[go: up one dir, main page]
More Web Proxy on the site http://driver.im/

BE905110A - Poly-4-aminopyrrole-2-carboxamides et derives, procede pour leur preparation et leurs utilisations therapeutiques. - Google Patents

Poly-4-aminopyrrole-2-carboxamides et derives, procede pour leur preparation et leurs utilisations therapeutiques.

Info

Publication number
BE905110A
BE905110A BE0/216924A BE216924A BE905110A BE 905110 A BE905110 A BE 905110A BE 0/216924 A BE0/216924 A BE 0/216924A BE 216924 A BE216924 A BE 216924A BE 905110 A BE905110 A BE 905110A
Authority
BE
Belgium
Prior art keywords
group
aminopyrrole
carboxamides
poly
derivatives
Prior art date
Application number
BE0/216924A
Other languages
English (en)
Inventor
Arcamone Federico
Mongelli Nicola
Penco Sergio
Original Assignee
Erba Farmitalia
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB858517922A external-priority patent/GB8517922D0/en
Priority claimed from GB868613594A external-priority patent/GB8613594D0/en
Application filed by Erba Farmitalia filed Critical Erba Farmitalia
Publication of BE905110A publication Critical patent/BE905110A/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/26—Acyclic or carbocyclic radicals, substituted by hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Communicable Diseases (AREA)
  • Molecular Biology (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Virology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
  • Polyamides (AREA)

Abstract

Des composés répondant à la formule générale dans laquelle n est égal à 0 ou à un nombre de 1 à 4 ; R représente un groupe amino libre, ou portant un ou deux substituants définis, ou un groupe -N02 ou -NH-CH0, chacun des symboles R1 représente un atome d'hydrogène ou un groupe alkyle en C1-C4 et R2 représente un groupe alkyle en C1-C6 terminé par un motif basique ou acide ou par un groupe hydroxy libre ou glucosylé, sous réserve de certaines restrictions, ont des propriétés antivirales et antitumeurs exploitables en thérapeutique. Certains de ces composés sont nouveaux; on les prépare par des procédés variés décrits en détail.
BE0/216924A 1985-07-16 1986-07-15 Poly-4-aminopyrrole-2-carboxamides et derives, procede pour leur preparation et leurs utilisations therapeutiques. BE905110A (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB858517922A GB8517922D0 (en) 1985-07-16 1985-07-16 Carboxamido derivatives
GB868613594A GB8613594D0 (en) 1986-06-04 1986-06-04 Poly-4-aminopyrrole-2-carboxamido derivatives

Publications (1)

Publication Number Publication Date
BE905110A true BE905110A (fr) 1987-01-15

Family

ID=26289538

Family Applications (1)

Application Number Title Priority Date Filing Date
BE0/216924A BE905110A (fr) 1985-07-16 1986-07-15 Poly-4-aminopyrrole-2-carboxamides et derives, procede pour leur preparation et leurs utilisations therapeutiques.

Country Status (26)

