JP4660203B2 - 歯科用ホワイトニング組成物および方法 - Google Patents
歯科用ホワイトニング組成物および方法 Download PDFInfo
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- JP4660203B2 JP4660203B2 JP2004568051A JP2004568051A JP4660203B2 JP 4660203 B2 JP4660203 B2 JP 4660203B2 JP 2004568051 A JP2004568051 A JP 2004568051A JP 2004568051 A JP2004568051 A JP 2004568051A JP 4660203 B2 JP4660203 B2 JP 4660203B2
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- 239000004743 Polypropylene Substances 0.000 description 1
- XBDQKXXYIPTUBI-UHFFFAOYSA-M Propionate Chemical compound CCC([O-])=O XBDQKXXYIPTUBI-UHFFFAOYSA-M 0.000 description 1
- 239000005708 Sodium hypochlorite Substances 0.000 description 1
- FEWJPZIEWOKRBE-UHFFFAOYSA-N Tartaric acid Natural products [H+].[H+].[O-]C(=O)C(O)C(O)C([O-])=O FEWJPZIEWOKRBE-UHFFFAOYSA-N 0.000 description 1
- DHXVGJBLRPWPCS-UHFFFAOYSA-N Tetrahydropyran Chemical compound C1CCOCC1 DHXVGJBLRPWPCS-UHFFFAOYSA-N 0.000 description 1
- MNOILHPDHOHILI-UHFFFAOYSA-N Tetramethylthiourea Chemical compound CN(C)C(=S)N(C)C MNOILHPDHOHILI-UHFFFAOYSA-N 0.000 description 1
- BZHJMEDXRYGGRV-UHFFFAOYSA-N Vinyl chloride Chemical compound ClC=C BZHJMEDXRYGGRV-UHFFFAOYSA-N 0.000 description 1
- 206010048222 Xerosis Diseases 0.000 description 1
- TVXBFESIOXBWNM-UHFFFAOYSA-N Xylitol Natural products OCCC(O)C(O)C(O)CCO TVXBFESIOXBWNM-UHFFFAOYSA-N 0.000 description 1
- UKLDJPRMSDWDSL-UHFFFAOYSA-L [dibutyl(dodecanoyloxy)stannyl] dodecanoate Chemical compound CCCCCCCCCCCC(=O)O[Sn](CCCC)(CCCC)OC(=O)CCCCCCCCCCC UKLDJPRMSDWDSL-UHFFFAOYSA-L 0.000 description 1
- 150000001252 acrylic acid derivatives Chemical class 0.000 description 1
- 239000000443 aerosol Substances 0.000 description 1
- 239000004479 aerosol dispenser Substances 0.000 description 1
- 150000001298 alcohols Chemical class 0.000 description 1
- 125000005210 alkyl ammonium group Chemical group 0.000 description 1
- 125000002947 alkylene group Chemical group 0.000 description 1
- XYLMUPLGERFSHI-UHFFFAOYSA-N alpha-Methylstyrene Chemical compound CC(=C)C1=CC=CC=C1 XYLMUPLGERFSHI-UHFFFAOYSA-N 0.000 description 1
- 230000004075 alteration Effects 0.000 description 1
- 150000001408 amides Chemical class 0.000 description 1
- 150000003863 ammonium salts Chemical class 0.000 description 1
- 229940035674 anesthetics Drugs 0.000 description 1
- 150000001449 anionic compounds Chemical class 0.000 description 1
- 150000001450 anions Chemical class 0.000 description 1
- 239000003242 anti bacterial agent Substances 0.000 description 1
- 239000004599 antimicrobial Substances 0.000 description 1
- 150000004982 aromatic amines Chemical class 0.000 description 1
- 125000003710 aryl alkyl group Chemical group 0.000 description 1
- 210000000988 bone and bone Anatomy 0.000 description 1
- 229930006711 bornane-2,3-dione Natural products 0.000 description 1
- 229910052796 boron Inorganic materials 0.000 description 1
- 125000005620 boronic acid group Chemical group 0.000 description 1
- 239000008376 breath freshener Substances 0.000 description 1
- 239000000872 buffer Substances 0.000 description 1
- 229910052792 caesium Inorganic materials 0.000 description 1
