JPH0780843B2 - ポリ−４−アミノピロ−ル−２−カルボキサミド誘導体 - Google Patents

ポリ−４−アミノピロ−ル−２−カルボキサミド誘導体

Info

Publication number: JPH0780843B2
Authority: JP; Japan
Prior art keywords: methyl; carboxamide; pyrrole; propyl; group
Prior art date: 1985-07-16
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired - Lifetime

Application number

JP61164879A

Other languages

English (en)

Japanese (ja)

Other versions

JPS6277362A (ja

Inventor

フエデリコ・アルカモーネ

ニコラ・モンジエルリ

セルジオ・ペンコ

Original Assignee

フア−ミタリア・カルロ・エルバ・ソシエタ・ペル・アツイオ−ニ

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1985-07-16

Filing date

1986-07-15

Publication date

1995-08-30

1985-07-16 Priority claimed from GB858517922A external-priority patent/GB8517922D0/en

1986-06-04 Priority claimed from GB868613594A external-priority patent/GB8613594D0/en

1986-07-15 Application filed by フア−ミタリア・カルロ・エルバ・ソシエタ・ペル・アツイオ−ニ filed Critical フア−ミタリア・カルロ・エルバ・ソシエタ・ペル・アツイオ−ニ

1987-04-09 Publication of JPS6277362A publication Critical patent/JPS6277362A/ja

1995-08-30 Publication of JPH0780843B2 publication Critical patent/JPH0780843B2/ja

2010-08-30 Anticipated expiration legal-status Critical

Status Expired - Lifetime legal-status Critical Current

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/26—Acyclic or carbocyclic radicals, substituted by hetero rings

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Communicable Diseases (AREA)
Molecular Biology (AREA)
Oncology (AREA)
Engineering & Computer Science (AREA)
Biochemistry (AREA)
Biotechnology (AREA)
Genetics & Genomics (AREA)
Virology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Saccharide Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Pyrrole Compounds (AREA)
Peptides Or Proteins (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
Polyamides (AREA)

JP61164879A 1985-07-16 1986-07-15 ポリ−４−アミノピロ−ル−２−カルボキサミド誘導体 Expired - Lifetime JPH0780843B2 (ja)

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date	Title
GB858517922A GB8517922D0 (en)	1985-07-16	1985-07-16	Carboxamido derivatives
GB8517922		1985-07-16
GB8613594		1986-06-04
GB868613594A GB8613594D0 (en)	1986-06-04	1986-06-04	Poly-4-aminopyrrole-2-carboxamido derivatives

Publications (2)

Publication Number	Publication Date
JPS6277362A JPS6277362A (ja)	1987-04-09
JPH0780843B2 true JPH0780843B2 (ja)	1995-08-30

Family

ID=26289538

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
JP61164879A Expired - Lifetime JPH0780843B2 (ja)	1985-07-16	1986-07-15	ポリ−４−アミノピロ−ル−２−カルボキサミド誘導体

Country Status (26)

