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ES8705858A1 - Procedimiento para preparar diselenobis-(amidas de acidos benzoicos) - Google Patents

Procedimiento para preparar diselenobis-(amidas de acidos benzoicos)

Info

Publication number
ES8705858A1
ES8705858A1 ES557248A ES557248A ES8705858A1 ES 8705858 A1 ES8705858 A1 ES 8705858A1 ES 557248 A ES557248 A ES 557248A ES 557248 A ES557248 A ES 557248A ES 8705858 A1 ES8705858 A1 ES 8705858A1
Authority
ES
Spain
Prior art keywords
primary
processes
secondary amines
diseleno
benzamides
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES557248A
Other languages
English (en)
Other versions
ES557248A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
A Natterman und Cie GmbH
Original Assignee
A Natterman und Cie GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE19853513071 external-priority patent/DE3513071A1/de
Priority claimed from DE19853513070 external-priority patent/DE3513070A1/de
Application filed by A Natterman und Cie GmbH filed Critical A Natterman und Cie GmbH
Publication of ES8705858A1 publication Critical patent/ES8705858A1/es
Publication of ES557248A0 publication Critical patent/ES557248A0/es
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C391/00—Compounds containing selenium
    • C07C391/02—Compounds containing selenium having selenium atoms bound to carbon atoms of six-membered aromatic rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Epidemiology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

METODO DE PREPARAR DISELENOBIS-(AMIDAS DE ACIDOS BENZOICOS). COMPRENDE: A) HACER REACCIONAR BENZOISOSELENAZOINONAS DE FORMULA (II) CON ETILMERCAPTANO (RSH), EN METANOL Y A TEMPERATURA AMBIENTE, PARA FORMAR UN COMPUESTO DE FORMULA (III); Y B) AMINAR EL COMPUESTO DE FORMULA (III) CON METILAMINA PARA FORMAR UN COMPUESTO DE FORMULA (I), SIENDO: R1 Y R2 IGUALES O DIFERENTES, H, ALQUILO DE C 1 A 8, FENILO Y OTROS; R3 Y R4 IGUALES O DIFERENTES, H, HAL, ALQUILO DE C 1 A 4 Y OTROS Y R, ALQUILO. SE UTILIZAN PARA TRATAR LESIONES HEPATICAS.
ES557248A 1985-04-12 1986-12-05 Procedimiento para preparar diselenobis-(amidas de acidos benzoicos) Expired ES8705858A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19853513071 DE3513071A1 (de) 1985-04-12 1985-04-12 Diselenobis-benzoesaeureamide primaerer und sekundaerer amine, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische praeparate
DE19853513070 DE3513070A1 (de) 1985-04-12 1985-04-12 Diselenobis-benzoesaeureamide primaerer amine, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische praeparate

Publications (2)

Publication Number Publication Date
ES8705858A1 true ES8705858A1 (es) 1987-05-16
ES557248A0 ES557248A0 (es) 1987-05-16

Family

ID=25831236

Family Applications (2)

Application Number Title Priority Date Filing Date
ES553899A Expired ES8703415A1 (es) 1985-04-12 1986-04-11 Procedimiento para preparar diselenobis-(amidas de acidos benzoicos).
ES557248A Expired ES8705858A1 (es) 1985-04-12 1986-12-05 Procedimiento para preparar diselenobis-(amidas de acidos benzoicos)

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES553899A Expired ES8703415A1 (es) 1985-04-12 1986-04-11 Procedimiento para preparar diselenobis-(amidas de acidos benzoicos).