- TVFDJXOCXUVLDH-UHFFFAOYSA-N caesium atom Chemical compound [Cs] TVFDJXOCXUVLDH-UHFFFAOYSA-N 0.000 description 1
- 239000001506 calcium phosphate Substances 0.000 description 1
- 229910000389 calcium phosphate Inorganic materials 0.000 description 1
- 235000011010 calcium phosphates Nutrition 0.000 description 1
- 125000002837 carbocyclic group Chemical group 0.000 description 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 description 1
- 125000004181 carboxyalkyl group Chemical group 0.000 description 1
- 150000001732 carboxylic acid derivatives Chemical group 0.000 description 1
- 150000001735 carboxylic acids Chemical class 0.000 description 1
- 125000002057 carboxymethyl group Chemical group [H]OC(=O)C([H])([H])[*] 0.000 description 1
- 239000004075 cariostatic agent Substances 0.000 description 1
- 150000001768 cations Chemical class 0.000 description 1
- 239000004568 cement Substances 0.000 description 1
- VZDYWEUILIUIDF-UHFFFAOYSA-J cerium(4+);disulfate Chemical compound [Ce+4].[O-]S([O-])(=O)=O.[O-]S([O-])(=O)=O VZDYWEUILIUIDF-UHFFFAOYSA-J 0.000 description 1
- 229910000355 cerium(IV) sulfate Inorganic materials 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 239000002738 chelating agent Substances 0.000 description 1
- BHDFTVNXJDZMQK-UHFFFAOYSA-N chloromethane;2-(dimethylamino)ethyl 2-methylprop-2-enoate Chemical compound ClC.CN(C)CCOC(=O)C(C)=C BHDFTVNXJDZMQK-UHFFFAOYSA-N 0.000 description 1
- 239000000701 coagulant Substances 0.000 description 1
- JAWGVVJVYSANRY-UHFFFAOYSA-N cobalt(3+) Chemical compound [Co+3] JAWGVVJVYSANRY-UHFFFAOYSA-N 0.000 description 1
- 239000000571 coke Substances 0.000 description 1
- 239000013068 control sample Substances 0.000 description 1
- 238000007334 copolymerization reaction Methods 0.000 description 1
- 239000003431 cross linking reagent Substances 0.000 description 1
- MRIZMKJLUDDMHF-UHFFFAOYSA-N cumene;hydrogen peroxide Chemical compound OO.CC(C)C1=CC=CC=C1 MRIZMKJLUDDMHF-UHFFFAOYSA-N 0.000 description 1
- 150000004292 cyclic ethers Chemical group 0.000 description 1
- 125000000753 cycloalkyl group Chemical group 0.000 description 1
- 239000008367 deionised water Substances 0.000 description 1
- 229910021641 deionized water Inorganic materials 0.000 description 1
- 210000003298 dental enamel Anatomy 0.000 description 1
- 210000004268 dentin Anatomy 0.000 description 1
- 238000010790 dilution Methods 0.000 description 1
- 239000012895 dilution Substances 0.000 description 1
- 239000004205 dimethyl polysiloxane Substances 0.000 description 1
- 238000004090 dissolution Methods 0.000 description 1
- POULHZVOKOAJMA-UHFFFAOYSA-M dodecanoate Chemical compound CCCCCCCCCCCC([O-])=O POULHZVOKOAJMA-UHFFFAOYSA-M 0.000 description 1
- GMSCBRSQMRDRCD-UHFFFAOYSA-N dodecyl 2-methylprop-2-enoate Chemical compound CCCCCCCCCCCCOC(=O)C(C)=C GMSCBRSQMRDRCD-UHFFFAOYSA-N 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 239000000975 dye Substances 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 125000003700 epoxy group Chemical group 0.000 description 1
- ZRSDQBKGDNPFLT-UHFFFAOYSA-N ethanol;oxolane Chemical compound CCO.C1CCOC1 ZRSDQBKGDNPFLT-UHFFFAOYSA-N 0.000 description 1
