HUP0402019A3 - Piperidine derivatives useful as ccr5 antagonists and pharmaceutical compositions containing them - Google Patents

Piperidine derivatives useful as ccr5 antagonists and pharmaceutical compositions containing them

Info

Publication number: HUP0402019A3
Authority: HU; Hungary
Prior art keywords: pharmaceutical compositions; compositions containing; derivatives useful; piperidine derivatives; ccr5 antagonists
Prior art date: 2001-08-29

Application number

HU0402019A

Other languages

English (en)

Original Assignee

Schering Corp

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2001-08-29

Filing date

2002-08-28

Publication date

2009-07-28

2002-08-28 Application filed by Schering Corp filed Critical Schering Corp

2005-02-28 Publication of HUP0402019A2 publication Critical patent/HUP0402019A2/hu

2009-07-28 Publication of HUP0402019A3 publication Critical patent/HUP0402019A3/hu

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/04—Antipruritics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Immunology (AREA)
Virology (AREA)
Dermatology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Pulmonology (AREA)
Biomedical Technology (AREA)
Oncology (AREA)
Communicable Diseases (AREA)
Rheumatology (AREA)
Tropical Medicine & Parasitology (AREA)
Hospice & Palliative Care (AREA)
Transplantation (AREA)
Psychiatry (AREA)
Pain & Pain Management (AREA)
AIDS & HIV (AREA)
Molecular Biology (AREA)
Orthopedic Medicine & Surgery (AREA)
Physical Education & Sports Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Plural Heterocyclic Compounds (AREA)

HU0402019A 2001-08-29 2002-08-28 Piperidine derivatives useful as ccr5 antagonists and pharmaceutical compositions containing them HUP0402019A3 (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US31568301P	2001-08-29	2001-08-29
PCT/US2002/027389 WO2003020716A1 (en)	2001-08-29	2002-08-28	Piperidine derivatives useful as ccr5 antagonists

Publications (2)

Publication Number	Publication Date
HUP0402019A2 HUP0402019A2 (hu)	2005-02-28
HUP0402019A3 true HUP0402019A3 (en)	2009-07-28

Family

ID=23225580

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
HU0402019A HUP0402019A3 (en)	2001-08-29	2002-08-28	Piperidine derivatives useful as ccr5 antagonists and pharmaceutical compositions containing them

Country Status (24)

