HK1154874A1 - Pegylated interleukin-10 -10 - Google Patents
Pegylated interleukin-10 -10Info
- Publication number
- HK1154874A1 HK1154874A1 HK11109139.0A HK11109139A HK1154874A1 HK 1154874 A1 HK1154874 A1 HK 1154874A1 HK 11109139 A HK11109139 A HK 11109139A HK 1154874 A1 HK1154874 A1 HK 1154874A1
- Authority
- HK
- Hong Kong
- Prior art keywords
- peg
- pegylated
- interleukin
- mono
- pegylated interleukin
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/20—Interleukins [IL]
- A61K38/2066—IL-10
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
- A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/54—Interleukins [IL]
- C07K14/5428—IL-10
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/31—Fusion polypeptide fusions, other than Fc, for prolonged plasma life, e.g. albumin
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Immunology (AREA)
- Biochemistry (AREA)
- Toxicology (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Peptides Or Proteins (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US23659600P | 2000-09-29 | 2000-09-29 |
Publications (1)
Publication Number | Publication Date |
---|---|
HK1154874A1 true HK1154874A1 (en) | 2012-05-04 |
Family
ID=22890150
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HK11109139.0A HK1154874A1 (en) | 2000-09-29 | 2011-08-30 | Pegylated interleukin-10 -10 |
Country Status (7)
Country | Link |
---|---|
US (9) | US7052686B2 (fr) |
EP (2) | EP1324779B1 (fr) |
AT (1) | ATE516820T1 (fr) |
AU (1) | AU2001296962A1 (fr) |
ES (1) | ES2367891T3 (fr) |
HK (1) | HK1154874A1 (fr) |
WO (1) | WO2002026265A2 (fr) |
Families Citing this family (106)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1173222B1 (fr) | 1999-04-23 | 2006-09-27 | ALZA Corporation | Conjugue a liaison pouvant etre clivee, destine a etre utilise dans un liposome |
US7238368B2 (en) | 1999-04-23 | 2007-07-03 | Alza Corporation | Releasable linkage and compositions containing same |
US7303760B2 (en) | 1999-04-23 | 2007-12-04 | Alza Corporation | Method for treating multi-drug resistant tumors |
EP1324779B1 (fr) * | 2000-09-29 | 2011-07-20 | Schering Corporation | Interleukine 10 pegylee |
CA2840490C (fr) * | 2002-01-18 | 2017-02-28 | Biogen Idec Ma Inc. | Poly(alcyleneglycol) comportant des entites pour conjuguer des composes biologiquement actifs |
AU2003280315A1 (en) * | 2002-11-14 | 2004-06-03 | Maxygen, Inc. | Conjugates of interleukin-10 and polymers |
CA2507530C (fr) * | 2002-11-29 | 2012-06-05 | Maria Grazia Roncarolo | Rapamycine et il-10 pour le traitement de maladies auto-immunes |
CA2511815A1 (fr) * | 2002-12-26 | 2004-07-22 | Mountain View Pharmaceuticals, Inc. | Conjugues polymeres de cytokines, de chimiomokines, de facteurs de croissance, d'hormones polypeptidiques et d'antagonistes de ceux-ci conservant une activite de liaison aux recepteurs |
US7261882B2 (en) | 2003-06-23 | 2007-08-28 | Reagents Of The University Of Colorado | Methods for treating neuropathic pain by administering IL-10 polypeptides |
CN100415801C (zh) * | 2003-10-28 | 2008-09-03 | 北京键凯科技有限公司 | 聚乙二醇氨基酸n-内环羰酐活性衍生物及其药物键合物和凝胶 |
US20060204512A1 (en) | 2004-09-23 | 2006-09-14 | Vasgene Therapeutics, Inc. | Polypeptide compounds for inhibiting angiogenesis and tumor growth |
DK1848458T3 (da) * | 2005-02-16 | 2010-02-01 | Micromet Ag | Anvendelse af aktiverede polymerer til separation af protein og polypeptidmultimerer |
WO2006116948A1 (fr) * | 2005-04-30 | 2006-11-09 | Chengdu Institute Of Biological Products | Conjugue de polyethylene glycol et d’interleukine-6 et son procede de preparation et son utilisation |
US20180311071A1 (en) | 2005-10-21 | 2018-11-01 | Daniel R. BURNETT | Method and apparatus for peritoneal oxygenation |
