FI72648B - Foerfarande foer framstaellning av fasta, laett resorberande och laongtidsverkande laekemedelspreparat innehaollande nifedipin. - Google Patents
Foerfarande foer framstaellning av fasta, laett resorberande och laongtidsverkande laekemedelspreparat innehaollande nifedipin. Download PDFInfo
- Publication number
- FI72648B FI72648B FI812758A FI812758A FI72648B FI 72648 B FI72648 B FI 72648B FI 812758 A FI812758 A FI 812758A FI 812758 A FI812758 A FI 812758A FI 72648 B FI72648 B FI 72648B
- Authority
- FI
- Finland
- Prior art keywords
- nifedipine
- och
- surface area
- crystals
- specific surface
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
- C07D211/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Heart & Thoracic Surgery (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Cardiology (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Hydrogenated Pyridines (AREA)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FI893544A FI893544A0 (fi) | 1980-09-09 | 1989-07-24 | Anvaendning av specifika nifedipinkristaller foer framstaellning av fasta laett resorberande laekemedelspreparat med foerdroejd verkan. |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19803033919 DE3033919A1 (de) | 1980-09-09 | 1980-09-09 | Feste arzneizubereitungen enthaltend nifedipin und verfahren zu ihrer herstellung |
DE3033919 | 1980-09-09 |
Publications (2)
Publication Number | Publication Date |
---|---|
FI812758L FI812758L (fi) | 1982-03-10 |
FI72648B true FI72648B (fi) | 1987-03-31 |
Family
ID=6111496
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FI812758A FI72648B (fi) | 1980-09-09 | 1981-09-07 | Foerfarande foer framstaellning av fasta, laett resorberande och laongtidsverkande laekemedelspreparat innehaollande nifedipin. |
Country Status (20)
Country | Link |
---|---|
EP (1) | EP0047899B2 (xx) |
JP (1) | JPS5914446B2 (xx) |
AR (1) | AR226377A1 (xx) |
AT (1) | ATE5761T1 (xx) |
AU (1) | AU558331B2 (xx) |
CA (1) | CA1180277A (xx) |
DD (1) | DD201974A5 (xx) |
DE (2) | DE3033919A1 (xx) |
DK (1) | DK154326C (xx) |
FI (1) | FI72648B (xx) |
GR (1) | GR78237B (xx) |
HU (1) | HU184879B (xx) |
IE (1) | IE51549B1 (xx) |
IL (1) | IL63749A (xx) |
NO (1) | NO157368B (xx) |
NZ (1) | NZ198285A (xx) |
PH (1) | PH24097A (xx) |
PL (1) | PL232951A1 (xx) |
PT (1) | PT73603B (xx) |
ZA (1) | ZA816213B (xx) |
Families Citing this family (32)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5264446A (en) * | 1980-09-09 | 1993-11-23 | Bayer Aktiengesellschaft | Solid medicament formulations containing nifedipine, and processes for their preparation |
JPS5846019A (ja) * | 1981-09-14 | 1983-03-17 | Kanebo Ltd | 持続性ニフエジピン製剤 |
DE3222367A1 (de) * | 1982-06-15 | 1983-12-15 | Bayer Ag, 5090 Leverkusen | Verwendung von 1,4-dihydropyridinen in antiarteriosklerotika und deren herstellung |
JPS59101423A (ja) * | 1982-12-02 | 1984-06-12 | Takada Seiyaku Kk | 新規なニフエジピン固形製剤 |
US4529733A (en) * | 1983-04-06 | 1985-07-16 | Merrell Dow Pharmaceuticals Inc. | Antihypertensive 3-furoyl-1,4-dihydropyridines |
DE3318649A1 (de) * | 1983-05-21 | 1984-11-22 | Bayer Ag, 5090 Leverkusen | Zweiphasenformulierung |
HU198844B (en) * | 1984-06-14 | 1989-12-28 | Sandoz Ag | Process for producing new galenic pharmaceutical composition ensuring retarded release of active ingredient |
IT1178511B (it) * | 1984-09-14 | 1987-09-09 | Pharmatec Spa | Procedimento per la preparazione di una forma solida per uso orale a base di nifedipina con rilascio |