- SUPCQIBBMFXVTL-UHFFFAOYSA-N ethyl 2-methylprop-2-enoate Chemical compound CCOC(=O)C(C)=C SUPCQIBBMFXVTL-UHFFFAOYSA-N 0.000 description 1
- ZAFFWOKULJCCSA-UHFFFAOYSA-N ethyl 2-methylprop-2-enoate;trimethylazanium;chloride Chemical compound [Cl-].C[NH+](C)C.CCOC(=O)C(C)=C ZAFFWOKULJCCSA-UHFFFAOYSA-N 0.000 description 1
- MKVYSRNJLWTVIK-UHFFFAOYSA-N ethyl carbamate;2-methylprop-2-enoic acid Chemical compound CCOC(N)=O.CC(=C)C(O)=O.CC(=C)C(O)=O MKVYSRNJLWTVIK-UHFFFAOYSA-N 0.000 description 1
- 125000003709 fluoroalkyl group Chemical group 0.000 description 1
- 229920001002 functional polymer Polymers 0.000 description 1
- 229940083124 ganglion-blocking antiadrenergic secondary and tertiary amines Drugs 0.000 description 1
- 239000000499 gel Substances 0.000 description 1
- 239000003193 general anesthetic agent Substances 0.000 description 1
- 210000004195 gingiva Anatomy 0.000 description 1
- 230000009477 glass transition Effects 0.000 description 1
- VOZRXNHHFUQHIL-UHFFFAOYSA-N glycidyl methacrylate Chemical compound CC(=C)C(=O)OCC1CO1 VOZRXNHHFUQHIL-UHFFFAOYSA-N 0.000 description 1
- 125000005843 halogen group Chemical group 0.000 description 1
- 150000002367 halogens Chemical class 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 125000005842 heteroatom Chemical group 0.000 description 1
- 125000000623 heterocyclic group Chemical group 0.000 description 1
- IPCSVZSSVZVIGE-UHFFFAOYSA-M hexadecanoate Chemical compound CCCCCCCCCCCCCCCC([O-])=O IPCSVZSSVZVIGE-UHFFFAOYSA-M 0.000 description 1
- 229920001519 homopolymer Polymers 0.000 description 1
- 229930195733 hydrocarbon Natural products 0.000 description 1
- 150000002430 hydrocarbons Chemical class 0.000 description 1
- XMBWDFGMSWQBCA-UHFFFAOYSA-N hydrogen iodide Chemical class I XMBWDFGMSWQBCA-UHFFFAOYSA-N 0.000 description 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 1
- 238000007654 immersion Methods 0.000 description 1
- 230000028993 immune response Effects 0.000 description 1
- 238000011534 incubation Methods 0.000 description 1
- 230000001939 inductive effect Effects 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 230000000977 initiatory effect Effects 0.000 description 1
- 229910001412 inorganic anion Inorganic materials 0.000 description 1
- 150000007529 inorganic bases Chemical class 0.000 description 1
- 125000003010 ionic group Chemical group 0.000 description 1
- 229920000554 ionomer Polymers 0.000 description 1
- 229910052742 iron Inorganic materials 0.000 description 1
- JEIPFZHSYJVQDO-UHFFFAOYSA-N iron(III) oxide Inorganic materials O=[Fe]O[Fe]=O JEIPFZHSYJVQDO-UHFFFAOYSA-N 0.000 description 1
- 229940070765 laurate Drugs 0.000 description 1
- PBOSTUDLECTMNL-UHFFFAOYSA-N lauryl acrylate Chemical compound CCCCCCCCCCCCOC(=O)C=C PBOSTUDLECTMNL-UHFFFAOYSA-N 0.000 description 1
- 125000005647 linker group Chemical group 0.000 description 1
- 239000012669 liquid formulation Substances 0.000 description 1
- HEBKCHPVOIAQTA-UHFFFAOYSA-N meso ribitol Natural products OCC(O)C(O)C(O)CO HEBKCHPVOIAQTA-UHFFFAOYSA-N 0.000 description 1
