JP4090415B2 - Antiseptic disinfectant and cosmetics, pharmaceuticals and foods containing the antiseptic disinfectant - Google Patents
Antiseptic disinfectant and cosmetics, pharmaceuticals and foods containing the antiseptic disinfectant Download PDFInfo
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- JP4090415B2 JP4090415B2 JP2003339014A JP2003339014A JP4090415B2 JP 4090415 B2 JP4090415 B2 JP 4090415B2 JP 2003339014 A JP2003339014 A JP 2003339014A JP 2003339014 A JP2003339014 A JP 2003339014A JP 4090415 B2 JP4090415 B2 JP 4090415B2
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- antiseptic
- octanediol
- cosmetics
- antiseptic disinfectant
- licorice extract
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- 239000000645 desinfectant Substances 0.000 title claims description 29
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- 239000003814 drug Substances 0.000 title description 21
- AEIJTFQOBWATKX-UHFFFAOYSA-N octane-1,2-diol Chemical compound CCCCCCC(O)CO AEIJTFQOBWATKX-UHFFFAOYSA-N 0.000 claims description 28
- 229940031723 1,2-octanediol Drugs 0.000 claims description 27
- 229940069445 licorice extract Drugs 0.000 claims description 26
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- FJKROLUGYXJWQN-UHFFFAOYSA-N 4-hydroxybenzoic acid Chemical compound OC(=O)C1=CC=C(O)C=C1 FJKROLUGYXJWQN-UHFFFAOYSA-N 0.000 description 2
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- NOPFSRXAKWQILS-UHFFFAOYSA-N docosan-1-ol Chemical compound CCCCCCCCCCCCCCCCCCCCCCO NOPFSRXAKWQILS-UHFFFAOYSA-N 0.000 description 2
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- BXWNKGSJHAJOGX-UHFFFAOYSA-N hexadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCO BXWNKGSJHAJOGX-UHFFFAOYSA-N 0.000 description 2
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- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 2
- OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 description 2
- 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 description 2
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- PRAKJMSDJKAYCZ-UHFFFAOYSA-N squalane Chemical compound CC(C)CCCC(C)CCCC(C)CCCCC(C)CCCC(C)CCCC(C)C PRAKJMSDJKAYCZ-UHFFFAOYSA-N 0.000 description 2
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- QCDWFXQBSFUVSP-UHFFFAOYSA-N 2-phenoxyethanol Chemical compound OCCOC1=CC=CC=C1 QCDWFXQBSFUVSP-UHFFFAOYSA-N 0.000 description 1
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- ODKSFYDXXFIFQN-BYPYZUCNSA-N L-arginine Chemical compound OC(=O)[C@@H](N)CCCN=C(N)N ODKSFYDXXFIFQN-BYPYZUCNSA-N 0.000 description 1
- 229930064664 L-arginine Natural products 0.000 description 1
- 235000014852 L-arginine Nutrition 0.000 description 1
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- 229920003171 Poly (ethylene oxide) Polymers 0.000 description 1
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- 229930182558 Sterol Chemical class 0.000 description 1
- OMOVVBIIQSXZSZ-UHFFFAOYSA-N [6-(4-acetyloxy-5,9a-dimethyl-2,7-dioxo-4,5a,6,9-tetrahydro-3h-pyrano[3,4-b]oxepin-5-yl)-5-formyloxy-3-(furan-3-yl)-3a-methyl-7-methylidene-1a,2,3,4,5,6-hexahydroindeno[1,7a-b]oxiren-4-yl] 2-hydroxy-3-methylpentanoate Chemical compound CC12C(OC(=O)C(O)C(C)CC)C(OC=O)C(C3(C)C(CC(=O)OC4(C)COC(=O)CC43)OC(C)=O)C(=C)C32OC3CC1C=1C=COC=1 OMOVVBIIQSXZSZ-UHFFFAOYSA-N 0.000 description 1
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- GZCGUPFRVQAUEE-SLPGGIOYSA-N aldehydo-D-glucose Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C=O GZCGUPFRVQAUEE-SLPGGIOYSA-N 0.000 description 1
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- 239000003963 antioxidant agent Substances 0.000 description 1
- 235000006708 antioxidants Nutrition 0.000 description 1
- 229940064004 antiseptic throat preparations Drugs 0.000 description 1
