HK1028206A1 - Use of four k-252a derivatives - Google Patents

Use of four k-252a derivatives

Info

Publication number: HK1028206A1
Authority: HK; Hong Kong
Prior art keywords: derivatives; disease; useful; treating parkinson; parkinson
Prior art date: 1992-07-24

Application number

HK00107421A

Other languages

English (en)

Inventor

Michael E Lewis

Nicola Neff

Jill Roberts-Lewis

Chikara Murakata

Hiromitsu Saito

Yuzuru Matsuda

James C Kauer

Marcie A Glicksman

Original Assignee

Cephalon Inc

Kyowa Hakko Kogyo Kk

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1992-07-24

Filing date

2000-11-21

Publication date

2001-02-09

2000-11-21 Application filed by Cephalon Inc, Kyowa Hakko Kogyo Kk filed Critical Cephalon Inc

2001-02-09 Publication of HK1028206A1 publication Critical patent/HK1028206A1/xx

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
- C07D487/14—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains four or more hetero rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/553—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having at least one nitrogen and one oxygen as ring hetero atoms, e.g. loxapine, staurosporine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/7056—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing five-membered rings with nitrogen as a ring hetero atom
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/04—Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Organic Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Epidemiology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Biomedical Technology (AREA)
Molecular Biology (AREA)
Psychology (AREA)
Virology (AREA)
Pain & Pain Management (AREA)
Hospice & Palliative Care (AREA)
Orthopedic Medicine & Surgery (AREA)
Urology & Nephrology (AREA)
Physical Education & Sports Medicine (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
Psychiatry (AREA)
Vascular Medicine (AREA)
Tropical Medicine & Parasitology (AREA)
Oncology (AREA)
Communicable Diseases (AREA)
AIDS & HIV (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Saccharide Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

HK00107421A 1992-07-24 2000-11-21 Use of four k-252a derivatives HK1028206A1 (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US92010292A	1992-07-24	1992-07-24

Publications (1)

Publication Number	Publication Date
HK1028206A1 true HK1028206A1 (en)	2001-02-09

Family

ID=25443161

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
HK00107421A HK1028206A1 (en)	1992-07-24	2000-11-21	Use of four k-252a derivatives

Country Status (18)

Country	Link
US (1)	US5461146A (xx)
EP (4)	EP0651754B1 (xx)
JP (3)	JP3762427B2 (xx)
KR (1)	KR100276008B1 (xx)
AT (3)	ATE304848T1 (xx)
AU (1)	AU675236B2 (xx)
BR (1)	BR9306789A (xx)
CA (1)	CA2140924A1 (xx)
DE (3)	DE69329397T2 (xx)
DK (3)	DK0651754T3 (xx)
ES (3)	ES2101331T3 (xx)
GR (2)	GR3023817T3 (xx)
HK (1)	HK1028206A1 (xx)
HU (5)	HU0301601D0 (xx)
NO (2)	NO305481B1 (xx)
NZ (2)	NZ254662A (xx)
PT (1)	PT768312E (xx)
WO (1)	WO1994002488A1 (xx)

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US5650407A (en) *	1995-04-05	1997-07-22	Cephalon, Inc.	Selected soluble esters of hydroxyl-containing indolocarbazoles
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UA67725C2 (en)	1996-06-03	2004-07-15	Cephalon Inc	K-252a derivatives and a method for improvement of functioning and cell survival enhancement
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WO1999033836A1 (en)	1997-12-31	1999-07-08	Cephalon, Inc.	3'-epimeric k-252a derivatives
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US6200968B1 (en)	1998-08-06	2001-03-13	Cephalon, Inc.	Particle-forming compositions containing fused pyrrolocarbazoles
US7795246B2 (en) *	1998-08-06	2010-09-14	Cephalon, Inc.	Particle-forming compositions containing fused pyrrolocarbazoles
EP1126855B1 (en)	1998-09-25	2007-05-09	Cephalon, Inc.	Use of fused pyrrolocarbazoles for preventing/treating damage to sensory hair cells and cochlear neurons
EP1121932A4 (en) *	1998-10-13	2001-12-19	Kyowa Hakko Kogyo Kk	DRUGS FOR EYE DISEASES
US6242473B1 (en) *	1999-01-08	2001-06-05	Maxim Pharmaceuticals, Inc.	Treatment and prevention of reactive oxygen metabolite-mediated cellular damage
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WO2002010768A2 (en) *	2000-07-31	2002-02-07	The Regents Of The University Of California	Model for alzheimer's disease and other neurodegenerative diseases
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DE60213842T2 (de)	2001-10-30	2007-09-06	Novartis Ag	Staurosporin-derivate als hemmer der flt3-rezeptor-tyrosinkinase-wirkung
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CN100513850C (zh) *	2005-08-23	2009-07-15	浙江华夏阀门有限公司	三角截面密封套
PL1919979T5 (pl) *	2005-08-25	2017-10-31	Creabilis Therapeutics Spa	Polimerowe koniugaty K-252a i ich pochodne
TW200803849A (en)	2005-09-16	2008-01-16	Schering Corp	Pharmaceutical compositions and methods using temozolomide and a protein kinase inhibitor
BRPI0617236A2 (pt)	2005-10-11	2011-07-19	Merck Patent Gmbh	modulação da expressão de quimiocina, dependente de egfr, e influência sobre a terapia e diagnóstico de tumores e efeitos colaterais da mesma
US20100150944A1 (en) *	2007-04-16	2010-06-17	Modgene, Llc	Methods and compositions for diagnosis and treatment of depression and anxiety
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BR112015013849A2 (pt)	2012-12-21	2017-07-11	Sykehuset Soerlandet Hf	terapia direcionada a egfr de distúrbios neurológicos e dor
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WO2024018245A1 (en)	2022-07-22	2024-01-25	INSERM (Institut National de la Santé et de la Recherche Médicale)	Use of calpain inhibitors for the treatment of the diabetic kidney disease
WO2024153744A1 (en)	2023-01-20	2024-07-25	Institut National de la Santé et de la Recherche Médicale	Autophagy activators for the treatment of rhabdomyolysis

