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KR100887164B1 - Ｌｉｐｇ 폴리펩타이드의 활성을 증가시키고 초저밀도 지단백질(ｖｌｄｌ) 콜레스테롤 및 저밀도 지단백질(ｌｄｌ) 콜레스테롤의 수준을 저하시키는 조성물 및 이를 위해 유용한 화합물을 동정하는 방법 - Google Patents

Ｌｉｐｇ 폴리펩타이드의 활성을 증가시키고 초저밀도 지단백질(ｖｌｄｌ) 콜레스테롤 및 저밀도 지단백질(ｌｄｌ) 콜레스테롤의 수준을 저하시키는 조성물 및 이를 위해 유용한 화합물을 동정하는 방법 Download PDF

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Publication number
KR100887164B1
KR100887164B1 KR1020017012300A KR20017012300A KR100887164B1 KR 100887164 B1 KR100887164 B1 KR 100887164B1 KR 1020017012300 A KR1020017012300 A KR 1020017012300A KR 20017012300 A KR20017012300 A KR 20017012300A KR 100887164 B1 KR100887164 B1 KR 100887164B1
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lipg
leu
gly
ser
val
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KR1020017012300A
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KR20020029651A (ko
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제이마이클
린치케빈제이
아민딜립브이
도안킴-안티
마캐디어돈
마우게에이스시릴
레이더다니엘제이
크레윅존에이
사우쓰빅토리아제이
Original Assignee
아벤티스 파마슈티칼스 인크.
더 트러스티즈 오브 더 유니버서티 오브 펜실베니아
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Priority claimed from US09/277,401 external-priority patent/US7008776B1/en
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/40—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • C12N9/18—Carboxylic ester hydrolases (3.1.1)
    • C12N9/20—Triglyceride splitting, e.g. by means of lipase
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy

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  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
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  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
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  • Genetics & Genomics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • Diabetes (AREA)
  • Cardiology (AREA)
  • Biophysics (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biomedical Technology (AREA)
  • Obesity (AREA)
  • Microbiology (AREA)
  • Hematology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • General Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Medicines Containing Plant Substances (AREA)
KR1020017012300A 1999-03-26 2000-03-24 Ｌｉｐｇ 폴리펩타이드의 활성을 증가시키고 초저밀도 지단백질(ｖｌｄｌ) 콜레스테롤 및 저밀도 지단백질(ｌｄｌ) 콜레스테롤의 수준을 저하시키는 조성물 및 이를 위해 유용한 화합물을 동정하는 방법 KR100887164B1 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/277,401 1999-03-26
US09/277,401 US7008776B1 (en) 1996-12-06 1999-03-26 Compositions and methods for effecting the levels of high density lipoprotein (HDL) cholesterol and apolipoprotein AI very low density lipoprotein (VLDL) cholesterol and low density lipoprotein (LDL) cholesterol

Related Child Applications (1)

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KR1020057005114A Division KR20050044812A (ko) 1999-03-26 2000-03-24 Ｌｉｐｇ의 발현을 저하시키고 고밀도 지단백질(ｈｄｌ)콜레스테롤 및 아포지단백질 ａｉ의 수준을 증가시키는조성물

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KR20020029651A KR20020029651A (ko) 2002-04-19
KR100887164B1 true KR100887164B1 (ko) 2009-03-10

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KR1020057005114A KR20050044812A (ko) 1999-03-26 2000-03-24 Ｌｉｐｇ의 발현을 저하시키고 고밀도 지단백질(ｈｄｌ)콜레스테롤 및 아포지단백질 ａｉ의 수준을 증가시키는조성물
KR1020017012300A KR100887164B1 (ko) 1999-03-26 2000-03-24 Ｌｉｐｇ 폴리펩타이드의 활성을 증가시키고 초저밀도 지단백질(ｖｌｄｌ) 콜레스테롤 및 저밀도 지단백질(ｌｄｌ) 콜레스테롤의 수준을 저하시키는 조성물 및 이를 위해 유용한 화합물을 동정하는 방법

Family Applications Before (1)

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KR1020057005114A KR20050044812A (ko) 1999-03-26 2000-03-24 Ｌｉｐｇ의 발현을 저하시키고 고밀도 지단백질(ｈｄｌ)콜레스테롤 및 아포지단백질 ａｉ의 수준을 증가시키는조성물

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EP (1) EP1171078A4 (ja)
JP (1) JP2002540127A (ja)
KR (2) KR20050044812A (ja)
AU (1) AU776684B2 (ja)
BR (1) BR0009333A (ja)
CA (1) CA2363486C (ja)
HK (1) HK1043309A1 (ja)
IL (2) IL145526A0 (ja)
MX (1) MXPA01009727A (ja)
NO (2) NO331779B1 (ja)
NZ (2) NZ514350A (ja)
WO (1) WO2000057837A2 (ja)
ZA (1) ZA200107598B (ja)

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NO20014657L (no) 2001-11-21
HK1043309A1 (zh) 2002-09-13
MXPA01009727A (es) 2002-07-22
IL145526A (en) 2010-11-30
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WO2000057837A2 (en) 2000-10-05
EP1171078A4 (en) 2002-11-06
AU3918700A (en) 2000-10-16
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NO20014657D0 (no) 2001-09-25
KR20050044812A (ko) 2005-05-12
WO2000057837A3 (en) 2001-01-25
AU776684B2 (en) 2004-09-16
WO2000057837A8 (en) 2001-09-27
EP1171078A2 (en) 2002-01-16
JP2002540127A (ja) 2002-11-26
KR20020029651A (ko) 2002-04-19

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