Country Link
JP (1) JPH0780843B2 (fr)
KR (1) KR930010496B1 (fr)
CN (1) CN1018825B (fr)
AT (1) AT387013B (fr)
AU (1) AU587841B2 (fr)
BE (1) BE905110A (fr)
CA (1) CA1285934C (fr)
CH (1) CH674206A5 (fr)
CS (1) CS276981B6 (fr)
DE (1) DE3623880A1 (fr)
DK (1) DK335986A (fr)
ES (1) ES2000502A6 (fr)
FI (1) FI83640C (fr)
FR (1) FR2585018B1 (fr)
GB (1) GB2178036B (fr)
GR (1) GR861841B (fr)
HU (1) HU205949B (fr)
IE (1) IE59073B1 (fr)
IL (1) IL79402A (fr)
IT (1) IT1196488B (fr)
NL (1) NL8601837A (fr)
NO (1) NO168826C (fr)
NZ (1) NZ216829A (fr)
PH (1) PH24714A (fr)
PT (1) PT82984B (fr)
SE (1) SE468642B (fr)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN85103908A (zh) * 1985-07-16 1986-11-05 法米塔利·卡洛·埃尔巴有限公司 制备4′-表多克索红菌素的新方法
GB8906709D0 (en) * 1989-03-23 1989-05-10 Creighton Andrew M Acryloyl substituted pyrrole derivatives
IT1243389B (it) * 1990-11-22 1994-06-10 Menarini Farma Ind Derivati poliaminopirrolcarbossiamidici, processi di preparazione e composizioni farmaceutiche che li contengono.
WO1992013838A1 (fr) * 1991-02-06 1992-08-20 Synphar Laboratories, Inc. Agents antiretroviraux oligopeptidiques
IT1247878B (it) * 1991-02-15 1995-01-05 Menarini Farma Ind Derivati poli-4-aminopirrol-2-carbossiamidici,processi di preparazione e composizioni farmaceutiche che li contengono
GB2260134A (en) * 1991-10-04 1993-04-07 Erba Carlo Spa Derivatives of poly-5-amino-3-carboxy-1-methyl compounds
IT1262921B (it) * 1992-01-10 1996-07-22 Federico Arcamone Agenti antitumorali analoghi di oligopeptidi pirrol-amidinici retroversi processi di preparazione e prodotti farmaceutici che li contengono
GB9416005D0 (en) * 1994-08-08 1994-09-28 Erba Carlo Spa Peptidic compounds analogous to distamycin a and process for their preparation
US5717110A (en) * 1995-09-12 1998-02-10 Kyowa Hakko Kogyo Co., Ltd. UCH15 compounds
WO1997028123A1 (fr) * 1996-02-02 1997-08-07 Pharmacia & Upjohn S.P.A. Derives de distamycine, procede de preparation de ces derives et leur utilisation en tant qu'agents antitumoraux et antiviraux
GB9615692D0 (en) * 1996-07-25 1996-09-04 Pharmacia Spa Acryloyl substituted distamycin derivatives, process for preparing them, and their use as antitumor and antiviral agents
GB0011059D0 (en) 2000-05-08 2000-06-28 Pharmacia & Upjohn Spa Use of substituted acryloyl distamycin derivatives in the treatment of tumours associated with high levels of glutathione
GB0015446D0 (en) 2000-06-23 2000-08-16 Pharmacia & Upjohn Spa Combined therapy against tumors comprising substituted acryloyl distamycin derivates,taxanes and/or antimetabolites
GB0015447D0 (en) 2000-06-23 2000-08-16 Pharmacia & Upjohn Spa Combined therapy against tumors comprising substituted acryloyl derivates and alkylating agents
GB0016447D0 (en) 2000-07-04 2000-08-23 Pharmacia & Upjohn Spa Process for preparing distamycin derivatives
US6969592B2 (en) 2001-09-26 2005-11-29 Pharmacia Italia S.P.A. Method for predicting the sensitivity to chemotherapy

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR86210E (fr) 1963-04-04 1966-03-23
DE1795539A1 (de) * 1963-07-26 1972-01-13 Farmaceutici Italia Verfahren zur Herstellung von neuen Pyrrolderivaten und ihren Salzen
BE666612A (fr) * 1963-07-26 1965-11-03
US3420844A (en) * 1963-07-26 1969-01-07 Farmaceutici Italia Pyrrole-2-carboxamido-propionamidines
NL130086C (fr) * 1964-07-14 1970-06-15
CN85103908A (zh) * 1985-07-16 1986-11-05 法米塔利·卡洛·埃尔巴有限公司 制备4′-表多克索红菌素的新方法

Also Published As

Publication number Publication date
KR930010496B1 (ko) 1993-10-25
SE468642B (sv) 1993-02-22
FI862959A (fi) 1987-01-17
JPS6277362A (ja) 1987-04-09
FR2585018B1 (fr) 1989-07-13
ES2000502A6 (es) 1988-03-01
NO168826B (no) 1991-12-30
IE861875L (en) 1987-01-16
IL79402A (en) 1991-06-10
CS8605412A2 (en) 1991-03-12
HU205949B (en) 1992-07-28
GR861841B (en) 1986-11-18
SE8603098L (sv) 1987-01-17
SE8603098D0 (sv) 1986-07-11
IL79402A0 (en) 1986-10-31
AT387013B (de) 1988-11-25
CN86104787A (zh) 1987-02-18
CH674206A5 (fr) 1990-05-15
AU587841B2 (en) 1989-08-31
DK335986A (da) 1987-01-17
IT1196488B (it) 1988-11-16
NO862860D0 (no) 1986-07-15
PT82984B (pt) 1989-01-30
DE3623880A1 (de) 1987-01-29
NO168826C (no) 1992-04-08
GB2178036A (en) 1987-02-04
CA1285934C (fr) 1991-07-09
GB2178036B (en) 1989-08-16
IT8621125A0 (it) 1986-07-15
FI862959A0 (fi) 1986-07-16
NZ216829A (en) 1989-03-29
NO862860L (no) 1987-01-19
IT8621125A1 (it) 1988-01-15
KR870001201A (ko) 1987-03-12
NL8601837A (nl) 1987-02-16
HUT43088A (en) 1987-09-28
JPH0780843B2 (ja) 1995-08-30
AU6020286A (en) 1987-01-22
CN1018825B (zh) 1992-10-28
PH24714A (en) 1990-10-01
ATA188886A (de) 1988-04-15
FI83640B (fi) 1991-04-30
GB8617292D0 (en) 1986-08-20
PT82984A (en) 1986-08-01
IE59073B1 (en) 1994-01-12
CS276981B6 (en) 1992-11-18
FI83640C (fi) 1991-08-12
FR2585018A1 (fr) 1987-01-23
DK335986D0 (da) 1986-07-15

