KR20110052095A

KR20110052095A - Cosmetic composition for moisturizing of skin containing tremella fuciformis extracts

Info

Publication number: KR20110052095A
Application number: KR1020090109002A
Authority: KR
Inventors: 김형대
Original assignee: (주)파파야 피부과학연구소
Priority date: 2009-11-12
Filing date: 2009-11-12
Publication date: 2011-05-18

Abstract

PURPOSE: A cosmetic composition containing Tremella fuciformis extract for skin moisturizing is provided to ensure synergetic effect of skin moisturizing. CONSTITUTION: A cosmetic composition for skin moisturizing contains 0.001-30.0 weight% of Tremella fuciformis extract and 0.001-10.0 weight% of hyaluronic acid as an active ingredient. The Tremella fuciformis extract is isolated from purified water, anhydrous alcohol of 1-4 carbon atoms, glycerin, butylene glycol, or propylene glycol. The composition is manufactured in the form of lotion, massage cream, essence, eye cream, cleansing cream, pack, or powder.

Description

Cosmetic composition for moisturizing skin containing agaricul mushroom extract {{Cosmetic composition for moisturizing of skin containing Tremella fuciformis extracts}

The present invention relates to a skin moisturizing cosmetic composition containing an extract of albino mushroom, wherein the albino mushroom extract contains 0.001 to 30.0% by weight relative to the total weight of the composition, and hyaluronic acid, a known moisturizer, is added to the total weight of the composition. It is characterized in that it further contains 0.001 to 10.0% by weight. The cosmetic composition of the present invention relates to a cosmetic composition in which the skin moisturizing effect is increased by applying the hyaluronic acid which is a well-known moisturizing agent together with the moisture retention ability of an extract of the white neck.

Skin is the organ that protects the human body by being located at the outermost part of the body. It prevents the loss of water and electrolyte in our body and protects it from the ingress of foreign objects. The skin is divided into epidermal, dermal and subcutaneous fat layers. The epidermal layer is composed of the basal layer, the pole layer, the granular layer and the stratum corneum, and the outermost layer of the stratum corneum plays a very important role in moisturizing the skin.

The moisture content of the epidermal layer is about 70% in the basal and polar layers, 30-50% in the granular layer and 15-30% in the stratum corneum (Journal of Investigative Dermatology, 116, 434442, 2001). However, those who complain of dry skin are known to have less than 10% water content in the stratum corneum.

Therefore, the moisture content in the stratum corneum is important to moisturize the skin, the moisture control in the stratum corneum is largely controlled by two factors. The first is the natural moisturizing factor, NMF (Natural Moisturizing Factor), which flows out of granule cells, and consists of amino acids, pyrrolidone carboxylic acid, lactate, urea, and inorganic salts, which are degradation products of filaggrin. These combine with moisture and play an important role in increasing water in the stratum corneum. Secondly, the intercellular lipids present in the stratum corneum are composed of ceramide, cholesterol, and free fatty acids, which are synthesized in keratinocytes and secreted out of the cells in the process of differentiation from the granular layer to the stratum corneum to form intercellular lipids. They act as a barrier to inhibit the evaporation of water into the external environment by passive diffusion of water supplied from the dermis.

As such, the skin can retain moisture by NMF and suppress moisture evaporation due to the skin barrier, but since the skin is in the outermost layer of the human body, it is chronically exposed to sunlight, air pollution, chemicals, wind and dry environment. Naturally, as the skin ages, the skin loses moisture and forms dry skin. As a result, the skin becomes rough, and an increasing number of people complain of dermatitis and itching.

Recently, as the number of people with dry skin increases, the need for a moisturizer is increasing. Conventionally, for this purpose, polyols such as glycerin, propylene glycol, butylene glycol, and amino acids, lactic acid, etc., which are components of NMF, have been used. However, polyols have a problem of stickiness and are used in winter. Rather, problems such as skin dryness and skin irritation are pointed out. When NMF is applied to cosmetics, there is a problem in the stability of the cosmetics, there is also a problem such as skin burning, it is difficult to expect the effect of continuous skin moisturizing.