Country	Link
US (4)	US20040010008A1 (hu)
EP (1)	EP1421075B1 (hu)
JP (2)	JP4223950B2 (hu)
KR (1)	KR20040029057A (hu)
CN (1)	CN1304389C (hu)
AR (1)	AR036366A1 (hu)
AT (1)	ATE328879T1 (hu)
BR (1)	BR0212108A (hu)
CA (1)	CA2457861A1 (hu)
CY (1)	CY1105198T1 (hu)
DE (1)	DE60212146T2 (hu)
DK (1)	DK1421075T3 (hu)
EC (1)	ECSP044993A (hu)
ES (1)	ES2264491T3 (hu)
HK (1)	HK1061563A1 (hu)
HU (1)	HUP0402019A3 (hu)
IL (1)	IL160060A0 (hu)
MX (1)	MXPA04001886A (hu)
NO (1)	NO20041266L (hu)
PL (1)	PL368827A1 (hu)
PT (1)	PT1421075E (hu)
RU (1)	RU2004109510A (hu)
WO (1)	WO2003020716A1 (hu)
ZA (1)	ZA200401594B (hu)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB0108876D0 (en) *	2001-04-09	2001-05-30	Novartis Ag	Organic Compounds
DK1404667T3 (da)	2001-07-02	2006-07-10	Astrazeneca Ab	Piperidinderivater, der er anvendelige som modulatorer af chemokinreceptoraktivitet
SE0200844D0 (sv)	2002-03-19	2002-03-19	Astrazeneca Ab	Chemical compounds
SE0200843D0 (sv)	2002-03-19	2002-03-19	Astrazeneca Ab	Chemical compounds
GB0223223D0 (en) *	2002-10-07	2002-11-13	Novartis Ag	Organic compounds
AU2003301299A1 (en) *	2002-10-15	2004-05-04	Janssen Pharmaceutica, N.V.	Benzyl substituted (piperidin-4-yl) aminobenzamido derivatives as delta-opiod receptor modulators
SE0300957D0 (sv)	2003-04-01	2003-04-01	Astrazeneca Ab	Chemical compounds
US7652142B2 (en) *	2003-11-03	2010-01-26	Schering Corporation	Bipiperidinyl derivatives useful as inhibitors of chemokine receptors
BRPI0415874A (pt) *	2003-11-10	2007-01-09	Schering Ag	compostos de amina de éter benzìlico como antagonistas de ccr-5
EA015517B1 (ru)	2004-04-13	2011-08-30	Инсайт Корпорейшн	Производные пиперазинилпиперидина в качестве антагонистов хемокинового рецептора
US7880002B2 (en)	2004-12-29	2011-02-01	Millennium Pharmaceuticals, Inc.	Substituted piperazinyl-pyrrolidine compounds useful as chemokine receptor antagonists
WO2006071958A1 (en)	2004-12-29	2006-07-06	Millennium Pharmaceuticals, Inc.	Compounds useful as chemokine receptor antagonists
WO2006077499A1 (en) *	2005-01-20	2006-07-27	Pfizer Limited	Chemical compounds
JP4822367B2 (ja) *	2005-02-23	2011-11-24	シェーリングコーポレイション	ケモカイン受容体のインヒビターとして有用なピペリジニルピペリジン誘導体
US20070010565A1 (en) *	2005-04-25	2007-01-11	Olaf Prien	New thiazolidinones without basic nitrogen, their production and use as pharmaceutical agents
US8314127B2 (en)	2005-07-21	2012-11-20	Astrazeneca Ab	Piperidine derivatives
US8119661B2 (en) *	2007-09-11	2012-02-21	Astrazeneca Ab	Piperidine derivatives and their use as muscarinic receptor modulators
WO2009043747A2 (en)	2007-10-01	2009-04-09	F. Hoffmann-La Roche Ag	N-heterocyclic biaryl carboxamides as ccr receptor antagonists
EP2297137A1 (en) *	2008-06-18	2011-03-23	F. Hoffmann-La Roche AG	Novel heteroaryl carboxamide derivatives
GB201017345D0 (en)	2010-10-14	2010-11-24	Proximagen Ltd	Receptor antagonists
JOP20200052A1 (ar)	2013-12-19	2017-06-16	Bayer Pharma AG	بيبريدينيل تتراهيدرو كوينولينات مستبدلة واستخدامها كمعضدات مستقبل أدريني ألفا- 2c
CN106029648A (zh)	2013-12-19	2016-10-12	拜耳制药股份公司	作为肾上腺素能受体α2C拮抗剂的取代的联哌啶基衍生物
EP3083593A1 (de)	2013-12-19	2016-10-26	Bayer Pharma Aktiengesellschaft	Substituierte piperidinyl-tetrahydrochinoline
WO2015091420A1 (de) *	2013-12-19	2015-06-25	Bayer Pharma Aktiengesellschaft	Substituierte bipiperidinyl-derivate als adrenrezeptor alpha 2c antagonisten
CN107438437B (zh)	2015-04-02	2021-01-01	普罗克斯马根有限责任公司	用于癌症的治疗
US11629196B2 (en)	2020-04-27	2023-04-18	Incelldx, Inc.	Method of treating SARS-CoV-2-associated hypercytokinemia by administering a human monoclonal antibody (PRO-140) that inhibits CCR5/CCL5 binding interactions

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4588722A (en) *	1984-01-09	1986-05-13	Janssen Pharmaceutica N.V.	N-(4-piperidinyl) bicyclic condensed 2-imidazolamine derivatives
TW531537B (en) *	1995-12-27	2003-05-11	Janssen Pharmaceutica Nv	1-(1,2-disubstituted piperidinyl)-4-substituted piperidine derivatives
US5952349A (en) *	1996-07-10	1999-09-14	Schering Corporation	Muscarinic antagonists for treating memory loss
JP3068206B2 (ja) *	1996-07-10	2000-07-24	シェーリングコーポレイション	ムスカリン様アンタゴニストとしての１，４―ジ―置換ピペリジン
CA2371587C (en) *	1999-05-04	2005-09-13	Schering Corporation	Piperidine derivatives useful as ccr5 antagonists
WO2001030348A1 (en) *	1999-10-25	2001-05-03	Janssen Pharmaceutica N.V.	Use of substance p antagonists for influencing the circadian timing system
AR033517A1 (es) *	2000-04-08	2003-12-26	Astrazeneca Ab	Derivados de piperidina, proceso para su preparacion y uso de estos derivados en la fabricacion de medicamentos
GB0108876D0 (en) *	2001-04-09	2001-05-30	Novartis Ag	Organic Compounds