IT1187751B (it) * | 1985-10-15 | 1987-12-23 | Eurand Spa | Procedimento per la preparazione di formulazioni solidi di nifedipina ad elevata biodisponibilita' e ad effetto prolungato e formulazioni cosi' ottenute |
US4940556A (en) * | 1986-01-30 | 1990-07-10 | Syntex (U.S.A.) Inc. | Method of preparing long acting formulation |
US5198226A (en) * | 1986-01-30 | 1993-03-30 | Syntex (U.S.A.) Inc. | Long acting nicardipine hydrochloride formulation |
CH673947A5 (xx) * | 1986-09-23 | 1990-04-30 | Sandoz Ag | |
JPS6464659A (en) * | 1987-09-03 | 1989-03-10 | Kenbi Kogaku Kenkyusho Kk | Preparation of safe and effective powder formulation |
SE8703881D0 (sv) * | 1987-10-08 | 1987-10-08 | Haessle Ab | New pharmaceutical preparation |
DE3814532A1 (de) * | 1988-04-29 | 1989-11-09 | Bayer Ag | Dhp-retard-zubereitung |
JPH0298550U (xx) * | 1989-01-25 | 1990-08-06 | ||
GB8903328D0 (en) * | 1989-02-14 | 1989-04-05 | Ethical Pharma Ltd | Nifedipine-containing pharmaceutical compositions and process for the preparation thereof |
US5271944A (en) * | 1991-04-05 | 1993-12-21 | Biofor, Ltd. | Pharmacologically enhanced formulations |
DE4130173A1 (de) * | 1991-09-11 | 1993-03-18 | Bayer Ag | Pharmazeutische zubereitungen mit einer speziellen kristallmodifikation des 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridindicarbonsaeure-isopropyl-(2-methoxyethyl)-esters |
GB9200607D0 (en) * | 1992-01-13 | 1992-03-11 | Ethical Pharma Ltd | Pharmaceutical compositions containing nifedipine and process for the preparation thereof |
US6726930B1 (en) | 1993-09-09 | 2004-04-27 | Penwest Pharmaceuticals Co. | Sustained release heterodisperse hydrogel systems for insoluble drugs |
US5773025A (en) * | 1993-09-09 | 1998-06-30 | Edward Mendell Co., Inc. | Sustained release heterodisperse hydrogel systems--amorphous drugs |
US5455046A (en) * | 1993-09-09 | 1995-10-03 | Edward Mendell Co., Inc. | Sustained release heterodisperse hydrogel systems for insoluble drugs |
US5543099A (en) * | 1994-09-29 | 1996-08-06 | Hallmark Pharmaceutical, Inc. | Process to manufacture micronized nifedipine granules for sustained release medicaments |
DE59410044D1 (de) * | 1994-12-29 | 2002-03-21 | Shire Deutschland Gmbh & Co Kg | Pharmazeutische zubereitungen, enthaltend nifedipin und verfahren zu ihrer herstellung |
JP3220373B2 (ja) | 1995-11-28 | 2001-10-22 | バイエル薬品株式会社 | 持続性ニフエジピン製剤 |
US6093420A (en) | 1996-07-08 | 2000-07-25 | Edward Mendell Co., Inc. | Sustained release matrix for high-dose insoluble drugs |
IT1284604B1 (it) * | 1996-09-27 | 1998-05-21 | Roberto Valducci | Composizioni farmaceutiche a rilascio controllato per somministrazione orale contenenti nifedipina come sostanza attiva |
US6056977A (en) | 1997-10-15 | 2000-05-02 | Edward Mendell Co., Inc. | Once-a-day controlled release sulfonylurea formulation |
WO2001022940A1 (en) | 1999-09-30 | 2001-04-05 | Edward Mendell Co., Inc. | Sustained release matrix systems for highly soluble drugs |
ATE512961T1 (de) | 2004-07-30 | 2011-07-15 | Torrent Pharmaceuticals Ltd | Amorphes nebivolol hydrochlorid und seine herstellung |
DE102004062475A1 (de) * | 2004-12-24 | 2006-07-06 | Bayer Healthcare Ag | Feste, oral applizierbare pharmazeutische Darreichungsformen mit modifizierter Freisetzung |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3330727A (en) * | 1960-04-19 | 1967-07-11 | Glaxo Lab Ltd | Griseofulvin with high specific surface area |