- 239000003212 astringent agent Substances 0.000 description 1
- 239000000022 bacteriostatic agent Substances 0.000 description 1
- WPYMKLBDIGXBTP-UHFFFAOYSA-N benzoic acid Chemical compound OC(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 description 1
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- 235000011194 food seasoning agent Nutrition 0.000 description 1
- 235000003599 food sweetener Nutrition 0.000 description 1
- 150000004676 glycans Chemical class 0.000 description 1
- YQEMORVAKMFKLG-UHFFFAOYSA-N glycerine monostearate Natural products CCCCCCCCCCCCCCCCCC(=O)OC(CO)CO YQEMORVAKMFKLG-UHFFFAOYSA-N 0.000 description 1
- SVUQHVRAGMNPLW-UHFFFAOYSA-N glycerol monostearate Natural products CCCCCCCCCCCCCCCCC(=O)OCC(O)CO SVUQHVRAGMNPLW-UHFFFAOYSA-N 0.000 description 1
- 229940075507 glyceryl monostearate Drugs 0.000 description 1
- 235000015201 grapefruit juice Nutrition 0.000 description 1
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- JXTPJDDICSTXJX-UHFFFAOYSA-N n-Triacontane Natural products CCCCCCCCCCCCCCCCCCCCCCCCCCCCCC JXTPJDDICSTXJX-UHFFFAOYSA-N 0.000 description 1
- OEIJHBUUFURJLI-UHFFFAOYSA-N octane-1,8-diol Chemical compound OCCCCCCCCO OEIJHBUUFURJLI-UHFFFAOYSA-N 0.000 description 1
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- WCVRQHFDJLLWFE-UHFFFAOYSA-N pentane-1,2-diol Chemical compound CCCC(O)CO WCVRQHFDJLLWFE-UHFFFAOYSA-N 0.000 description 1
- 229960005323 phenoxyethanol Drugs 0.000 description 1
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- Non-Alcoholic Beverages (AREA)
- Medicinal Preparation (AREA)
- Cosmetics (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Food Preservation Except Freezing, Refrigeration, And Drying (AREA)
Description
本発明は防腐殺菌剤並びに該防腐殺菌剤を配合した化粧料、医薬品及び食品に係り、その目的は、オクタンジオールと甘草抽出物とを有効成分として配合することにより、１，２−オクタンジオールが本来有する抗菌力を増強する防腐殺菌剤並びに該防腐殺菌剤を配合した化粧料、医薬品及び食品を提供することにある。 The present invention relates to an antiseptic fungicide and cosmetics, pharmaceuticals and foods containing the antiseptic fungicide, the purpose of which is to add 1,2-octanediol as an active ingredient by blending octanediol and licorice extract as active ingredients. An object of the present invention is to provide an antiseptic and fungicide that enhances the inherent antibacterial activity, and cosmetics, pharmaceuticals, and foods containing the antiseptic and fungicide.
化粧品（医薬部外品を含む）、医薬品及び食品などには、防腐殺菌剤として、パラベン、安息香酸類、サリチル酸類等が用いられている。しかしながら、上記した従来の防腐殺菌剤は皮膚刺激性が高いなど安全性が低いため、使用濃度範囲が制限されやすいといった欠点を有していた。例えば、パラベンや安息香酸塩の使用制限濃度は１％、安息香酸やサリチル酸の使用制限濃度は０．２％とされている。また、これら防腐殺菌剤はｐＨによる影響を受け易いため、防腐殺菌効果の安定性が悪く、界面活性剤などの他の配合成分との併用によりその防腐抗菌効果が著しく低下する場合があるといった問題も有していた。また、近年これらの防腐殺菌剤に対してアレルギー反応を起こす人が増えているために生活者の安全性に対する指向がより高まり、これら防腐殺菌剤を全く配合していないか、或いはその配合量を低減させた化粧料、医薬品及び食品の需要が高まっている。 Parabens, benzoic acids, salicylic acids, and the like are used as antiseptic fungicides in cosmetics (including quasi drugs), pharmaceuticals, and foods. However, the above-mentioned conventional antiseptic disinfectant has a drawback that the concentration range in use is easily limited because of low safety such as high skin irritation. For example, the use restriction concentration of paraben and benzoate is 1%, and the use restriction concentration of benzoic acid and salicylic acid is 0.2%. In addition, since these antiseptic fungicides are easily affected by pH, the stability of the antiseptic disinfection effect is poor, and the antibacterial antibacterial effect may be significantly reduced when used in combination with other components such as surfactants. Also had. In recent years, the number of people who cause allergic reactions to these antiseptic disinfectants has increased, so the consumer's safety orientation has increased. There is an increasing demand for reduced cosmetics, pharmaceuticals and foods.
