FI107608B - Menetelmä antifungaalisen yhdisteen valmistamiseksi sekä menetelmässä käytettävät välituotteet - Google Patents

Menetelmä antifungaalisen yhdisteen valmistamiseksi sekä menetelmässä käytettävät välituotteet Download PDF

Info

Publication number: FI107608B
Authority: FI; Finland
Prior art keywords: compound; formula; process according; reduction; triazol
Prior art date: 1990-02-02

Application number

FI910508A

Other languages

English (en)

Finnish (fi)

Swedish (sv)

Other versions

FI910508A0 (fi

FI910508A (fi

Inventor

Kenneth Richardson

Stephen James Ray

Original Assignee

Pfizer

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1990-02-02

Filing date

1991-02-01

Publication date

2001-09-14

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=10670334&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=FI107608(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

1991-02-01 Application filed by Pfizer filed Critical Pfizer

1991-02-01 Publication of FI910508A0 publication Critical patent/FI910508A0/fi

1991-08-03 Publication of FI910508A publication Critical patent/FI910508A/fi

1997-03-25 Priority to FI971238A priority Critical patent/FI971238A/fi

2001-09-14 Application granted granted Critical

2001-09-14 Publication of FI107608B publication Critical patent/FI107608B/fi

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/30—Halogen atoms or nitro radicals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/61—Halogen atoms or nitro radicals
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Oncology (AREA)
Pharmacology & Pharmacy (AREA)
Communicable Diseases (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Pyridine Compounds (AREA)
Agricultural Chemicals And Associated Chemicals (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

FI910508A 1990-02-02 1991-02-01 Menetelmä antifungaalisen yhdisteen valmistamiseksi sekä menetelmässä käytettävät välituotteet FI107608B (fi)

Priority Applications (1)

Application Number	Priority Date	Filing Date	Title
FI971238A FI971238A (fi)	1990-02-02	1997-03-25	Triatsolisienitautilääkkeet

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GB909002375A GB9002375D0 (en)	1990-02-02	1990-02-02	Triazole antifungal agents
GB9002375		1990-02-02

Publications (3)

Publication Number	Publication Date
FI910508A0 FI910508A0 (fi)	1991-02-01
FI910508A FI910508A (fi)	1991-08-03
FI107608B true FI107608B (fi)	2001-09-14

Family

ID=10670334

Family Applications (3)

Application Number	Title	Priority Date	Filing Date
FI910508A FI107608B (fi)	1990-02-02	1991-02-01	Menetelmä antifungaalisen yhdisteen valmistamiseksi sekä menetelmässä käytettävät välituotteet
FI971238A FI971238A (fi)	1990-02-02	1997-03-25	Triatsolisienitautilääkkeet
FI20000084A FI20000084A (fi)	1990-02-02	2000-01-17	Menetelmä sieniä tuhoavan farmaseuttisen koostumuksen valmistamiseksi

Family Applications After (2)

Application Number	Title	Priority Date	Filing Date
FI971238A FI971238A (fi)	1990-02-02	1997-03-25	Triatsolisienitautilääkkeet
FI20000084A FI20000084A (fi)	1990-02-02	2000-01-17	Menetelmä sieniä tuhoavan farmaseuttisen koostumuksen valmistamiseksi

Country Status (42)

Country	Link
US (2)	US5567817A (lv)
EP (1)	EP0440372B1 (lv)
JP (2)	JP2625584B2 (lv)
KR (1)	KR930011039B1 (lv)
CN (2)	CN1026788C (lv)
AP (2)	AP9000237A0 (lv)
AT (1)	ATE90090T1 (lv)
AU (1)	AU625188B2 (lv)
BA (1)	BA97298A (lv)
BG (1)	BG60032B2 (lv)
BR (1)	BR9100435A (lv)
CA (2)	CA2285891C (lv)
CZ (1)	CZ279339B6 (lv)
DE (2)	DE10299035I2 (lv)
DK (1)	DK0440372T3 (lv)
EG (1)	EG19750A (lv)
ES (1)	ES2055523T4 (lv)
FI (3)	FI107608B (lv)
GB (1)	GB9002375D0 (lv)
HK (1)	HK219396A (lv)
HU (2)	HU205351B (lv)
IE (1)	IE64774B1 (lv)
IL (2)	IL97045A (lv)
IN (1)	IN176148B (lv)
IS (1)	IS1629B (lv)
LU (1)	LU90960I2 (lv)
LV (1)	LV10615B (lv)
MA (1)	MA22054A1 (lv)
MX (1)	MX24363A (lv)
MY (1)	MY105494A (lv)
NL (1)	NL300100I2 (lv)
NO (2)	NO176796C (lv)
NZ (1)	NZ247205A (lv)
OA (1)	OA09480A (lv)
PE (1)	PE31691A1 (lv)
PL (3)	PL169307B1 (lv)
PT (1)	PT96617B (lv)
RO (1)	RO109648B1 (lv)
RU (2)	RU2114838C1 (lv)
SK (1)	SK278215B6 (lv)
YU (1)	YU48105B (lv)
ZA (1)	ZA91761B (lv)

