NO991045L - FremgangsmÕte ved fremstilling av simvastatin og/eller dets derivater - Google Patents
FremgangsmÕte ved fremstilling av simvastatin og/eller dets derivaterInfo
- Publication number
- NO991045L NO991045L NO991045A NO991045A NO991045L NO 991045 L NO991045 L NO 991045L NO 991045 A NO991045 A NO 991045A NO 991045 A NO991045 A NO 991045A NO 991045 L NO991045 L NO 991045L
- Authority
- NO
- Norway
- Prior art keywords
- compound
- formula
- iii
- general formula
- agent
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
- C07D309/16—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D309/28—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D309/30—Oxygen atoms, e.g. delta-lactones
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
- C07C235/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton
- C07C235/30—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being unsaturated and containing rings other than six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D319/04—1,3-Dioxanes; Hydrogenated 1,3-dioxanes
- C07D319/06—1,3-Dioxanes; Hydrogenated 1,3-dioxanes not condensed with other rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2602/00—Systems containing two condensed rings
- C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
- C07C2602/14—All rings being cycloaliphatic
- C07C2602/26—All rings being cycloaliphatic the ring system containing ten carbon atoms
- C07C2602/28—Hydrogenated naphthalenes
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pyrane Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
- Steroid Compounds (AREA)
Abstract
Fremgangsmåte ved fremstilling av en forbindelse med formel VI: omfattende trinnene å: - omsette en forbindelse av den generelle formel (I): med et ring-åpnede middel for å gi en forbindelse som har den generelle formel II: og, beskytte hydroksygruppene av den således dannede forbin- delse (II) med et beskyttende middle for i hovedsak å nedsette reaktiviteten derav og gi forbindelse (III) eller (VII) , CO-NH-Rj VlO-Rj * 0" ks*^ (III) .CO-NH-R, (VII) hvori det beskyttende midlet nedsetter reaktiviteten av i det minste forbindelse (II) ved å erstatte hydrogenatomet av minst en av hydroksygruppene derav med en karbon-termi- nert gruppe, hvorved i tilfellet med forbindelse (III) minst en av R3 og R4 ikke er hydrogen. - omsette forbindelse (III) og/eller (VII) med et alky- leringsmiddel av formel R,X for å gi en forbindelse hen- holdsvis med formel (IV) eller (VIII), (IV) .CO-NH-R, (VIII) hvor R, fortrinnsvis representerer en metyl- eller etyl- gruppe og X representerer et halid, fortrinnsvis klor, brom eller jod; - hydrolysere de beskyttende gruppene R3, R4 og R5, R6 av forbindelser henholdsvis (IV) og (VIII) for å gi en forbindelse med formel (V) - CO-NH-R, : c: (V) relaktonisere forbindelse (V) for å gi forbindelse (VI).
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| NL1008502 | 1998-03-05 | ||
| EP98201762A EP0940395A1 (en) | 1998-03-05 | 1998-05-27 | Process for producing simvastatin and/or its derivatives |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| NO991045D0 NO991045D0 (no) | 1999-03-03 |
| NO991045L true NO991045L (no) | 1999-09-06 |
Family
ID=26150393
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO991045A NO991045L (no) | 1998-03-05 | 1999-03-03 | FremgangsmÕte ved fremstilling av simvastatin og/eller dets derivater |
| NO20004357A NO321444B1 (no) | 1998-03-05 | 2000-09-01 | Fremgangsmate ved fremstilling av simvastatin-derivater samt intermediater egnet for fremstillingen. |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO20004357A NO321444B1 (no) | 1998-03-05 | 2000-09-01 | Fremgangsmate ved fremstilling av simvastatin-derivater samt intermediater egnet for fremstillingen. |
Country Status (14)
| Country | Link |
|---|---|
| EP (1) | EP1064275B2 (no) |
| JP (1) | JP2002505327A (no) |
| CN (2) | CN1232030A (no) |
| AT (1) | ATE227280T1 (no) |
| AU (1) | AU759878B2 (no) |
| CA (1) | CA2321676A1 (no) |