そこで、従来の防腐殺菌剤を低減できる技術として、１，２−ペンタンジオールと２−フェノキシエタノールを組み合わせて配合した外用組成物（特許文献１参照）や、１，２−アルカンジオールとパラベンからなる防腐殺菌剤（特許文献２参照）が開示されている。しかし、これらは、従来の防腐剤と１，２−アルカンジオールを併用して防腐剤の効果を向上させようとするものであって、従来の防腐剤自体を完全に排除しようとするものではなく、また、１，２−アルカンジオールが有する抗菌力を増強させようとするものでもなかった。 Therefore, as a technique capable of reducing the conventional antiseptic disinfectant, an external composition (see Patent Document 1) containing a combination of 1,2-pentanediol and 2-phenoxyethanol, or an antiseptic comprising 1,2-alkanediol and paraben. A disinfectant (see Patent Document 2) is disclosed. However, these are intended to improve the effect of the preservative by using a conventional preservative and 1,2-alkanediol together, and are not intended to completely eliminate the conventional preservative itself. Also, it was not intended to enhance the antibacterial activity of 1,2-alkanediol.
一方、従来の防腐殺菌剤を排除できる技術として、１，２−アルカンジオールからなる防腐殺菌剤（特許文献３参照）や、１，２−オクタンジオールからなる洗浄性又は非洗浄性化粧料用保湿静菌剤（特許文献４参照）などが開示されている。しかし、１，２−オクタンジオールなどの１，２−アルカンジオールを単独で防腐殺菌剤として用いた場合、充分な効果性を得るためには高配合量を必要とする場合があり、また、１，２−オクタンジオールは特有の原料臭を有することから、低配合量でも充分な防腐殺菌効果を発揮できる技術が望まれている。 On the other hand, as a technique that can eliminate the conventional antiseptic disinfectant, an antiseptic disinfectant composed of 1,2-alkanediol (see Patent Document 3) and a moisturizing agent for cleansing or non-detergency cosmetics composed of 1,2-octanediol. A bacteriostatic agent (see Patent Document 4) and the like are disclosed. However, when 1,2-alkanediol such as 1,2-octanediol is used alone as an antiseptic disinfectant, a high blending amount may be required to obtain sufficient effectiveness. Since 2-octanediol has a unique raw material odor, a technique capable of exhibiting a sufficient antiseptic sterilization effect even at a low blending amount is desired.
本発明は前記従来技術に鑑みてなされたものであって、１，２−オクタンジオールと甘草抽出物とを有効成分として共に用いると、１，２−オクタンジオールが本来有する抗菌力を増強することができる防腐殺菌剤並びに該防腐殺菌剤を配合した化粧料、医薬品及び食品を提供することを課題とする。 The present invention has been made in view of the prior art, and when 1,2-octanediol and licorice extract are used as active ingredients, the antibacterial activity inherent in 1,2-octanediol is enhanced. It is an object of the present invention to provide an antiseptic disinfectant that can be prepared, and cosmetics, pharmaceuticals, and foods containing the antiseptic disinfectant.
すなわち、請求項１に係る発明は、１，２−オクタンジオールと、甘草抽出物とを有効成分として含有することを特徴とする防腐殺菌剤に関する。
また、請求項２に係る発明は、防腐殺菌剤として請求項１に記載の防腐殺菌剤を配合したことを特徴とする化粧料、医薬品又は食品に関する。
That is, the invention according to claim 1 relates to an antiseptic disinfectant characterized by containing 1,2-octanediol and licorice extract as active ingredients.
