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ES8307249A1 - Procedimiento de preparacion de nuevos derivados del adamantano. - Google Patents

Procedimiento de preparacion de nuevos derivados del adamantano.

Info

Publication number
ES8307249A1
ES8307249A1 ES516158A ES516158A ES8307249A1 ES 8307249 A1 ES8307249 A1 ES 8307249A1 ES 516158 A ES516158 A ES 516158A ES 516158 A ES516158 A ES 516158A ES 8307249 A1 ES8307249 A1 ES 8307249A1
Authority
ES
Spain
Prior art keywords
acylamino
adamantanes
aza
preparation
therapeutic use
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES516158A
Other languages
English (en)
Other versions
ES516158A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Nativelle SA Ets
Original Assignee
Nativelle SA Ets
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nativelle SA Ets filed Critical Nativelle SA Ets
Publication of ES8307249A1 publication Critical patent/ES8307249A1/es
Publication of ES516158A0 publication Critical patent/ES516158A0/es
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/18—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Cardiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Luminescent Compositions (AREA)
  • Inks, Pencil-Leads, Or Crayons (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

PROCEDIMIENTO PARA LA OBTENCION DE DERIVADOS DE ADAMANTANO, DE LA SERIE 4-ACILAMINO 1-AZA ADAMANTANOS DE FORMULA (I), EN LA QUE R ES ALQUILO O ARILO. CONSISTE EN LA REACCION DE ACILACION DE 4-AMINO 1-AZA 4,8,8-TRIMETIL ADAMANTANO. LA REACCION SE LLEVA A CABO POR TRATAMIENTO CON UN ACIDO, UN ANHIDRIDO, UN ESTER O UN CLORURO DE ACIDO, EN UN DISOLVENTE ORGANICO INERTE, A UNA TEMPERATURA COMPRENDIDA ENTRE 0 C Y LA AMBIENTE. ESTOS COMPUESTOS TIENEN APLICACIONES FARMACOLOGICAS PARA EL TRATAMIENTO DE ARITMIAS CARDIACAS, SUPRAVENTRICULARES Y VENTRICULARES.
ES516158A 1981-10-05 1982-10-01 Procedimiento de preparacion de nuevos derivados del adamantano. Granted ES516158A0 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR8118682A FR2514006A1 (fr) 1981-10-05 1981-10-05 Acylamino-4 aza-1 adamantanes, procede pour leur preparation, et application en therapeutique

Publications (2)

Publication Number Publication Date
ES8307249A1 true ES8307249A1 (es) 1983-07-01
ES516158A0 ES516158A0 (es) 1983-07-01

Family

ID=9262734

Family Applications (1)

Application Number Title Priority Date Filing Date
ES516158A Granted ES516158A0 (es) 1981-10-05 1982-10-01 Procedimiento de preparacion de nuevos derivados del adamantano.

Country Status (12)

Country Link
US (1) US4578382A (es)
EP (1) EP0076755B1 (es)
JP (1) JPS5867686A (es)
AT (1) ATE31928T1 (es)
AU (1) AU568064B2 (es)
CA (1) CA1187879A (es)
DE (1) DE3277971D1 (es)
DK (1) DK160712C (es)
ES (1) ES516158A0 (es)
FR (1) FR2514006A1 (es)
GR (1) GR77667B (es)
IE (1) IE54025B1 (es)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2543954B1 (fr) * 1983-04-08 1985-09-06 Nativelle Sa Ets Acylamino-4 aza-1 adamantanes, procede pour leur preparation et application en therapeutique
FR2557110B1 (fr) * 1983-12-23 1989-11-24 Sandoz Sa Nouveaux derives d'amines cycliques, leur preparation et leur utilisation comme medicaments
GB8523211D0 (en) * 1985-09-19 1985-10-23 Beecham Group Plc Compounds
US5840903A (en) * 1992-07-27 1998-11-24 G. D. Searle & Co. 4-aminomethyl-1-azaadamantane derived benzamides
US5354757A (en) * 1992-12-15 1994-10-11 G. D. Searle & Co. Azanoradamantanes
ES2175614T3 (es) * 1997-04-10 2002-11-16 Pfizer Derivados fluorosustituidos de adamantano.
US8314119B2 (en) * 2006-11-06 2012-11-20 Abbvie Inc. Azaadamantane derivatives and methods of use
SG2014013460A (en) 2010-09-23 2014-09-26 Abbvie Inc Monohydrate of an azaadamantane derivative

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR76755E (fr) * 1957-12-23 1961-12-01 Int Standard Electric Corp Perfectionnements aux dispositifs d'exploitation de données
CH451954A (de) * 1965-06-02 1968-05-15 Geigy Ag J R Verfahren zur Herstellung von neuen Guanidinderivaten
CH455790A (de) * 1965-11-18 1968-05-15 Geigy Ag J R Verfahren zur Herstellung eines neuen Amins
GB1293446A (en) * 1970-07-23 1972-10-18 Rech S Et D Applic Scient Soge Quinuclidine derivatives, the preparation thereof and pharmaceutical compositions containing them
FI763021A (es) * 1975-11-03 1977-05-04 Thomae Gmbh Dr K
FR2358404A1 (fr) * 1976-07-16 1978-02-10 Anvar Composes a structure du type de l'adamantane et leur preparation

Also Published As

Publication number Publication date
DE3277971D1 (en) 1988-02-18
AU568064B2 (en) 1987-12-17
IE822391L (en) 1983-04-05
AU8879482A (en) 1983-04-14
JPH0339073B2 (es) 1991-06-12
EP0076755B1 (fr) 1988-01-13
GR77667B (es) 1984-09-25
ATE31928T1 (de) 1988-01-15
JPS5867686A (ja) 1983-04-22
DK160712C (da) 1991-09-16
ES516158A0 (es) 1983-07-01
IE54025B1 (en) 1989-05-24
FR2514006B1 (es) 1984-12-28
FR2514006A1 (fr) 1983-04-08
US4578382A (en) 1986-03-25
DK160712B (da) 1991-04-08
DK439082A (da) 1983-04-06
CA1187879A (fr) 1985-05-28
EP0076755A1 (fr) 1983-04-13

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19970519