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ES2182493T3 - Procedimiento para producir simvastatina y/o sus derivados. - Google Patents

Procedimiento para producir simvastatina y/o sus derivados.

Info

Publication number
ES2182493T3
ES2182493T3 ES99909407T ES99909407T ES2182493T3 ES 2182493 T3 ES2182493 T3 ES 2182493T3 ES 99909407 T ES99909407 T ES 99909407T ES 99909407 T ES99909407 T ES 99909407T ES 2182493 T3 ES2182493 T3 ES 2182493T3
Authority
ES
Spain
Prior art keywords
compound
formula
iii
general formula
agent
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES99909407T
Other languages
English (en)
Other versions
ES2182493T5 (es
Inventor
Dalen Frans Van
Jacobus Maria Lemmens
Helvoirt Gertruda Antonett Van
Theodorus Hendricus Ant Peters
Frantisek Picha
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Synthon BV
Original Assignee
Synthon BV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26150393&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ES2182493(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from EP98201762A external-priority patent/EP0940395A1/en
Application filed by Synthon BV filed Critical Synthon BV
Publication of ES2182493T3 publication Critical patent/ES2182493T3/es
Application granted granted Critical
Publication of ES2182493T5 publication Critical patent/ES2182493T5/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/16—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D309/28—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D309/30—Oxygen atoms, e.g. delta-lactones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
    • C07C235/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton
    • C07C235/30—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being unsaturated and containing rings other than six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D319/04—1,3-Dioxanes; Hydrogenated 1,3-dioxanes
    • C07D319/06—1,3-Dioxanes; Hydrogenated 1,3-dioxanes not condensed with other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/14—All rings being cycloaliphatic
    • C07C2602/26—All rings being cycloaliphatic the ring system containing ten carbon atoms
    • C07C2602/28—Hydrogenated naphthalenes
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pyrane Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)

Abstract

Procedimiento para producir simvastatina y/o sus derivados, que comprende hacer reaccionar un compuesto de fórmula (II): **(Ver fórmula)** en la que R1 representa hidrógeno o metilo y R2 representa un grupo alquilo de cadena lineal o ramificada que tiene de 1 a 8 átomos de carbono, un grupo cicloalquilo que tiene de 3 a 7 átomos de carbono, o un grupo aralquilo que tiene de 1 a 6 átomos de carbono en la cadena alquílica.
ES99909407T 1998-03-05 1999-03-05 Procedimiento para producir simvastatina y/o sus derivados. Expired - Lifetime ES2182493T5 (es)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
NL1008502 1998-03-05
NL1008502 1998-03-05
EP98201762A EP0940395A1 (en) 1998-03-05 1998-05-27 Process for producing simvastatin and/or its derivatives
EP98201762 1998-05-27

Publications (2)

Publication Number Publication Date
ES2182493T3 true ES2182493T3 (es) 2003-03-01
ES2182493T5 ES2182493T5 (es) 2006-11-16

Family

ID=26150393

Family Applications (1)

Application Number Title Priority Date Filing Date
ES99909407T Expired - Lifetime ES2182493T5 (es) 1998-03-05 1999-03-05 Procedimiento para producir simvastatina y/o sus derivados.

Country Status (14)

Country Link
EP (1) EP1064275B2 (es)
JP (1) JP2002505327A (es)
CN (2) CN1232030A (es)
AT (1) ATE227280T1 (es)
AU (1) AU759878B2 (es)
CA (1) CA2321676A1 (es)
DE (1) DE69903799T3 (es)
DK (1) DK1064275T4 (es)
ES (1) ES2182493T5 (es)
IL (1) IL138119A (es)
NO (2) NO991045L (es)
PT (1) PT1064275E (es)
SI (1) SI1064275T2 (es)
WO (1) WO1999045003A1 (es)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SK2172003A3 (en) * 2000-07-27 2003-06-03 Plus Chemicals Bv Highly purified simvastatin compositions
CN1277826C (zh) * 2003-12-01 2006-10-04 叶红平 辉伐他汀及其合成方法和以辉伐他汀为原料药的制剂
HUE027872T2 (en) 2006-05-03 2016-11-28 Msn Laboratories Private Ltd A novel process for statins and their pharmaceutically acceptable salts
ES2567171T3 (es) * 2006-10-09 2016-04-20 Msn Laboratories Private Limited Nuevo procedimiento para la preparación de estatinas y sus sales farmacéuticamente aceptables
CN101289440B (zh) * 2007-06-29 2010-08-25 中国热带农业科学院热带生物技术研究所 一种多烯大环类化合物及其制备方法与应用
WO2010089770A2 (en) 2009-01-19 2010-08-12 Msn Laboratories Limited Improved process for the preparation of highly pure (3r,5s)-7-[2-cyclopropyl-4-(4-fluorophenyl) quinolin-3-yl]-3,5-dihydroxy-6(e)-heptenoic acid and pharmaceutically acceptable salts thereof
EP3190123B1 (en) 2009-09-30 2019-07-24 Codexis, Inc. Improved lov-d acyltransferase mediated acylation
CN102695792B (zh) 2009-10-08 2015-02-18 加利福尼亚大学董事会 对辛伐他汀合成表现出改善性质的LovD突变体
US8987444B2 (en) 2010-01-18 2015-03-24 Msn Laboratories Private Limited Process for the preparation of amide intermediates and their use thereof
HU229260B1 (en) * 2010-11-29 2013-10-28 Egis Gyogyszergyar Nyrt Process for preparation of rosuvastatin salts
CN105147659A (zh) * 2013-12-24 2015-12-16 深圳华润九新药业有限公司 一种洛伐他汀羟基酸化物的应用

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4820850A (en) * 1987-07-10 1989-04-11 Merck & Co., Inc. Process for α-C-alkylation of the 8-acyl group on mevinolin and analogs thereof
US5393893A (en) † 1993-11-08 1995-02-28 Apotex, Inc. Process for producing simvastatin and analogs thereof
US5763646A (en) * 1997-03-13 1998-06-09 Ranbaxy Laboratories, Ltd. Process for manufacturing simvastatin from lovastatin or mevinolinic acid
US6294680B1 (en) 1997-01-28 2001-09-25 Plus Chemicals, B.V. Process for the production of semi synthetic statins via novel intermediates

Also Published As

Publication number Publication date
DK1064275T3 (da) 2003-01-27
SI1064275T1 (en) 2003-04-30
NO20004357L (no) 2000-11-06
CN1232030A (zh) 1999-10-20
DE69903799D1 (de) 2002-12-12
IL138119A (en) 2004-05-12
CN1292786A (zh) 2001-04-25
EP1064275B1 (en) 2002-11-06
NO321444B1 (no) 2006-05-08
ATE227280T1 (de) 2002-11-15
NO991045D0 (no) 1999-03-03
NO991045L (no) 1999-09-06
DE69903799T3 (de) 2006-11-16
DE69903799T2 (de) 2003-09-04
EP1064275B2 (en) 2006-04-19
PT1064275E (pt) 2003-03-31
AU759878B2 (en) 2003-05-01
CA2321676A1 (en) 1999-09-10
SI1064275T2 (sl) 2006-08-31
WO1999045003A1 (en) 1999-09-10
DK1064275T4 (da) 2006-05-29
NO20004357D0 (no) 2000-09-01
IL138119A0 (en) 2001-10-31
ES2182493T5 (es) 2006-11-16
AU2861299A (en) 1999-09-20
JP2002505327A (ja) 2002-02-19
EP1064275A1 (en) 2001-01-03

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