Moreover, the invention which concerns on Claim 2 is related with cosmetics, a pharmaceutical, or a foodstuff which mix | blended the antiseptic disinfectant of Claim 1 as an antiseptic disinfectant.
本発明によれば、１，２−オクタンジオールの本来有する抗菌力が増強された防腐殺菌剤並びに該防腐殺菌剤を配合した化粧料、医薬品及び食品を提供することができる。 ADVANTAGE OF THE INVENTION According to this invention, the antiseptic disinfectant with which the antibacterial power which 1, 2- octanediol originally has was enhanced, and the cosmetics, the pharmaceutical, and the foodstuff which mix | blended this antiseptic disinfectant can be provided.
本発明に係る防腐殺菌剤は、１，２−オクタンジオールと甘草抽出物を有効成分として含有する。 The antiseptic disinfectant according to the present invention contains 1,2-octanediol and a licorice extract as active ingredients.
本発明に係る第一の成分は、１，２−オクタンジオールであり、より具体的には、１，２−ｎ−オクタンジオールである。１，２−オクタンジオールは、それ自体単独でも抗菌活性を有するが、後述する第二の成分と組み合わせることにより、抗菌活性が更に増強される。 The first component according to the present invention is 1,2-octanediol, and more specifically 1,2-n-octanediol. 1,2-octanediol itself has antibacterial activity, but the antibacterial activity is further enhanced by combining with the second component described later.
本発明に係る防腐殺菌剤の第二の成分は、甘草抽出物である。甘草抽出物は、甘草を無水又は含水のアセトン、エタノール、１，３−ブチレングリコール、プロピレングリコール等の親水性有機溶媒、或いは水で抽出して調製することができ、市販の甘草抽出物をそのまま用いることもできる。このような市販の甘草抽出物としては、油溶性甘草エキス（商品名、丸善製薬社製）、サンリコリス（商品名、東京フードテクノ社製）等を例示することができる。 The second component of the antiseptic disinfectant according to the present invention is a licorice extract. Licorice extract can be prepared by extracting licorice with anhydrous or hydrous hydrophilic organic solvents such as acetone, ethanol, 1,3-butylene glycol, propylene glycol, or water, and the commercially available licorice extract can be used as it is. It can also be used. Examples of such commercially available licorice extract include oil-soluble licorice extract (trade name, manufactured by Maruzen Pharmaceutical Co., Ltd.), Sun Licorice (trade name, manufactured by Tokyo Food Techno Co., Ltd.), and the like.
本発明に係る防腐殺菌剤においては、第一の成分である１，２−オクタンジオールと第二の成分である甘草抽出物の含有量は特に限定されないが、重量比で０．１：１〜１０：１、好ましくは０．２：１〜５：１となるように配合する。１，２−オクタンジオールを甘草抽出物の含有量の１０重量倍を超えて配合すると、また０．１重量倍未満の場合、抗菌力の増強効果が期待できないために好ましくない。 In the antiseptic fungicide according to the present invention, the content of 1,2-octanediol as the first component and the licorice extract as the second component is not particularly limited, but is 0.1: 1 to 1 by weight. It mix | blends so that it may be 10: 1, Preferably 0.2: 1-5: 1. If 1,2-octanediol is added in an amount exceeding 10 times the content of the licorice extract, and if it is less than 0.1 times by weight, an antibacterial activity enhancing effect cannot be expected, such being undesirable.
本発明に係る防腐殺菌剤は、第一の成分である１，２−オクタンジオールと、第二の成分である甘草抽出物とを含有するから、後述する試験に示されるように、第一の成分と第二の成分との相乗効果によって、抗菌力の優れた増強作用が発揮される。したがって、パラベン、安息香酸類、サリチル酸類のような従来から用いられる防腐殺菌剤を低配合又は配合する必要がなく、極めて安全性の高い防腐殺菌剤を得ることができる。 Since the antiseptic disinfectant according to the present invention contains 1,2-octanediol as the first component and licorice extract as the second component, as shown in the test described later, Due to the synergistic effect of the component and the second component, an excellent enhancing action of antibacterial activity is exhibited. Therefore, it is not necessary to blend or blend conventionally used antiseptics such as parabens, benzoic acids, and salicylic acids, and an extremely safe antiseptic can be obtained.