Similar Documents

Publication Publication Date Title
BE905110A (fr) Poly-4-aminopyrrole-2-carboxamides et derives, procede pour leur preparation et leurs utilisations therapeutiques.
TNSN87042A1 (fr) Procede de preparation de nouveaux steroides comportant un cycle spirannique en position 17
FR2603588A1 (fr) Thiazolo (4,5-c) quinoleines, procede de preparation et medicaments les contenant
BE900345A (fr) Composition pharmaceutique ophtalmiques a base d'un derive d'acide phenylacetique.
BE902213A (fr) Composes de phenethanolamine.
BE901545A (fr) Nouveaux derives de la furo-(3,4-c)-pyridine substitues en position 6, un procede pour leur preparation et compositions therapeutiques a base de ces derives.
BE900842A (fr) Nouveaux complexes de platine et leur application en therapeutique.
EP0287353A3 (fr) Synthèse chirale d'anthracyclines à partir d'anthraquinones substituées
FR2637286A1 (fr) Nouveaux derives benzoxazolinoniques, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent
FR2506772A1 (fr) Glycosides d'anthracycline, procede pour les preparer et leur usage comme medicament
FR2452483A1 (fr) Derives d'alcenylphenylmaleimides, leurs dimeres lineaires et leur procede de preparation
EP0262053A3 (fr) Nouveaux dérivés d'amino-acides, leur procédé de préparation et compositions pharmaceutiques les contenant
FR2407941A1 (fr) Nouveaux derives de cholesterol
FR2413358A1 (fr) Nouveaux derives de 2-aminomethylphenol, utiles notamment comme agents anti-inflammatoires, et leur procede de preparation
FR2506313A1 (fr) Derives de l'acide n-acetylneuraminique et leur preparation
FR2447375A1 (fr) Analogues de la prostaglandine e1 et compositions pharmaceutiques les contenant
FR2397425A1 (fr) Nouveaux derives de la daunorubicine, leur preparation et les compositions qui les contiennent
FR2455596A1 (fr) Nouveaux antibiotiques presentant une activite antibacterienne, leur procede de production, leur souche servant a leur obtention et les compositions pharmaceutiques les contenant
FR2445316A1 (fr) Nouveaux derives n-substitues de l'acide aziridinyl 2-carboxylique presentant une activite immunostimulante, leur procede de preparation et leurs applications therapeutiques
BE905654A (fr) Derives de la armstrong 2-1,2,4-triazoline-5-one, procede pour leur preparation et leurs utilisations.
BE904865A (fr) Derives du phenanthrene, leur procede de preparation et compositions fongicides les contenant.
BE904864A (fr) Derives de la quinoleine, leur procede de preparation et compositions pharmaceutiques les contenant.
FR2399417A1 (fr) Nouveaux derives de la dibenzo (d,g) (1,3,6)dioxazocine, procedes de preparation de ces derives et medicaments contenant ceux-ci
FR2449689A1 (fr) Nouveaux derives condenses de pyrrolidine ou de piperidine, leur procede de preparation et leurs applications en therapeutique
BE904835A (fr) Nouveaux derives d'isoquinoleine, leur procede de preparation, leur application en therapeutique et produits intermediaires.

Legal Events

Date Code Title Description
CA Change of address of the owner of the patent
CH Change of patent owner
CN Change of patent owner's name
RE Patent lapsed

Owner name: PHARMACIA & UPJOHN S.P.A.

Effective date: 19980731