ATE152111T1 - K-252a derivate - Google Patents

K-252a derivate

Info

Publication number: ATE152111T1
Authority: AT; Austria
Prior art keywords: derivatives; disease; useful; treating parkinson; parkinson
Prior art date: 1992-07-24

Application number

AT93917337T

Other languages

English (en)

Inventor

Michael E Lewis

Nicola Neff

Jill Roberts-Lewis

Chikara Murakata

Hiromitsu Saito

Yuzuru Matsuda

James C Kauer

Original Assignee

Cephalon Inc

Kyowa Hakko Kogyo Kk

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1992-07-24

Filing date

1993-07-26

Publication date

1997-05-15

1993-07-26 Application filed by Cephalon Inc, Kyowa Hakko Kogyo Kk filed Critical Cephalon Inc

1997-05-15 Application granted granted Critical

1997-05-15 Publication of ATE152111T1 publication Critical patent/ATE152111T1/de

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains four or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
- C07D487/14—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/553—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having at least one nitrogen and one oxygen as ring hetero atoms, e.g. loxapine, staurosporine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/7056—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing five-membered rings with nitrogen as a ring hetero atom
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/04—Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Organic Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Epidemiology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Biomedical Technology (AREA)
Molecular Biology (AREA)
Psychology (AREA)
Virology (AREA)
Pain & Pain Management (AREA)
Hospice & Palliative Care (AREA)
Orthopedic Medicine & Surgery (AREA)
Urology & Nephrology (AREA)
Physical Education & Sports Medicine (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
Psychiatry (AREA)
Vascular Medicine (AREA)
Tropical Medicine & Parasitology (AREA)
Oncology (AREA)
Communicable Diseases (AREA)
AIDS & HIV (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Saccharide Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

AT93917337T 1992-07-24 1993-07-26 K-252a derivate ATE152111T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US92010292A	1992-07-24	1992-07-24

Publications (1)

Publication Number	Publication Date
ATE152111T1 true ATE152111T1 (de)	1997-05-15

Family

ID=25443161

Family Applications (3)

Application Number	Title	Priority Date	Filing Date
AT99120008T ATE304848T1 (de)	1992-07-24	1993-07-26	Verwendung von vier k-252a derivaten
AT93917337T ATE152111T1 (de)	1992-07-24	1993-07-26	K-252a derivate
AT96116661T ATE196142T1 (de)	1992-07-24	1993-07-26	Vervendung von k-252a derivaten zur förderung der funktion eines stritialen neurons

Family Applications Before (1)

Application Number	Title	Priority Date	Filing Date
AT99120008T ATE304848T1 (de)	1992-07-24	1993-07-26	Verwendung von vier k-252a derivaten

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
AT96116661T ATE196142T1 (de)	1992-07-24	1993-07-26	Vervendung von k-252a derivaten zur förderung der funktion eines stritialen neurons

Country Status (18)

Country	Link
US (1)	US5461146A (de)
EP (4)	EP0651754B1 (de)
JP (3)	JP3762427B2 (de)
KR (1)	KR100276008B1 (de)
AT (3)	ATE304848T1 (de)
AU (1)	AU675236B2 (de)
BR (1)	BR9306789A (de)
CA (1)	CA2140924A1 (de)
DE (3)	DE69329397T2 (de)
DK (3)	DK0651754T3 (de)
ES (3)	ES2101331T3 (de)
GR (2)	GR3023817T3 (de)
HK (1)	HK1028206A1 (de)
HU (5)	HU0301601D0 (de)
NO (2)	NO305481B1 (de)
NZ (2)	NZ254662A (de)
PT (1)	PT768312E (de)
WO (1)	WO1994002488A1 (de)

