HK1042699A1 - N-triazolylmethyl-piperazine derivatives as neurokinin receptor antagonists. - Google Patents

N-triazolylmethyl-piperazine derivatives as neurokinin receptor antagonists.

Info

Publication number: HK1042699A1
Authority: HK; Hong Kong
Prior art keywords: triazolylmethyl; receptor antagonists; piperazine derivatives; neurokinin receptor; neurokinin
Prior art date: 2000-07-28

Application number

HK02104096A

Other languages

English (en)

Inventor

Daniel Jasserand

Uwe Schon

Holger Sann

Reinhard Bruckner

Christian Eeckhout

Original Assignee

Solvay Pharm Gmbh

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2000-07-28

Filing date

2002-05-31

Publication date

2002-08-23

2002-05-31 Application filed by Solvay Pharm Gmbh filed Critical Solvay Pharm Gmbh

2002-08-23 Publication of HK1042699A1 publication Critical patent/HK1042699A1/xx

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/06—Anti-spasmodics, e.g. drugs for colics, esophagic dyskinesia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Public Health (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Pain & Pain Management (AREA)
Rheumatology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Plural Heterocyclic Compounds (AREA)

HK02104096A 2000-07-28 2002-05-31 N-triazolylmethyl-piperazine derivatives as neurokinin receptor antagonists. HK1042699A1 (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
DE10036818A DE10036818A1 (de)	2000-07-28	2000-07-28	Neue N-Triazolylmethyl-Piperazinderivate als Neurokininrezeptor-Antagonisten

Publications (1)

Publication Number	Publication Date
HK1042699A1 true HK1042699A1 (en)	2002-08-23

Family

ID=7650544

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
HK02104096A HK1042699A1 (en)	2000-07-28	2002-05-31	N-triazolylmethyl-piperazine derivatives as neurokinin receptor antagonists.

Country Status (28)

Country	Link
US (1)	US6407106B1 (xx)
EP (1)	EP1176144B1 (xx)
JP (1)	JP2002053577A (xx)
KR (1)	KR100924405B1 (xx)
CN (1)	CN1167698C (xx)
AR (1)	AR028743A1 (xx)
AT (1)	ATE244716T1 (xx)
AU (1)	AU779318B2 (xx)
BR (1)	BR0103048A (xx)
CA (1)	CA2354213C (xx)
CZ (1)	CZ301695B6 (xx)
DE (2)	DE10036818A1 (xx)
DK (1)	DK1176144T3 (xx)
DZ (1)	DZ3119A1 (xx)
ES (1)	ES2201007T3 (xx)
HK (1)	HK1042699A1 (xx)
HU (1)	HU226687B1 (xx)
IL (1)	IL144299A (xx)
IN (1)	IN191021B (xx)
NO (1)	NO323233B1 (xx)
NZ (1)	NZ513041A (xx)
PL (1)	PL210436B1 (xx)
PT (1)	PT1176144E (xx)
RU (1)	RU2288918C2 (xx)
SK (1)	SK284802B6 (xx)
TW (1)	TWI304403B (xx)
UA (1)	UA73728C2 (xx)
ZA (1)	ZA200105737B (xx)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
UA77515C2 (en)	2002-04-04	2006-12-15		Diazabicyclo alkane derivatives possessing neuroldnin-nk1 receptor antagonistic activity
PT1501809E (pt) *	2002-04-26	2008-03-18	Lilly Co Eli	Derivados de triazole como antagonistas de receptores de taquiquinina
JP4895476B2 (ja) *	2002-04-26	2012-03-14	イーライリリーアンドカンパニー	タキキニン受容体アンタゴニスト
US20060160794A1 (en) *	2003-06-12	2006-07-20	Amegadzie Albert K	Tachykinin receptor antagonists
US20070082905A1 (en) *	2005-05-27	2007-04-12	De Vries Michiel H	Pharmaceutical compositions comprising n-triazolymethyl-piperazine compounds and methods of using same
ATE487704T1 (de) *	2005-07-25	2010-11-15	Hoffmann La Roche	Substituierte triazolderivate und ihre verwendung als antagonisten des neurokinin-3-rezeptors
PE20081229A1 (es) *	2006-12-01	2008-08-28	Merck & Co Inc	Antagonistas de receptor de orexina de diazepam sustituido
JP2010516731A (ja)	2007-01-24	2010-05-20	グラクソグループリミテッド	２−メトキシ−５−（５−トリフルオロメチル−テトラゾール−１−イル）−ベンジル］−（２ｓ−フェニル−ピペリジン−３ｓ−イル）−アミンを含む医薬組成物
US20120258093A1 (en)	2009-08-20	2012-10-11	Institut National De La Sante Et De La Recherche Medicale (Inserm)	Vla-4 as a biomarker for prognosis and target for therapy in duchenne muscular dystrophy
ES2672099T3 (es)	2011-07-04	2018-06-12	Irbm - Science Park S.P.A.	Antagonistas del receptor NK-1 para el tratamiento de la neovascularización corneal
RU2020131446A (ru)	2018-02-26	2022-03-28	Оспедале Сан Раффаэле С.Р.Л.	Антагонисты nk-1 для применения в лечении глазной боли
WO2021180885A1 (en)	2020-03-11	2021-09-16	Ospedale San Raffaele S.R.L.	Treatment of stem cell deficiency
CN115184498B (zh) *	2022-07-15	2023-02-21	山东京卫制药有限公司	N-Boc-哌嗪中有关物质哌嗪的检测方法