- 150000002734 metacrylic acid derivatives Chemical class 0.000 description 1
- 125000005641 methacryl group Chemical group 0.000 description 1
- 150000007522 mineralic acids Chemical class 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 239000003607 modifier Substances 0.000 description 1
- 125000000896 monocarboxylic acid group Chemical group 0.000 description 1
- 210000000214 mouth Anatomy 0.000 description 1
- 210000004400 mucous membrane Anatomy 0.000 description 1
- 125000000740 n-pentyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 description 1
- QNILTEGFHQSKFF-UHFFFAOYSA-N n-propan-2-ylprop-2-enamide Chemical compound CC(C)NC(=O)C=C QNILTEGFHQSKFF-UHFFFAOYSA-N 0.000 description 1
- 239000004745 nonwoven fabric Substances 0.000 description 1
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 1
- HMZGPNHSPWNGEP-UHFFFAOYSA-N octadecyl 2-methylprop-2-enoate Chemical compound CCCCCCCCCCCCCCCCCCOC(=O)C(C)=C HMZGPNHSPWNGEP-UHFFFAOYSA-N 0.000 description 1
- 150000007524 organic acids Chemical class 0.000 description 1
- 150000002891 organic anions Chemical class 0.000 description 1
- 150000007530 organic bases Chemical class 0.000 description 1
- 125000005375 organosiloxane group Chemical group 0.000 description 1
- 235000006408 oxalic acid Nutrition 0.000 description 1
- AHHWIHXENZJRFG-UHFFFAOYSA-N oxetane Chemical compound C1COC1 AHHWIHXENZJRFG-UHFFFAOYSA-N 0.000 description 1
- WKGDNXBDNLZSKC-UHFFFAOYSA-N oxido(phenyl)phosphanium Chemical compound O=[PH2]c1ccccc1 WKGDNXBDNLZSKC-UHFFFAOYSA-N 0.000 description 1
- 125000005702 oxyalkylene group Chemical group 0.000 description 1
- 239000006072 paste Substances 0.000 description 1
- 229940059574 pentaerithrityl Drugs 0.000 description 1
- WXZMFSXDPGVJKK-UHFFFAOYSA-N pentaerythritol Chemical compound OCC(CO)(CO)CO WXZMFSXDPGVJKK-UHFFFAOYSA-N 0.000 description 1
- PNJWIWWMYCMZRO-UHFFFAOYSA-N pent‐4‐en‐2‐one Natural products CC(=O)CC=C PNJWIWWMYCMZRO-UHFFFAOYSA-N 0.000 description 1
- 239000008194 pharmaceutical composition Substances 0.000 description 1
- 239000000546 pharmaceutical excipient Substances 0.000 description 1
- 125000000843 phenylene group Chemical group C1(=C(C=CC=C1)*)* 0.000 description 1
- 125000004437 phosphorous atom Chemical group 0.000 description 1
- 229910000073 phosphorus hydride Inorganic materials 0.000 description 1
- 239000000049 pigment Substances 0.000 description 1
- 229920000435 poly(dimethylsiloxane) Polymers 0.000 description 1
- 239000004584 polyacrylic acid Substances 0.000 description 1
- 229920006254 polymer film Polymers 0.000 description 1
- 230000000379 polymerizing effect Effects 0.000 description 1
- 229920005862 polyol Polymers 0.000 description 1
- 150000003077 polyols Chemical class 0.000 description 1
- 229920001155 polypropylene Polymers 0.000 description 1
- 229920001451 polypropylene glycol Polymers 0.000 description 1
- 229920001296 polysiloxane Polymers 0.000 description 1
- 239000002243 precursor Substances 0.000 description 1
- 150000003141 primary amines Chemical class 0.000 description 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 1
