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ES8101068A1 - Procedimiento para la preparacion de anilidas de acidos 4- amino-2-ureido-(o-tioureido)-pirimidin-5-carboxilicos - Google Patents

Procedimiento para la preparacion de anilidas de acidos 4- amino-2-ureido-(o-tioureido)-pirimidin-5-carboxilicos

Info

Publication number
ES8101068A1
ES8101068A1 ES491224A ES491224A ES8101068A1 ES 8101068 A1 ES8101068 A1 ES 8101068A1 ES 491224 A ES491224 A ES 491224A ES 491224 A ES491224 A ES 491224A ES 8101068 A1 ES8101068 A1 ES 8101068A1
Authority
ES
Spain
Prior art keywords
pyrimidine
amino
carbanilides
preparation
salts
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES491224A
Other languages
English (en)
Other versions
ES491224A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hoechst AG
Original Assignee
Hoechst AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst AG filed Critical Hoechst AG
Publication of ES8101068A1 publication Critical patent/ES8101068A1/es
Publication of ES491224A0 publication Critical patent/ES491224A0/es
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/48—Two nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Obesity (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Hematology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Diabetes (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Child & Adolescent Psychology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
  • Polymers With Sulfur, Phosphorus Or Metals In The Main Chain (AREA)
  • Pyrrole Compounds (AREA)

Abstract

PROCEDIMIENTO DE OBTENCION DE ANILIDAS DE ACIDOS 4-AMINO-2-UREIDO- (O -TIOUREIDO)-PIRIMIDIN-5-CARBOXILICOS. CONSISTE EN HACER REACCIONAR SU ISOCIANATO DE FORMULA R ELEVADO A 2-N=C=O O DE FORMULA R ELEVADO A 2-N=C=S CON UN COMPUESTO DE FORMULA GENERAL (I), OBTENIENDOSE ANILIDAS DE ACIDOS 4-AMINO-2-UREIDO (O -TIOUREIDO)-PIRIMIDIN-5-CARBOXILICOS DE FORMULA GENERAL (II). *FORMULA* TRATAMIENTO DE PERTURBACIONES DE LIPIDOS Y DE LA ADIPOSIDAD.
ES491224A 1978-12-09 1980-05-07 Procedimiento para la preparacion de anilidas de acidos 4- amino-2-ureido-(o-tioureido)-pirimidin-5-carboxilicos Granted ES491224A0 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19782853220 DE2853220A1 (de) 1978-12-09 1978-12-09 Neue amino-pyrimidin-carbanilide, verfahren zu ihrer herstellung, diese verbindungen enthaltende arzneimittel und ihre verwendung

Publications (2)

Publication Number Publication Date
ES8101068A1 true ES8101068A1 (es) 1980-12-01
ES491224A0 ES491224A0 (es) 1980-12-01

Family

ID=6056720

Family Applications (3)

Application Number Title Priority Date Filing Date
ES486536A Expired ES8102121A1 (es) 1978-12-09 1979-12-03 Procedimiento para la preparacion de anilidas de acido-4- amino-2-ureido-(o-tioureido)-pirimidin-5-carboxilico
ES491225A Granted ES491225A0 (es) 1978-12-09 1980-05-07 Procedimiento para la preparacion de 2,4-diamino-pirimidin-5-carbanilidas
ES491224A Granted ES491224A0 (es) 1978-12-09 1980-05-07 Procedimiento para la preparacion de anilidas de acidos 4- amino-2-ureido-(o-tioureido)-pirimidin-5-carboxilicos

Family Applications Before (2)

Application Number Title Priority Date Filing Date
ES486536A Expired ES8102121A1 (es) 1978-12-09 1979-12-03 Procedimiento para la preparacion de anilidas de acido-4- amino-2-ureido-(o-tioureido)-pirimidin-5-carboxilico
ES491225A Granted ES491225A0 (es) 1978-12-09 1980-05-07 Procedimiento para la preparacion de 2,4-diamino-pirimidin-5-carbanilidas