Country Status (8)

Country Link
US (1) US4873350A (es)
EP (1) EP0198277B1 (es)
JP (1) JPH0761994B2 (es)
DE (1) DE3663139D1 (es)
DK (1) DK160302C (es)
ES (2) ES8703415A1 (es)
GR (1) GR860869B (es)
PT (1) PT82374B (es)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3626554A1 (de) * 1986-08-06 1988-02-18 Nattermann A & Cie Diselenobis-benzoesaeureamide primaerer heterocyclischer amine, verfahren zur ihrer herstellung und diese enthaltende pharmazeutische praeparate
US5128365A (en) * 1989-07-19 1992-07-07 The Trustees Of Columbia University In The City Of New York Compounds having glutathione peroxidase activity and use thereof
DE3937169A1 (de) * 1989-11-08 1991-05-16 Nattermann A & Cie Benzylselenobenzamide von anilinen und benzylaminen
CA2126465C (en) * 1992-01-17 2002-03-05 Kazuhisa Kodama Inhibitor for restenosis after percutaneous coronary arterioplasty
SE9200502D0 (sv) * 1992-02-20 1992-02-20 Astra Ab Novel antioxidants
JP2000016935A (ja) * 1998-07-01 2000-01-18 Dai Ichi Seiyaku Co Ltd シクロオキシゲナーゼ阻害剤
US7671211B1 (en) 1999-03-31 2010-03-02 Arne Holmgren Substrates for thioredoxin reductase
CN1166651C (zh) * 2001-06-08 2004-09-15 北京大学药学院 具有抗炎和抗肿瘤作用r-双或糖苯丙异硒唑取代化合物
US7820829B2 (en) 2001-06-08 2010-10-26 Peking University Bisbenzisoselenazolonyl derivatives having antineoplastic, anti-inflammatory and antithrombotic activities as well as their use
US10058542B1 (en) 2014-09-12 2018-08-28 Thioredoxin Systems Ab Composition comprising selenazol or thiazolone derivatives and silver and method of treatment therewith

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB191402787A (en) * 1914-02-03 1914-07-30 Henry Solomon Wellcome Manufacture of New Therapeutic Compounds.
DE633344C (de) * 1934-09-04 1936-07-27 Ernst Theobald Dipl Ing Verfahren zur Herstellung von Diacyldiaminodiphenylseleniden
BE758241A (fr) * 1969-11-03 1971-04-30 Agfa Gevaert Nv Bereiding van 2-alkyl-thiazolen en 2-alkyl-selenazolen met een geanelleerde aromatische ring
US3811896A (en) * 1971-05-03 1974-05-21 Eastman Kodak Co Silver halide emulsion stabilized with isoselenoureas or ketoselenozolidines
GB1352196A (en) * 1971-06-28 1974-05-08 Iflord Ltd Amido-seleno ethers
SU891656A1 (ru) * 1980-04-16 1981-12-23 Ленинградский Ордена Октябрьской Революции И Ордена Трудового Красного Знамени Технологический Институт Им. Ленсовета Способ получени ароматических диселенидов
DE3027075A1 (de) * 1980-07-17 1982-02-18 A. Nattermann & Cie GmbH, 5000 Köln Benzisoselenazolone, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische praeparate
DE3027073C2 (de) * 1980-07-17 1985-03-07 A. Nattermann & Cie GmbH, 5000 Köln Pharmazeutische Präparate, enthaltend 2-Phenyl-1,2-benzisoselenazol-3(2H)-on
EP0165534B1 (de) * 1984-06-22 1989-03-15 A. Nattermann & Cie. GmbH S-(Carbamoyl-phenylselenyl)-Derivate des Glutathions und von Aminomercaptocarbonsäuren, Verfahren zu ihrer Herstellung und diese enthaltende pharmazeutische Präparate

Also Published As

Publication number Publication date
DE3663139D1 (en) 1989-06-08
ES557248A0 (es) 1987-05-16
JPS61275264A (ja) 1986-12-05
ES553899A0 (es) 1987-02-16
PT82374A (en) 1986-05-01
EP0198277B1 (de) 1989-05-03
JPH0761994B2 (ja) 1995-07-05
PT82374B (pt) 1988-03-03
ES8703415A1 (es) 1987-02-16
DK167386D0 (da) 1986-04-11
EP0198277A1 (de) 1986-10-22
DK160302B (da) 1991-02-25
US4873350A (en) 1989-10-10
GR860869B (en) 1986-07-31
DK167386A (da) 1986-10-13
DK160302C (da) 1991-08-05

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 20041102