WO2007056362A2 (fr) | 2005-11-07 | 2007-05-18 | Indiana University Research And Technology Corporation | Analogues de glucagon a solubilite et a stabilite physiologiques ameliorees |
EP1834963A1 (fr) * | 2006-03-13 | 2007-09-19 | Siegfried Ltd. | Conjugues de proteines et de dipolymeres et leurs procedes de preparation |
US20100028328A1 (en) * | 2006-06-12 | 2010-02-04 | Therakine, Ltd. | Topical treatment for diseases of eye surface |
CN101631560B (zh) | 2006-09-28 | 2013-12-25 | 默沙东公司 | 聚乙二醇化的白细胞介素-10治疗癌的用途 |
EP2727936B1 (fr) | 2006-11-22 | 2016-09-07 | Bristol-Myers Squibb Company | Agents thérapeutiques ciblés sur la base des protéines modifiées de récepteurs de tyrosine kinases, dont le IGF-IR |
ES2628063T3 (es) * | 2007-01-05 | 2017-08-01 | Indiana University Research And Technology Corporation | Análogos de glucagón que muestran una mayor solubilidad en tampones de pH fisiológicos |
US20100144599A1 (en) | 2007-02-02 | 2010-06-10 | Bristol-Myers Squibb Company | Vegf pathway blockade |
WO2008101017A2 (fr) | 2007-02-15 | 2008-08-21 | Indiana Unversity Research And Technology Corporation | Co-agonistes des récepteurs du glucagon/glp-1 |
US20110159523A1 (en) * | 2007-06-27 | 2011-06-30 | Cedars-Sinai Medical Center | N-terminal specific chemical labeling for proteomics applications |
US20090094368A1 (en) * | 2007-10-08 | 2009-04-09 | Steven Francis Best | Instant messaging general queue depth management |
WO2009058662A2 (fr) | 2007-10-30 | 2009-05-07 | Indiana University Research And Technology Corporation | Antagonistes du glucagon |
JP5771005B2 (ja) * | 2007-10-30 | 2015-08-26 | インディアナ ユニバーシティー リサーチ アンド テクノロジー コーポレーションIndiana University Research And Technology Corporation | グルカゴンアンタゴニスト及びglp−1アゴニスト活性を示す化合物 |
US20110065633A1 (en) | 2008-01-30 | 2011-03-17 | Indiana University Research And Technology Corporation | Ester-based peptide prodrugs |
EP2095829A1 (fr) * | 2008-02-27 | 2009-09-02 | LEK Pharmaceuticals D.D. | Sélénium contenant des agents à modifications et conjugués |
WO2009142773A2 (fr) | 2008-05-22 | 2009-11-26 | Bristol-Myers Squibb Company | Protéines à domaines d’échafaudage à base de fibronectine multivalente |
NZ589847A (en) | 2008-06-17 | 2013-01-25 | Univ Indiana Res & Tech Corp | Glucagon/glp-1 receptor co-agonists |
NZ603445A (en) * | 2008-06-17 | 2014-03-28 | Univ Indiana Res & Tech Corp | Gip-based mixed agonists for treatment of metabolic disorders and obesity |
WO2009155257A1 (fr) * | 2008-06-17 | 2009-12-23 | Indiana University Research And Technology Corporation | Analogues de glucagon présentant des tampons de ph physiologique présentant une solubilité et une stabilité améliorées |
TWI496582B (zh) | 2008-11-24 | 2015-08-21 | 必治妥美雅史谷比公司 | 雙重專一性之egfr/igfir結合分子 |
AU2013205045B2 (en) * | 2008-12-17 | 2015-10-15 | Merck Sharp & Dohme Corp. | Mono- and di-peg IL-10 production; and uses |
HUE037936T2 (hu) * | 2008-12-17 | 2018-09-28 | Merck Sharp & Dohme | Mono- és di-pegil IL-10 elõállítása és alkalmazása |
MX2011006527A (es) * | 2008-12-19 | 2011-08-17 | Univ Indiana Res & Tech Corp | Agentes medicinales unidos a dipeptido. |
CA2747499A1 (fr) | 2008-12-19 | 2010-06-24 | Indiana University Research And Technology Corporation | Promedicaments peptidiques de la superfamille du glucagon a base d'amide |
EP2376520B1 (fr) | 2008-12-19 | 2014-02-12 | Indiana University Research&Technology Corporation | Analogues d'insuline |
JP5755566B2 (ja) | 2008-12-19 | 2015-07-29 | インディアナ ユニバーシティー リサーチ アンド テクノロジー コーポレーションIndiana University Research And Technology Corporation | アミド系インスリンプロドラッグ |
US20110293515A1 (en) * | 2009-01-13 | 2011-12-01 | The Uab Research Foundation | Heterofunctional segment-poly (ethylene glycol) polymers as delivery vehicles |