- POSICDHOUBKJKP-UHFFFAOYSA-N prop-2-enoxybenzene Chemical compound C=CCOC1=CC=CC=C1 POSICDHOUBKJKP-UHFFFAOYSA-N 0.000 description 1
- HJWLCRVIBGQPNF-UHFFFAOYSA-N prop-2-enylbenzene Chemical compound C=CCC1=CC=CC=C1 HJWLCRVIBGQPNF-UHFFFAOYSA-N 0.000 description 1
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 238000010926 purge Methods 0.000 description 1
- 125000001453 quaternary ammonium group Chemical group 0.000 description 1
- 210000003296 saliva Anatomy 0.000 description 1
- 229920006395 saturated elastomer Polymers 0.000 description 1
- 238000007790 scraping Methods 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- SUKJFIGYRHOWBL-UHFFFAOYSA-N sodium hypochlorite Chemical compound [Na+].Cl[O-] SUKJFIGYRHOWBL-UHFFFAOYSA-N 0.000 description 1
- 229910001495 sodium tetrafluoroborate Inorganic materials 0.000 description 1
- 210000004872 soft tissue Anatomy 0.000 description 1
- 239000006104 solid solution Substances 0.000 description 1
- 239000007921 spray Substances 0.000 description 1
- 238000005507 spraying Methods 0.000 description 1
- 239000003381 stabilizer Substances 0.000 description 1
- 239000007858 starting material Substances 0.000 description 1
- 230000003068 static effect Effects 0.000 description 1
- 125000004079 stearyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 125000000446 sulfanediyl group Chemical group *S* 0.000 description 1
- 229940124530 sulfonamide Drugs 0.000 description 1
- 150000003456 sulfonamides Chemical class 0.000 description 1
- 150000008054 sulfonate salts Chemical class 0.000 description 1
- 125000000542 sulfonic acid group Chemical group 0.000 description 1
- 239000004094 surface-active agent Substances 0.000 description 1
- 239000011975 tartaric acid Substances 0.000 description 1
- 235000002906 tartaric acid Nutrition 0.000 description 1
- ISIJQEHRDSCQIU-UHFFFAOYSA-N tert-butyl 2,7-diazaspiro[4.5]decane-7-carboxylate Chemical compound C1N(C(=O)OC(C)(C)C)CCCC11CNCC1 ISIJQEHRDSCQIU-UHFFFAOYSA-N 0.000 description 1
- 150000003512 tertiary amines Chemical class 0.000 description 1
- CIHOLLKRGTVIJN-UHFFFAOYSA-N tert‐butyl hydroperoxide Chemical compound CC(C)(C)OO CIHOLLKRGTVIJN-UHFFFAOYSA-N 0.000 description 1
- 238000010998 test method Methods 0.000 description 1
- DHCDFWKWKRSZHF-UHFFFAOYSA-L thiosulfate(2-) Chemical class [O-]S([S-])(=O)=O DHCDFWKWKRSZHF-UHFFFAOYSA-L 0.000 description 1
- 150000003585 thioureas Chemical class 0.000 description 1
- 239000013008 thixotropic agent Substances 0.000 description 1
- 229910052723 transition metal Inorganic materials 0.000 description 1
- 150000003623 transition metal compounds Chemical class 0.000 description 1
- IEKWPPTXWFKANS-UHFFFAOYSA-K trichlorocobalt Chemical compound Cl[Co](Cl)Cl IEKWPPTXWFKANS-UHFFFAOYSA-K 0.000 description 1
- 229910052721 tungsten Inorganic materials 0.000 description 1
- 239000010937 tungsten Substances 0.000 description 1
- 229920001567 vinyl ester resin Polymers 0.000 description 1
- NLVXSWCKKBEXTG-UHFFFAOYSA-N vinylsulfonic acid Chemical compound OS(=O)(=O)C=C NLVXSWCKKBEXTG-UHFFFAOYSA-N 0.000 description 1
