180842A1 (en) 2004-09-16
NL300150I1 (nl) 2004-08-02
AR013086A1 (es) 2000-12-13
EP0988310B9 (en) 2006-03-08
TW472060B (en) 2002-01-11
CZ442199A3 (cs) 2000-07-12
OA11224A (en) 2003-07-16
HK1028048A1 (en) 2001-02-02
AU7347598A (en) 1998-12-30
HN1998000086A (es) 1999-03-08
EP0988310B1 (en) 2003-10-01
AP1231A (en) 2003-12-11
NO996106D0 (no) 1999-12-10
FR04C0013I2 (sr) 2005-10-21
ES2205487T3 (es) 2004-05-01
KR20010013632A (ko) 2001-02-26
WO1998056802A1 (en) 1998-12-17
US20020061858A1 (en) 2002-05-23
TNSN98082A1 (fr) 2005-03-15
DE69818665T2 (de) 2004-04-29
MA24564A1 (fr) 1998-12-31
DK0988310T3 (da) 2003-12-15
CN1793155A (zh) 2006-06-28

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