Country Status (9)

Country Link
US (1) US4285946A (es)
EP (1) EP0012361B1 (es)
JP (1) JPS5581863A (es)
AT (1) ATE1288T1 (es)
AU (1) AU529426B2 (es)
CA (1) CA1136623A (es)
DE (2) DE2853220A1 (es)
ES (3) ES8102121A1 (es)
ZA (1) ZA796651B (es)

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4436911A (en) * 1981-05-12 1984-03-13 William H. Rorer, Inc. Heterocyclic amidinoureas
JPS58501468A (ja) * 1981-08-24 1983-09-01 ロウラ−　インタ−ナシヨナル　（オ−バ−シ−ズ）　インコ−ポレ−テツド 複素環アミジノ置換尿素およびそれらの薬剤利用
DE3522940A1 (de) * 1985-06-27 1987-01-08 Hoechst Ag 4-amino-2-(imidazolidin-2-on-1-yl)-pyrimidin-5-carbonsaeure-(n-(3-trifluormethyl-phenyl)-amide) zur antithrombotischen prophylaxe und behandlung sowie ihre verwendung zur herstellung von antithrombotisch wirksamen arzneimitteln
DK0557879T3 (da) * 1992-02-22 1997-06-16 Hoechst Ag 4-amino-2-ureido-pyrimidin-5-carboxylsyreamider, fremgangsmåde til deres fremstilling, lægemidler med indhold af disse forbindelser og deres anvendelse
EP0557877B1 (de) * 1992-02-22 1997-09-24 Hoechst Aktiengesellschaft Lösliche Salze von 4-Amino-2-(4,4-dimethyl-imidazolidin-2-on-1-yl)-pyrimidin-5 -carbonsäure- N-methyl-N-(3-trifluormethyl-phenyl)- amid, Verfahren zu ihrer Herstellung, ihre Verwendung als Arzneimittel und Ausgangsprodukte
DE19625089A1 (de) * 1996-06-24 1998-01-02 Hoechst Ag 4-Amino-2-ureido-pyrimidin-5-carbonsäureamide, Verfahren zu deren Herstellung, diese Verbindungen enthaltende Arzneimittel und deren Verwendung
DE19625088A1 (de) * 1996-06-24 1998-01-02 Hoechst Ag 4-Amino-2-ureido-pyrimidin-5-carbonsäureamide, Verfahren zu deren Herstellung, diese Verbindungen enthaltende Arzneimittel und deren Verwendung
EP1223170B1 (en) 1999-10-12 2005-12-28 Takeda Pharmaceutical Company Limited Pyrimidine-5-carboxamide compounds, process for producing the same and use thereof
US7176310B1 (en) * 2002-04-09 2007-02-13 Ucb Sa Pyrimidinecarboxamide derivatives and their use as anti-inflammatory agents
EA015890B1 (ru) * 2005-06-14 2011-12-30 Тайджен Байотекнолоджи Ко. Лтд. Производные пиримидина
US8193206B2 (en) * 2005-06-14 2012-06-05 Taigen Biotechnology Co., Ltd. Pyrimidine compounds
CA2718528C (en) * 2008-03-18 2016-10-25 Merck Sharp & Dohme Corp. Substituted 4-hydroxypyrimidine-5-carboxamides
JP5317263B2 (ja) * 2008-09-24 2013-10-16 株式会社ユニバーサルエンターテインメント 紙葉類処理装置
CN104125947A (zh) * 2011-12-21 2014-10-29 生物区欧洲有限公司 杂环脲化合物
US10442788B2 (en) 2015-04-01 2019-10-15 Enanta Pharmaceuticals, Inc. Hepatitis B antiviral agents
US10738035B2 (en) * 2015-05-13 2020-08-11 Enanta Pharmaceuticals, Inc. Hepatitis B antiviral agents
WO2017011552A1 (en) 2015-07-13 2017-01-19 Enanta Pharmaceuticals, Inc. Hepatitis b antiviral agents