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SG10201405886WA (en)	2009-10-01	2014-11-27	Adare Pharmaceuticals Inc	Orally administered corticosteroid compositions
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JP2013516394A (ja)	2009-12-30	2013-05-13	メディケムソシエダアノニマ	医薬用途用の１−（１ｈ−１，２，４−トリアゾール−１−イル）ブタン−２−オール誘導体、および前記１−（１ｈ−１，２，４−トリアゾール−１−イル）ブタン−２−オール誘導体を調製するための、実質的に不定の結晶形状を有する１−（１ｈ−１，２，４−トリアゾール−１−イル）ブタン−２−オール誘導体の使用
KR100971371B1 (ko) *	2010-02-04	2010-07-20	동국제약 주식회사	신규한 중간체를 이용한 보리코나졸의 제조방법
WO2011110198A1 (en)	2010-03-10	2011-09-15	Synthron B.V.	A process for making voriconazole
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PL2678333T3 (pl)	2011-02-21	2015-08-31	Ranbaxy Laboratories Ltd	Ulepszony sposób otrzymywania worykonazolu i jego produktów pośrednich
PL2720723T3 (pl)	2011-06-15	2018-10-31	Synthon Bv	Stabilizowana kompozycja worykonazolu
EP2561863A1 (en)	2011-08-22	2013-02-27	Farmaprojects, S.A.U.	Pharmaceutical compositions comprising voriconazole
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PT2906555T (pt)	2012-10-15	2017-02-15	Pfizer Ireland Pharmaceuticals	Processo para a preparação de voriconazol e análogos do mesmo
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CN104987325B (zh) *	2015-06-30	2017-03-29	扬子江药业集团南京海陵药业有限公司	一种伏立康唑的制备方法
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1990
- 1990-02-02 GB GB909002375A patent/GB9002375D0/en active Pending
1991
- 1991-01-24 DE DE2002199035 patent/DE10299035I2/de active Active
- 1991-01-24 AT AT91300553T patent/ATE90090T1/de active
- 1991-01-24 DK DK91300553.4T patent/DK0440372T3/da active
- 1991-01-24 EP EP91300553A patent/EP0440372B1/en not_active Expired - Lifetime
- 1991-01-24 DE DE9191300553T patent/DE69100095T2/de not_active Expired - Lifetime
- 1991-01-24 ES ES91300553T patent/ES2055523T4/es not_active Expired - Lifetime
- 1991-01-25 IL IL9704591A patent/IL97045A/en not_active IP Right Cessation
- 1991-01-25 IL IL11032291A patent/IL110322A/en not_active IP Right Cessation
- 1991-01-25 IN IN74DE1991 patent/IN176148B/en unknown
- 1991-01-28 AP AP90/00237A patent/AP9000237A0/xx unknown
- 1991-01-28 RO RO146821A patent/RO109648B1/ro unknown
- 1991-01-28 AP APAP/P/1991/000237A patent/AP223A/en active
- 1991-01-29 NZ NZ247205A patent/NZ247205A/xx unknown
- 1991-01-29 PE PE1991180888A patent/PE31691A1/es not_active IP Right Cessation
- 1991-01-29 BG BG093726A patent/BG60032B2/bg unknown
- 1991-01-30 CA CA002285891A patent/CA2285891C/en not_active Expired - Lifetime
- 1991-01-30 CA CA002035314A patent/CA2035314C/en not_active Expired - Lifetime