SG176858A1 (en) | 2009-06-16 | 2012-02-28 | Univ Indiana Res & Tech Corp | Gip receptor-active glucagon compounds |
WO2011014438A1 (fr) | 2009-07-31 | 2011-02-03 | N.V. Organon | Anticorps totalement humains dirigés contre le btla |
EP2480578A4 (fr) * | 2009-09-25 | 2013-04-17 | Vybion Inc | Modification de polypeptide |
US8703701B2 (en) | 2009-12-18 | 2014-04-22 | Indiana University Research And Technology Corporation | Glucagon/GLP-1 receptor co-agonists |
IN2012DN06437A (fr) | 2010-01-27 | 2015-10-09 | Univ Indiana Res & Tech Corp | |
CA2797095A1 (fr) | 2010-05-13 | 2011-11-17 | Indiana University Research And Technology Corporation | Peptides de la superfamille des glucagons presentant une activite de recepteur nucleaire d'hormone |
CA2797089A1 (fr) | 2010-05-13 | 2011-11-17 | Indiana University Research And Technology Corporation | Peptides de la superfamille du glucagon manifestant une activite de recepteur couple a une proteine g |
CN103180339B (zh) | 2010-05-26 | 2016-04-27 | 百时美施贵宝公司 | 具有改善的稳定性的基于纤连蛋白的支架蛋白质 |
US8940860B2 (en) | 2010-06-16 | 2015-01-27 | Indiana University Research And Technology Corporation | Single-chain insulin agonists exhibiting high activity at the insulin receptor |
AU2011270832B2 (en) | 2010-06-24 | 2016-05-12 | Indiana University Research And Technology Corporation | Amide-based insulin prodrugs |
WO2011163460A1 (fr) * | 2010-06-24 | 2011-12-29 | Indiana University Research And Technology Corporation | Facteurs de croissance insulinomimétiques à base d'yl à activité élevée sur le récepteur de l'insuline |
JP2013540102A (ja) | 2010-06-24 | 2013-10-31 | インディアナ ユニバーシティー リサーチ アンド テクノロジー コーポレーション | アミド結合を介して修飾されたグルカゴンスーパーファミリーのペプチドプロドラッグ |
ES2713952T3 (es) | 2010-12-22 | 2019-05-24 | Univ Indiana Res & Tech Corp | Análogos de glucagón que muestran actividad de receptor de GIP |
EP2709669A1 (fr) | 2011-05-17 | 2014-03-26 | Bristol-Myers Squibb Company | Procédés de maintien de la pegylation de polypeptides |
WO2012177443A2 (fr) | 2011-06-22 | 2012-12-27 | Indiana University Research And Technology Corporation | Co-agonistes du récepteur du glucagon et du récepteur du gpl-1 |
WO2012177444A2 (fr) | 2011-06-22 | 2012-12-27 | Indiana University Research And Technology Corporation | Co-agonistes du récepteur du glucagon et du récepteur du gpl-1 |
RU2654231C2 (ru) | 2011-06-28 | 2018-05-17 | Алтернатив Инновейтив Текнолоджиз, Ллц | Способ применения белков теплового шока-70 (бтш70) для повышения выносливости и лечения бтш70-зависимых заболеваний (варианты) |
WO2013056197A1 (fr) | 2011-10-14 | 2013-04-18 | Alternative Innovative Technologies Llc | Formulations d'hsp70 résistantes à la dégradation et leurs utilisations |
US9522951B2 (en) | 2011-10-31 | 2016-12-20 | Bristol-Myers Squibb Company | Fibronectin binding domains with reduced immunogenicity |
EP2780031B1 (fr) | 2011-11-17 | 2018-03-07 | Indiana University Research and Technology Corporation | Peptides de la superfamille du glucagon présentant une action sur les récepteurs aux glucocorticoïdes |
RU2685867C2 (ru) | 2011-12-15 | 2019-04-23 | Алтернатив Инновейтив Текнолоджиз Ллц | Гибридные белки и белковые конъюгаты на основе белка теплового шока-70 (БТШ70) и способы их применения (варианты) |
JP6392123B2 (ja) | 2011-12-20 | 2018-09-19 | インディアナ ユニバーシティー リサーチ アンド テクノロジー コーポレーションIndiana University Research And Technology Corporation | 糖尿病治療のためのctp系インスリンアナローグ |
CA2868883C (fr) | 2012-03-30 | 2022-10-04 | Sorrento Therapeutics Inc. | Anticorps completement humains qui se lient a vegfr2 |
CN115093480A (zh) | 2012-05-31 | 2022-09-23 | 索伦托药业有限公司 | 与pd-l1结合的抗原结合蛋白 |