Therefore, the present inventors conducted a study in order to solve the above-mentioned conventional problems, it was found that the mushroom extract of the white neck has an excellent water retention ability and has an improvement effect on skin drying when applied to cosmetics. In addition, when applied to cosmetics with hyaluronic acid, it was possible to obtain an elevated skin moisturizing effect and provides a cosmetic and its composition that can be used for sensitive skin as there is no big problem in skin irritation.

Skin moisturizing cosmetic composition of the present invention is characterized in that the white neck contains mushroom extract in an amount of 0.001 to 30.0% by weight based on the total weight.

In addition, the skin moisturizing cosmetic composition of the present invention is characterized by further containing hyaluronic acid as a moisturizing agent in an amount of 0.001 to 10.0% by weight.

The tremella mushroom (Tremella fuciformis) used in the present invention belongs to the tremella family, and its origin is China, Japan, and Korea, and is a mushroom that occurs in decayed trees and fallen trees of hardwoods in hilly areas and mountains. Fruiting bodies are 3-8 cm in diameter and 2-5 cm high. When dry, it will retract and harden. Fruiting bodies are pure white, translucent gelatinous, and sometimes called silver because they resemble human ears. According to traditional Chinese pharmacological theory, the white-headed mushroom is not only used to treat chronic bronchitis, but also according to the records of Chinese ancient Chinese medicine, 'Cheongeumbang', 'Fingerangbangbang' and 'Pacific Sacred Bang', White-necked mushrooms were eaten as a beauty food and are a traditional drug used as a tonic in China.

On the other hand, hyaluronic acid used in the present invention is a kind of mucopolysaccharide is a component that plays an important role in moisturizing by combining with moisture in the dermal layer of the human body.

The fungus mushroom extract contained in the cosmetic composition of the present invention is characterized in that it is extracted using an extraction solvent. The white wood mushroom is dried in a cool place and then physically pulverized, and then extracted by adding an extraction solvent to the pulverized product. As the extraction solvent, one selected from the group consisting of purified water, anhydrous alcohols having 1 to 4 carbon atoms (methanol, ethanol, propanol, butanol), glycerin, butylene glycol, and propylene glycol may be used alone, or two solvents may be mixed. use. The ratio of the pulverized product and the solvent is 1: 5 to 1:30, preferably 1:10. The extractor is extracted at 40-100 ° C. for 5-20 hours or at 4-40 ° C. for 1-15 days and freeze-dried.

On the other hand, the baekryeok mushroom extract is characterized in that it contains 0.001 to 30.0% by weight based on the total weight of the cosmetic composition. Preferably it is 0.1-10.0 weight%. When the content of the mushroom extract is less than 0.001% by weight, it is difficult to expect the effect, when it exceeds 30.0% by weight does not appear to increase the apparent effect of increasing the content.

On the other hand, the content of hyaluronic acid in the present invention is characterized in that it contains 0.001 ~ 10.0% by weight based on the total weight of the composition. When the hyaluronic acid is 0.001% by weight or less, there is no synergistic effect of skin moisturizing, and when it exceeds 10.0% by weight, there is a problem in the stability of the formulation and skin irritation.

The moisturizing cosmetic composition of the present invention is not particularly limited in the formulation, and the skin moisturizing composition of the present invention may be prepared in any formulation commonly prepared in the art, for example, solutions, suspensions, emulsions Liquids, pastes, gels, creams, lotions, powders, soaps, surfactant-containing cleansing, oils, powder foundations, emulsion foundations, wax foundations, sprays, and the like, but are not limited thereto.

As an active ingredient included in the cosmetic composition of the present invention, the white neck, including mushroom extract, hyaluronic acid, and other components commonly used in cosmetic compositions, such as antioxidants, stabilizers, solubilizers, vitamins, pigments and flavorings, such as conventional And the like.

As described in detail above, it was observed that the white neck mushroom extract has excellent water retention ability, and when the white neck mushroom was applied together with the mushroom extract and hyaluronic acid as a moisturizer, the moisturizing effect was found to be increased as a skin moisturizing cosmetic. It can be usefully used.

Hereinafter, the present invention will be described in more detail with reference to the following examples. These examples are only for illustrating the present invention in more detail, and the scope of the present invention is not limited to these embodiments according to the gist of the present invention to those skilled in the art to which the present invention pertains. Will be self explanatory.