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ES2162843T3 (es) *	1993-12-07	2002-01-16	Lilly Co Eli	Inhibidores de la proteina quinasa c.
US5723456A (en) *	1993-12-07	1998-03-03	Eli Lilly & Company	Therapeutic treatment for cardiovascular diseases
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US5985877A (en) †	1997-08-15	1999-11-16	Cephalon, Inc.	Combination of tyrosine kinase inhibitor and chemical castration to treat prostate cancer
WO1999033836A1 (en)	1997-12-31	1999-07-08	Cephalon, Inc.	3'-epimeric k-252a derivatives
US6811992B1 (en)	1998-05-14	2004-11-02	Ya Fang Liu	Method for identifying MLK inhibitors for the treatment of neurological conditions
US6127401A (en) *	1998-06-05	2000-10-03	Cephalon, Inc.	Bridged indenopyrrolocarbazoles
US6013646A (en) *	1998-07-02	2000-01-11	Bayer Corporation	Indolocarbazole derivatives useful for the treatment of neurodegenerative diseases and cancer
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US7795246B2 (en) *	1998-08-06	2010-09-14	Cephalon, Inc.	Particle-forming compositions containing fused pyrrolocarbazoles
EP1126855B1 (de)	1998-09-25	2007-05-09	Cephalon, Inc.	Methoden zur prophylaxe und behandlung von schäden der wahrnehmungshärchenzellen und der cochlearen neuronen
EP1121932A4 (de) *	1998-10-13	2001-12-19	Kyowa Hakko Kogyo Kk	Heilmittel für augenerkrankungen
US6242473B1 (en) *	1999-01-08	2001-06-05	Maxim Pharmaceuticals, Inc.	Treatment and prevention of reactive oxygen metabolite-mediated cellular damage
US6841567B1 (en)	1999-02-12	2005-01-11	Cephalon, Inc.	Cyclic substituted fused pyrrolocarbazoles and isoindolones
KR20020027486A (ko)	1999-07-09	2002-04-13	오르토-맥네일 파마슈티칼, 인코퍼레이티드	신경영양성 피롤리딘 및 피페리딘, 및 그를 함유하는관련된 조성물
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US20020002169A1 (en)	1999-12-08	2002-01-03	Griffin John H.	Protein kinase inhibitors
US7129250B2 (en)	2000-05-19	2006-10-31	Aegera Therapeutics Inc.	Neuroprotective and anti-proliferative compounds
WO2002010768A2 (en) *	2000-07-31	2002-02-07	The Regents Of The University Of California	Model for alzheimer's disease and other neurodegenerative diseases
DE10113513A1 (de) *	2001-03-20	2002-10-02	Medinnova Ges Med Innovationen	Kombinationspräparat zur Prophylaxe und/oder Therapie von Nervenzell- und/oder Gliazellschäden durch ein neues Behandlungsverfahren
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DE60213842T2 (de)	2001-10-30	2007-09-06	Novartis Ag	Staurosporin-derivate als hemmer der flt3-rezeptor-tyrosinkinase-wirkung
US20050130877A1 (en) *	2003-03-14	2005-06-16	Children's Medical Center Corporation	Axon regeneration with PKC inhibitors
US6664266B2 (en) *	2002-03-14	2003-12-16	Children's Medical Center Corporation	Axon regeneration with PKC inhibitiors
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US8592368B2 (en)	2003-12-19	2013-11-26	University Of South Florida	JAK/STAT inhibitors and MAPK/ERK inhibitors for RSV infection
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WO2006020145A2 (en) *	2004-07-19	2006-02-23	The Johns Hopkins University	Flt3 inhibitors for immune suppression
CN100513850C (zh) *	2005-08-23	2009-07-15	浙江华夏阀门有限公司	三角截面密封套
PL1919979T5 (pl) *	2005-08-25	2017-10-31	Creabilis Therapeutics Spa	Polimerowe koniugaty K-252a i ich pochodne
TW200803849A (en)	2005-09-16	2008-01-16	Schering Corp	Pharmaceutical compositions and methods using temozolomide and a protein kinase inhibitor
BRPI0617236A2 (pt)	2005-10-11	2011-07-19	Merck Patent Gmbh	modulação da expressão de quimiocina, dependente de egfr, e influência sobre a terapia e diagnóstico de tumores e efeitos colaterais da mesma
US20100150944A1 (en) *	2007-04-16	2010-06-17	Modgene, Llc	Methods and compositions for diagnosis and treatment of depression and anxiety
WO2009067221A2 (en) *	2007-11-20	2009-05-28	Cephalon, Inc.	Microemulsion containing indolocarbazole compound and dosage forms containing the same
BR112015013849A2 (pt)	2012-12-21	2017-07-11	Sykehuset Soerlandet Hf	terapia direcionada a egfr de distúrbios neurológicos e dor
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WO2024018245A1 (en)	2022-07-22	2024-01-25	INSERM (Institut National de la Santé et de la Recherche Médicale)	Use of calpain inhibitors for the treatment of the diabetic kidney disease
WO2024153744A1 (en)	2023-01-20	2024-07-25	Institut National de la Santé et de la Recherche Médicale	Autophagy activators for the treatment of rhabdomyolysis

