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ES2064941T3 - Nuevas acil-benzoxazolinonas, su procedimiento de preparacion y las composiciones farmaceuticas que las contienen. - Google Patents

Nuevas acil-benzoxazolinonas, su procedimiento de preparacion y las composiciones farmaceuticas que las contienen.

Info

Publication number
ES2064941T3
ES2064941T3 ES91401678T ES91401678T ES2064941T3 ES 2064941 T3 ES2064941 T3 ES 2064941T3 ES 91401678 T ES91401678 T ES 91401678T ES 91401678 T ES91401678 T ES 91401678T ES 2064941 T3 ES2064941 T3 ES 2064941T3
Authority
ES
Spain
Prior art keywords
group
lower alkyl
linear
substituted
branched
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES91401678T
Other languages
English (en)
Inventor
Hocine Aichaoui
Daniel Lesieur
Charles Lespagnol
Michelle Devissaguet
Beatrice Guardiola
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
ADIR SARL
Original Assignee
ADIR SARL
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ADIR SARL filed Critical ADIR SARL
Application granted granted Critical
Publication of ES2064941T3 publication Critical patent/ES2064941T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/52—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/52—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems
    • C07D263/54—Benzoxazoles; Hydrogenated benzoxazoles
    • C07D263/58—Benzoxazoles; Hydrogenated benzoxazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/52—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems
    • C07D263/60—Naphthoxazoles; Hydrogenated naphthoxazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Hematology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Diabetes (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

DERIVADOS DE FORMULA GENERAL (I): EN LA QUE: R SUB 1 REPRESENTA UN ATOMO DE HIDROGENO O UN GRUPO ALQUILO INFERIOR, A REPRESENTA UN ATOMO DE HIDROGENO Y EN EL CASO B REPRESENTA UN GRUPO CO-G, SIENDO G: FURANO, INDOL, PIRROL, PIRIDINA, QUINOLEINA, ISOQUINOLEINA, BENZOFURANO EVENTUALMENTE SUSTITUIDO POR UNO O VARIOS GRUPOS ALQUILO INFERIOR O ALCOXI INFERIOR, O ATOMO DE HALOGENO, GRUPO ALQUILO INFERIOR LINEAL O RAMIFICADO SUSTITUIDO POR UN GRUPO CARBOXILO, MIFICADA SUSTITUIDO POR UN GRUPO CARBOXILO, NILO O NAFTILO SUSTITUIDO POR UN GRUPO CARBOXILO, ORMA CON B UN GRUPO CO (CH SUB 2) SUB N CH (CH SUB 3) CON N NUMERO ENTERO IGUAL A 1, 2, 3 O 4, ESTANDO EL GRUPO CO FIJADO AL CICLO AROMATICO DE LA BENZOXAZOLINA EN POSICION 5 O 6, ASI COMO OPCIONALMENTE , SUS ISOMEROS Y, CUANDO EL COMPUESTO DE FORMULA (I) POSEE UN GRUPO ACIDO CARBOXILICO, SUS SALES DE ADICION A UNA BASE FARMACEUTICAMENTE ACEPTABLE Y CUANDO EL COMPUESTO DE FORMULA (I) COMPRENDE UN GRUPO BASICO, SUS SALES DE ADICION CON UN ACIDO FARMACEUTICAMENTE ACEPTABLE, ENTENDIENDOSE QUE ALQUILO INFERIOR Y ALCENILO INFERIOR SIGNIFICAN GRUPOS LINEALES O RAMIFICADOS QUE COMPRENDEN DE 1 A 6 ATOMOS DE CARBONO. MEDICAMENTOS.
ES91401678T 1990-06-22 1991-06-21 Nuevas acil-benzoxazolinonas, su procedimiento de preparacion y las composiciones farmaceuticas que las contienen. Expired - Lifetime ES2064941T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9007812A FR2663634B1 (fr) 1990-06-22 1990-06-22 Nouvelles acyl benzoxazolinones, leur procede de preparation et les compositions pharmaceutiques qui les contiennent.