US3401221A (en) * | 1964-08-25 | 1968-09-10 | Norwich Pharma Co | Treatment of urinary tract infection |
DE2348334C2 (de) * | 1973-09-26 | 1982-11-11 | Boehringer Mannheim Gmbh, 6800 Mannheim | Neue Zubereitungsform des N-4-[2-(5-Chlor-2-methoxybenzamido)äthyl]- phenyl-sulfonyl-N'-cyclohexylharnstoffs |
DE2400819C2 (de) * | 1974-01-09 | 1982-04-22 | Bayer Ag, 5090 Leverkusen | Verfahren zur Herstellung fester Zubereitungen von schwerlöslichen Arzneimittelwirkstoffen in feinster Verteilung |
GB1579818A (en) * | 1977-06-07 | 1980-11-26 | Yamanouchi Pharma Co Ltd | Nifedipine-containing solid preparation composition |
JPS55129221A (en) * | 1979-03-29 | 1980-10-06 | Kaken Pharmaceut Co Ltd | Preparation of oral preparation containing hardly soluble medicine |
CA1146866A (en) * | 1979-07-05 | 1983-05-24 | Yamanouchi Pharmaceutical Co. Ltd. | Process for the production of sustained release pharmaceutical composition of solid medical material |
-
1980
- 1980-09-09 DE DE19803033919 patent/DE3033919A1/de not_active Ceased
- 1980-12-27 JP JP55185148A patent/JPS5914446B2/ja not_active Expired
-
1981
- 1981-08-25 NO NO812879A patent/NO157368B/no unknown
- 1981-08-28 AT AT81106729T patent/ATE5761T1/de not_active IP Right Cessation
- 1981-08-28 DE DE8181106729T patent/DE3161838D1/de not_active Expired
- 1981-08-28 EP EP81106729A patent/EP0047899B2/de not_active Expired - Lifetime
- 1981-08-31 PH PH26121A patent/PH24097A/en unknown
- 1981-08-31 PT PT73603A patent/PT73603B/pt unknown
- 1981-09-01 DD DD81232939A patent/DD201974A5/de not_active IP Right Cessation
- 1981-09-07 GR GR65968A patent/GR78237B/el unknown
- 1981-09-07 FI FI812758A patent/FI72648B/fi not_active Application Discontinuation
- 1981-09-07 NZ NZ198285A patent/NZ198285A/en unknown
- 1981-09-07 IL IL63749A patent/IL63749A/xx not_active IP Right Cessation
- 1981-09-08 DK DK396381A patent/DK154326C/da not_active IP Right Cessation
- 1981-09-08 ZA ZA816213A patent/ZA816213B/xx unknown
- 1981-09-08 AR AR286686A patent/AR226377A1/es active
- 1981-09-08 CA CA000385365A patent/CA1180277A/en not_active Expired
- 1981-09-08 IE IE2075/81A patent/IE51549B1/en not_active IP Right Cessation
- 1981-09-08 AU AU75063/81A patent/AU558331B2/en not_active Expired
- 1981-09-08 PL PL23295181A patent/PL232951A1/xx unknown
- 1981-09-09 HU HU812594A patent/HU184879B/hu unknown
Also Published As
Publication number | Publication date |
---|---|
ZA816213B (en) | 1982-09-29 |
NO812879L (no) | 1982-03-10 |
AU558331B2 (en) | 1987-01-29 |
DE3161838D1 (en) | 1984-02-09 |
FI812758L (fi) | 1982-03-10 |
DK396381A (da) | 1982-03-10 |
DD201974A5 (de) | 1983-08-24 |
HU184879B (en) | 1984-10-29 |
NO157368B (no) | 1987-11-30 |
AU7506381A (en) | 1982-03-18 |
IL63749A (en) | 1984-06-29 |
JPS5750913A (en) | 1982-03-25 |
EP0047899B2 (de) | 1996-02-28 |
DK154326C (da) | 1995-03-13 |
JPS5914446B2 (ja) | 1984-04-04 |
DE3033919A1 (de) | 1982-04-22 |
NZ198285A (en) | 1984-04-27 |
IL63749A0 (en) | 1981-12-31 |
AR226377A1 (es) | 1982-06-30 |
PL232951A1 (xx) | 1982-10-11 |
IE51549B1 (en) | 1987-01-07 |
IE812075L (en) | 1982-03-09 |
ATE5761T1 (de) | 1984-01-15 |
PH24097A (en) | 1990-03-05 |
CA1180277A (en) | 1985-01-02 |
PT73603A (en) | 1981-09-01 |
DK154326B (da) | 1988-11-07 |
PT73603B (en) | 1982-11-10 |
GR78237B (xx) | 1984-09-26 |
EP0047899B1 (de) | 1984-01-04 |
EP0047899A1 (de) | 1982-03-24 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FC | Application refused |
Owner name: BAYER AKTIENGESELLSCHAFT |