- 239000004034 viscosity adjusting agent Substances 0.000 description 1
- 239000000080 wetting agent Substances 0.000 description 1
- 229910052724 xenon Inorganic materials 0.000 description 1
- FHNFHKCVQCLJFQ-UHFFFAOYSA-N xenon atom Chemical compound [Xe] FHNFHKCVQCLJFQ-UHFFFAOYSA-N 0.000 description 1
- 239000000811 xylitol Substances 0.000 description 1
- HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 description 1
- 229960002675 xylitol Drugs 0.000 description 1
- 235000010447 xylitol Nutrition 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/81—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions involving only carbon-to-carbon unsaturated bonds
- A61K8/817—Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by a single or double bond to nitrogen or by a heterocyclic ring containing nitrogen; Compositions or derivatives of such polymers, e.g. vinylimidazol, vinylcaprolactame, allylamines (Polyquaternium 6)
- A61K8/8182—Copolymers of vinyl-pyrrolidones. Compositions of derivatives of such polymers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/20—Halogens; Compounds thereof
- A61K8/21—Fluorides; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/22—Peroxides; Oxygen; Ozone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/81—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions involving only carbon-to-carbon unsaturated bonds
- A61K8/8141—Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by only one carboxyl radical, or of salts, anhydrides, esters, amides, imides or nitriles thereof; Compositions of derivatives of such polymers
- A61K8/8158—Homopolymers or copolymers of amides or imides, e.g. (meth) acrylamide; Compositions of derivatives of such polymers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Chemical & Material Sciences (AREA)
- Inorganic Chemistry (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Emergency Medicine (AREA)
- Dental Preparations (AREA)
- Cosmetics (AREA)
- Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
Description
CH2=CR2G−(COOH)d
(式中、R2=H、メチル、エチル、シアノ、カルボキシまたはカルボキシメチル、d=1〜5、そしてGは、結合であるか、または原子価d+1の1〜12個の炭素原子を含有するヒドロカルビル基連結基であって、置換もしくは未置換ヘテロ原子(例えば、O、S、NおよびP)によって任意に置換されており、そして/または中断されている)によって表される、一官能性または多官能性カルボキシル基含有分子から誘導されてよい。任意に、この単位は塩の形態で提供されてもよい。この種類の好ましいモノマーは、アクリル酸、メタクリル酸、イタコン酸およびN−アクリロイルグリシンである。
CH2=CR2−CO−L−R3−(OH)d
(式中、R2=H、メチル、エチル、シアノ、カルボキシまたはカルボキシアルキル、L=O、NH、d=1〜5、そしてR3は、1〜12個の炭素原子を含有する原子価d+1のヒドロカルビル基である)によって表される、一官能性または多官能性ヒドロキシ基含有分子から誘導されてよい。この種類の好ましいモノマーは、(メタ)アクリル酸ヒドロキシエチル、(メタ)アクリル酸ヒドロキシプロピル、(メタ)アクリル酸ヒドロキシブチル、モノ(メタ)アクリル酸グリセロール、モノアクリル酸トリス(ヒドロキシメチル)エタン、モノ(メタ)アクリル酸ペンタエリスリトール、N−ヒドロキシメチル(メタ)アクリルアミド、ヒドロキシエチル(メタ)アクリルアミドおよびヒドロキシプロピル(メタ)アクリルアミドである。
CH2=CR2−CO−L−R3−(NR4R5)d
(式中、R2、L、R3およびdは、上記で定義された通りであり、そしてR4およびR5は、Hまたは1〜12個の炭素原子のアルキル基であるか、あるいはそれらは、一緒になって炭素環または複素環基を構成する)によって表される、一官能性または多官能性アミノ基含有分子から誘導されてよい。この種類の好ましいモノマーは、(メタ)アクリル酸アミノエチル、(メタ)アクリル酸アミノプロピル、(メタ)アクリル酸N,N−ジメチルアミノエチル、(メタ)アクリル酸N,N−ジエチルアミノエチル、N,N−ジメチルアミノプロピル(メタ)アクリルアミド、N−イソプロピルアミノプロピル(メタ)アクリルアミドおよび4−メチル−1−アクリロイル−ピペリジンである。
SM−1:トリメチルアンモニウムエチルメタクリレートテトラフルオロボレート(TMA−BF4)の合成
