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DZ3119A1 - Nouveaux dérivés de n-triazolylmethyl-piperazines comme antagonistes des recepteurs de la neurokinine. - Google Patents

Nouveaux dérivés de n-triazolylmethyl-piperazines comme antagonistes des recepteurs de la neurokinine.

Info

Publication number
DZ3119A1
DZ3119A1 DZ010054A DZ010054A DZ3119A1 DZ 3119 A1 DZ3119 A1 DZ 3119A1 DZ 010054 A DZ010054 A DZ 010054A DZ 010054 A DZ010054 A DZ 010054A DZ 3119 A1 DZ3119 A1 DZ 3119A1
Authority
DZ
Algeria
Prior art keywords
triazolylmethyl
piperazines
receptor antagonists
new derivatives
neurokinin receptor
Prior art date
Application number
DZ010054A
Other languages
English (en)
Inventor
Daniel Jasserand
Uwe Schoen
Holger Sann
Reinhard Bruckner
Christian Eekhout
Original Assignee
Solvay Pharm Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Solvay Pharm Gmbh filed Critical Solvay Pharm Gmbh
Application granted granted Critical
Publication of DZ3119A1 publication Critical patent/DZ3119A1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/06—Anti-spasmodics, e.g. drugs for colics, esophagic dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
DZ010054A 2000-07-28 2001-07-28 Nouveaux dérivés de n-triazolylmethyl-piperazines comme antagonistes des recepteurs de la neurokinine. DZ3119A1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE10036818A DE10036818A1 (de) 2000-07-28 2000-07-28 Neue N-Triazolylmethyl-Piperazinderivate als Neurokininrezeptor-Antagonisten

Publications (1)

Publication Number Publication Date
DZ3119A1 true DZ3119A1 (fr) 2004-09-19

Family

ID=7650544

Family Applications (1)

Application Number Title Priority Date Filing Date
DZ010054A DZ3119A1 (fr) 2000-07-28 2001-07-28 Nouveaux dérivés de n-triazolylmethyl-piperazines comme antagonistes des recepteurs de la neurokinine.

Country Status (28)

Country Link
US (1) US6407106B1 (fr)
EP (1) EP1176144B1 (fr)
JP (1) JP2002053577A (fr)
KR (1) KR100924405B1 (fr)
CN (1) CN1167698C (fr)
AR (1) AR028743A1 (fr)
AT (1) ATE244716T1 (fr)
AU (1) AU779318B2 (fr)
BR (1) BR0103048A (fr)
CA (1) CA2354213C (fr)
CZ (1) CZ301695B6 (fr)
DE (2) DE10036818A1 (fr)
DK (1) DK1176144T3 (fr)
DZ (1) DZ3119A1 (fr)
ES (1) ES2201007T3 (fr)
HK (1) HK1042699A1 (fr)
HU (1) HU226687B1 (fr)
IL (1) IL144299A (fr)
IN (1) IN191021B (fr)
NO (1) NO323233B1 (fr)
NZ (1) NZ513041A (fr)
PL (1) PL210436B1 (fr)
PT (1) PT1176144E (fr)
RU (1) RU2288918C2 (fr)
SK (1) SK284802B6 (fr)
TW (1) TWI304403B (fr)
UA (1) UA73728C2 (fr)
ZA (1) ZA200105737B (fr)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
UA77515C2 (en) 2002-04-04 2006-12-15 Diazabicyclo alkane derivatives possessing neuroldnin-nk1 receptor antagonistic activity
JP4559087B2 (ja) * 2002-04-26 2010-10-06 イーライ リリー アンド カンパニー タキキニン受容体アンタゴニストとしてのトリアゾール誘導体
US7179804B2 (en) * 2002-04-26 2007-02-20 Eli Lilly And Company Tachykinin receptor antagonists
US20060160794A1 (en) * 2003-06-12 2006-07-20 Amegadzie Albert K Tachykinin receptor antagonists
US20070082905A1 (en) * 2005-05-27 2007-04-12 De Vries Michiel H Pharmaceutical compositions comprising n-triazolymethyl-piperazine compounds and methods of using same
CN101228137B (zh) * 2005-07-25 2010-09-29 弗·哈夫曼-拉罗切有限公司 被取代的三唑衍生物和它们作为神经激肽3受体拮抗剂的用途
PE20081229A1 (es) * 2006-12-01 2008-08-28 Merck & Co Inc Antagonistas de receptor de orexina de diazepam sustituido
JP2010516731A (ja) 2007-01-24 2010-05-20 グラクソ グループ リミテッド ２−メトキシ−５−（５−トリフルオロメチル−テトラゾール−１−イル）−ベンジル］−（２ｓ−フェニル−ピペリジン−３ｓ−イル）−アミンを含む医薬組成物
US20120258093A1 (en) 2009-08-20 2012-10-11 Institut National De La Sante Et De La Recherche Medicale (Inserm) Vla-4 as a biomarker for prognosis and target for therapy in duchenne muscular dystrophy
WO2013004766A1 (fr) 2011-07-04 2013-01-10 Ferrari Giulio Antagonistes des récepteurs nk-1 pour traiter une néovascularisation cornéenne
US20210015834A1 (en) 2018-02-26 2021-01-21 Ospedale San Raffaele S.R.L. Nk-1 antagonists for use in the treatment of ocular pain
US20230134843A1 (en) 2020-03-11 2023-05-04 Ospedale San Raffaele S.R.L. Treatment of stem cell deficiency
CN115184498B (zh) * 2022-07-15 2023-02-21 山东京卫制药有限公司 N-Boc-哌嗪中有关物质哌嗪的检测方法