Preparation Example 1 Preparation of Albinus Mushroom Extract

Albino mushrooms were imported from the Fujian province of China. In a cool place, dry white wood mushrooms 20g of powdered mushrooms using a grinder, and then, 10 times the weight of white wood mushrooms is added to the purified water and heated at 70 ℃ for 10 hours to extract hot water. The extract was filtered with a 400 mesh filter cloth, and the filtrate was collected and dried using a lyophilizer.

Experimental Example 2 Evaluation of Water Retention Ability for Extracts

The extract obtained in Preparation Example 1, hyaluronic acid, the extract and the mixture of hyaluronic acid and glycerin and 1,3-butylene glycol were prepared in the form of an aqueous solution in purified water, and then the water retention capacity under the conditions of 25 ℃ and 45% relative humidity was measured. . 10 g of each aqueous solution was placed in a petri dish, and the weight change was measured in a desiccator containing CaCl 2. Weighed once daily for three days. The results of this experiment are shown in Table 1 below.

Table 1

time Preparation Example 1
(10.0%) Hyaluronic acid
(10.0%) Preparation Example 1
Mixed solution of hyaluronic acid
(5.0% + 5.0%) glycerin
(10.0%) Butylene Glycol
(10.0%) Purified water Initial value 10.05 10.08 10.04 10.05 10.03 10.04 1 day 8.47 8.34 9.54 8.39 8.21 7.85 2 days 7.22 6.98 8.91 7.10 6.94 5.44 3 days 6.94 5.40 7.78 6.15 6.02 3.01

As can be seen from the results of the experimental example, it was observed that the white-necked mushroom extract samples had better water retention than hyaluronic acid, glycerin and butylene glycol, which are moisturizing agents. It was confirmed that there is a synergistic effect.

[Production Example 2]

To the emulsion composition having a composition ratio of the following Table 2 was prepared a cosmetic composition containing the white neck mushroom extract, hyaluronic acid.

[Table 2]

ingredient Example 1 (% by weight) Example 2 (% by weight) Comparative Example 1 (% by weight) Comparative Example 2 (wt%) Comparative Example 3 (wt%) Albino Mushroom Extract 2.5 5.0 Hyaluronic acid 2.5 5.0 glycerin 5.0 Liquid paraffin 8.0 8.0 8.0 8.0 8.0 Polysorbate 60 2.0 2.0 2.0 2.0 2.0 Sorbitan sesquirololeate 1.0 1.0 1.0 1.0 1.0 Squalane 5.0 5.0 5.0 5.0 5.0 Beeswax 2.0 2.0 2.0 2.0 2.0 Triethanolamine 0.5 0.5 0.5 0.5 0.5 Propylene glycol 1.0 1.0 1.0 1.0 1.0 Carboxyl Vinyl Polymer 1.5 1.5 1.5 1.5 1.5 Purified water Balance Balance Balance Balance Balance system 100 100 100 100 100

Experimental Example 2 Skin Patch Test

In the past, skin irritation has not been shown to be irritable, and a skin test was performed on 20 women in their 20s and 30s with no skin disease or skin allergy symptoms to confirm the skin safety of the present invention. First the test site was wiped with 70% ethanol and dried. 15 μg of the prepared test substance was dropped in a Fin chamber (Finn chamber, 100 × 10, EPITEST, Finland), and then sealed in the forearm inner part of the test subject. The patch was marked for 24 hours, the patch was removed, and the test site was marked with a pen. 1 hour and 24 hours after marking, the test site was observed using a magnifying glass (8MC-150, DAZOR, United States of America) to observe erythema and edema. Skin response was determined according to the regulations of the International Contact Dermaitis Research Group (ICDRG), and the average skin response rate was calculated according to Equation 1. The results are shown in Table 3.