WO2013192129A1 (fr) | 2012-06-21 | 2013-12-27 | Indiana University Research And Technology Corporation | Analogues du glucagon présentant une activité sur le récepteur du gip |
CN105050618B (zh) | 2012-06-21 | 2018-11-16 | 索伦托治疗有限公司 | 与c-Met结合的抗原结合蛋白 |
WO2013192596A2 (fr) | 2012-06-22 | 2013-12-27 | Sorrento Therapeutics Inc. | Protéines de liaison à un antigène qui se lient à ccr2 |
CN104981251B (zh) | 2012-09-26 | 2018-03-20 | 印第安纳大学研究及科技有限公司 | 胰岛素类似物二聚体 |
WO2014120891A2 (fr) | 2013-02-01 | 2014-08-07 | Bristol-Myers Squibb Company | Protéines d'échafaudage à base de fibronectine |
CN105324397B (zh) | 2013-03-14 | 2020-01-14 | 印第安纳大学研究及科技有限公司 | 胰岛素-肠促胰岛素缀合物 |
BR112015026122A8 (pt) * | 2013-04-18 | 2020-01-21 | Armo Biosciences Inc | agente de polietileno glicol-il-10 (peg-il-10), seu uso, composição farmacêutica, contentor estéril e kit |
WO2014176373A2 (fr) * | 2013-04-24 | 2014-10-30 | Armo Biosciences, Inc. | Compositions d'interleukine-10 et leurs utilisations |
EP3434277A1 (fr) | 2013-06-17 | 2019-01-30 | Armo Biosciences, Inc. | Procédé permettant d'évaluer l'identité et la stabilité de protéines |
CN105658232A (zh) * | 2013-08-30 | 2016-06-08 | 阿尔莫生物科技股份有限公司 | 使用白细胞介素-10治疗疾病和病症的方法 |
JP2016535770A (ja) | 2013-11-01 | 2016-11-17 | スフェリウム バイオメッド エス.エル. | 治療用及び美容用物質を経皮送達するための封入体 |
RU2016122957A (ru) * | 2013-11-11 | 2017-12-19 | Армо Байосайенсиз, Инк. | Способы применения интерлейкина-10 для лечения заболеваний и расстройств |
CN109498815B (zh) * | 2013-12-30 | 2022-07-22 | 江苏众红生物工程创药研究院有限公司 | 重组人激肽释放酶的化学修饰物及其应用 |
US10293043B2 (en) | 2014-06-02 | 2019-05-21 | Armo Biosciences, Inc. | Methods of lowering serum cholesterol |
JO3663B1 (ar) | 2014-08-19 | 2020-08-27 | Merck Sharp & Dohme | الأجسام المضادة لمضاد lag3 وأجزاء ربط الأنتيجين |
MX2017002380A (es) | 2014-08-22 | 2017-09-15 | Sorrento Therapeutics Inc | Proteinas de union de antigeno que se unen a cxcr3. |
US10232020B2 (en) | 2014-09-24 | 2019-03-19 | Indiana University Research And Technology Corporation | Incretin-insulin conjugates |
WO2016049174A1 (fr) | 2014-09-24 | 2016-03-31 | Indiana University Research And Technology Corporation | Promédicaments insuliniques à base d'amide lipidique |
CA2963989A1 (fr) | 2014-10-14 | 2016-04-21 | Armo Biosciences, Inc. | Compositions d'interleukine-15 et leurs utilisations |
MX2017004983A (es) | 2014-10-22 | 2017-11-13 | Armo Biosciences Inc | Metodos para usar interleucina 10 para tratar enfermedades y trastornos. |
WO2016126615A1 (fr) | 2015-02-03 | 2016-08-11 | Armo Biosciences, Inc. | Procédés d'utilisation de l'interleukine-10 pour le traitement de maladies et de troubles |
WO2016191587A1 (fr) | 2015-05-28 | 2016-12-01 | Armo Biosciences, Inc. | Interleukine 10 pégylée utilisée pour le traitement du cancer |
CA2986774A1 (fr) | 2015-05-29 | 2016-12-08 | Armo Biosciences, Inc. | Procedes d'utilisation de l'interleukine-10 pour le traitement de maladies et de troubles |
US10398761B2 (en) | 2015-08-25 | 2019-09-03 | Armo Biosciences, Inc. | Methods of using combinations of PEG-IL-10 and IL-15 for treating cancers |
CA3131983C (fr) | 2015-11-18 | 2023-12-05 | Merck Sharp & Dohme Corp. | Liants pd1 et/ou lag3 |
UA125337C2 (uk) | 2015-11-18 | 2022-02-23 | Мерк Шарп І Доум Корп. | Ctla4-зв'язувальні речовини |
EP3377526A1 (fr) | 2015-11-18 | 2018-09-26 | Merck Sharp & Dohme Corp. | Liants pd1/ctla4 |
BR112018012352A2 (pt) | 2015-12-16 | 2018-12-11 | Merck Sharp & Dohme Corp. | anticorpos anti-lag3 e fragmentos de ligação ao antígeno |
AU2016385474A1 (en) * | 2016-01-05 | 2018-07-05 | Armo Biosciences, Inc. | Methods of using interleukin-10 for treating diseases and disorders |
AU2017207282A1 (en) | 2016-01-11 | 2018-07-05 | Armo Biosciences, Inc. | Interleukin-10 in production of antigen-specific CD8+ T cells and methods of use of same |
