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KR900009064A - 활성 성분으로서 피소스티그민으로 구성된 경피 치료계 및 그것의 제조방법 - Google Patents

활성 성분으로서 피소스티그민으로 구성된 경피 치료계 및 그것의 제조방법 Download PDF

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Publication number
KR900009064A
KR900009064A KR1019890019755A KR890019755A KR900009064A KR 900009064 A KR900009064 A KR 900009064A KR 1019890019755 A KR1019890019755 A KR 1019890019755A KR 890019755 A KR890019755 A KR 890019755A KR 900009064 A KR900009064 A KR 900009064A
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therapeutic system
transdermal therapeutic
physostigmine
weight
polymer
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KR1019890019755A
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KR950015057B1 (ko
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힐레 토마스
호프만 한스-라이너
후버 한스-요아힘
악셀크노흐
슈나이더 게라르트
슈타니스라우스 프리츠
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원본미기재
엘테에스 로만 테라파 시스테메 게엠베하 운트 콤파니 카게
클링게 파르마 게엠베하
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
    • A61K9/7084—Transdermal patches having a drug layer or reservoir, and one or more separate drug-free skin-adhesive layers, e.g. between drug reservoir and skin, or surrounding the drug reservoir; Liquid-filled reservoir patches
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
    • A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
    • A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
    • A61K9/7053—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained by reactions only involving carbon to carbon unsaturated bonds, e.g. polyvinyl, polyisobutylene, polystyrene
    • A61K9/7061—Polyacrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

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  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Dermatology (AREA)
  • Epidemiology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Psychiatry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hospice & Palliative Care (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Materials For Medical Uses (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Media Introduction/Drainage Providing Device (AREA)
  • Steroid Compounds (AREA)
  • Saccharide Compounds (AREA)

Abstract

내용 없음.

Description

활성 성분으로서 피소스티그민으로 구성된 경피 치료계 및 그것의 제조방법
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
제1도는 매트릭스(1)에 도포된 부직포(2)를 나타낸다.
제2도는 분리후 매트릭스(1)과 밀폐커버(3)위에 배치된 활성제 수용체(2)의 정면도를 나타낸다.
제3도는 분리후 매트릭스(1)과 밀폐커버(3)위에 배치된 활성기제 수용체(2)의 측면도를 나타낸다.

Claims (16)

  1. 활성물질, 압감 접찹 수요층, 및 임의의 제거성 보호층에 불투과성인 커버층을 경유하여 피부에 피소스티그민을 투여하는 경피 치료계에 있어서, 수용층의 스티렌과 1,3-디엔을 기초로한 블록 공중합체, 폴리이소부틸렌, 아크릴레이트 및/또는 메타아크릴레이트 및 수소화 콜로포늄의 에스테르를 기초로한 중합체로 구성된 군으로부터 선택된 10-90중량%의 중합물질, 탄화수소 및/또는 에스테르를 기초로한 0-30중량%의 연질제로 구성되며, 제조직후 융착된 활성물질이 0.1-70중량%의 피소스티그민중에 15-85중량%로 구성되는 것을 특징으로 하는 경피 치료계.
  2. 제1항에 있어서, 중합물질이 Z-에틸헥실 아크릴레이트, 비닐아세테이트, 아크릴산 및 그것의 티탄 킬레이트의 자기 가교결합 아크릴 레이트 공중합체로 구성되는 것을 특징으로 하는 경피 치료계.
  3. 제1항에 있어서, 중합물질이 Z-에틸헥실 아크릴레이트, 비닐 아세테이트 및 아크릴산의 비자기 가교결합 아크릴레이트 공중합체로 구성되는 것을 특징으로 하는 경피 치료계.
  4. 제1항에 있어서, 중합물질이 메타아크릴레이트를 기초로한 중합체, 디메틸 아미노에틸 메타아크릴레이트 및 중성 메타 아크릴산 에스테르를 기초로한 공중합체로 구성되는 것을 특징으로 하는 경피 치료계.
  5. 제1항에 있어서, 중합물질이 수소화 콜로포늄의 에스테르 또는 그것의 메틸 에스테르로 구성되는 것을 특징으로 하는 경피 치료계.
  6. 제1항에 있어서, 중합물질이 수소화 콜로포늄의 에스테르 또는 그것의 글리콜 에스테르로 구성되는 것을 특징으로 하는 경피 치료계.
  7. 제1항에 있어서, 수용층이 디옥틸시클로 헥산 연질제로서 구성되는 것을 특징으로 하는 경피 치료계.
  8. 제1항에 있어서, 수용층이다.-n-부틸 아디페이트 연질제로 구성되는 것을 특징으로 하는 경피 치료계.
  9. 제1항에 있어서, 수용층이 트리글리세리드 연질제로 구성되는 것을 특징으로 하는 경피 치료계.
  10. 제1항에 있어서, 수용층이 이소프로필미스테이트 연질제로 구성되는 것을 특징으로 하는 경피 치료계.
  11. 제1항에 있어서, 활성 융착 물질내에서 피소스티그민 용액의 용매가 최소한 하나의 산기를 가진 화합물인 것을 특징으로 하는 경피 치료계.
  12. 제1항에 있어서, 적어도 하나의 산기로 구성된 화합물이 카르복실산인 것을 특징으로 하는 경피 치료계.
  13. 제12항에 있어서, 카르복실산이 올레인 산 또는 운데센 산으로 구성되는 것을 특징으로 하는 경피 치료계.
  14. 제12항에 있어서, 카르복실산이 운데칸 산의 혼합물로 구성되는 것을 특징으로 하는 경피 치료계.
  15. 제12항에 있어서, 카르복실산이 베르사틴 산으로 구성되는 것을 특징으로 하는 경피 치료계.
  16. 제거성 보호층이 선택적으로 제공된 예비 제조된 자기 접착매트릭스 위에 위치딘 직물에 피소스티그민 또는 그것의 약학적 허용염을 용액내에서 첨가한 다음, 매트릭스와 활성 융착 물질에 커버층이 제공되는 것을 특징으로 하는 제1항의 경피 치료계의 제조방법.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019890019755A 1988-12-22 1989-12-22 활성 성분으로서 피소스티그민을 포함하는 경피 치료계 및 이의 제조방법 KR950015057B1 (ko)

