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NO20100214L - Preparat for a redusere LIPG ekspresjon hos en pasient og anvendelsen av dette - Google Patents

Preparat for a redusere LIPG ekspresjon hos en pasient og anvendelsen av dette

Info

Publication number
NO20100214L
NO20100214L NO20100214A NO20100214A NO20100214L NO 20100214 L NO20100214 L NO 20100214L NO 20100214 A NO20100214 A NO 20100214A NO 20100214 A NO20100214 A NO 20100214A NO 20100214 L NO20100214 L NO 20100214L
Authority
NO
Norway
Prior art keywords
patient
reducing
preparation
lipg
expression
Prior art date
Application number
NO20100214A
Other languages
English (en)
Other versions
NO331784B1 (no
Inventor
Michael Jaye
Kevin J Lynch
Dilip V Amin
Kim-Anh Thi Doan
Dawn Marchadier
Cyrille Maugeais
Daniel J Rader
John A Krawiec
Victoria J South
Original Assignee
Aventis Pharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US09/277,401 external-priority patent/US7008776B1/en
Publication of NO20100214L publication Critical patent/NO20100214L/no
Application filed by Aventis Pharma Inc filed Critical Aventis Pharma Inc
Publication of NO331784B1 publication Critical patent/NO331784B1/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/40—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • C12N9/18—Carboxylic ester hydrolases (3.1.1)
    • C12N9/20—Triglyceride splitting, e.g. by means of lipase
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Genetics & Genomics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Biophysics (AREA)
  • Diabetes (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biomedical Technology (AREA)
  • Cardiology (AREA)
  • Microbiology (AREA)
  • Vascular Medicine (AREA)
  • Obesity (AREA)
  • General Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

Preparater og fremgangsmåter for å forhøye nivået av HDL-kolesterol og apolipoprotein AI i en pasient og for reduksjon av nivået av VLDL-kolelsterol og LDL-kolesterol i en pasient, innbefattet preparater og fremgangsmåter som påvirker ekspresjonen av et gen, LIPG, som koder for et lipaseenzym som er et medlem av triacylglyserollipasefamilien, eller som påvirker enzymets enzymatiske aktivitet.
NO20100214A 1999-03-26 2010-02-11 Anvendelse av et ribozym for fremstilling av et preparat i stand til a redusere den enzymatiske aktiviteten av LIPG hos en pasient. NO331784B1 (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/277,401 US7008776B1 (en) 1996-12-06 1999-03-26 Compositions and methods for effecting the levels of high density lipoprotein (HDL) cholesterol and apolipoprotein AI very low density lipoprotein (VLDL) cholesterol and low density lipoprotein (LDL) cholesterol
PCT/US2000/007870 WO2000057837A2 (en) 1999-03-26 2000-03-24 Compositions and methods for effecting the levels of cholesterol

Publications (2)

Publication Number Publication Date
NO20100214L true NO20100214L (no) 2001-11-21
NO331784B1 NO331784B1 (no) 2012-03-26

Family

ID=23060703

Family Applications (2)

Application Number Title Priority Date Filing Date
NO20014657A NO331779B1 (no) 1999-03-26 2001-09-25 Fremgangsmater for a bestemme hvorvidt en testforbindelse kan inhibere den enzymatiske reaksjonen mellom LIPG polypeptidet og HDL kolesterol og apolipoprotein A1 eller fremme den enzymatiske reaksjonen mellom LIPG polypeptidet og VLDL kolesterol eller LDL kolesterol
NO20100214A NO331784B1 (no) 1999-03-26 2010-02-11 Anvendelse av et ribozym for fremstilling av et preparat i stand til a redusere den enzymatiske aktiviteten av LIPG hos en pasient.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
NO20014657A NO331779B1 (no) 1999-03-26 2001-09-25 Fremgangsmater for a bestemme hvorvidt en testforbindelse kan inhibere den enzymatiske reaksjonen mellom LIPG polypeptidet og HDL kolesterol og apolipoprotein A1 eller fremme den enzymatiske reaksjonen mellom LIPG polypeptidet og VLDL kolesterol eller LDL kolesterol

Country Status (13)

Country Link
EP (1) EP1171078A4 (no)
JP (1) JP2002540127A (no)
KR (2) KR100887164B1 (no)
AU (1) AU776684B2 (no)
BR (1) BR0009333A (no)
CA (1) CA2363486C (no)
HK (1) HK1043309A1 (no)
IL (2) IL145526A0 (no)
MX (1) MXPA01009727A (no)
NO (2) NO331779B1 (no)
NZ (2) NZ514350A (no)
WO (1) WO2000057837A2 (no)
ZA (1) ZA200107598B (no)

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CA2771172C (en) 2009-08-25 2021-11-30 Opko Curna, Llc Treatment of 'iq motif containing gtpase activating protein' (iqgap) related diseases by inhibition of natural antisense transcript to iqgap
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Also Published As

Publication number Publication date
NO20014657D0 (no) 2001-09-25
WO2000057837A2 (en) 2000-10-05
NZ514350A (en) 2004-12-24
BR0009333A (pt) 2002-01-08
CA2363486C (en) 2012-12-18
EP1171078A2 (en) 2002-01-16
WO2000057837A9 (en) 2001-10-18
CA2363486A1 (en) 2000-10-05
AU3918700A (en) 2000-10-16
IL145526A (en) 2010-11-30
JP2002540127A (ja) 2002-11-26
ZA200107598B (en) 2003-05-28
NO20014657L (no) 2001-11-21
MXPA01009727A (es) 2002-07-22
NO331784B1 (no) 2012-03-26
IL145526A0 (en) 2002-06-30
KR20050044812A (ko) 2005-05-12
EP1171078A4 (en) 2002-11-06
WO2000057837A3 (en) 2001-01-25
HK1043309A1 (zh) 2002-09-13
NO331779B1 (no) 2012-03-26
WO2000057837A8 (en) 2001-09-27
KR100887164B1 (ko) 2009-03-10
AU776684B2 (en) 2004-09-16
NZ531180A (en) 2005-06-24
KR20020029651A (ko) 2002-04-19

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