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1993
- 1993-07-22 US US08/096,561 patent/US5461146A/en not_active Expired - Lifetime
- 1993-07-26 DE DE69329397T patent/DE69329397T2/de not_active Expired - Lifetime
- 1993-07-26 DE DE69333874T patent/DE69333874T2/de not_active Expired - Lifetime
- 1993-07-26 AT AT99120008T patent/ATE304848T1/de not_active IP Right Cessation
- 1993-07-26 CA CA002140924A patent/CA2140924A1/en not_active Abandoned
- 1993-07-26 ES ES93917337T patent/ES2101331T3/es not_active Expired - Lifetime
- 1993-07-26 EP EP93917337A patent/EP0651754B1/en not_active Expired - Lifetime
- 1993-07-26 HU HU0301601A patent/HU0301601D0/hu unknown
- 1993-07-26 DK DK93917337.3T patent/DK0651754T3/da active
- 1993-07-26 ES ES99120008T patent/ES2248950T3/es not_active Expired - Lifetime
- 1993-07-26 JP JP50473194A patent/JP3762427B2/ja not_active Expired - Lifetime
- 1993-07-26 EP EP96116661A patent/EP0768312B1/en not_active Expired - Lifetime
- 1993-07-26 DK DK96116661T patent/DK0768312T3/da active
- 1993-07-26 ES ES96116661T patent/ES2151629T3/es not_active Expired - Lifetime
- 1993-07-26 BR BR9306789A patent/BR9306789A/pt not_active Application Discontinuation
- 1993-07-26 NZ NZ254662A patent/NZ254662A/en not_active IP Right Cessation
- 1993-07-26 PT PT96116661T patent/PT768312E/pt unknown
- 1993-07-26 KR KR1019950700251A patent/KR100276008B1/ko not_active IP Right Cessation
- 1993-07-26 EP EP99120008A patent/EP1002534B1/en not_active Expired - Lifetime
- 1993-07-26 WO PCT/US1993/006974 patent/WO1994002488A1/en active IP Right Grant
- 1993-07-26 HU HU0301601A patent/HU225341B1/hu unknown
- 1993-07-26 DK DK99120008T patent/DK1002534T3/da active
- 1993-07-26 NZ NZ286198A patent/NZ286198A/en not_active IP Right Cessation
- 1993-07-26 HU HU9500192A patent/HU225297B1/hu unknown
- 1993-07-26 AU AU46881/93A patent/AU675236B2/en not_active Expired
- 1993-07-26 HU HU0301425A patent/HU0301425D0/hu unknown
- 1993-07-26 EP EP04025114A patent/EP1512688A1/en not_active Withdrawn
- 1993-07-26 HU HU0301425A patent/HU225342B1/hu unknown
- 1993-07-26 DE DE69310178T patent/DE69310178T2/de not_active Expired - Lifetime
- 1993-07-26 AT AT93917337T patent/ATE152111T1/de not_active IP Right Cessation
- 1993-07-26 AT AT96116661T patent/ATE196142T1/de not_active IP Right Cessation
1995
- 1995-01-23 NO NO950242A patent/NO305481B1/no not_active IP Right Cessation
1997
- 1997-06-19 GR GR970401455T patent/GR3023817T3/el unknown
1999
- 1999-02-05 NO NO990542A patent/NO307446B1/no not_active IP Right Cessation
2000
- 2000-11-21 HK HK00107421A patent/HK1028206A1/xx not_active IP Right Cessation
- 2000-11-28 GR GR20000402623T patent/GR3034917T3/el not_active IP Right Cessation
2002
- 2002-08-23 JP JP2002244111A patent/JP3723533B2/ja not_active Expired - Fee Related
2005
- 2005-01-27 JP JP2005019891A patent/JP2005170955A/ja active Pending