[Evaluation Criteria and Score of Skin Response]

Symbol score Evaluation standard - 0 No response ± 0.5 Faint or light erythema + One Boundary but weak erythema, edema and papules ++ 2 Pronounced erythema, papules and vesicles +++ 3 Severe erythema and alveolar, scleroderma

[Equation 1]

Average skin reactivity = (score x responses x 100 x 1/2) / [3 (maximum score) x total number of subjects (n)]

[Table 3]

Test substance After 1 hour After 24 hours Reactivity (%)
(n = 20) ± + ++ ± + ++ Example 1 - - - - - - 0.00 Example 2 - - - - - - 0.00 Comparative Example 1 - - - - - - 0.00 Comparative Example 2 - - - - - - 0.00 Comparative Example 3 - - - - - - 0.00

As can be seen in Table 3, skin skin test did not appear skin irritation in the cosmetics containing mushroom extract and hyaluronic acid in the skin patch test is excellent skin safety.

Experimental Example 3 Evaluation of Skin Moisturizing Device

Moisturizing effect in the stratum corneum was measured using the cosmetics prepared in Examples and Comparative Examples. 100 women aged 30 to 40 years with dry skin were used to apply the cosmetics prepared in Examples 1 to 2 and Comparative Examples 1 to 3 twice a day to the face for 1 month. 1 week, 2 weeks, 4 weeks after application and 2 weeks after application stop using the moisture measuring instrument (corneometer CM825, courage Khazaka electronic GmbH, Germany) at constant temperature and humidity conditions (25 ℃, humidity 45%) The skin conductivity after (6 weeks) was measured to evaluate the rate of increase of skin moisturizing. The results are shown in Table 4 below, and the results are expressed as average values.

Table 4

Cosmetics 1 week (%) 2 weeks (%) 4 weeks (%) 6 weeks (%) Example 1 9.5 16.7 49.6 42.5 Example 2 4.5 7.3 23.2 17.3 Comparative Example 1 3.9 6.7 19.7 13.3 Comparative Example 2 4.3 6.8 21.9 16.9 Comparative Example 3 0.1 0.4 0.7 0.2

As can be seen from the results of Table 4, the white neck was shown to have a skin moisturizing effect in Examples 1 and 2 containing the mushroom extract. In particular, in the case of Example 1, which contains white mushrooms as a mushroom extract and hyaluronic acid, it was observed that the skin moisturizing effect is increased than using the active ingredient alone, and it was confirmed that the moisturizing effect was superior to Comparative Example 2 containing glycerin. Could.

Experimental Example 4 Skin Moisturizing Questionnaire Evaluation

For the test subjects of Test Example 3, a questionnaire about the improvement effect of moisture retention after using Examples 1 and 2 and Comparative Examples 1 to 3 was conducted. Evaluation points were evaluated in the following five stages and summarized the average value. The results are shown in Table 5.

[Rating]

4: very satisfied

3: a little satisfied

2: satisfied

1: No effect

[Table 5]

Cosmetics Example 1 Example 2 Comparative Example 1 Comparative Example 2 Comparative Example 3 Score 3.8 3.3 2.5 3.0 1.1

As can be seen from the results of Table 5, Examples 1 and 2 according to the present invention showed an effect of improving the skin moisturizing, in particular, in the case of Example 1 containing the white neck mushroom extract and hyaluronic acid Moisturizing effect was found to be superior.

Hereinafter, as an example of the cosmetic formulation of the present invention, the softening lotion, lotion, essence, massage cream, shampoo and body cleanser containing the active ingredient of the present invention are exemplified, but the formulation of the cosmetic of the present invention is not necessarily limited thereto. .

Formulation Example 1 Flexible Cosmetics

Softwood longevity containing the mushroom extract and hyaluronic acid was prepared according to a conventional method.

Table 6

Raw material name Content (% by weight) Albino Mushroom Extract 2.5 Hyaluronic acid 2.5 1,3-butylene glycol 5.2 Oleyl alcohol 1.5 ethanol 3.2 Polysorbate 20 3.2 Benzophenone-9 2.0 Carboxyl Vinyl Polymer 1.0 glycerin 3.5 incense a very small amount antiseptic a very small amount Purified water Balance system 100

[Formulation Example 2] Lotion

A lotion containing mushroom extract and hyaluronic acid was prepared according to a conventional method.