本発明の防腐殺菌剤は、化粧料、医薬品及び食品などに配合して使用することができる。具体的には、洗顔剤、化粧水、乳液、スキンクリーム、ファンデーション、マスカラ、ネールエナメル、口紅等の皮膚用化粧料、シャンプー、ヘアトリートメント、育毛・養毛剤、ヘアクリーム、ヘアフォーム、パーマネントウェーブ剤などの頭髪用化粧料、しみやそばかすなどの特定の使用目的を有した薬用化粧料（医薬部外品）、にきび治療薬、うがい薬、トローチ等の医薬品、チューインガム、キャンディー、飲料水等の食品に好適に用いることができる。 The antiseptic disinfectant of the present invention can be used by blending it in cosmetics, pharmaceuticals, foods and the like. Specifically, facial cleanser, lotion, milky lotion, skin cream, foundation, mascara, nail enamel, lipstick and other skin cosmetics, shampoo, hair treatment, hair growth / hair restorer, hair cream, hair foam, permanent wave agent, etc. For cosmetics for specific hair use such as cosmetics for hair, freckles and other medicinal cosmetics (quasi-drugs), acne medicines, gargles, lozenges, chewing gum, candy, drinking water and other foods It can be used suitably.
本発明の防腐殺菌剤を用いて化粧料、医薬品又は食品を調製する場合、本発明の効果を損なわない範囲内であれば、化粧料、医薬品又は食品に通常用いられる成分を適宜任意に配合することができる。例えば、化粧料（医薬部外品を含む）や医薬品の場合、油脂、ロウ類、高級脂肪酸、低級アルコール、高級アルコール、ステロール類、脂肪酸エステル、保湿剤、界面活性剤、高分子化合物、無機顔料、色素、酸化防止剤、紫外線吸収剤、ビタミン類、収斂剤、美白剤、動植物抽出物、金属イオン封鎖剤、精製水等を例示することができる。また、食品の場合は、動植物油、多糖類、甘味料、着色料、ガムベース等を例示することができる。 When preparing cosmetics, pharmaceuticals or foods using the antiseptic disinfectant of the present invention, the components usually used in cosmetics, pharmaceuticals or foods are optionally arbitrarily blended as long as the effects of the present invention are not impaired. be able to. For example, in the case of cosmetics (including quasi-drugs) and pharmaceuticals, fats and oils, waxes, higher fatty acids, lower alcohols, higher alcohols, sterols, fatty acid esters, humectants, surfactants, polymer compounds, inorganic pigments , Pigments, antioxidants, ultraviolet absorbers, vitamins, astringents, whitening agents, animal and plant extracts, sequestering agents, purified water, and the like. In the case of food, animal and vegetable oils, polysaccharides, sweeteners, colorants, gum bases and the like can be exemplified.
化粧料、医薬品又は食品に本発明の防腐殺菌剤を配合する場合、配合量は特に限定されないが、組成物中０．０１〜２０重量％、好ましくは０．０５〜５重量％である。配合量が０．０１重量％未満の場合、抗菌効果に劣るために、また、２０重量％を超えて配合したとしてもそれ以上の効果が望めないからである。 When the antiseptic disinfectant of the present invention is blended in cosmetics, pharmaceuticals or foods, the blending amount is not particularly limited, but is 0.01 to 20% by weight, preferably 0.05 to 5% by weight in the composition. This is because when the amount is less than 0.01% by weight, the antibacterial effect is inferior, and even if the amount exceeds 20% by weight, no further effect can be expected.
実施例１
（共試菌）
共試菌としてStaphylococcus aureus IFO13276（黄色ブドウ状球菌）及びAspergillus niger IFO9455（クロカビ）を用いた。
Example 1
(Co-test)
Staphylococcus aureus IFO13276 (Staphylococcus aureus) and Aspergillus niger IFO9455 (Black mold) were used as co-test bacteria.