Country	Link
JP (1)	JPH0780843B2 (fr)
KR (1)	KR930010496B1 (fr)
CN (1)	CN1018825B (fr)
AT (1)	AT387013B (fr)
AU (1)	AU587841B2 (fr)
BE (1)	BE905110A (fr)
CA (1)	CA1285934C (fr)
CH (1)	CH674206A5 (fr)
CS (1)	CS276981B6 (fr)
DE (1)	DE3623880A1 (fr)
DK (1)	DK335986A (fr)
ES (1)	ES2000502A6 (fr)
FI (1)	FI83640C (fr)
FR (1)	FR2585018B1 (fr)
GB (1)	GB2178036B (fr)
GR (1)	GR861841B (fr)
HU (1)	HU205949B (fr)
IE (1)	IE59073B1 (fr)
IL (1)	IL79402A (fr)
IT (1)	IT1196488B (fr)
NL (1)	NL8601837A (fr)
NO (1)	NO168826C (fr)
NZ (1)	NZ216829A (fr)
PH (1)	PH24714A (fr)
PT (1)	PT82984B (fr)
SE (1)	SE468642B (fr)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CN85103908A (zh) *	1985-07-16	1986-11-05	法米塔利·卡洛·埃尔巴有限公司	制备4′-表多克索红菌素的新方法
GB8906709D0 (en) *	1989-03-23	1989-05-10	Creighton Andrew M	Acryloyl substituted pyrrole derivatives
IT1243389B (it) *	1990-11-22	1994-06-10	Menarini Farma Ind	Derivati poliaminopirrolcarbossiamidici, processi di preparazione e composizioni farmaceutiche che li contengono.
WO1992013838A1 (fr) *	1991-02-06	1992-08-20	Synphar Laboratories, Inc.	Agents antiretroviraux oligopeptidiques
IT1247878B (it) *	1991-02-15	1995-01-05	Menarini Farma Ind	Derivati poli-4-aminopirrol-2-carbossiamidici,processi di preparazione e composizioni farmaceutiche che li contengono
GB2260134A (en) *	1991-10-04	1993-04-07	Erba Carlo Spa	Derivatives of poly-5-amino-3-carboxy-1-methyl compounds
IT1262921B (it) *	1992-01-10	1996-07-22	Federico Arcamone	Agenti antitumorali analoghi di oligopeptidi pirrol-amidinici retroversi processi di preparazione e prodotti farmaceutici che li contengono
GB9416005D0 (en) *	1994-08-08	1994-09-28	Erba Carlo Spa	Peptidic compounds analogous to distamycin a and process for their preparation
US5717110A (en) *	1995-09-12	1998-02-10	Kyowa Hakko Kogyo Co., Ltd.	UCH15 compounds
WO1997028123A1 (fr) *	1996-02-02	1997-08-07	Pharmacia & Upjohn S.P.A.	Derives de distamycine, procede de preparation de ces derives et leur utilisation en tant qu'agents antitumoraux et antiviraux
GB9615692D0 (en) *	1996-07-25	1996-09-04	Pharmacia Spa	Acryloyl substituted distamycin derivatives, process for preparing them, and their use as antitumor and antiviral agents
GB0011059D0 (en)	2000-05-08	2000-06-28	Pharmacia & Upjohn Spa	Use of substituted acryloyl distamycin derivatives in the treatment of tumours associated with high levels of glutathione
GB0015446D0 (en)	2000-06-23	2000-08-16	Pharmacia & Upjohn Spa	Combined therapy against tumors comprising substituted acryloyl distamycin derivates,taxanes and/or antimetabolites
GB0015447D0 (en)	2000-06-23	2000-08-16	Pharmacia & Upjohn Spa	Combined therapy against tumors comprising substituted acryloyl derivates and alkylating agents
GB0016447D0 (en)	2000-07-04	2000-08-23	Pharmacia & Upjohn Spa	Process for preparing distamycin derivatives
US6969592B2 (en)	2001-09-26	2005-11-29	Pharmacia Italia S.P.A.	Method for predicting the sensitivity to chemotherapy

Citations (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB1004974A (en)	1963-04-04	1965-09-22	Rhone Poulenc Sa	New amidines, process for their preparation and pharmaceutical compositions containing them
NL6508459A (fr)	1964-07-14	1966-01-17

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE1795539A1 (de) *	1963-07-26	1972-01-13	Farmaceutici Italia	Verfahren zur Herstellung von neuen Pyrrolderivaten und ihren Salzen
BE666612A (fr) *	1963-07-26	1965-11-03
US3420844A (en) *	1963-07-26	1969-01-07	Farmaceutici Italia	Pyrrole-2-carboxamido-propionamidines
CN85103908A (zh) *	1985-07-16	1986-11-05	法米塔利·卡洛·埃尔巴有限公司	制备4′-表多克索红菌素的新方法

1986
- 1986-07-11 SE SE8603098A patent/SE468642B/sv not_active IP Right Cessation
- 1986-07-11 AT AT0188886A patent/AT387013B/de not_active IP Right Cessation
- 1986-07-14 HU HU862904A patent/HU205949B/hu not_active IP Right Cessation
- 1986-07-14 AU AU60202/86A patent/AU587841B2/en not_active Ceased
- 1986-07-14 ES ES8600290A patent/ES2000502A6/es not_active Expired
- 1986-07-14 IL IL79402A patent/IL79402A/xx not_active IP Right Cessation
- 1986-07-14 NL NL8601837A patent/NL8601837A/xx not_active Application Discontinuation
- 1986-07-14 NZ NZ216829A patent/NZ216829A/xx unknown
- 1986-07-14 IE IE187586A patent/IE59073B1/en not_active IP Right Cessation
- 1986-07-15 PH PH34014A patent/PH24714A/en unknown
- 1986-07-15 CH CH2820/86A patent/CH674206A5/de not_active IP Right Cessation
- 1986-07-15 CA CA000513760A patent/CA1285934C/fr not_active Expired - Fee Related
- 1986-07-15 JP JP61164879A patent/JPH0780843B2/ja not_active Expired - Lifetime
- 1986-07-15 KR KR1019860005715A patent/KR930010496B1/ko not_active IP Right Cessation
- 1986-07-15 PT PT82984A patent/PT82984B/pt not_active IP Right Cessation
- 1986-07-15 IT IT21125/86A patent/IT1196488B/it active
- 1986-07-15 DE DE3623880A patent/DE3623880A1/de not_active Withdrawn
- 1986-07-15 BE BE0/216924A patent/BE905110A/fr not_active IP Right Cessation
- 1986-07-15 NO NO862860A patent/NO168826C/no unknown
- 1986-07-15 FR FR868610294A patent/FR2585018B1/fr not_active Expired
- 1986-07-15 DK DK335986A patent/DK335986A/da not_active Application Discontinuation
- 1986-07-15 GR GR861841A patent/GR861841B/el unknown
- 1986-07-16 GB GB8617292A patent/GB2178036B/en not_active Expired
- 1986-07-16 CS CS865412A patent/CS276981B6/cs unknown
- 1986-07-16 FI FI862959A patent/FI83640C/fi not_active IP Right Cessation
- 1986-07-16 CN CN86104787A patent/CN1018825B/zh not_active Expired

