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FI78087B - Foerfarande foer framstaellning av nya n-dihydrotiazolyl-3-kinolinkarboxamidderivat, vilka har anxiolytisk aktivitet. - Google Patents

Foerfarande foer framstaellning av nya n-dihydrotiazolyl-3-kinolinkarboxamidderivat, vilka har anxiolytisk aktivitet. Download PDF

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Publication number
FI78087B
FI78087B FI822067A FI822067A FI78087B FI 78087 B FI78087 B FI 78087B FI 822067 A FI822067 A FI 822067A FI 822067 A FI822067 A FI 822067A FI 78087 B FI78087 B FI 78087B
Authority
FI
Finland
Prior art keywords
formula
compound
starting material
process according
radical
Prior art date
Application number
FI822067A
Other languages
English (en)
Finnish (fi)
Other versions
FI78087C (sv
FI822067A0 (fi
Inventor
Francois Clemence
Martret Odile Le
Daniel Humbert
Peter Francis Hunt
Original Assignee
Roussel Uclaf
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from FR8111607A external-priority patent/FR2507602A1/fr
Priority claimed from FR8204331A external-priority patent/FR2523130A1/fr
Application filed by Roussel Uclaf filed Critical Roussel Uclaf
Publication of FI822067A0 publication Critical patent/FI822067A0/fi
Publication of FI78087B publication Critical patent/FI78087B/fi
Application granted granted Critical
Publication of FI78087C publication Critical patent/FI78087C/sv

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
    • C07D215/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3 with oxygen atoms in position 4

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Claims (9)

1. CO-NH—ft (I) N R väri R betecknar en väteatom eller en alkylradikal med 1-4 kolatomer och R^ i ställning 6 eller 7 betecknar en 15 väteatom eller en halogenatom, en rakkedjad alkylradikal med 1-4 kolatomer, en förgrenad alkylradikal med 3-5 kolatomer, en alkoxiradikal med 1-4 kolatomer, en trifluor-metyltio-, metyltio-, trifluormetoxi- eller trifluormetyl-radikal, samt deras additionssalter med oorganiska eller 20 organiska syror, kännetecknat därav, att en förening med formeln (II): °H o R väri R och R^ har ovan angivna betydelse och X är en klor-eller bromatom, eller en hydroxiradikal eller en alkoxiradikal med 1-5 kolatomer, omsätts med 2-aminotiazolin, 30 och att den sälunda erhällna föreningen isoleras och vid behov omvandlas tili ett sait.
1. Förfarande för framställning av nya N-dihydro-tiazolyl-3-kinolinkarboxamidderivat, vilka har anxiolytisk 5 aktivitet och vilka har den allmänna formeln (I): a OH N
2. Förfarande enligt patentkravet 1, kännetecknat därav, att man utgingsföreningen utgörs av en förening med formeln (II), väri X är en klor- eller 35 bromatom och att reaktionen utförs i närvaro av ett syra-bindande medel.
FI822067A 1981-06-12 1982-06-10 Förfarande för framställning av nya N-dihydrotiazolyl-3-kinolinkarboxa midderivat, vilka har anxiolytisk aktivitet FI78087C (sv)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
FR8111607 1981-06-12
FR8111607A FR2507602A1 (fr) 1981-06-12 1981-06-12 Nouveau derive dihydrothiazole de la quinoleine, ses sels, procede de preparation, application a titre de medicaments et compositions les renfermant
FR8204331 1982-03-15
FR8204331A FR2523130A1 (fr) 1982-03-15 1982-03-15 Nouveaux derives de la n-dihydrothiazolyl-3-quinoleine carboxamide, leurs sels, procede de preparation, application a titre de medicaments et compositions les renfermant

Publications (3)

Publication Number Publication Date
FI822067A0 FI822067A0 (fi) 1982-06-10
FI78087B true FI78087B (fi) 1989-02-28
FI78087C FI78087C (sv) 1989-06-12

Family

ID=26222434

Family Applications (1)

Application Number Title Priority Date Filing Date
FI822067A FI78087C (sv) 1981-06-12 1982-06-10 Förfarande för framställning av nya N-dihydrotiazolyl-3-kinolinkarboxa midderivat, vilka har anxiolytisk aktivitet

Country Status (16)