KR20190026642A (ko) | 2016-01-29 | 2019-03-13 | 소렌토 쎄라퓨틱스, 인코포레이티드 | Pd-l1에 결합하는 항원 결합 단백질 |
WO2017160599A1 (fr) | 2016-03-14 | 2017-09-21 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Utilisation d'antagonistes de cd300b pour traiter un sepsis et un choc septique |
EP3551047A1 (fr) | 2016-12-07 | 2019-10-16 | Progenity, Inc. | Procédés, dispositifs et systèmes de détection du tractus gastro-intestinal |
US20180251522A1 (en) * | 2017-02-21 | 2018-09-06 | The Regents Of The University Of Michigan | Il-22bp compositions and method for the treatment of disease therewith |
CA3054156A1 (fr) | 2017-03-30 | 2018-10-04 | Progenity Inc. | Traitement d'une maladie du tractus gastro-intestinal au moyen d'il-10 ou d'un agoniste d'il-10 |
EP3706779B1 (fr) | 2017-11-10 | 2022-12-14 | Armo Biosciences, Inc. | Compositions et procédés d'utilisation de l'interleukine-10 en association avec des inhibiteurs de voies de points de contrôle immunitaire |
WO2019245817A1 (fr) | 2018-06-19 | 2019-12-26 | Armo Biosciences, Inc. | Compositions et méthodes d'utilisation d'agents il-10 conjointement avec une thérapie par cellules à récepteur antigénique chimérique |
WO2020106704A2 (fr) | 2018-11-19 | 2020-05-28 | Progenity, Inc. | Dispositif ingestible pour administrer un agent therapeutique dans le tractus digestif |
AU2020261076A1 (en) * | 2019-04-26 | 2021-11-18 | Prolynx Llc | Slow-release cytokine conjugates |
CA3152665A1 (fr) | 2019-08-27 | 2021-03-04 | Tonix Pharma Limited | Polypeptides tff2 modifies |
EP3870261B1 (fr) | 2019-12-13 | 2024-01-31 | Biora Therapeutics, Inc. | Dispositif ingestible pour la livraison d'un agent thérapeutique au système gastro-intestinal |
GB202003428D0 (en) | 2020-03-10 | 2020-04-22 | Univ Dundee | IL-10 mutiens |
Family Cites Families (73)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US591974A (en) * | 1897-10-19 | Bicycle-brake | ||
US2003A (en) * | 1841-03-12 | Improvement in horizontal windivhlls | ||
US3270960A (en) | 1964-09-11 | 1966-09-06 | Sperry Rand Corp | Fluid sensor |
US3773919A (en) | 1969-10-23 | 1973-11-20 | Du Pont | Polylactide-drug mixtures |
JPH0630164B2 (ja) * | 1985-12-16 | 1994-04-20 | キヤノン株式会社 | 光ヘツド装置 |
JPS63152393A (ja) | 1986-07-03 | 1988-06-24 | Takeda Chem Ind Ltd | グリコシル誘導体 |
US4965195A (en) | 1987-10-26 | 1990-10-23 | Immunex Corp. | Interleukin-7 |
US5714585A (en) | 1987-10-26 | 1998-02-03 | Sterling Winthrop, Inc. | Antibodies that are immunoreactive with interleukin-7 |
US5032396A (en) | 1989-02-17 | 1991-07-16 | Immunex Corporation | IL-7 to stimulate platelet production |
US6217857B1 (en) | 1989-06-28 | 2001-04-17 | Schering Corporation | Cytokine synthesis inhibitory factor (IL-10) and pharmaceutical compositions thereof |
US5231012A (en) | 1989-06-28 | 1993-07-27 | Schering Corporation | Nucleic acids encoding cytokine synthesis inhibitory factor (interleukin-10) |
US5229115A (en) | 1990-07-26 | 1993-07-20 | Immunex Corporation | Adoptive immunotherapy with interleukin-7 |
US5252714A (en) | 1990-11-28 | 1993-10-12 | The University Of Alabama In Huntsville | Preparation and use of polyethylene glycol propionaldehyde |
MX9200161A (es) | 1991-01-16 | 1992-07-01 | Schering Corp | Uso de interleucina-10 en inmunoterapia adoptiva de cancer |
CA2100553A1 (fr) | 1991-01-16 | 1992-07-17 | Paulo J. M. Vieira | Traitement des affections neoplasiques avec l'interleukine-10 |
US6277635B1 (en) | 1992-03-04 | 2001-08-21 | Schering Corporation | Use of interleukin-10 to produce a population of suppressor cells |
US5552303A (en) | 1993-03-08 | 1996-09-03 | Immunex Corporation | DNA encoding epithelium-derived T-cell factor |