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB1004974A (en)	1963-04-04	1965-09-22	Rhone Poulenc Sa	New amidines, process for their preparation and pharmaceutical compositions containing them
NL6508459A (fr)	1964-07-14	1966-01-17

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Ｚｈ．Ｏｒｇ．Ｋｈｉｍ．，１７（３），６５７−６３（１９８１）

Also Published As

Publication number	Publication date
KR930010496B1 (ko)	1993-10-25
SE468642B (sv)	1993-02-22
FI862959A (fi)	1987-01-17
JPS6277362A (ja)	1987-04-09
FR2585018B1 (fr)	1989-07-13
ES2000502A6 (es)	1988-03-01
NO168826B (no)	1991-12-30
IE861875L (en)	1987-01-16
IL79402A (en)	1991-06-10
CS8605412A2 (en)	1991-03-12
HU205949B (en)	1992-07-28
GR861841B (en)	1986-11-18
SE8603098L (sv)	1987-01-17
SE8603098D0 (sv)	1986-07-11
IL79402A0 (en)	1986-10-31
AT387013B (de)	1988-11-25
CN86104787A (zh)	1987-02-18
CH674206A5 (fr)	1990-05-15
AU587841B2 (en)	1989-08-31
DK335986A (da)	1987-01-17
IT1196488B (it)	1988-11-16
NO862860D0 (no)	1986-07-15
PT82984B (pt)	1989-01-30
DE3623880A1 (de)	1987-01-29
NO168826C (no)	1992-04-08
GB2178036A (en)	1987-02-04
CA1285934C (fr)	1991-07-09
GB2178036B (en)	1989-08-16
IT8621125A0 (it)	1986-07-15
FI862959A0 (fi)	1986-07-16
NZ216829A (en)	1989-03-29
NO862860L (no)	1987-01-19
IT8621125A1 (it)	1988-01-15
KR870001201A (ko)	1987-03-12
NL8601837A (nl)	1987-02-16
HUT43088A (en)	1987-09-28
AU6020286A (en)	1987-01-22
CN1018825B (zh)	1992-10-28
PH24714A (en)	1990-10-01
ATA188886A (de)	1988-04-15
FI83640B (fi)	1991-04-30
GB8617292D0 (en)	1986-08-20
BE905110A (fr)	1987-01-15
PT82984A (en)	1986-08-01
IE59073B1 (en)	1994-01-12
CS276981B6 (en)	1992-11-18
FI83640C (fi)	1991-08-12
FR2585018A1 (fr)	1987-01-23
DK335986D0 (da)	1986-07-15

Publication	Publication Date	Title
US5017599A (en)	1991-05-21	Site specific alkylating agents
JPH0780843B2 (ja)	1995-08-30	ポリ−４−アミノピロ−ル−２−カルボキサミド誘導体
RU2094430C1 (ru)	1997-10-27	Акрилоилзамещенные производные пиррола и их фармацевтически приемлемые кислотно-аддитивные соли, фармацевтическая композиция на их основе и способ их получения
KR940003495B1 (ko)	1994-04-23	디스타마이신 a유도체의 제조방법
US6165980A (en)	2000-12-26	Distamycin derivatives, process for preparing them, and their use as antitumor and antiviral agents
JP2001504109A (ja)	2001-03-27	ベンゾ複素環ジスタマイシン誘導体、それらを製造する方法および抗腫瘍および抗ウイルス剤としてのそれらの用途
EP0915845B1 (fr)	2001-09-12	Derives de la distamycine acryloyl-substitues, procede de fabrication associe et leur utilisation comme agents antitumoraux et antiviraux
EP0912509B1 (fr)	2001-07-11	Derives de distamycine, leur procede de preparation et leur utilisation en tant qu'agents antitumoraux et antiviraux
JP2002509930A (ja)	2002-04-02	ベンゾ複素環ジスタマイシン誘導体、その製造方法および抗腫瘍薬としてのそれの使用
US6753316B1 (en)	2004-06-22	Acryloyl derivatives analogous to distamycin, process for preparing them, and their use as antitumor agents
US5049579A (en)	1991-09-17	Site specific alkylating agents
US5310752A (en)	1994-05-10	Site specific alkylating agents
KR100469778B1 (ko)	2005-05-16	디스타마이신유도체,이의제조방법,및항종양성및항바이러스성제제로서의이들의용도
JPH05148227A (ja)	1993-06-15	抗腫瘍活性を有するヘテロ環式オリゴペプチド