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5883098A (en) 1993-11-29 1999-03-16 Fujisawa Pharmaceutical Co., Ltd. Piperazine derivatives
IL111730A (en) 1993-11-29 1998-12-06 Fujisawa Pharmaceutical Co Piperazine derivatives, processes for their preparation and pharmaceutical preparations containing them
EP0846116A1 (fr) * 1995-05-25 1998-06-10 Fujisawa Pharmaceutical Co., Ltd. Derives de 1-benzoyl-2-(indolyl-3-alkyl)-piperazine utilises comme antagonistes du recepteur de la neurokinine
GB9513118D0 (en) * 1995-06-28 1995-08-30 Merck Sharp & Dohme Therapeutic agents
ATE219064T1 (de) * 1995-12-18 2002-06-15 Fujisawa Pharmaceutical Co Piperazinderivative als tachykinin antagonisten
KR100458346B1 (ko) * 1996-03-29 2005-06-21 듀파 인터내셔날 리서치 베 파우 피페라진및피페리딘화합물
AUPO735997A0 (en) * 1997-06-17 1997-07-10 Fujisawa Pharmaceutical Co., Ltd. Piperazine derivatives
ATE396187T1 (de) * 1997-08-27 2008-06-15 Solvay Pharm Gmbh Indolmethyl-n,n'-bisacylpiperazine als neurokininrezeptorantagonisten
DE19824865A1 (de) * 1997-08-27 1999-03-04 Solvay Pharm Gmbh Neue Harnstoffderivate
ES2162731B1 (es) * 1999-06-04 2003-02-16 Faes Fabrica Espanola De Produ Nuevas arilpiperacilnilalquil-3(2h)-piridacinonas.

Also Published As

Publication number Publication date
HUP0102931A2 (hu) 2002-11-28
BR0103048A (pt) 2002-04-02
NO20013709D0 (no) 2001-07-27
CA2354213C (fr) 2010-04-27
AU779318B2 (en) 2005-01-13
SK7572001A3 (en) 2002-02-05
IN191021B (fr) 2003-09-13
NO20013709L (no) 2002-01-29
CN1335316A (zh) 2002-02-13
ZA200105737B (en) 2002-01-22
TWI304403B (en) 2008-12-21
US6407106B1 (en) 2002-06-18
NO323233B1 (no) 2007-02-05
RU2288918C2 (ru) 2006-12-10
IL144299A (en) 2004-08-31
IL144299A0 (en) 2002-05-23
PL210436B1 (pl) 2012-01-31
CZ20011813A3 (cs) 2002-03-13
KR20020010482A (ko) 2002-02-04
PL348946A1 (en) 2002-02-11
CN1167698C (zh) 2004-09-22
CZ301695B6 (cs) 2010-05-26
ATE244716T1 (de) 2003-07-15
DE50100358D1 (de) 2003-08-14
UA73728C2 (en) 2005-09-15
HU0102931D0 (en) 2001-09-28
ES2201007T3 (es) 2004-03-16
SK284802B6 (sk) 2005-11-03
US20020065276A1 (en) 2002-05-30
HU226687B1 (en) 2009-06-29
KR100924405B1 (ko) 2009-10-29
HUP0102931A3 (en) 2003-07-28
DE10036818A1 (de) 2002-02-07
HK1042699A1 (en) 2002-08-23
AR028743A1 (es) 2003-05-21
JP2002053577A (ja) 2002-02-19
EP1176144A1 (fr) 2002-01-30
AU5767501A (en) 2002-01-31
DK1176144T3 (da) 2003-10-27
PT1176144E (pt) 2003-11-28
EP1176144B1 (fr) 2003-07-09
CA2354213A1 (fr) 2002-01-28
NZ513041A (en) 2002-12-20

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