2002
- 2002-08-27 AR ARP020103217A patent/AR036366A1/es unknown
- 2002-08-28 KR KR10-2004-7002835A patent/KR20040029057A/ko not_active Application Discontinuation
- 2002-08-28 IL IL16006002A patent/IL160060A0/xx unknown
- 2002-08-28 DE DE60212146T patent/DE60212146T2/de not_active Expired - Lifetime
- 2002-08-28 BR BR0212108-5A patent/BR0212108A/pt not_active IP Right Cessation
- 2002-08-28 WO PCT/US2002/027389 patent/WO2003020716A1/en active IP Right Grant
- 2002-08-28 EP EP02766142A patent/EP1421075B1/en not_active Expired - Lifetime
- 2002-08-28 ES ES02766142T patent/ES2264491T3/es not_active Expired - Lifetime
- 2002-08-28 CN CNB028166795A patent/CN1304389C/zh not_active Expired - Fee Related
- 2002-08-28 PT PT02766142T patent/PT1421075E/pt unknown
- 2002-08-28 HU HU0402019A patent/HUP0402019A3/hu unknown
- 2002-08-28 MX MXPA04001886A patent/MXPA04001886A/es active IP Right Grant
- 2002-08-28 JP JP2003524986A patent/JP4223950B2/ja not_active Expired - Fee Related
- 2002-08-28 CA CA002457861A patent/CA2457861A1/en not_active Abandoned
- 2002-08-28 DK DK02766142T patent/DK1421075T3/da active
- 2002-08-28 AT AT02766142T patent/ATE328879T1/de not_active IP Right Cessation
- 2002-08-28 RU RU2004109510/04A patent/RU2004109510A/ru not_active Application Discontinuation
- 2002-08-28 US US10/229,466 patent/US20040010008A1/en not_active Abandoned
- 2002-08-28 PL PL02368827A patent/PL368827A1/xx not_active Application Discontinuation
2003
- 2003-07-29 US US10/629,466 patent/US7442703B2/en not_active Expired - Fee Related
- 2003-07-29 US US10/628,933 patent/US7384948B2/en not_active Expired - Fee Related
2004
- 2004-02-25 ZA ZA200401594A patent/ZA200401594B/en unknown
- 2004-02-27 EC EC2004004993A patent/ECSP044993A/es unknown
- 2004-03-26 NO NO20041266A patent/NO20041266L/no not_active Application Discontinuation
- 2004-06-19 HK HK04104463A patent/HK1061563A1/xx not_active IP Right Cessation
2006
- 2006-09-06 CY CY20061101271T patent/CY1105198T1/el unknown
2008
- 2008-04-17 US US12/104,914 patent/US8034933B2/en not_active Expired - Fee Related
- 2008-05-22 JP JP2008134844A patent/JP2008222722A/ja active Pending

Also Published As

Publication number	Publication date
WO2003020716A1 (en)	2003-03-13
JP2008222722A (ja)	2008-09-25
HK1061563A1 (en)	2004-09-24
US7384948B2 (en)	2008-06-10
EP1421075A1 (en)	2004-05-26
JP2005502682A (ja)	2005-01-27
BR0212108A (pt)	2004-08-24
IL160060A0 (en)	2004-06-20
CN1304389C (zh)	2007-03-14
MXPA04001886A (es)	2004-06-15
NO20041266L (no)	2004-03-26
US20040010008A1 (en)	2004-01-15
US8034933B2 (en)	2011-10-11
ECSP044993A (es)	2004-04-28
DK1421075T3 (da)	2006-09-18
JP4223950B2 (ja)	2009-02-12
ZA200401594B (en)	2004-11-24
ES2264491T3 (es)	2007-01-01
EP1421075B1 (en)	2006-06-07
KR20040029057A (ko)	2004-04-03
US7442703B2 (en)	2008-10-28
US20040092745A1 (en)	2004-05-13
US20080214575A1 (en)	2008-09-04
DE60212146D1 (de)	2006-07-20
US20040092551A1 (en)	2004-05-13
HUP0402019A2 (hu)	2005-02-28
DE60212146T2 (de)	2007-06-06
PL368827A1 (en)	2005-04-04
CN1551877A (zh)	2004-12-01
AR036366A1 (es)	2004-09-01
RU2004109510A (ru)	2005-10-20
PT1421075E (pt)	2006-10-31
ATE328879T1 (de)	2006-06-15
CY1105198T1 (el)	2010-03-03
CA2457861A1 (en)	2003-03-13

