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KR840003641A - 피라졸로옥사진, 피라졸로티아진 및 피라졸로퀴놀린의 제조방법 - Google Patents

피라졸로옥사진, 피라졸로티아진 및 피라졸로퀴놀린의 제조방법 Download PDF

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Publication number
KR840003641A
KR840003641A KR1019830000448A KR830000448A KR840003641A KR 840003641 A KR840003641 A KR 840003641A KR 1019830000448 A KR1019830000448 A KR 1019830000448A KR 830000448 A KR830000448 A KR 830000448A KR 840003641 A KR840003641 A KR 840003641A
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South Korea
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carbon atoms
aralkyl
alkyl
aryl
amino
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KR1019830000448A
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English (en)
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마딘 마타르 (외 5)
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귄터 슈마허, 에리히 대브리츠
바이엘 아크티엔 게젤샤프트
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Publication of KR840003641A publication Critical patent/KR840003641A/ko

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
    • C07D265/34—1,4-Oxazines; Hydrogenated 1,4-oxazines condensed with carbocyclic rings
    • C07D265/36—1,4-Oxazines; Hydrogenated 1,4-oxazines condensed with carbocyclic rings condensed with one six-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

내용 없음

Description

피라졸로옥사진, 피라졸로티아진 및 피라졸로퀴놀린의 제조방법
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (1)

  1. 다음 일반식(Ⅱ)의 화합물을 디메틸로름 아미드 및 포스포러스 옥시클로라이드와 반응시키고 생성된 염을 -80℃내지 100℃에서 다음 일반식(Ⅳ)의 하이드라진과 반응시킴을 특징으로 하는, 이성체 형태의 다음 일반식(Ⅰ)의 화합물의 제조방법.
    R5-NH-NH2(Ⅳ)
    상기 일반식에서, X는 산소, 유황, SO, SO2또는 메틸렌 (CH2)이고, R1및 R2는 아릴 또는 헤테로 아릴 환상에 융합되는데, 이 환은 차례로 알콕시, 알킬, 아르알킬, 사이클로알킬, 아릴, 알킬아미노, 디알킬아미노, 아릴아미노, 아릴옥시, 아릴티오, 알킬티오, 카복실, 카보알콕시, 시아노, 카바모일, 설포닐, 알킬설포닐, 할로게노알킬, 할로게노알콕시, 할로겐, 아미노, 치환된 아미노, 하이드록실, 설폰아미노, 메틸렌카복실, 메틸렌카복시알킬, 프로필렌카복시알킬 또는 디옥시메틸렌그룹을 함유하는 그룹으로부터 선택한 5개까지의 동일하거나 또는 다른 치환기로 임의로 치환될 수 있으며, R3및 R4는 동일하거나 또는 다를 수 있고, 수소; 탄소수 1내지 18의 알킬(이 알킬기는 산소, 유황 또는 질소로 1 또는 수회 차달될 수 있다); 탄소수 2내지 12의 알케닐 또는 알키닐, 탄소수 7내지 12의 아르알킬(이 아케닐, 알키닐 및 아르알킬기는 산소, 유황 또는 질소로 1 또는 수회 또 차단될 수 있다); 탄소수 6 내지 10의 알릴, 헤테로아릴, 헤테로-아르알킬, 탄소수 1내지 18의 알킬카보닐, 헤테로아릴카보닐 및 탄소수 7내지 11의 아릴카보닐 (이 기들은 알콕시, 알킬, 아르알킬, 사이클로알킬, 아릴, 알킬아미노, 디알킬아미노, 아릴아미노, 아릴옥시, 아릴티오, 알킬티오, 카복실, 카보알콕시, 시아노, 카바모일, 설포닐, 알킬설포닐, 할로게노알킬, 할로게노알콕시, 할로겐, 아미노-, 하이드록실, 설폰아미도, 메틸렌카복시, 메틸렌카복시알킬 또는 프로필렌카복시알킬을 함유하는 그룹으로부터 선택한 5개까지의 동일하거나 또는 다른 치환기로 임의로 치환될 수 있다)이고, R5는 수소; 탄소수 1내지 18의 알킬, 탄소수 7내지 12의 아르알킬 또는 헤테로아르알킬(이 알킬, 아르알킬 및 헤테로아르알킬기는 산소, 유화 및 질소로 1 또는 수회 차단될 수 있다); 탄소수 6 내지 10의 아릴 및 헤테로아릴(이 아릴 및 헤테로아릴기는 알콕시, 알킬, 아르알킬, 사이클로알킬, 아릴, 알킬아미노, 디알킬아미노, 아릴아미노, 아릴옥시, 아릴티오, 알킬티오, 카복실, 카보알콕시, 시아노, 카바모일, 설포닐, 알킬설포닐, 할로게노알킬, 할로게노알콕시, 할로겐, 아미노 또는 치환된 아미노, 설폰아미도, 메틸렌카복실, 메틸렌카복시알킬 또는 프로필렌카복시알킬을 함유하는 그룹으로부터 선택한 5개까지의 동일 하거나 또는 다른 치환기로 치환될 수 있다)이다.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019830000448A 1982-02-06 1983-02-05 피라졸로옥사진, 피라졸로티아진 및 피라졸로퀴놀린의 제조방법 KR840003641A (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DEP3204126.8 1982-02-06
DE19823204126 DE3204126A1 (de) 1982-02-06 1982-02-06 Pyrazoloxazine, -thiazine, -chinoline, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel

