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PE20060003A1 - Formulacion farmaceutica polimerica para moldear por inyeccion - Google Patents

Formulacion farmaceutica polimerica para moldear por inyeccion

Info

Publication number
PE20060003A1
PE20060003A1 PE2005000274A PE2005000274A PE20060003A1 PE 20060003 A1 PE20060003 A1 PE 20060003A1 PE 2005000274 A PE2005000274 A PE 2005000274A PE 2005000274 A PE2005000274 A PE 2005000274A PE 20060003 A1 PE20060003 A1 PE 20060003A1
Authority
PE
Peru
Prior art keywords
weight
peso
talc
simply
modified
Prior art date
Application number
PE2005000274A
Other languages
English (en)
Inventor
Stephen Mark Mcallister
Ronald K Raby Jr
Daniel N Margetson
Adrian Brown
Wayne M Matthews
Original Assignee
Smithkline Beecham Plc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smithkline Beecham Plc filed Critical Smithkline Beecham Plc
Publication of PE20060003A1 publication Critical patent/PE20060003A1/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1617—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1617—Organic compounds, e.g. phospholipids, fats
    • A61K9/1623—Sugars or sugar alcohols, e.g. lactose; Derivatives thereof; Homeopathic globules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
    • A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4816—Wall or shell material
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5026—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5036—Polysaccharides, e.g. gums, alginate; Cyclodextrin
    • A61K9/5042—Cellulose; Cellulose derivatives, e.g. phthalate or acetate succinate esters of hydroxypropyl methylcellulose
    • A61K9/5047—Cellulose ethers containing no ester groups, e.g. hydroxypropyl methylcellulose

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Injection Moulding Of Plastics Or The Like (AREA)

Abstract

SE REFIERE A UNA FORMULACION PARA MOLDEAR COMPONENTES QUE COMPRENDE: A) EUDRAGIT RL 100 O RS 100 DE APROXIMADAMENTE 10-80% PESO/PESO; B) EXCIPIENTE MODIFICADOR DE DISOLUCION DE 20-70% PESO/PESO; C) UN LUBRICANTE ENTRE 5-25% PESO/PESO TAL COMO ALCOHOL ESTEARILICO, MONOESTEARATO DE GLICEROL, TALCO, ENTRE OTROS; D) TENSIOACTIVO COMO DODECIL-SULFATO SODICO O COPOLIMERO DE BLOQUES DE OXIDO DE ETILENO Y PROPILENO; PLASTIFICANTE COMO ETIL CELULOSA, ACETATO-FTALATO DE CELULOSA, HIDROXIPROPIL-CELULOSA, ENTRE OTROS Y UN AGENTE DE POLIMERIZACION COMO TALCO ENTRE 0-10% PESO/PESO. DICHA COMPOSICION PROPORCIONA DIFERENTES CARACTERISTICAS FISICOQUIMICAS EN EL CUAL SE PUEDE ELEGIR UNA FORMA DE DOSIFICACION QUE PUEDE INCLUIR UNA DISOLUCION RAPIDA, LIBERACION INMEDIATA, RETARDADA, EN PULSOS O MODIFICADA SIMPLEMENTE SELECCIONANDO LOS POLIMEROS ADECUADOS, SIENDO UTILES PARA PREPARAR CUBIERTAS, CONECTORES O ESPACIADORES DE CAPSULAS MOLDEADOS POR INYECCION
PE2005000274A 2004-03-12 2005-03-10 Formulacion farmaceutica polimerica para moldear por inyeccion PE20060003A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US55249904P 2004-03-12 2004-03-12

Publications (1)

Publication Number Publication Date
PE20060003A1 true PE20060003A1 (es) 2006-03-01

Family

ID=34993424

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2005000274A PE20060003A1 (es) 2004-03-12 2005-03-10 Formulacion farmaceutica polimerica para moldear por inyeccion

Country Status (17)

Country Link
US (3) US8147871B2 (es)
EP (1) EP1729744A4 (es)
JP (2) JP2007528901A (es)
KR (3) KR20130010511A (es)
CN (1) CN1953739B (es)
AR (1) AR048033A1 (es)
AU (1) AU2005222612C1 (es)
BR (1) BRPI0508342A (es)
CA (1) CA2559227A1 (es)
IL (1) IL177566A (es)
MA (1) MA28489B1 (es)
NO (1) NO20064570L (es)
NZ (1) NZ549264A (es)
PE (1) PE20060003A1 (es)
RU (2) RU2447885C2 (es)
TW (2) TW201240679A (es)
WO (1) WO2005089726A1 (es)

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