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DEP3843238.2 1988-12-22
DE3843238A DE3843238C1 (ko) 1988-12-22 1988-12-22

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KR900009064A true KR900009064A (ko) 1990-07-02
KR950015057B1 KR950015057B1 (ko) 1995-12-21

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US (1) US5391375A (ko)
EP (1) EP0377147B1 (ko)
JP (1) JPH0784380B2 (ko)
KR (1) KR950015057B1 (ko)
CN (1) CN1044226A (ko)
AT (1) ATE105489T1 (ko)
AU (1) AU613814B2 (ko)
CA (1) CA2006398C (ko)
CS (1) CS277067B6 (ko)
DD (1) DD290582A5 (ko)
DE (2) DE3843238C1 (ko)
DK (1) DK651189A (ko)
ES (1) ES2057080T3 (ko)
FI (1) FI95774C (ko)
GE (1) GEP19980993B (ko)
HU (1) HU206041B (ko)
IE (1) IE64834B1 (ko)
IL (1) IL92679A0 (ko)
LT (1) LT3705B (ko)
LV (1) LV10383B (ko)
MY (1) MY105073A (ko)
NO (1) NO180107C (ko)
NZ (1) NZ231908A (ko)
PH (1) PH25852A (ko)
PL (1) PL160971B1 (ko)
PT (1) PT92651B (ko)
RU (1) RU2052997C1 (ko)
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DK651189D0 (da) 1989-12-20
LT3705B (en) 1996-02-26
US5391375A (en) 1995-02-21
NO895172L (no) 1990-06-25
PT92651A (pt) 1990-06-29
HU206041B (en) 1992-08-28
ATE105489T1 (de) 1994-05-15
FI896098A0 (fi) 1989-12-19
CS719289A3 (en) 1992-06-17
IE64834B1 (en) 1995-09-06
LTIP1589A (en) 1995-06-26
DK651189A (da) 1990-06-23
YU240689A (en) 1991-04-30
ZA899882B (en) 1990-09-26
KR950015057B1 (ko) 1995-12-21
ES2057080T3 (es) 1994-10-16
YU47076B (sh) 1994-12-28
JPH0315476A (ja) 1991-01-23
LV10383B (en) 1995-10-20
RU2052997C1 (ru) 1996-01-27
JPH0784380B2 (ja) 1995-09-13
PH25852A (en) 1991-12-02
FI95774C (fi) 1996-03-25
CS277067B6 (en) 1992-11-18
NO180107B (no) 1996-11-11
EP0377147A3 (en) 1990-12-27
HUT54043A (en) 1991-01-28
GEP19980993B (en) 1998-03-26
NZ231908A (en) 1991-10-25
FI95774B (fi) 1995-12-15
LV10383A (lv) 1995-02-20
HU896714D0 (en) 1990-02-28
MY105073A (en) 1994-07-30
IL92679A0 (en) 1990-09-17
PT92651B (pt) 1995-09-12
DD290582A5 (de) 1991-06-06
EP0377147A2 (de) 1990-07-11
DE58907649D1 (de) 1994-06-16
AU613814B2 (en) 1991-08-08
CN1044226A (zh) 1990-08-01
CA2006398C (en) 1997-04-15
DE3843238C1 (ko) 1990-02-22
NO895172D0 (no) 1989-12-21
AU4684489A (en) 1990-06-28
PL160971B1 (en) 1993-05-31
EP0377147B1 (de) 1994-05-11
IE894078L (en) 1990-06-22
CA2006398A1 (en) 1990-06-22
NO180107C (no) 1997-02-26

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