（接種用菌液の調製）
接種用菌液としては、黄色ブドウ状球菌の場合、寒天培地で３５℃で培養後、更にブイヨン培地に移植して３５℃で培養した。得られた培養液をブイヨン培地で約１０８個／ｍｌに希釈したものを接種用菌液とした。
また、クロカビの場合は、２５℃で培養後にTween 80（ポリオキシエチレン（２０）ソルビタンモノオレエート）２％加生理食塩水に胞子を懸濁させ約１０６個／ｍｌに調製したものを接種用菌液とした
(Preparation of bacterial solution for inoculation)
As a bacterial solution for inoculation, in the case of Staphylococcus aureus, after culturing at 35 ° C. on an agar medium, it was further transplanted to a bouillon medium and cultured at 35 ° C. A solution obtained by diluting the obtained culture solution to about 10 8 cells / ml with a bouillon medium was used as a bacterial solution for inoculation.
In the case of black mold, after incubating at 25 ° C., inoculated with spores suspended in 2% Tween 80 (polyoxyethylene (20) sorbitan monooleate) 2% physiological saline to prepare about 10 6 cells / ml Bacteria solution
（被験物質の希釈系列の調製）
２０ｗ／ｗ％エチルセルソルブを希釈溶媒とし、５、４、３、２．５、２．２５、２、１．７５、１．５、１．２５、１ｗ／ｖ％の１，２−オクタンジオール液を調製した。
また、甘草抽出物（商品名サンリコリス、東京フードテクノ社製）及び１，２−オクタンジオールと甘草抽出物の等量混合物については、５ｗ／ｖ％の液を倍倍希釈して希釈系列を調製した。
(Preparation of dilution series of test substance)
5, 4-, 3, 2.5, 2.25, 2, 1.75, 1.5, 1.25, 1 w / v% 1,2-octane using 20 w / w% ethyl cellosolve as a diluent solvent A diol solution was prepared.
For licorice extract (trade name Sanricoris, manufactured by Tokyo Food Techno Co., Ltd.) and 1,2-octanediol and an equivalent mixture of licorice extract, a 5 w / v% solution was diluted twice to obtain a dilution series. Prepared.
（最小発育阻止濃度（ＭＩＣ）の測定）
上記被験物質を含む希釈系列１ｍＬに対して各寒天培地９ｍＬをシャーレに入れ、それぞれについて、上記接種用菌液を約１ｃｍの長さに画線した。培養は、黄色ブドウ状球菌については、３５℃で行い、２日後の菌の生育の有無を判定した。また、クロカビについては、２５℃で培養を行い、３日後の菌の生育の有無を判定した。このとき、生育が認められなかった最小の濃度をＭＩＣとして求めた。
その結果、黄色ブドウ状球菌については、１，２−オクタンジオールは2250μg/ml、甘草抽出物は2500μg/ml、１，２−オクタンジオールと甘草抽出物の等重量混合物は1250μg/mlであった。また、クロカビについては、１，２−オクタンジオールは1250μg/ml、甘草抽出物は5000μg/ml以上、１，２−オクタンジオールと甘草抽出物の等重量混合物は10μg/ml以下であった。
尚、ＭＩＣによって、抗菌力を評価することができる。被験物質の濃度が薄いときには微生物への影響はないが、濃度を増していくと発育抑制が起こる。この程度は、濃度に依存して発育抑制が進み、ついには発育が停止する。このときの濃度がＭＩＣとして表される。したがって、ＭＩＣ以上の濃度になると、微生物は死滅していくことになる。
(Measurement of minimum inhibitory concentration (MIC))
For each 1 mL of the dilution series containing the test substance, 9 mL of each agar medium was placed in a petri dish, and the inoculum for the inoculum was streaked to a length of about 1 cm. The culture was performed at 35 ° C. for Staphylococcus aureus, and the presence or absence of the growth of the bacteria after 2 days was determined. Moreover, about black mold, it culture | cultivated at 25 degreeC and the presence or absence of the growth of a microbe after 3 days was determined. At this time, the minimum concentration at which no growth was observed was determined as MIC.
As a result, for Staphylococcus aureus, 1,2-octanediol was 2250 μg / ml, licorice extract was 2500 μg / ml, and an equal weight mixture of 1,2-octanediol and licorice extract was 1250 μg / ml. . As for black mold, 1,2-octanediol was 1250 μg / ml, licorice extract was 5000 μg / ml or more, and an equal weight mixture of 1,2-octanediol and licorice extract was 10 μg / ml or less.