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KR840003641A true KR840003641A (ko) 1984-09-15

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Country Link
US (1) US4552874A (ko)
EP (1) EP0085881A3 (ko)
JP (1) JPS58146583A (ko)
KR (1) KR840003641A (ko)
AU (1) AU1112583A (ko)
DE (1) DE3204126A1 (ko)
DK (1) DK49283A (ko)
ES (1) ES519559A0 (ko)
FI (1) FI830378L (ko)
GR (1) GR77960B (ko)
HU (1) HU190063B (ko)
IE (1) IE830227L (ko)
IL (1) IL67826A0 (ko)
NO (1) NO830236L (ko)
PT (1) PT76147A (ko)
ZA (1) ZA83743B (ko)

Families Citing this family (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NO834401L (no) * 1982-12-14 1984-06-15 Troponwerke Gmbh & Co Kg Pyrazolo(4.3-b)(1.4)oxasiner, fremgangsmaate til deres fremstilling og deres anvendelse som legemiddel
US4634766A (en) * 1983-10-31 1987-01-06 Merck Frosst Canada, Inc. 1,4-diaza-phenothiazines
US4749699A (en) * 1983-10-31 1988-06-07 Merck Frosst Canada, Inc. 5-lipoxygenease inhibitors
ES537162A0 (es) * 1983-10-31 1985-12-01 Merck Frosst Canada Inc Una composicion farmaceutica
US5756747A (en) * 1989-02-27 1998-05-26 Riker Laboratories, Inc. 1H-imidazo 4,5-c!quinolin-4-amines
US5037986A (en) * 1989-03-23 1991-08-06 Minnesota Mining And Manufacturing Company Olefinic 1H-imidazo[4,5-c]quinolin-4-amines
US4929624A (en) * 1989-03-23 1990-05-29 Minnesota Mining And Manufacturing Company Olefinic 1H-imidazo(4,5-c)quinolin-4-amines
US5116837A (en) * 1990-12-21 1992-05-26 Ortho Pharmaceutical Corporation 2,9-dihydro-(6 or 7)-(3-oxo-2,3,4,5-tetrahydropyridazinyl)-pyrazolo [4,3-B]-1,4-benzoxazines
US5271944A (en) * 1991-04-05 1993-12-21 Biofor, Ltd. Pharmacologically enhanced formulations
DE4122035A1 (de) * 1991-07-03 1993-01-07 Henkel Kgaa Die verwendung von 1,9-dihydro-pyrazolo(4,3-b) (1,4)-benzoxazinen als kuppler fuer oxidationsfaerbemittel
US5608067A (en) * 1993-12-09 1997-03-04 Afonso; Adriano 4-substituted pyrazoloquinoline derivatives
US5786480A (en) * 1994-04-28 1998-07-28 Schering Corporation 4-substituted pyrazoloquinoline derivatives
EP0913395A1 (en) * 1995-12-08 1999-05-06 Ube Industries, Ltd. N-phenylcarbamate compounds, process for producing the same, and agricultural or horticultural bactericides
TW200524927A (en) 2003-08-12 2005-08-01 3M Innovative Properties Co Hydroxylamine substituted imidazo-containing compounds
NZ545412A (en) 2003-08-27 2008-12-24 Coley Pharm Group Inc Aryloxy and arylalkyleneoxy substituted imidazoquinolines
EP1660026A4 (en) 2003-09-05 2008-07-16 3M Innovative Properties Co TREATMENT FOR CD5 + B CELL LYMPHOMA
US7544697B2 (en) 2003-10-03 2009-06-09 Coley Pharmaceutical Group, Inc. Pyrazolopyridines and analogs thereof
CA2540541C (en) 2003-10-03 2012-03-27 3M Innovative Properties Company Alkoxy substituted imidazoquinolines
CA2545825A1 (en) 2003-11-14 2005-06-02 3M Innovative Properties Company Hydroxylamine substituted imidazo ring compounds
CA2545774A1 (en) 2003-11-14 2005-06-02 3M Innovative Properties Company Oxime substituted imidazo ring compounds
AU2004293078B2 (en) 2003-11-25 2012-01-19 3M Innovative Properties Company Substituted imidazo ring systems and methods