WO1994022473A1 (fr) | 1993-04-01 | 1994-10-13 | University Of Washington | Utilisation d'interleukine 7 pour ameliorer l'efficacite d'un vaccin |
US5665345A (en) | 1993-05-24 | 1997-09-09 | The United States Of America As Represented By The Department Of Health And Human Services | Methods of inhibiting viral replication using IL-10 |
WO1995003411A1 (fr) | 1993-07-26 | 1995-02-02 | Schering Corporation | Agonistes et antagonistes d'interleukine-10 humaine |
GB9317618D0 (en) * | 1993-08-24 | 1993-10-06 | Royal Free Hosp School Med | Polymer modifications |
US5919455A (en) | 1993-10-27 | 1999-07-06 | Enzon, Inc. | Non-antigenic branched polymer conjugates |
US5643575A (en) | 1993-10-27 | 1997-07-01 | Enzon, Inc. | Non-antigenic branched polymer conjugates |
US5951974A (en) | 1993-11-10 | 1999-09-14 | Enzon, Inc. | Interferon polymer conjugates |
EP0740552A1 (fr) | 1994-01-20 | 1996-11-06 | Schering Corporation | Utilisation d'interleukine-10 pour stimuler l'activite cytolytique de cellules mononucleaires du sang peripherique |
US5696234A (en) | 1994-08-01 | 1997-12-09 | Schering Corporation | Muteins of mammalian cytokine interleukin-13 |
US5824784A (en) * | 1994-10-12 | 1998-10-20 | Amgen Inc. | N-terminally chemically modified protein compositions and methods |
US6410008B1 (en) | 1994-12-12 | 2002-06-25 | Beth Israel Hospital Association | Chimeric IL-10 proteins and uses thereof |
US5932462A (en) | 1995-01-10 | 1999-08-03 | Shearwater Polymers, Inc. | Multiarmed, monofunctional, polymer for coupling to molecules and surfaces |
US5866134A (en) | 1995-03-24 | 1999-02-02 | Schering Corporation | Method for enhancing the antibody response to specific antigens with Interleukin-10 |
US5770190A (en) | 1995-07-14 | 1998-06-23 | Schering Corporation | Method of treatment of acute leukemia with inteleukin-10 |
GB2304047A (en) | 1995-08-09 | 1997-03-12 | Univ Manchester | Pharmaceutical compositions containing cytokines |
US5744451A (en) * | 1995-09-12 | 1998-04-28 | Warner-Lambert Company | N-substituted glutamic acid derivatives with interleukin-1 β converting enzyme inhibitory activity |
US5908621A (en) | 1995-11-02 | 1999-06-01 | Schering Corporation | Polyethylene glycol modified interferon therapy |
US5759859A (en) | 1996-07-15 | 1998-06-02 | United States Of America As Represented By The Secretary Of The Army | Sensor and method for detecting trace underground energetic materials |
US5989867A (en) | 1996-09-23 | 1999-11-23 | Knappe; Andrea | DNA encoding IL-10-like homologue; related reagents |
US5985263A (en) | 1997-12-19 | 1999-11-16 | Enzon, Inc. | Substantially pure histidine-linked protein polymer conjugates |
CA2316834C (fr) | 1998-01-07 | 2006-01-03 | Shearwater Polymers, Inc. | Acrylates de polyethyleneglycol heterobifonctionnel degradables, et gels et conjugues derives de ces acrylates |
US5908921A (en) * | 1998-11-03 | 1999-06-01 | Eastman Kodak Company | Method of manufacturing gelatin |
US7666400B2 (en) | 2005-04-06 | 2010-02-23 | Ibc Pharmaceuticals, Inc. | PEGylation by the dock and lock (DNL) technique |
WO2001005821A2 (fr) | 1999-07-16 | 2001-01-25 | Maria Teresa Bejarano | Utilisations de l'il-10 virale |
US6989377B2 (en) | 1999-12-21 | 2006-01-24 | Wisconsin Alumni Research Foundation | Treating vitamin D responsive diseases |
WO2001058950A1 (fr) | 2000-02-11 | 2001-08-16 | Maxygen Aps | Interleukine-10 amelioree |
US20030186386A1 (en) * | 2000-02-11 | 2003-10-02 | Hansen Christian Karsten | Interleukin 10 |
EP1324779B1 (fr) | 2000-09-29 | 2011-07-20 | Schering Corporation | Interleukine 10 pegylee |
US6838452B2 (en) | 2000-11-24 | 2005-01-04 | Vascular Biogenics Ltd. | Methods employing and compositions containing defined oxidized phospholipids for prevention and treatment of atherosclerosis |