In addition, antibacterial power can be evaluated by MIC. When the test substance concentration is low, there is no effect on microorganisms, but growth increases when the concentration is increased. This degree of growth proceeds depending on the concentration, and finally the growth stops. The concentration at this time is expressed as MIC. Therefore, when the concentration is higher than MIC, the microorganisms are killed.
（二元最小発育阻止濃度）
得られた１，２−オクタンジオール、甘草抽出物、及び１，２−オクタンジオールと甘草抽出物の等重量混合物の各ＭＩＣを、１，２−オクタンジオール及び甘草抽出の配合量に対してプロットし、二元最小発育阻止濃度図を求めた。結果を図１及び図２に示す。
尚、二元最小発育阻止濃度により、抗菌性を有する二種類の物質を配合した場合の作用効果を判定することができる。具体的には、抗菌性を有する二種類の物質を配合した場合、それにより生ずる作用は、相乗作用、相加作用、拮抗作用に大別される。相乗作用とは、二薬剤が相乗的に作用し、本来有する抗菌力が更に増強される作用である。相加作用とは、各薬剤の抗菌力が合わさった作用である。拮抗作用とは、一薬剤が他剤の抗菌力を打ち消す場合の作用である。そして、二元最小発育阻止濃度図による方法は、例えば、図３に示すように、Ａ物質とＢ物質について、それぞれの割合を変えてＭＩＣを測定し、グラフから判定する方法である。これによると、Ａ物質のみにおけるＭＩＣ（点Ａ）とＢ物質のみにおけるＭＩＣ（点Ｂ）とをプロットした点を結び、両物質を併用したときのＭＩＣが、この線上より内側にある場合（点Ｃ）は、併用により抗菌力が増強された相乗作用であると、線上（点Ｄ）にある場合は相加作用であると、線上より外側にある場合（点Ｅ）は、一方又は双方の抗菌力を打ち消し抗菌力を減少させる拮抗作用であると判定することができる。
(Dual minimum inhibitory concentration)
Each MIC of the obtained 1,2-octanediol, licorice extract, and an equal weight mixture of 1,2-octanediol and licorice extract is plotted against the blending amount of 1,2-octanediol and licorice extract. Then, a binary minimum growth inhibition concentration diagram was obtained. The results are shown in FIGS.
In addition, the effect at the time of mix | blending two types of substances which have antimicrobial property can be determined with a binary minimum growth inhibitory density | concentration. Specifically, when two types of substances having antibacterial properties are blended, the action caused by the substances is roughly classified into a synergistic action, an additive action, and an antagonistic action. The synergistic action is an action in which two drugs act synergistically to further enhance the inherent antibacterial power. The additive action is an action in which the antibacterial powers of the respective drugs are combined. Antagonism is an action when one drug counteracts the antibacterial activity of another drug. Then, the method based on the binary minimum growth inhibition concentration diagram is a method of determining from the graph by measuring the MIC for each of the A substance and B substance while changing their ratios, as shown in FIG. According to this, when MIC (point A) in only substance A and MIC (point B) only in substance B are connected, the MIC when both substances are used is on the inner side of this line (point C) is a synergistic effect in which the antibacterial activity is enhanced by the combined use, if it is on the line (point D), if it is an additive action, if it is outside the line (point E), either or both It can be determined that the antagonistic action counteracts the antibacterial activity and decreases the antibacterial activity.
（抗菌効果の評価）
図１及び図２の結果から、１，２−オクタンジオールと甘草抽出物との組合せにより、抗菌力の相乗効果が認められた。
(Evaluation of antibacterial effect)
From the results of FIG. 1 and FIG. 2, a synergistic effect of antibacterial activity was recognized by the combination of 1,2-octanediol and licorice extract.