WO2005066170A1 (en) 2003-12-29 2005-07-21 3M Innovative Properties Company Arylalkenyl and arylalkynyl substituted imidazoquinolines
US8735421B2 (en) 2003-12-30 2014-05-27 3M Innovative Properties Company Imidazoquinolinyl sulfonamides
US8697873B2 (en) 2004-03-24 2014-04-15 3M Innovative Properties Company Amide substituted imidazopyridines, imidazoquinolines, and imidazonaphthyridines
US8017779B2 (en) 2004-06-15 2011-09-13 3M Innovative Properties Company Nitrogen containing heterocyclyl substituted imidazoquinolines and imidazonaphthyridines
WO2006038923A2 (en) 2004-06-18 2006-04-13 3M Innovative Properties Company Aryl substituted imidazonaphthyridines
US7915281B2 (en) 2004-06-18 2011-03-29 3M Innovative Properties Company Isoxazole, dihydroisoxazole, and oxadiazole substituted imidazo ring compounds and method
WO2006009826A1 (en) 2004-06-18 2006-01-26 3M Innovative Properties Company Aryloxy and arylalkyleneoxy substituted thiazoloquinolines and thiazolonaphthyridines
ES2392647T3 (es) 2004-12-30 2012-12-12 3M Innovative Properties Company Compuestos tetracíclicos quirales que inducen la biosíntesis de interferón
US8034938B2 (en) 2004-12-30 2011-10-11 3M Innovative Properties Company Substituted chiral fused [1,2]imidazo[4,5-c] ring compounds
US9248127B2 (en) 2005-02-04 2016-02-02 3M Innovative Properties Company Aqueous gel formulations containing immune response modifiers
AU2006213746A1 (en) 2005-02-11 2006-08-17 Coley Pharmaceutical Group, Inc. Oxime and hydroxylamine substituted imidazo(4,5-c) ring compounds and methods
WO2006107851A1 (en) 2005-04-01 2006-10-12 Coley Pharmaceutical Group, Inc. 1-substituted pyrazolo (3,4-c) ring compounds as modulators of cytokine biosynthesis for the treatment of viral infections and neoplastic diseases
CA2602683A1 (en) 2005-04-01 2006-10-12 Coley Pharmaceutical Group, Inc. Pyrazolopyridine-1,4-diamines and analogs thereof
WO2008008432A2 (en) 2006-07-12 2008-01-17 Coley Pharmaceutical Group, Inc. Substituted chiral fused( 1,2) imidazo (4,5-c) ring compounds and methods
US7872002B2 (en) * 2007-06-08 2011-01-18 Helicon Therapeutics, Inc. Therapeutic pyrazoloquinoline derivatives
CA2688405A1 (en) * 2007-06-08 2008-12-18 Helicon Therapeutics, Inc. Therapeutic pyrazoloquinoline urea derivatives
KR20100036306A (ko) * 2007-06-08 2010-04-07 헬리콘 테라퓨틱스 인코퍼레이티드 치료용 피라졸로나프티리딘 유도체

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS4891096A (ko) * 1972-03-08 1973-11-27
US3790576A (en) * 1972-03-20 1974-02-05 Parke Davis & Co 9 substituted 4,9-dihydro-1,3,4,4-tetraalkyl-1h-pyrazolo(3,4-b)quinolines

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IL67826A0 (en) 1983-06-15
DK49283D0 (da) 1983-02-04
AU1112583A (en) 1983-08-11
US4552874A (en) 1985-11-12
FI830378A0 (fi) 1983-02-03
ES8402591A1 (es) 1984-02-01
PT76147A (en) 1983-02-01
JPS58146583A (ja) 1983-09-01
HU190063B (en) 1986-08-28
IE830227L (en) 1983-08-06
ZA83743B (en) 1983-11-30
NO830236L (no) 1983-08-08
EP0085881A2 (de) 1983-08-17
DK49283A (da) 1983-08-07
DE3204126A1 (de) 1983-08-11
FI830378L (fi) 1983-08-07
GR77960B (ko) 1984-09-25
EP0085881A3 (de) 1984-03-07
ES519559A0 (es) 1984-02-01

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