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1993
- 1993-07-22 US US08/096,561 patent/US5461146A/en not_active Expired - Lifetime
- 1993-07-26 DE DE69329397T patent/DE69329397T2/de not_active Expired - Lifetime
- 1993-07-26 DE DE69333874T patent/DE69333874T2/de not_active Expired - Lifetime
- 1993-07-26 AT AT99120008T patent/ATE304848T1/de not_active IP Right Cessation
- 1993-07-26 CA CA002140924A patent/CA2140924A1/en not_active Abandoned
- 1993-07-26 ES ES93917337T patent/ES2101331T3/es not_active Expired - Lifetime
- 1993-07-26 EP EP93917337A patent/EP0651754B1/de not_active Expired - Lifetime
- 1993-07-26 HU HU0301601A patent/HU0301601D0/hu unknown
- 1993-07-26 DK DK93917337.3T patent/DK0651754T3/da active
- 1993-07-26 ES ES99120008T patent/ES2248950T3/es not_active Expired - Lifetime
- 1993-07-26 JP JP50473194A patent/JP3762427B2/ja not_active Expired - Lifetime
- 1993-07-26 EP EP96116661A patent/EP0768312B1/de not_active Expired - Lifetime
- 1993-07-26 DK DK96116661T patent/DK0768312T3/da active
- 1993-07-26 ES ES96116661T patent/ES2151629T3/es not_active Expired - Lifetime
- 1993-07-26 BR BR9306789A patent/BR9306789A/pt not_active Application Discontinuation
- 1993-07-26 NZ NZ254662A patent/NZ254662A/en not_active IP Right Cessation
- 1993-07-26 PT PT96116661T patent/PT768312E/pt unknown
- 1993-07-26 KR KR1019950700251A patent/KR100276008B1/ko not_active IP Right Cessation
- 1993-07-26 EP EP99120008A patent/EP1002534B1/de not_active Expired - Lifetime
- 1993-07-26 WO PCT/US1993/006974 patent/WO1994002488A1/en active IP Right Grant
- 1993-07-26 HU HU0301601A patent/HU225341B1/hu unknown
- 1993-07-26 DK DK99120008T patent/DK1002534T3/da active
- 1993-07-26 NZ NZ286198A patent/NZ286198A/en not_active IP Right Cessation
- 1993-07-26 HU HU9500192A patent/HU225297B1/hu unknown
- 1993-07-26 AU AU46881/93A patent/AU675236B2/en not_active Expired
- 1993-07-26 HU HU0301425A patent/HU0301425D0/hu unknown
- 1993-07-26 EP EP04025114A patent/EP1512688A1/de not_active Withdrawn
- 1993-07-26 HU HU0301425A patent/HU225342B1/hu unknown
- 1993-07-26 DE DE69310178T patent/DE69310178T2/de not_active Expired - Lifetime
- 1993-07-26 AT AT93917337T patent/ATE152111T1/de not_active IP Right Cessation
- 1993-07-26 AT AT96116661T patent/ATE196142T1/de not_active IP Right Cessation
1995
- 1995-01-23 NO NO950242A patent/NO305481B1/no not_active IP Right Cessation
1997
- 1997-06-19 GR GR970401455T patent/GR3023817T3/el unknown
1999
- 1999-02-05 NO NO990542A patent/NO307446B1/no not_active IP Right Cessation
2000
- 2000-11-21 HK HK00107421A patent/HK1028206A1/xx not_active IP Right Cessation
- 2000-11-28 GR GR20000402623T patent/GR3034917T3/el not_active IP Right Cessation
2002
- 2002-08-23 JP JP2002244111A patent/JP3723533B2/ja not_active Expired - Fee Related
2005
- 2005-01-27 JP JP2005019891A patent/JP2005170955A/ja active Pending