Also Published As

Publication number	Publication date
NZ286198A (en)	2001-06-29
JPH08501080A (ja)	1996-02-06
US5461146A (en)	1995-10-24
WO1994002488A1 (en)	1994-02-03
NO307446B1 (no)	2000-04-10
DE69310178D1 (de)	1997-05-28
NO990542L (no)	1999-02-05
EP0768312A3 (en)	1997-06-04
ATE196142T1 (de)	2000-09-15
GR3034917T3 (en)	2001-02-28
HU225341B1 (en)	2006-10-28
DE69333874T2 (de)	2006-05-04
ATE304848T1 (de)	2005-10-15
DK1002534T3 (da)	2006-01-23
HU0301601D0 (en)	2003-08-28
DE69333874D1 (de)	2006-02-02
DE69329397D1 (de)	2000-10-12
HU225297B1 (en)	2006-09-28
ES2248950T3 (es)	2006-03-16
GR3023817T3 (en)	1997-09-30
NO950242L (no)	1995-03-07
AU4688193A (en)	1994-02-14
EP1002534A1 (en)	2000-05-24
EP0768312A2 (en)	1997-04-16
ES2151629T3 (es)	2001-01-01
HU0301425D0 (en)	2003-07-28
AU675236B2 (en)	1997-01-30
KR950702564A (ko)	1995-07-29
HU9500192D0 (en)	1995-03-28
DK0651754T3 (da)	1997-10-27
KR100276008B1 (ko)	2000-12-15
ATE152111T1 (de)	1997-05-15
NO950242D0 (no)	1995-01-23
CA2140924A1 (en)	1994-01-25
PT768312E (pt)	2001-03-30
HU225342B1 (en)	2006-10-28
DK0768312T3 (da)	2000-12-11
EP0651754A1 (en)	1995-05-10
NZ254662A (en)	1996-11-26
JP3723533B2 (ja)	2005-12-07
NO305481B1 (no)	1999-06-07
DE69310178T2 (de)	1997-09-25
JP2005170955A (ja)	2005-06-30
EP0768312B1 (en)	2000-09-06
EP1512688A1 (en)	2005-03-09
EP0651754A4 (en)	1995-08-09
JP3762427B2 (ja)	2006-04-05
JP2003113184A (ja)	2003-04-18
EP1002534B1 (en)	2005-09-21
EP0651754B1 (en)	1997-04-23
NO990542D0 (no)	1999-02-05
DE69329397T2 (de)	2001-03-15
HUT71239A (en)	1995-11-28
ES2101331T3 (es)	1997-07-01
BR9306789A (pt)	1998-12-08

Publication	Publication Date	Title
HK1028206A1 (en)	2001-02-09	Use of four k-252a derivatives
EP0363415A4 (en)	1993-03-17	Compounds for the treatment of alzheimer's disease
SG54203A1 (en)	1998-11-16	Novel 7- (substituted)-8-(substituted)-9- [(substituted glycyl]-6-demethyl-6-deoxytetracyclines
AU8979191A (en)	1992-06-25	3,7-disubstituted indole derivatives
EP0331620A3 (en)	1990-05-23	Agent for the treatment of parkinson's disease
AU7777794A (en)	1995-05-25	Melatonin derivatives for use in treating sleep disorders
ITMI931181A1 (it)	1994-12-04	Procedimento per l'ulteriore trattamento di salcicce
AU8185491A (en)	1992-01-07	Treatment of disease
ZA924128B (en)	1993-03-25	New combination preparations for treatment of Parkinson's disease.
GB9013868D0 (en)	1990-08-15	Spinal traction machine for self-application of traction
GR3034688T3 (en)	2001-01-31	Use of 6,7-substituted-2-aminotetralines for preparing pharmaceutical compositions useful for the treatment of septic shock, and antipyretic and antiinflammatory pharmaceutical compositions
PH24501A (en)	1990-07-18	Substituted 3-phenyl-7h-thiazolo(3,2-b)(1,2,4)triazin-7-ones
IL104756A0 (en)	1993-06-10	Composition for the treatment of glaucoma
EP0593285A3 (en)	1994-07-13	Intermediates, and processes there to, for the preparation of 5,6-dihydropyrrolo(2,3-d)pyrimidines
AU619410B2 (en)	1992-01-23	Method of treatment using 17 beta-cyclopropylaminoandrostene derivatives
AU7715291A (en)	1991-11-21	Treatment of horses using ethylestrenol
AU4973690A (en)	1991-09-05	Apparatus for treatment of disorders
GR900100297A (en)	1992-07-30	Cylinder for the treatment of furs

Legal Events

Date	Code	Title	Description
2013-08-23	PE	Patent expired	Effective date: 20130725