メカニカルスターラー、滴下漏斗および冷却管を備えた三つ口フラスコに、80部のテトラフルオロホウ酸ナトリウム(マサチューセッツ州、ワードヒルのアルファ アーサー インオーガニックス(Alfa Aesar Inorganics,Ward Hill,MA))および130部のDI水を充填した。混合物を15分間撹拌し、そして透明溶液を得た。滴下漏斗から、202.4部のメタクリル酸ジメチルアミノエチル−塩化メチル(トリメチルアンモニウムエチルメタクリレートクロリド;イリノイ州、クリスタルレークのCPS カンパニー チバ(CPS Company,Ciba,Crystal Lake,IL))および80部のDI水の溶液をゆっくり添加した。固体生成物が直後に沈殿を開始する。添加完了後、混合物を30分間撹拌し、そして固体を濾過によって単離し、30部のDI水で洗浄し、そして真空下40℃で乾燥させた。固体生成物のNMR分析によって、構造が、純粋なトリメチルアンモニウムエチルメタクリレートテトラフルオロボレートであることが明らかとなった。
500ml丸底フラスコに、42.2部のDMAEMA、154.7部のアセトン、93.2部の1−ブロモヘキサデカン(シグマ−アルドリッチ(Sigma−Aldrich))および0.34部のBHTを充填した。混合物を16時間、35℃で撹拌し、次いで室温まで冷却した。得られた白色固体沈殿物を濾過により単離し、冷酢酸エチルで洗浄し、そして真空下40℃で乾燥させた。固体生成物のNMR分析によって、構造が、純粋なジメチルヘキサデシルアンモニウムエチルメタクリレートブロミドであることが明らかとなった。
THF中でのポリ(AA(40)/ITA(20)/NIPAAM(20)/TMA−BF4(20))の調製
反応容器中で、AA(40部)、ITA(20部)、NIPAAM(20部)、TMA−BF4(20部)、VAZO−67(1.0部)およびTHF(300部)を組み合わせて、得られた混合物に2分間、窒素パージした。容器を密封し、そして18時間、装置を回転させながら65℃の一定温度に維持し、この間、白色沈殿が形成した。室温まで冷却後、固体が溶解するまで、撹拌しながら水(300部)を混合物に添加した。得られたポリマー溶液を実施例1と名付け、そしてカッコ内に示された重量比を有するAA(40部)、ITA(20部)、NIPAAM(20部)およびTMA−BF4(20部)のポリマーであることを確認した。ポリマー溶液は、18.4%固体を有することが決定された。
THF溶媒中でのNIPAAM含有ポリマーの調製
実施例1に関して記載される通り、実施例2〜8と名付けられたポリマー溶液を調製し、以下に記載する。モノマー単位、重量比および%固体を示す。
実施例2:AA(40)/ITA(20)/NIPAAM(20)/TMA−BF4(18)/LA(2);21.7%固体
実施例3:AA(40)/ITA(20)/NIPAAM(20)/TMA−BF4(18)/SiMac(2);19.2%固体
実施例4:AA(40)/ITA(20)/NIPAAM(20)/TMA−BF4(18)/ODA(2);18.8%固体
実施例5:AA(40)/ITA(20)/NIPAAM(20)/TMA−BF4(19)/SiMac(1);25.7%固体
実施例6*:AA(40)/ITA(17)/NIPAAM(20)/TMA−BF4(18)/ODA(2)/A−174(3);20.0%固体
実施例7:AA(40)/ITA(20)/MeFBSEA(1)/NIPAAM(20)/TMA−BF4(19);15.3%固体
実施例8:AA(40)/ITA(20)/MeFBSEA(1)/NIPAAM(20)/TMA−BF4(19);13.3%固体
*実施例6ポリマー溶液は、1:1THF−エタノール溶媒において製造され、重合後、水を添加しなかった。
水中でのポリ(AA(40)/ITA(20)/NIPAAM(20)/TMA−BF4(18/SiMac(2))の調製
反応容器中で、AA(40部)、ITA(20部)、NIPAAM(20部)、TMA−BF4(18部)、SiMac(2部)、V−50(1部)およびDI水(300部)を組み合わせて、得られた混合物に5分間、窒素パージした。容器を密封し、そして30時間、装置を回転させながら60℃の一定温度に維持した。室温まで冷却時に、粘性ポリマー溶液が得られ、これを実施例9と名付け、そしてカッコ内に示された重量比を有するAA(40)、ITA(20)、NIPAAM(20)、TMA−BF4(20)およびSiMac(2部)のポリマーであることを確認した。ポリマー溶液は、20.0%固体を有することが決定された。
水中での様々な性ポリマーの調製
実施例9に関して記載される通り、実施例10〜13と名付けられたポリマー溶液を調製し、以下に記載する。モノマー単位、重量比および%固体を示す。
実施例10:AA(40)/ITA(20)/NIPAAM(20)/TMA−BF4(14)/DMA−C16Br(4)/SiMac(2);19.7%固体
実施例11:AA(40)/ITA(20)/F127(20)/TMA−BF4(18)/SiMac(2);19.0%固体
実施例12:AA(10)/ITA(10)/NIPAAM(60)/TMA−BF4(20);15.2%固体
実施例13:AA(20)/ITA(20)/NIPAAM(20)/NVP(20)/TMA−BF4(20);17.0%固体
IEMによって誘導されたポリマー
反応容器中で、AA(40部)、ITA(20部)、NIPAAM(20部)、TMA−BF4(18部)、ODA(2部)、VAZO−65(1部)およびTHF(300部)を組み合わせて、得られた混合物に2分間、窒素パージした。容器を密封し、そして18時間、装置を回転させながら65℃の一定温度に維持し、この間、白色沈殿が形成した。室温まで冷却後、DMF(30部)を混合物に添加して固体を溶解させ、そして得られた溶液にIEM(1.1部)、DBTDL(0.04部)およびBHT(0.001部)を添加した。40℃で1時間加熱後、得られたポリマー溶液を大過剰量の酢酸エチル中に注ぎ入れ、そして沈殿固体を濾過によって回収した。固体を酢酸エチルで2回洗浄し、乾燥させ、そしてDI水中に溶解し、22.5%固体溶液を製造し、これを実施例14と名付け、そしてカッコ内に示された重量比を有し、かつ以下の構造(Me=CH3):
CH2=C(Me)CO2CH2CH2NHC(O)−ポリマー骨格鎖
のモノマー単位を提供するためにIEMによって誘導された多数(約10モル%)のカルボキシ酸単位を有するAA(40)、ITA(20)、NIPAAM(20)、TMAEMA−BF4(18)およびODA(2)のポリマーであることを確認した。
実施例15:AA(40)/ITA(20)/NIPAAM(20)/MeFBSEMA(1)TMA−BF4(19)/〜IEM;12.8%固体
実施例16:AA(40)/ITA(20)/NIPAAM(20)/MeFBSEMA(5)TMA−BF4(15)/〜IEM;21.8%固体
イソプロパノール中でのポリ(NIPAAM(55)/AA(20)/IBMA(20)/LA(5))の調製