Country Link
US (1) US4450166A (sv)
EP (1) EP0067772B1 (sv)
KR (1) KR880000808B1 (sv)
AU (1) AU552029B2 (sv)
CA (1) CA1216795A (sv)
DE (1) DE3262536D1 (sv)
DK (1) DK150070C (sv)
ES (1) ES512852A0 (sv)
FI (1) FI78087C (sv)
GR (1) GR77201B (sv)
HU (1) HU190796B (sv)
IE (1) IE53520B1 (sv)
IL (1) IL65943A (sv)
MA (1) MA19488A1 (sv)
NZ (1) NZ200931A (sv)
PT (1) PT75023B (sv)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2557570B1 (fr) * 1984-01-04 1986-04-18 Adir Nouveaux derives de la quinoleine, leur procede de preparation et les compositions pharmaceutiques les renfermant
FR2566405B1 (fr) * 1984-06-25 1986-09-26 Roussel Uclaf Nouveaux derives de l'acide 4-hydroxy 3-quinoleine carboxylique substitues en 2 par une fonction aminee, leur preparation, leur application comme medicaments, les compositions les renfermant et les intermediaires nouveaux obtenus
US4602014A (en) * 1984-07-09 1986-07-22 Ciba-Geigy Corporation Ring-fused pyrazolo[3,4-d]-pyridin-3-one derivatives as benzodiazepine receptor modulators
US4560692A (en) * 1984-07-18 1985-12-24 Hoffmann-La Roche Inc. 4-Piperidino-2-phenylquinolines
US4786644A (en) * 1987-11-27 1988-11-22 Hoechst-Roussel Pharmaceuticals Inc. 1-aryl-3-quinolinecarboxamide
WO1999043661A2 (en) * 1998-02-26 1999-09-02 Neurogen Corporation Substituted cycloalkyl-4-oxonicotinic carboxamides; gaba brain receptor ligands
EP1177177B1 (en) * 1999-05-06 2005-02-23 Neurogen Corporation Substituted 4-oxo-quinoline-3-carboxamides: gaba brain receptor ligands
US20100074949A1 (en) 2008-08-13 2010-03-25 William Rowe Pharmaceutical composition and administration thereof
CN101006076B (zh) 2004-06-24 2010-09-29 沃泰克斯药物股份有限公司 Atp-结合弹夹转运蛋白的调控剂
US8354427B2 (en) * 2004-06-24 2013-01-15 Vertex Pharmaceutical Incorporated Modulators of ATP-binding cassette transporters
CN101374849A (zh) * 2005-12-24 2009-02-25 沃泰克斯药物股份有限公司 作为abc转运蛋白调控剂的喹啉-4-酮衍生物
DK3219705T3 (da) 2005-12-28 2020-04-14 Vertex Pharma Farmaceutiske sammensætninger af den amorfe form af n-[2,4-bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinolin-3-carboxamid
EP2821400B1 (en) 2009-03-20 2017-09-27 Vertex Pharmaceuticals Incorporated Process for making modulators of cystic fibrosis transmembrane conductance regulator
US8802700B2 (en) 2010-12-10 2014-08-12 Vertex Pharmaceuticals Incorporated Modulators of ATP-Binding Cassette transporters
MX2014010253A (es) 2012-02-27 2014-11-12 Vertex Pharma Composicion farmaceutica y administraciones de la misma.
WO2016057730A1 (en) 2014-10-07 2016-04-14 Strohmeier Mark Co-crystals of modulators of cystic fibrosis transmembrane conductance regulator

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1364605A (fr) * 1962-03-01 1964-06-26 Procédé de préparation d'amides des acides carboxyliques
FR2281761A1 (fr) * 1974-08-13 1976-03-12 Roussel Uclaf Nouveaux derives de l'acide 3-quinoleine carboxylique, leur procede de preparation et leur application comme medicament
FR2324304A2 (fr) * 1975-09-22 1977-04-15 Roussel Uclaf Nouveaux derives de l'acide 3-quinoleine carboxylique, leur procede de preparation et leur application comme medicament
FR2340735A1 (fr) * 1976-02-11 1977-09-09 Roussel Uclaf Nouveaux derives de l'acide 3-quinoleine carboxylique, leur procede de preparation et leur application comme medicament
FR2377400A2 (fr) * 1977-01-18 1978-08-11 Roussel Uclaf Nouveaux derives de l'acide 3-quinoleine carboxylique, leur procede de preparation et leur application comme medicament
FR2443467A1 (fr) * 1978-12-08 1980-07-04 Roussel Uclaf Nouveaux derives de l'acide 3-quinoleine carboxylique, leur procede de preparation et leur application comme medicament
FR2482596A1 (fr) * 1980-05-19 1981-11-20 Roussel Uclaf Nouveaux derives de l'acide 4-hydroxy 3-quinoleine carboxylique substitues en 2, leur procede de preparation et leur application comme medicament

Also Published As

Publication number Publication date
ES8304567A1 (es) 1983-03-01
IL65943A (en) 1985-12-31
KR840000541A (ko) 1984-02-25
AU552029B2 (en) 1986-05-22
MA19488A1 (fr) 1982-12-31
IL65943A0 (en) 1982-09-30
KR880000808B1 (ko) 1988-05-11
NZ200931A (en) 1984-12-14
GR77201B (sv) 1984-09-11
DK150070B (da) 1986-12-01
DK150070C (da) 1987-11-09
IE53520B1 (en) 1988-12-07
EP0067772B1 (fr) 1985-03-13
PT75023A (fr) 1982-07-01
PT75023B (fr) 1985-05-17
DK262782A (da) 1982-12-13
DE3262536D1 (en) 1985-04-18
EP0067772A1 (fr) 1982-12-22
FI78087C (sv) 1989-06-12
IE821394L (en) 1982-12-12
CA1216795A (fr) 1987-01-20
AU8482782A (en) 1982-12-16
ES512852A0 (es) 1983-03-01
FI822067A0 (fi) 1982-06-10
US4450166A (en) 1984-05-22
HU190796B (en) 1986-11-28

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Owner name: ROUSSEL UCLAF SOCIETE ANONYME