Publication	Publication Date	Title
HUP0402019A3 (en)	2009-07-28	Piperidine derivatives useful as ccr5 antagonists and pharmaceutical compositions containing them
HUP0203528A3 (en)	2003-11-28	Piperidine derivatives useful as ccr5 antagonists, pharmaceutical compositions containing them and their use
HUP0402679A3 (en)	2011-05-30	Pyrrolidine and piperidine derivatives as nki antagonists and pharmaceutical compositions containing them
HUP0202867A3 (en)	2004-01-28	Piperazine derivatives useful as ccr5 antagonists and pharmaceutical compositions containing them
IL152718A0 (en)	2003-06-24	Piperidine derivatives and pharmaceutical compositions containing the same
HUP0303258A3 (en)	2004-06-28	N-substituted nonaryl-heterocyclic nmda/nr2b antagonists and pharmaceutical compositions containing them
HUP0303376A3 (en)	2007-08-28	Acylated piperidine derivatives as melanocortin-4 receptor agonists, and pharmaceutical compositions containing them and use thereof
HUP0300138A3 (en)	2003-06-30	Cyclic amine derivatives as ccr5 antagonists, their production and use and pharmaceutical compositions containing them
HUP0400384A3 (en)	2008-08-28	Benzamidine derivative and pharmaceutical compositions containing them and their use
HUP0500443A3 (en)	2009-12-28	Himbacine analogues as thrombin receptor antagonists and pharmaceutical compositions containing them
IL164987A0 (en)	2005-12-18	Proline derivatives and pharmaceutical compositions containing
HUP0101275A3 (en)	2002-12-28	Amide derivatives and pharmaceutical compositions containing them as nociceptin antagonists
HUP0204496A3 (en)	2004-07-28	Novel piperidine compounds and pharmaceutical compositions containing the same and process for preparation the same
HUP0303325A3 (en)	2008-03-28	Pharmaceutical salts and pharmaceutical compositions containing them
IL209444A0 (en)	2011-07-31	O-desmethyl-venlafaxine succinate salts and pharmaceutical compositions containing them
HK1085658A1 (en)	2006-09-01	Pharmaceutical compositions comprising 1-aminocyclohexane derivatives and acetylcholinesterase inhibitors
HUP0500173A3 (en)	2009-03-30	Alpha-sulphonamido-acetamide derivatives as beta-amyloid inhibitors and pharmaceutical compositions containing them
IL159725A0 (en)	2004-06-20	Pharmaceutical compositions containing benzimidazole derivatives
HUP0303758A3 (en)	2009-08-28	Heterocyclylalkyl piperidine derivatives and their preparation and pharmaceutical compositions containing them
HUP0400349A3 (en)	2010-03-29	Ccr5 antagonists useful for treating aids and pharmaceutical compositions containing them
HUP0104910A2 (en)	2002-10-28	Piperidines as ccr5 modulators and pharmaceutical compositions containing them
HUP0204458A3 (en)	2004-07-28	Derivatives of quinoline as alpha-2 antagonists and pharmaceutical compositions containing them
HUP0301391A3 (en)	2010-03-29	Piperazine and piperidine derivatives pharmaceutical compositions containing them and their use
IL165389A0 (en)	2006-01-15	Piperidine derivatives and pharmaceutical compositions containing the same
HUP0303184A3 (en)	2008-03-28	Substituted c-cyclohexylmethylamine derivatives and pharmaceutical compositions containing them

Legal Events

Date	Code	Title	Description
2011-05-30	FD9A	Lapse of provisional protection due to non-payment of fees