反応容器中で、NIPAAM(55部)、AA(20部)、IBMA(20部)、LA(5部)、VAZO−67(1.0部)およびイソプロパノール(200部)を組み合わせて、得られた混合物に2分間、窒素パージした。容器を密封し、そして18時間、装置を回転させながら65℃の一定温度に維持し、この間、透明粘性ポリマー溶液が形成した。二回目のVAZO−67(0.20部)の充填を反応容器に添加し、そして溶液を65℃でさらに8時間加熱した。室温まで冷却後、得られたポリマー溶液を大過剰量の酢酸エチル中に注ぎ入れ、そして沈殿固体ポリマーを濾過によって回収した。固体を酢酸エチルで2回洗浄し、真空オーブン中40℃で乾燥させた。乾燥固体を実施例17と名付け、そしてカッコ内に示された重量比を有するNIPAAM(55)、AA(20)、IBMA(20)およびLA(5)のポリマーであることを確認した。
実施例18:NIPAAM(45)、AA(20)、ITA(10)、IBMA(20)、LA(5)
実施例19:NIPAAM(45)、AA(30)、IBMA(20)、SiMac(5)
実施例20:NIPAAM(35)、AA(30)、ITA(10)、IBMA(25)
実施例21:NIPAAM(55)、AA(20)、IBMA(20)、SiMac(5)
実施例22:NIPAAM(20)、AA(50)、IBMA(25)、SiMac(5)
実施例23:NIPAAM(60)、AA(20)、IBMA(20)
実施例24:NIPAAM(55)、AA(20)、IBMA(20)、LA(5)
歯表面におけるポリマー保持時間の評価
実施例2〜5および21と名付けられたポリマー溶液に、0.014重量%の赤色顔料(D&C レッド30 タルク レーク センシエント コード(D&C Red 30 Talc Lake Sensient code):K7094,ミズーリ州、セントルイスのセンシエント テクノロジー(Sensient Technologies,St.Louis,MO))を添加し、表1に記載された試料A〜Dを提供した。同様に、商品名シンプリー ホワイト(SIMPLY WHITE)(ニューヨーク州、ニューヨークのコルゲート(Colgate,New York,NY))で入手可能な生成物に赤色顔料を添加し、対照試料A(CR−A)を提供した。次いで、以下の手順を使用することによって、歯の上での保持に関してこれらの試料を評価した。
実施例2〜5と名付けられたポリマー溶液に、18重量%の過酸化カルバミド(シグマ−アルドリッチ(Sigma−Aldrich))を添加して、表2に記載された試料E〜Hを提供した。次いで、以下の手順を使用することによって、歯のホワイトニングに関してこれらの試料を評価した。
Claims (6)
- 口腔表面をコーティングするために適切な歯科用ホワイトニング組成物であって、
歯用ホワイトニング剤と、
極性基または分極性基を含む繰り返し単位、および
フッ化物放出基を含む繰り返し単位
を含むポリマーと、
を含み、
前記ポリマーがペンダントエチレン系不飽和部分を含まない、歯科用ホワイトニング組成物。 - 口腔表面をコーティングするために適切な歯科用ホワイトニング組成物であって、
歯用ホワイトニング剤と、
極性基または分極性基を含む繰り返し単位、ならびに
疎水性炭化水素基、グラフトポリシロキサン鎖、疎水性フッ素含有基およびそれらの組み合わせよりなる群から選択される基を含む繰り返し単位
を含むポリマーと、
を含み、
前記疎水性炭化水素基は少なくとも160の分子量を有し、
前記ポリマーがペンダントエチレン系不飽和部分を含まない、歯科用ホワイトニング組成物。 - 口腔表面をコーティングするために適切な歯科用ホワイトニング組成物であって、
歯用ホワイトニング剤と、
極性基または分極性基を含む繰り返し単位、および
フッ化物放出基を含む繰り返し単位
を含むポリマーと、
を含み、
過酸化水素を含まない、歯科用ホワイトニング組成物。 - 口腔表面をコーティングするために適切な歯科用ホワイトニング組成物であって、
歯用ホワイトニング剤と、
極性基または分極性基を含む繰り返し単位、ならびに
疎水性炭化水素基、グラフトポリシロキサン鎖、疎水性フッ素含有基およびそれらの組み合わせよりなる群から選択される基を含む繰り返し単位
を含むポリマーと、
を含み、
前記疎水性炭化水素基は少なくとも160の分子量を有し、
過酸化水素を含まない、歯科用ホワイトニング組成物。 - 歯科用ホワイトニング組成物の総重量を基準として、10重量%より多い歯用ホワイトニング剤と、
極性基または分極性基を含む繰り返し単位、および
フッ化物放出基を含む繰り返し単位
を含むポリマーと、
を含む、口腔表面をコーティングするために適切な、請求項1または3に記載の歯科用ホワイトニング組成物。 - 歯科用ホワイトニング組成物の総重量を基準として、10重量%より多い歯用ホワイトニング剤と、
極性基または分極性基を含む繰り返し単位、ならびに
疎水性炭化水素基、グラフトポリシロキサン鎖、疎水性フッ素含有基およびそれらの組み合わせよりなる群から選択される基を含む繰り返し単位
を含むポリマーであって、前記疎水性炭化水素基は少なくとも160の分子量を有する、ポリマーと、
を含む、口腔表面をコーティングするために適切な、請求項2または4に記載の歯科用ホワイトニング組成物。
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- 2003-07-24 US US10/626,142 patent/US20040185013A1/en not_active Abandoned
- 2003-12-29 WO PCT/US2003/041406 patent/WO2004069215A2/en active Application Filing
- 2003-12-29 AU AU2003300402A patent/AU2003300402A1/en not_active Abandoned
- 2003-12-29 AT AT03815790T patent/ATE486635T1/de not_active IP Right Cessation
- 2003-12-29 DE DE60334849T patent/DE60334849D1/de not_active Expired - Lifetime
- 2003-12-29 EP EP03815790A patent/EP1587489B1/en not_active Expired - Lifetime
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JP2006519164A (ja) | 2006-08-24 |
DE60334849D1 (de) | 2010-12-16 |
AU2003300402A1 (en) | 2004-08-30 |
US20040185013A1 (en) | 2004-09-23 |
EP1587489B1 (en) | 2010-11-03 |
WO2004069215A2 (en) | 2004-08-19 |
EP1587489A2 (en) | 2005-10-26 |
ATE486635T1 (de) | 2010-11-15 |
WO2004069215A3 (en) | 2004-10-07 |
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