Table 7

Raw material name Content (% by weight) Albino Mushroom Extract 2.5 Hyaluronic acid 2.5 Cetostearyl alcohol 1.0 Glyceryl Monostearate 0.8 Sorbitan monostearate 0.3 Porofilparaben 0.1 Polysorbate 60 1.0 Mineral oil 5.0 Pyromethicone 3.0 Dimethicone 0.5 Allantoin 0.1 glycerin 5.0 Alcohol 2 Propylene glycol 3.0 incense a very small amount antiseptic a very small amount Purified water Balance system 100

Formulation Example 3 Essence

Essences containing agaric mushroom extract and hyaluronic acid were prepared according to a conventional method.

Table 8

Raw material name Content (% by weight) Albino Mushroom Extract 2.5 Hyaluronic acid 2.5 1,3-butylene glycol 4.0 glycerin 3.0 Allantoin 0.5 Panthenol 0.1 EDTA-2Na 0.01 ethanol 5.0 Triethanolamine 1.5 Squalane 2.0 Beeswax 2.5 Polysorbate 60 3.5 Carboxyl Vinyl Polymer 1.0 Sorbitan sesquioleate 2.5 incense a very small amount antiseptic a very small amount Purified water Balance system 100

Formulation Example 5 Massage Cream

Massage creams containing mushroom extract and hyaluronic acid were prepared according to a conventional method.

Table 9

Raw material name Content (% by weight) Albino Mushroom Extract 2.5 Hyaluronic acid 2.5 glycerin 4.0 Vaseline 3.5 Triethanolamine 0.5 Liquid paraffin 24.0 Squalane 3.0 Beeswax 2.1 Tocopheryl acetate 0.1 Polysorbate 60 2.4 Carboxyl Vinyl Polymer 1.0 Sorbitan sesquioleate 2.3 incense a very small amount antiseptic a very small amount Purified water Balance system 100

Formulation Example 6 Shampoo

Shampoos containing albino mushroom extract and hyaluronic acid were prepared according to a conventional method.

TABLE 10

Raw material name Content (% by weight) Albino Mushroom Extract 2.5 Hyaluronic acid 2.5 Alkyl ether sulfate (30%) 20.0 Alkylamidobetaine (30%) 5.0 Propylene glycol 3.0 Lauramid 4.0 EDTA-2Na 0.1 Polyquaternium-10 0.05 NaCl 0.1 Citric acid 2.4 incense a very small amount antiseptic a very small amount Purified water Balance system 100

Formulation Example 7 Body Cleanser

A body cleanser containing albino mushroom extract and hyaluronic acid was prepared according to a conventional method.

TABLE 11

Raw material name Content (% by weight) White Throat Mushroom 2.5 Hyaluronic acid 2.5 Alkyl ether saccharide (30%) 30.0 Alkyl ether sulfosuccinate (30%) 20.0 Alkylamidobetaine (30%) 5.0 Propylene glycol 5.0 Betaine 5.0 Lauramiddiei 4.0 Cellulose gum 0.05 Hydrolyzed protein 0.1 Citric acid a very small amount NaCl a very small amount incense a very small amount antiseptic a very small amount Purified water Balance system 100

Claims

Cosmetic composition for moisturizing skin, characterized in that the white neck contains mushroom extract and hyaluronic acid as an active ingredient.

The method of claim 1, wherein the chalcoccus mushroom extract is used alone with one selected from the group consisting of purified water, anhydrous alcohols having 1 to 4 carbon atoms (methanol, ethanol, propanol, butanol), glycerin, butylene glycol, and propylene glycol. Or, a skin composition for moisturizing the skin, characterized in that the mixture is extracted by using two solvents.

The cosmetic composition for moisturizing skin according to claim 1, wherein the extract of A. oleracea is contained in an amount of 0.001% to 30.0% by weight in the cosmetic composition.

The cosmetic composition for moisturizing skin according to claim 1, wherein the hyaluronic acid is contained in an amount of 0.001% to 10.0% by weight in the cosmetic composition.

The composition of claim 1, wherein the composition has a formulation selected from the group consisting of softener, nourishing lotion, nourishing cream, massage cream, essence, eye cream, cleansing cream, cleansing foam, cleansing water, pack, spray and powder. A cosmetic composition for skin moisturizing, characterized in that.