以下、本発明の防腐殺菌剤を配合した化粧料、医薬品及び食品の配合例を示す。尚、配合量は重量％である。
（配合例１：保湿クリーム）
モノラウリン酸デカグリセリル 1.0
モノステアリン酸ポリオキシエチレン（１５）グリセリル 1.0
水素添加大豆リン脂質 1.0
ステアリン酸 4.0
セタノール 2.0
ベヘニルアルコール 2.0
パラフィン 3.0
スクワラン 12.0
ホホバ油 4.0
メチルポリシロキサン 0.2
１，３−ブチレングリコール 3.0
Ｌ−アルギニン 0.1
キサンタンガム 0.001
１，２−オクタンジオール 0.25
甘草抽出物 0.1
精製水 残分
合 計 100.0
Hereinafter, formulation examples of cosmetics, pharmaceuticals and foods containing the antiseptic disinfectant of the present invention will be shown. In addition, a compounding quantity is weight%.
(Formulation example 1: moisturizing cream)
Decaglyceryl monolaurate 1.0
Polyoxyethylene (15) glyceryl monostearate 1.0
Hydrogenated soybean phospholipid 1.0
Stearic acid 4.0
Cetanol 2.0
Behenyl alcohol 2.0
Paraffin 3.0
Squalane 12.0
Jojoba oil 4.0
Methyl polysiloxane 0.2
1,3-butylene glycol 3.0
L-Arginine 0.1
Xanthan gum 0.001
1,2-octanediol 0.25
Licorice extract 0.1
Purified water residue
Total 100.0
（配合例２：親水性軟膏）
アスコルビン酸 0.5
ポリオキシエチレンセチルエーテル 2.0
水素添加大豆リン脂質 1.0
ステアリン酸 4.0
グリセリンモノステアレート 10.0
流動パラフィン 10.0
ワセリン 4.0
セタノール 5.0
プロピレングリコール 5.0
１，２−オクタンジオール 0.5
甘草抽出物 0.2
精製水 残分
合 計 100.0
(Formulation example 2: hydrophilic ointment)
Ascorbic acid 0.5
Polyoxyethylene cetyl ether 2.0
Hydrogenated soybean phospholipid 1.0
Stearic acid 4.0
Glycerol monostearate 10.0
Liquid paraffin 10.0
Vaseline 4.0
Cetanol 5.0
Propylene glycol 5.0
1,2-octanediol 0.5
Licorice extract 0.2
Purified water residue
Total 100.0
（配合例３：飲料）
アスコルビン酸 0.5
ブドウ糖液糖 33.0
グレープフルーツ果汁 64.0
１，２−オクタンジオール 0.5
甘草抽出物 0.1
酸味料 適量
合 計 100.0
(Formulation Example 3: Beverage)
Ascorbic acid 0.5
Glucose liquid sugar 33.0
Grapefruit juice 64.0
1,2-octanediol 0.5
Licorice extract 0.1
Sour seasoning
Total 100.0
以上詳述した如く、本発明の防腐殺菌剤は、１，２−オクタンジオールが本来有する抗菌力を増強する効果を奏する。よって、従来の防腐殺菌剤を配合する必要がなくなり、高い安全性を得ることもできる。
また、本発明の防腐殺菌剤を配合した化粧料、医薬品及び食品は、パラベン、安息香酸、サリチル酸等の従来の防腐剤を含有する必要がなく、しかも本発明の防腐殺菌剤は優れた増強された抗菌活性を有しているので、防腐殺菌剤自体を低配合量とすることができ、極めて安全性の高いものである。
As described above in detail, the antiseptic disinfectant of the present invention has an effect of enhancing the antibacterial power inherent to 1,2-octanediol. Therefore, it is not necessary to add a conventional antiseptic disinfectant, and high safety can be obtained.
In addition, cosmetics, pharmaceuticals and foods containing the antiseptic disinfectant of the present invention do not need to contain conventional preservatives such as parabens, benzoic acid and salicylic acid, and the antiseptic disinfectant of the present invention is excellently enhanced. Since the antibacterial activity is high, the antiseptic disinfectant itself can be blended in a low amount, which is extremely safe.
Claims (2)
A cosmetic, pharmaceutical product or food comprising the antiseptic agent according to claim 1 as an antiseptic agent.
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| JP5750404B2 (en) * | 2012-06-14 | 2015-07-22 | 株式会社山田蜂蜜研究所 | Antibacterial agents and cosmetics |
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