WO2002085300A2 (fr) | 2001-04-23 | 2002-10-31 | The Regents Of The University Of California | Utilisation de l'interleukine 7 pour moduler des processus physiologiques des fibroblastes pulmonaires de mammiferes |
EP1276028A1 (fr) | 2001-07-09 | 2003-01-15 | Telefonaktiebolaget L M Ericsson (Publ) | Appareil et méthode de détection d'indication de statut |
GB0212648D0 (en) | 2002-05-31 | 2002-07-10 | Immunoclin Lab Ltd | Treatment with cytokines |
EP1391513A1 (fr) | 2002-08-08 | 2004-02-25 | Cytheris | Substance médicamenteuse IL-7, composition comprenant IL-7, procédé de sa préparation et ses utilisations |
AU2003280315A1 (en) | 2002-11-14 | 2004-06-03 | Maxygen, Inc. | Conjugates of interleukin-10 and polymers |
CA2507530C (fr) | 2002-11-29 | 2012-06-05 | Maria Grazia Roncarolo | Rapamycine et il-10 pour le traitement de maladies auto-immunes |
CA2511815A1 (fr) | 2002-12-26 | 2004-07-22 | Mountain View Pharmaceuticals, Inc. | Conjugues polymeres de cytokines, de chimiomokines, de facteurs de croissance, d'hormones polypeptidiques et d'antagonistes de ceux-ci conservant une activite de liaison aux recepteurs |
ATE459647T1 (de) | 2003-04-15 | 2010-03-15 | Glaxosmithkline Llc | Humane il-18 substitutionsmutanten und deren konjugate |
US7261882B2 (en) | 2003-06-23 | 2007-08-28 | Reagents Of The University Of Colorado | Methods for treating neuropathic pain by administering IL-10 polypeptides |
JPWO2005033307A1 (ja) | 2003-09-30 | 2006-12-14 | 技術研究組合 生物分子工学研究所 | 新規のリフォールディング方法およびその方法によって得られたタンパク質 |
WO2005052159A1 (fr) | 2003-11-28 | 2005-06-09 | The University Of Sydney | Homologue d'interleukine-10 et ses utilisations |
WO2005063820A2 (fr) | 2003-12-30 | 2005-07-14 | Merck Patent Gmbh | Proteines de fusion de il-7 |
DE602005020837D1 (de) | 2004-12-09 | 2010-06-02 | Merck Patent Gmbh | Il-7-varianten mit reduzierter immunogenität |
WO2006094530A1 (fr) | 2005-03-11 | 2006-09-14 | Siegfried Ltd. | Conjugues de proteines et de dipolymeres et leurs procedes de preparation |
EP1901769A2 (fr) | 2005-05-02 | 2008-03-26 | Avigen, Inc. | Utilisation de peptides derives de cytokine pour traiter la douleur et une maladie neurodegenerative |
DE602006011311D1 (de) | 2005-05-31 | 2010-02-04 | Univ Colorado | Il-10 mutante |
EP1746161A1 (fr) | 2005-07-20 | 2007-01-24 | Cytheris | IL-7 glycosylée, préparation et utilisations |
ATE491722T1 (de) | 2005-10-04 | 2011-01-15 | Zymogenetics L L C | Herstellung und reinigung von il-29 |
WO2007061657A2 (fr) | 2005-11-14 | 2007-05-31 | The Brigham & Women's Hospital, Inc. | Compositions d’interleukine-10 destinees au traitement des adenocarcinomes |
CN101631560B (zh) | 2006-09-28 | 2013-12-25 | 默沙东公司 | 聚乙二醇化的白细胞介素-10治疗癌的用途 |
WO2008070117A1 (fr) | 2006-12-04 | 2008-06-12 | Promedior, Inc. | Thérapie conjointe pour le traitement de maladies fibrotiques |
CA2702494A1 (fr) | 2007-10-19 | 2009-04-23 | The Regents Of The University Of California | Compositions et procedes permettant d'ameliorer l'inflammation du sn, la psychose, le delire, le ptsd ou le sspt |
GB0724231D0 (en) | 2007-12-12 | 2008-01-30 | Renono Ltd | Methods for inhibiting scarring |
CN103025342A (zh) | 2010-06-16 | 2013-04-03 | Abbvie公司 | 蛋白质样品的比较 |
US8759617B2 (en) | 2010-09-21 | 2014-06-24 | National Institute Of Agrobiological Sciences | Method for extraction and purification of recombinant proteins from transgenic plants |
EP2537933A1 (fr) | 2011-06-24 | 2012-12-26 | Institut National de la Santé et de la Recherche Médicale (INSERM) | Immunocytokines basées sur le domaine IL-15 et IL-15Ralpha sushi |
US20190290733A1 (en) | 2015-03-11 | 2019-09-26 | Nektar Therapeutics | Conjugates of an il-7 moiety and a polymer |