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IL111730A (en) *	1993-11-29	1998-12-06	Fujisawa Pharmaceutical Co	Piperazine derivatives processes for the preparation thereof and pharmaceutical compositions containing the same
US5883098A (en)	1993-11-29	1999-03-16	Fujisawa Pharmaceutical Co., Ltd.	Piperazine derivatives
CA2222041A1 (en) *	1995-05-25	1996-11-28	Fujisawa Pharmaceutical Co., Ltd.	1-benzoyl-2-(indolyl-3-alkyl)-piperazine derivatives as neurokinin receptor antagonists
GB9513118D0 (en) *	1995-06-28	1995-08-30	Merck Sharp & Dohme	Therapeutic agents
HUP9901037A3 (en) *	1995-12-18	2001-11-28	Fujisawa Pharmaceutical Co	Piperazine derivatives,preparation and use thereof, pharmaceutical compositions containing these compounds
KR100458346B1 (ko) *	1996-03-29	2005-06-21	듀파 인터내셔날 리서치 베 파우	피페라진및피페리딘화합물
AUPO735997A0 (en) *	1997-06-17	1997-07-10	Fujisawa Pharmaceutical Co., Ltd.	Piperazine derivatives
DE19824865A1 (de)	1997-08-27	1999-03-04	Solvay Pharm Gmbh	Neue Harnstoffderivate
ATE396187T1 (de) *	1997-08-27	2008-06-15	Solvay Pharm Gmbh	Indolmethyl-n,n'-bisacylpiperazine als neurokininrezeptorantagonisten
ES2162731B1 (es) *	1999-06-04	2003-02-16	Faes Fabrica Espanola De Produ	Nuevas arilpiperacilnilalquil-3(2h)-piridacinonas.

2000
- 2000-07-28 DE DE10036818A patent/DE10036818A1/de not_active Withdrawn
2001
- 2001-05-23 CZ CZ20011813A patent/CZ301695B6/cs not_active IP Right Cessation
- 2001-06-01 SK SK757-2001A patent/SK284802B6/sk not_active IP Right Cessation
- 2001-06-21 AR ARP010102959A patent/AR028743A1/es active IP Right Grant
- 2001-07-10 CN CNB011228261A patent/CN1167698C/zh not_active Expired - Fee Related
- 2001-07-11 HU HU0102931A patent/HU226687B1/hu not_active IP Right Cessation
- 2001-07-12 ZA ZA200105737A patent/ZA200105737B/xx unknown
- 2001-07-12 TW TW090117136A patent/TWI304403B/zh not_active IP Right Cessation
- 2001-07-12 IL IL14429901A patent/IL144299A/en not_active IP Right Cessation
- 2001-07-16 IN IN672MU2001 patent/IN191021B/en unknown
- 2001-07-18 KR KR1020010043215A patent/KR100924405B1/ko not_active IP Right Cessation
- 2001-07-18 NZ NZ513041A patent/NZ513041A/xx not_active IP Right Cessation
- 2001-07-19 AT AT01117433T patent/ATE244716T1/de active
- 2001-07-19 DK DK01117433T patent/DK1176144T3/da active
- 2001-07-19 PT PT01117433T patent/PT1176144E/pt unknown
- 2001-07-19 EP EP01117433A patent/EP1176144B1/de not_active Expired - Lifetime
- 2001-07-19 DE DE50100358T patent/DE50100358D1/de not_active Expired - Lifetime
- 2001-07-19 ES ES01117433T patent/ES2201007T3/es not_active Expired - Lifetime
- 2001-07-25 JP JP2001224792A patent/JP2002053577A/ja active Pending
- 2001-07-26 CA CA2354213A patent/CA2354213C/en not_active Expired - Fee Related
- 2001-07-26 BR BR0103048-5A patent/BR0103048A/pt not_active IP Right Cessation
- 2001-07-26 AU AU57675/01A patent/AU779318B2/en not_active Ceased
- 2001-07-27 NO NO20013709A patent/NO323233B1/no not_active IP Right Cessation
- 2001-07-27 PL PL348946A patent/PL210436B1/pl not_active IP Right Cessation
- 2001-07-27 RU RU2001121084/04A patent/RU2288918C2/ru not_active IP Right Cessation
- 2001-07-27 US US09/915,558 patent/US6407106B1/en not_active Expired - Lifetime
- 2001-07-27 UA UA2001075403A patent/UA73728C2/uk unknown
- 2001-07-28 DZ DZ010054A patent/DZ3119A1/xx active
2002
- 2002-05-31 HK HK02104096A patent/HK1042699A1/xx not_active IP Right Cessation