US10301255B2 (en) 2015-07-22 2019-05-28 Enanta Pharmaceuticals, Inc. Hepatitis B antiviral agents
WO2017136403A1 (en) 2016-02-02 2017-08-10 Enanta Pharmaceuticals, Inc. Hepatitis b antiviral agents
SG11201807543YA (en) 2016-03-07 2018-09-27 Enanta Pharm Inc Hepatitis b antiviral agents
AU2017277664A1 (en) 2016-06-10 2019-01-24 Enanta Pharmaceuticals, Inc. Hepatitis B antiviral agents
EP3675637A4 (en) 2017-08-28 2021-05-19 Enanta Pharmaceuticals, Inc. ANTIVIRAL AGENTS AGAINST HEPATITIS B
TW201927789A (zh) 2017-12-06 2019-07-16 美商因那塔製藥公司 B型肝炎抗病毒試劑
US10723733B2 (en) 2017-12-06 2020-07-28 Enanta Pharmaceuticals, Inc. Hepatitis B antiviral agents
US11058678B2 (en) 2018-01-22 2021-07-13 Enanta Pharmaceuticals, Inc. Substituted heterocycles as antiviral agents
WO2019191166A1 (en) 2018-03-29 2019-10-03 Enanta Pharmaceuticals, Inc. Hepatitis b antiviral agents
CA3113235A1 (en) 2018-09-21 2020-03-26 Enanta Pharmaceuticals, Inc. Functionalized heterocycles as antiviral agents
BR112021009854A2 (pt) 2018-11-21 2021-08-17 Enanta Pharmaceuticals, Inc. heterociclos funcionalizados como agentes antivirais
WO2020247444A1 (en) 2019-06-03 2020-12-10 Enanta Pharmaceuticals, Inc, Hepatitis b antiviral agents
WO2020247575A1 (en) 2019-06-04 2020-12-10 Enanta Pharmaceuticals, Inc. Hepatitis b antiviral agents
WO2020247561A1 (en) 2019-06-04 2020-12-10 Enanta Pharmaceuticals, Inc, Hepatitis b antiviral agents
US11738019B2 (en) 2019-07-11 2023-08-29 Enanta Pharmaceuticals, Inc. Substituted heterocycles as antiviral agents
US11236108B2 (en) 2019-09-17 2022-02-01 Enanta Pharmaceuticals, Inc. Functionalized heterocycles as antiviral agents
US11802125B2 (en) 2020-03-16 2023-10-31 Enanta Pharmaceuticals, Inc. Functionalized heterocyclic compounds as antiviral agents

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1031265A (en) * 1963-11-12 1966-06-02 Geigy Co Ltd Tri-tertiary aminopyrimidines and their production
US3479357A (en) * 1967-10-20 1969-11-18 Searle & Co (6 - phenylpyrimidine)mono/bis(1h - 1,2,3-triazole- 4,5-dicarboxylic acid) lower alkyl esters

Also Published As

Publication number Publication date
DE2963278D1 (en) 1982-08-19
JPS5581863A (en) 1980-06-20
ES8101069A1 (es) 1980-12-01
JPH0457675B2 (es) 1992-09-14
EP0012361A1 (de) 1980-06-25
DE2853220A1 (de) 1980-07-03
ZA796651B (en) 1981-05-27
ES491225A0 (es) 1980-12-01
ES486536A0 (es) 1980-12-16
ES8102121A1 (es) 1980-12-16
CA1136623A (en) 1982-11-30
US4285946A (en) 1981-08-25
ES491224A0 (es) 1980-12-01
ATE1288T1 (de) 1982-07-15
AU529426B2 (en) 1983-06-09
AU5357179A (en) 1980-06-12
EP0012361B1 (de) 1982-06-30

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 20010303