- 1991-01-30 IS IS3671A patent/IS1629B/is unknown
- 1991-01-31 PL PL91306941A patent/PL169307B1/pl unknown
- 1991-01-31 PT PT96617A patent/PT96617B/pt not_active IP Right Cessation
- 1991-01-31 PL PL91288901A patent/PL167294B1/pl unknown
- 1991-01-31 JP JP3031977A patent/JP2625584B2/ja not_active Expired - Lifetime
- 1991-01-31 PL PL91306940A patent/PL169332B1/pl unknown
- 1991-01-31 MX MX2436391A patent/MX24363A/es unknown
- 1991-01-31 MY MYPI91000155A patent/MY105494A/en unknown
- 1991-01-31 NO NO910368A patent/NO176796C/no not_active IP Right Cessation
- 1991-01-31 KR KR1019910001613A patent/KR930011039B1/ko not_active IP Right Cessation
- 1991-02-01 HU HU91366A patent/HU205351B/hu unknown
- 1991-02-01 RU SU5010394A patent/RU2114838C1/ru active
- 1991-02-01 IE IE34291A patent/IE64774B1/en active Protection Beyond IP Right Term
- 1991-02-01 AU AU70223/91A patent/AU625188B2/en not_active Expired
- 1991-02-01 MA MA22327A patent/MA22054A1/fr unknown
- 1991-02-01 RU SU914894374A patent/RU2036194C1/ru active
- 1991-02-01 OA OA59945A patent/OA09480A/xx unknown
- 1991-02-01 FI FI910508A patent/FI107608B/fi active Protection Beyond IP Right Term
- 1991-02-01 CZ CS91249A patent/CZ279339B6/cs not_active IP Right Cessation
- 1991-02-01 SK SK249-91A patent/SK278215B6/sk active Protection Beyond IP Right Term
- 1991-02-01 BR BR919100435A patent/BR9100435A/pt not_active Application Discontinuation
- 1991-02-01 ZA ZA91761A patent/ZA91761B/xx unknown
- 1991-02-01 YU YU17591A patent/YU48105B/sh unknown
- 1991-02-02 EG EG6591A patent/EG19750A/xx active
- 1991-02-02 CN CN91100706A patent/CN1026788C/zh not_active Expired - Lifetime
1993
- 1993-11-15 LV LVP-93-1224A patent/LV10615B/lv unknown
1994
- 1994-02-26 CN CN94102354A patent/CN1040504C/zh not_active Expired - Lifetime
1995
- 1995-05-01 US US08/432,414 patent/US5567817A/en not_active Expired - Lifetime
- 1995-06-09 HU HU95P/P00179P patent/HU211582A9/hu active Protection Beyond IP Right Term
1996
- 1996-07-18 US US08/683,694 patent/US5773443A/en not_active Expired - Lifetime
- 1996-07-19 JP JP8190918A patent/JP2848811B2/ja not_active Expired - Lifetime
- 1996-12-24 HK HK219396A patent/HK219396A/xx not_active IP Right Cessation
1997
- 1997-03-25 FI FI971238A patent/FI971238A/fi unknown
1998
- 1998-03-30 BA BA970298A patent/BA97298A/bs unknown
2000
- 2000-01-17 FI FI20000084A patent/FI20000084A/fi unknown
2002
- 2002-09-05 NO NO2002006C patent/NO2002006I2/no unknown
- 2002-09-06 NL NL300100C patent/NL300100I2/nl unknown
- 2002-09-11 LU LU90960C patent/LU90960I2/fr unknown