Also Published As

Publication number	Publication date
PL210436B1 (pl)	2012-01-31
EP1176144B1 (de)	2003-07-09
CN1167698C (zh)	2004-09-22
ES2201007T3 (es)	2004-03-16
DE50100358D1 (de)	2003-08-14
IL144299A0 (en)	2002-05-23
RU2288918C2 (ru)	2006-12-10
EP1176144A1 (de)	2002-01-30
DZ3119A1 (fr)	2004-09-19
DK1176144T3 (da)	2003-10-27
ATE244716T1 (de)	2003-07-15
HUP0102931A3 (en)	2003-07-28
NO20013709L (no)	2002-01-29
IL144299A (en)	2004-08-31
SK284802B6 (sk)	2005-11-03
AU779318B2 (en)	2005-01-13
CA2354213A1 (en)	2002-01-28
CA2354213C (en)	2010-04-27
IN191021B (xx)	2003-09-13
JP2002053577A (ja)	2002-02-19
HU226687B1 (en)	2009-06-29
HUP0102931A2 (hu)	2002-11-28
CZ20011813A3 (cs)	2002-03-13
US6407106B1 (en)	2002-06-18
CN1335316A (zh)	2002-02-13
KR100924405B1 (ko)	2009-10-29
AR028743A1 (es)	2003-05-21
US20020065276A1 (en)	2002-05-30
KR20020010482A (ko)	2002-02-04
AU5767501A (en)	2002-01-31
PT1176144E (pt)	2003-11-28
BR0103048A (pt)	2002-04-02
NO20013709D0 (no)	2001-07-27
NZ513041A (en)	2002-12-20
SK7572001A3 (en)	2002-02-05
HU0102931D0 (en)	2001-09-28
UA73728C2 (en)	2005-09-15
ZA200105737B (en)	2002-01-22
TWI304403B (en)	2008-12-21
DE10036818A1 (de)	2002-02-07
NO323233B1 (no)	2007-02-05
CZ301695B6 (cs)	2010-05-26
PL348946A1 (en)	2002-02-11

Publication	Publication Date	Title
MXPA03001143A (es)	2003-06-24	Derivados de 4-fenil-piridina como antagonistas del receptor de neuroquinina-1.
ZA200204395B (en)	2003-11-26	Selective neurokinin antagonists.
MXPA03002907A (es)	2003-06-24	Antagonistas receptores metabotropicos de glutamato.
EP1349839B8 (en)	2005-06-22	Phenylethenyl or phenylethinyl derivatives as glutamate receptor antagonists
HK1058360A1 (en)	2004-05-14	4-Phenyl-pyridine derivatives as neurokinin-1 receptor antagonists.
MXPA03000738A (es)	2003-06-04	Antagonistas de grelina.
ZA200408670B (en)	2005-10-26	Trizole derivatives as tachykinin receptor antagonists.
AU6751301A (en)	2001-12-17	1,3,8-triaza-spiro'4,5]decan-4-one derivatives as neurokinin receptor antagonists
PL365377A1 (en)	2005-01-10	Amide derivatives as nmda receptor antagonists
HK1084394A1 (en)	2006-07-28	Substituted 1,4-di-piperidin-4-yl-piperazine derivatives and their use for preparing neurokinin antagonists
HK1039330A1 (en)	2002-04-19	Piperidine derivatives useful as ccr5 antagonists.
ZA991413B (en)	1999-08-30	Substituted quinoxaline derivatives as interleukin-8 receptor antagonists.
HK1046909A1 (en)	2003-01-30	Piperazine derivatives as 5-ht1b antagonists.
MXPA03006991A (es)	2003-11-18	Derivados de piperidina como antagonistas de neurocinina 1.
PL356990A1 (en)	2004-07-12	Isoxazolecarboxamide derivatives as alpha1-adrenergic receptor antagonists
HK1051863A1 (en)	2003-08-22	Indol-3-yl derivatives.
MXPA03004652A (es)	2003-09-05	Derivados de piperidina como antagonistas selectivos de subtipo de n-metil-d-aspartato.
HK1042699A1 (en)	2002-08-23	N-triazolylmethyl-piperazine derivatives as neurokinin receptor antagonists.
HK1045684A1 (en)	2002-12-06	Biphenyl derivatives as antagonists of the neurokinine-1 receptor.
ZA200201789B (en)	2003-06-25	Substituted pyrrolidin-2,3,4-trion-3-oxime drivatives useful as NMDA-receptor antagonists.
MXPA03003892A (es)	2003-07-28	Antagonistas del receptor bombesin.
ZA200206151B (en)	2003-11-03	Substituted amionomethyl-phenyl-cyclohexane derivatives.
HK1052925A1 (en)	2003-10-03	Substituted 1-aminobutan-3-ol derivatives.
EP1351687A4 (en)	2004-01-21	UROTENSIN II RECEPTOR ANTAGONISTS
AU2673201A (en)	2001-07-03	Alpha-arylethylpiperazine derivatives as neurokinin antagonists

Legal Events

Date	Code	Title	Description
2013-02-01	PC	Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee)	Effective date: 20120710