-
2001
- 2001-09-28 EP EP01977878A patent/EP1324779B1/fr not_active Expired - Lifetime
- 2001-09-28 EP EP10013313.1A patent/EP2295450B1/fr not_active Expired - Lifetime
- 2001-09-28 ES ES01977878T patent/ES2367891T3/es not_active Expired - Lifetime
- 2001-09-28 WO PCT/US2001/042431 patent/WO2002026265A2/fr active Application Filing
- 2001-09-28 AT AT01977878T patent/ATE516820T1/de active
- 2001-09-28 US US09/967,223 patent/US7052686B2/en not_active Expired - Lifetime
- 2001-09-28 AU AU2001296962A patent/AU2001296962A1/en not_active Abandoned
-
2006
- 2006-05-25 US US11/440,962 patent/US20060210534A1/en not_active Abandoned
-
2008
- 2008-08-28 US US12/200,486 patent/US20080317707A1/en not_active Abandoned
-
2009
- 2009-11-18 US US12/620,854 patent/US20100297069A1/en not_active Abandoned
-
2010
- 2010-11-19 US US12/950,329 patent/US20110064690A1/en not_active Abandoned
-
2011
- 2011-08-26 US US13/218,929 patent/US8697045B2/en not_active Expired - Fee Related
- 2011-08-30 HK HK11109139.0A patent/HK1154874A1/xx not_active IP Right Cessation
-
2014
- 2014-02-21 US US14/186,954 patent/US9238079B2/en not_active Expired - Fee Related
-
2015
- 2015-12-10 US US14/965,607 patent/US9925245B2/en not_active Expired - Lifetime
-
2018
- 2018-02-06 US US15/889,953 patent/US10471126B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
US20110064690A1 (en) | 2011-03-17 |
EP2295450B1 (fr) | 2015-01-28 |
US20020044921A1 (en) | 2002-04-18 |
ES2367891T3 (es) | 2011-11-10 |
US20060210534A1 (en) | 2006-09-21 |
AU2001296962A1 (en) | 2002-04-08 |
US20100297069A1 (en) | 2010-11-25 |
WO2002026265A2 (fr) | 2002-04-04 |
US7052686B2 (en) | 2006-05-30 |
US8697045B2 (en) | 2014-04-15 |
US9238079B2 (en) | 2016-01-19 |
US20160166647A1 (en) | 2016-06-16 |
US10471126B2 (en) | 2019-11-12 |
US20140227223A1 (en) | 2014-08-14 |
ATE516820T1 (de) | 2011-08-15 |
EP1324779B1 (fr) | 2011-07-20 |
US20110305665A1 (en) | 2011-12-15 |
US20180250363A1 (en) | 2018-09-06 |
US20080317707A1 (en) | 2008-12-25 |
EP2295450A1 (fr) | 2011-03-16 |
WO2002026265A3 (fr) | 2003-01-23 |
US9925245B2 (en) | 2018-03-27 |
EP1324779A2 (fr) | 2003-07-09 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
HK1154874A1 (en) | Pegylated interleukin-10 -10 | |
GB9922124D0 (en) | Phosphodiesterase enzymes | |
CY1119848T1 (el) | Απομονωμενη τετραμερικη ουρικαση | |
DE69942231D1 (de) | Ortspezifische duale pegylation von proteine | |
AU7761594A (en) | Polyethylene glycols | |
HK1053128A1 (en) | Long lasting fusion peptide inhibitors of viral infection | |
AU2001278797A1 (en) | Expression vector using for animal cell | |
EP1454138A4 (fr) | Immunocytokines a selectivite modulee | |
HUP0300548A2 (hu) | Poliol-ifn-béta konjugátumok | |
MXPA02006215A (es) | Metodo para preparar esteres de 1-benzotriazolil carbonato de poli(etilenglicol). | |
WO1999004820A3 (fr) | Cytolyse orientee de cellules cibles, agents et compostions a l'origine de cette cytolyse et composes pouvant etre utilises pour produire ces agents | |
ATE380822T1 (de) | Funf-helix protein | |
AU2001290312A1 (en) | Peg-modified erythropoietin | |
NZ509595A (en) | Peg-urate oxidase conjugates and use thereof | |
HUP0200705A2 (hu) | Herbicid hatású 2,3-piridindikarboxamidok és alkalmazásuk | |
WO2003049699A3 (fr) | Nouveaux aldehydes de polyethyleneglycol monofonctionnels | |
ATE348158T1 (de) | Neuartiges collectin | |
AU4884001A (en) | Novel collectins | |
MXPA02002489A (es) | Analogos monomericos de insulina humana. | |
AU2043597A (en) | Human taki dna encoding the same | |
ITVE990040A1 (it) | Sci articolato ad elevata stabilita' e manovrabilita'. |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
PE | Patent expired |
Effective date: 20210927 |