Also Published As

Publication number	Publication date
NZ286198A (en)	2001-06-29
JPH08501080A (ja)	1996-02-06
US5461146A (en)	1995-10-24
WO1994002488A1 (en)	1994-02-03
NO307446B1 (no)	2000-04-10
DE69310178D1 (de)	1997-05-28
NO990542L (no)	1999-02-05
EP0768312A3 (de)	1997-06-04
ATE196142T1 (de)	2000-09-15
GR3034917T3 (en)	2001-02-28
HU225341B1 (en)	2006-10-28
DE69333874T2 (de)	2006-05-04
ATE304848T1 (de)	2005-10-15
DK1002534T3 (da)	2006-01-23
HU0301601D0 (en)	2003-08-28
DE69333874D1 (de)	2006-02-02
DE69329397D1 (de)	2000-10-12
HU225297B1 (en)	2006-09-28
ES2248950T3 (es)	2006-03-16
GR3023817T3 (en)	1997-09-30
NO950242L (no)	1995-03-07
AU4688193A (en)	1994-02-14
EP1002534A1 (de)	2000-05-24
EP0768312A2 (de)	1997-04-16
ES2151629T3 (es)	2001-01-01
HU0301425D0 (en)	2003-07-28
AU675236B2 (en)	1997-01-30
KR950702564A (ko)	1995-07-29
HU9500192D0 (en)	1995-03-28
DK0651754T3 (da)	1997-10-27
KR100276008B1 (ko)	2000-12-15
NO950242D0 (no)	1995-01-23
CA2140924A1 (en)	1994-01-25
PT768312E (pt)	2001-03-30
HU225342B1 (en)	2006-10-28
DK0768312T3 (da)	2000-12-11
EP0651754A1 (de)	1995-05-10
NZ254662A (en)	1996-11-26
JP3723533B2 (ja)	2005-12-07
NO305481B1 (no)	1999-06-07
HK1028206A1 (en)	2001-02-09
DE69310178T2 (de)	1997-09-25
JP2005170955A (ja)	2005-06-30
EP0768312B1 (de)	2000-09-06
EP1512688A1 (de)	2005-03-09
EP0651754A4 (de)	1995-08-09
JP3762427B2 (ja)	2006-04-05
JP2003113184A (ja)	2003-04-18
EP1002534B1 (de)	2005-09-21
EP0651754B1 (de)	1997-04-23
NO990542D0 (no)	1999-02-05
DE69329397T2 (de)	2001-03-15
HUT71239A (en)	1995-11-28
ES2101331T3 (es)	1997-07-01
BR9306789A (pt)	1998-12-08

Publication	Publication Date	Title
DE69310178D1 (de)	1997-05-28	K-252a DERIVATE
DK0582788T3 (da)	1999-02-01	7-(Substituerede)-9-[(substitueret glycyl)-amido]-demethyl-6-deoxytetracycliner
ES2161220T3 (es)	2001-12-01	9-((glicil sustituido)amido)-6-desmetil-6-desoxitetraciclinas como agentes antibioticos.
ES2177665T3 (es)	2002-12-16	Inhibidores de proteina quinasa para el tratamiento de trastornos neurologicos.
IN172468B (de)	1993-08-14
FI915920A0 (fi)	1991-12-16	Serotoninantagonister.
EP0363415A4 (en)	1993-03-17	Compounds for the treatment of alzheimer's disease
KR900009625A (ko)	1990-07-05	피리미딘류 및 그의 약리학적으로 허용되는 염류 및 그 용도
NO944339D0 (no)	1994-11-14	Melatoninderivater for anvendelse ved behandling av sövnforstyrrelser
NO307364B1 (no)	2000-03-27	Anvendelse av melatoninderivater
PT889044E (pt)	2005-01-31	Derivados do 5-(heteroaril)alquil-3-oxo-pirido-(1,2-a)benzimidazole-4-carboxamida (pbi) uteis no tratamento de perturbacoes do sistema nervoso central
MX9306395A (es)	1994-04-29	Intermediarios novedosos para la preparacion de derivados 5,6-dihidropirrolo /2,3-d/-pirimidina y procesamiento para su obtencion.
OA09208A (fr)	1992-06-30	"Procédé de préparation de dérivés de la thiéno-triazolo-diazépine".

Legal Events

Date	Code	Title	Description
1997-10-15	UEP	Publication of translation of european patent specification
2010-04-15	REN	Ceased due to non-payment of the annual fee