Also Published As

Publication number	Publication date
DE10299035I2 (de)	2003-06-26
KR910021398A (ko)	1991-12-20
FI910508A0 (fi)	1991-02-01
CN1026788C (zh)	1994-11-30
ATE90090T1 (de)	1993-06-15
PT96617B (pt)	1998-07-31
YU48105B (sh)	1997-03-07
FI971238A0 (fi)	1997-03-25
BR9100435A (pt)	1991-10-22
IL110322A (en)	1996-10-31
ES2055523T3 (es)	1994-08-16
CA2285891A1 (en)	1991-08-03
EP0440372A1 (en)	1991-08-07
MA22054A1 (fr)	1991-10-01
US5567817A (en)	1996-10-22
NL300100I2 (nl)	2003-01-06
IL97045A (en)	1995-11-27
BA97298A (bs)	2001-09-14
HU205351B (en)	1992-04-28
GB9002375D0 (en)	1990-04-04
CS9100249A2 (en)	1991-09-15
AU7022391A (en)	1991-09-05
IE910342A1 (en)	1991-08-14
NO910368L (no)	1991-08-05
KR930011039B1 (ko)	1993-11-20
IN176148B (lv)	1996-02-10
DE69100095D1 (de)	1993-07-08
HK219396A (en)	1997-01-03
HU211582A9 (en)	1995-12-28
LV10615B (en)	1995-12-20
IL97045A0 (en)	1992-03-29
PL288901A1 (en)	1992-01-27
FI971238A (fi)	1997-03-25
OA09480A (fr)	1992-11-15
CA2285891C (en)	2004-01-06
LV10615A (lv)	1995-04-20
DK0440372T3 (da)	1993-06-28
LU90960I2 (fr)	2003-04-02
IS1629B (is)	1996-07-19
US5773443A (en)	1998-06-30
ZA91761B (en)	1992-09-30
EP0440372B1 (en)	1993-06-02
DE69100095T2 (de)	1993-09-09
RO109648B1 (ro)	1995-04-28
AP9000237A0 (en)	1991-01-31
PE31691A1 (es)	1991-11-29
NO910368D0 (no)	1991-01-31
PL169307B1 (pl)	1996-06-28
CA2035314C (en)	2000-01-18
PL167294B1 (pl)	1995-08-31
BG60032B2 (bg)	1993-07-30
IL110322A0 (en)	1994-10-21
PT96617A (pt)	1991-10-15
JP2848811B2 (ja)	1999-01-20
HUT56361A (en)	1991-08-28
RU2036194C1 (ru)	1995-05-27
DE10299035I1 (de)	2003-05-22
FI910508A (fi)	1991-08-03
CN1100421A (zh)	1995-03-22
RU2114838C1 (ru)	1998-07-10
JPH04211078A (ja)	1992-08-03
MX24363A (es)	1993-09-01
AU625188B2 (en)	1992-07-02
ES2055523T4 (es)	2011-04-11
NL300100I1 (nl)	2002-11-01
IS3671A7 (is)	1991-08-03
JPH09208583A (ja)	1997-08-12
YU17591A (sh)	1994-01-20
JP2625584B2 (ja)	1997-07-02
CN1053787A (zh)	1991-08-14
FI20000084A (fi)	2000-01-17
AP223A (en)	1992-08-27
EG19750A (en)	1996-01-31
NO2002006I2 (no)	2004-10-11
CN1040504C (zh)	1998-11-04
NO176796C (no)	1995-05-31
PL169332B1 (pl)	1996-07-31
CZ279339B6 (cs)	1995-04-12
MY105494A (en)	1994-10-31
NZ247205A (en)	1993-09-27
NO176796B (no)	1995-02-20
CA2035314A1 (en)	1991-08-03
SK278215B6 (en)	1996-04-03
IE64774B1 (en)	1995-09-06

Publication	Publication Date	Title
FI107608B (fi)	2001-09-14	Menetelmä antifungaalisen yhdisteen valmistamiseksi sekä menetelmässä käytettävät välituotteet
AU602638B2 (en)	1990-10-18	Triazole antifungal agents
RU2176244C2 (ru)	2001-11-27	Производные триазола, способы их получения, фармацевтическая композиция, способ лечения или профилактики грибковых инфекций, промежуточный продукт
US5620994A (en)	1997-04-15	Azolylamine derivative
EP0973768B1 (en)	2003-07-09	Azole compounds, their production and their use
US5278175A (en)	1994-01-11	Triazole antifungal agents
FI108131B (fi)	2001-11-30	Menetelmä terapeuttisesti käyttökelpoisen triatsolijohdannaisen valmistamiseksi sekä uusi välituote
IE58738B1 (en)	1993-11-03	Antifungal azole compounds
HU194838B (en)	1988-03-28	Process for producing 1,3-bis/1,2,4-triazol-1-yl/-2-aryl-butan-2-ol derivatives and pharmaceutical compositions containing them
IE840320L (en)	1984-08-16	Triazole antifungal agents.
JPS6346072B2 (lv)	1988-09-13
JPH01102066A (ja)	1989-04-19	抗糸状菌剤
KR102395842B1 (ko)	2022-05-09	에폭시트리아졸 유도체의 신규 제조방법
JP3437695B2 (ja)	2003-08-18	アゾリルアミン誘導体
EP0005980B1 (en)	1984-08-29	Derivatives of substituted n-alkyl imidazoles, their preparation and these compounds for pharmaceutical use

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2014-01-30	SPCE	Application for extension of a supplementary protection certificate [pediatric extension]	Spc suppl protection certif: L20020006
2014-09-24	SPCP	Extension of a supplementary protection certificate [pediatric extension]	Spc suppl protection certif: 212 Extension date: 20160801