Publications (1)

Publication Number Publication Date
ES2064941T3 true ES2064941T3 (es) 1995-02-01

Family

ID=9397888

Family Applications (1)

Application Number Title Priority Date Filing Date
ES91401678T Expired - Lifetime ES2064941T3 (es) 1990-06-22 1991-06-21 Nuevas acil-benzoxazolinonas, su procedimiento de preparacion y las composiciones farmaceuticas que las contienen.

Country Status (15)

Country Link
US (1) US5147883A (es)
EP (1) EP0463944B1 (es)
JP (1) JPH07108904B2 (es)
AT (1) ATE112562T1 (es)
AU (1) AU631498B2 (es)
CA (1) CA2045257A1 (es)
DE (1) DE69104416T2 (es)
DK (1) DK0463944T3 (es)
ES (1) ES2064941T3 (es)
FR (1) FR2663634B1 (es)
IE (1) IE912147A1 (es)
NZ (1) NZ238648A (es)
OA (1) OA09372A (es)
PT (1) PT98067A (es)
ZA (1) ZA914801B (es)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2674524B1 (fr) * 1991-03-25 1993-05-21 Adir Nouveaux amides alkyl heterocycliques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent.
FR2756825B1 (fr) * 1996-12-10 1999-01-08 Adir Nouveaux derives [3h]-benzoxazole-2-thiones et [3h]- benzothiazole-2-thiones substitues, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
US7794761B2 (en) * 2000-04-13 2010-09-14 Seroctin Research & Technology, Inc. Methods for inducing anti-anxiety and calming effects in animals and humans
US20040192669A1 (en) * 2000-04-13 2004-09-30 Rosenfeld Mark J. Novel compounds for use in weight loss and appetite suppression in humans
AU784967B2 (en) * 2002-06-13 2006-08-10 Frank J. Daniel Apparatus for flushing and cleaning a refrigeration system
US7524877B2 (en) 2003-11-20 2009-04-28 Seroctin Research & Technology, Inc. Compounds for use in weight loss and appetite suppression in humans
DE102005026808A1 (de) 2005-06-09 2006-12-14 Sanofi-Aventis Deutschland Gmbh Benzooxazol-2-on-derivate als Inhibitoren von Lipasen und Phospholipasen
DE102005026762A1 (de) * 2005-06-09 2006-12-21 Sanofi-Aventis Deutschland Gmbh Azolopyridin-2-on-derivate als Inhibitoren von Lipasen und Phospholipasen
DE102008022221A1 (de) * 2008-05-06 2009-11-12 Universität des Saarlandes Inhibitoren der humanen Aldosteronsynthase CYP11B2

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2244506B1 (es) * 1973-06-26 1977-02-25 Inst Nat Sante Rech Med
FR2491066A1 (fr) * 1980-09-29 1982-04-02 Cerm Cent Europ Rech Mauvernay Benzoxazolinones substituees en 6 par une chaine aminoalcool ou aminocetone, leur preparation et leur application en therapeutique
JPS589877A (ja) * 1981-07-08 1983-01-20 松下電器産業株式会社 高誘電率磁器組成物
FR2645149A1 (es) * 1989-03-30 1990-10-05 Adir

Also Published As

Publication number Publication date
JPH04230272A (ja) 1992-08-19
JPH07108904B2 (ja) 1995-11-22
AU7917191A (en) 1992-01-02
EP0463944A1 (fr) 1992-01-02
EP0463944B1 (fr) 1994-10-05
DE69104416D1 (de) 1994-11-10
FR2663634A1 (fr) 1991-12-27
FR2663634B1 (fr) 1992-09-04
NZ238648A (en) 1992-08-26
DK0463944T3 (da) 1995-04-03
AU631498B2 (en) 1992-11-26
ATE112562T1 (de) 1994-10-15
US5147883A (en) 1992-09-15
OA09372A (fr) 1992-09-15
DE69104416T2 (de) 1995-05-04
PT98067A (pt) 1992-03-31
ZA914801B (en) 1992-04-29
IE912147A1 (en) 1992-01-01
CA2045257A1 (fr) 1991-12-23

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