| DE (1) | DE69903799T3 (no) |
| DK (1) | DK1064275T4 (no) |
| ES (1) | ES2182493T5 (no) |
| IL (1) | IL138119A (no) |
| NO (2) | NO991045L (no) |
| PT (1) | PT1064275E (no) |
| SI (1) | SI1064275T2 (no) |
| WO (1) | WO1999045003A1 (no) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2002009697A1 (en) * | 2000-07-27 | 2002-02-07 | Plus Chemicals, B.V | Highly purified simvastatin compositions |
| CN1277826C (zh) * | 2003-12-01 | 2006-10-04 | 叶红平 | 辉伐他汀及其合成方法和以辉伐他汀为原料药的制剂 |
| SI2024341T1 (sl) | 2006-05-03 | 2016-04-29 | Msn Laboratories Private Limited | Novi postopek za statine in njihove farmacevtsko sprejemljive soli |
| US8404841B2 (en) | 2006-10-09 | 2013-03-26 | Msn Laboratories Limited | Process for the preparation of statins and their pharmaceutically acceptable salts thereof |
| CN101289440B (zh) * | 2007-06-29 | 2010-08-25 | 中国热带农业科学院热带生物技术研究所 | 一种多烯大环类化合物及其制备方法与应用 |
| US8487105B2 (en) | 2009-01-19 | 2013-07-16 | Msn Laboratories Limited | Process for preparing pitavastatin, intermediates and pharmaceuctically acceptable salts thereof |
| EP3190123B1 (en) | 2009-09-30 | 2019-07-24 | Codexis, Inc. | Improved lov-d acyltransferase mediated acylation |
| CN102695792B (zh) | 2009-10-08 | 2015-02-18 | 加利福尼亚大学董事会 | 对辛伐他汀合成表现出改善性质的LovD突变体 |
| WO2011086584A2 (en) | 2010-01-18 | 2011-07-21 | Msn Laboratories Limited | Improved process for the preparation of amide intermediates and their use thereof |
| HU229260B1 (en) * | 2010-11-29 | 2013-10-28 | Egis Gyogyszergyar Nyrt | Process for preparation of rosuvastatin salts |
| CN105147659A (zh) * | 2013-12-24 | 2015-12-16 | 深圳华润九新药业有限公司 | 一种洛伐他汀羟基酸化物的应用 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4820850A (en) * | 1987-07-10 | 1989-04-11 | Merck & Co., Inc. | Process for α-C-alkylation of the 8-acyl group on mevinolin and analogs thereof |
| US5393893A (en) † | 1993-11-08 | 1995-02-28 | Apotex, Inc. | Process for producing simvastatin and analogs thereof |
| US5763646A (en) * | 1997-03-13 | 1998-06-09 | Ranbaxy Laboratories, Ltd. | Process for manufacturing simvastatin from lovastatin or mevinolinic acid |
| AU747219C (en) * | 1997-01-28 | 2003-11-20 | Plus Chemicals B.V. | Process for the production of semi synthetic statins via novel intermediates |
-
1999
- 1999-03-03 NO NO991045A patent/NO991045L/no not_active Application Discontinuation
- 1999-03-05 CA CA002321676A patent/CA2321676A1/en not_active Abandoned
- 1999-03-05 DE DE69903799T patent/DE69903799T3/de not_active Expired - Fee Related
- 1999-03-05 ES ES99909407T patent/ES2182493T5/es not_active Expired - Lifetime
- 1999-03-05 AU AU28612/99A patent/AU759878B2/en not_active Ceased
- 1999-03-05 WO PCT/NL1999/000119 patent/WO1999045003A1/en not_active Application Discontinuation
- 1999-03-05 CN CN99103408A patent/CN1232030A/zh active Pending
- 1999-03-05 AT AT99909407T patent/ATE227280T1/de not_active IP Right Cessation
- 1999-03-05 SI SI9930186T patent/SI1064275T2/sl unknown
- 1999-03-05 CN CN998036927A patent/CN1292786A/zh active Pending
- 1999-03-05 EP EP99909407A patent/EP1064275B2/en not_active Expired - Lifetime
- 1999-03-05 PT PT99909407T patent/PT1064275E/pt unknown
- 1999-03-05 JP JP2000534546A patent/JP2002505327A/ja active Pending
- 1999-03-05 DK DK99909407T patent/DK1064275T4/da active
- 1999-03-05 IL IL13811999A patent/IL138119A/en not_active IP Right Cessation
-
2000
- 2000-09-01 NO NO20004357A patent/NO321444B1/no unknown
Also Published As
| Publication number | Publication date |
|---|---|
| DE69903799T3 (de) | 2006-11-16 |
| AU759878B2 (en) | 2003-05-01 |
| SI1064275T1 (en) | 2003-04-30 |
| PT1064275E (pt) | 2003-03-31 |
| EP1064275A1 (en) | 2001-01-03 |
| NO321444B1 (no) | 2006-05-08 |
| SI1064275T2 (sl) | 2006-08-31 |
| JP2002505327A (ja) | 2002-02-19 |
| DK1064275T3 (da) | 2003-01-27 |
| EP1064275B2 (en) | 2006-04-19 |
| DK1064275T4 (da) | 2006-05-29 |
| CA2321676A1 (en) | 1999-09-10 |
| IL138119A0 (en) | 2001-10-31 |
| DE69903799T2 (de) | 2003-09-04 |
| DE69903799D1 (de) | 2002-12-12 |
| ES2182493T5 (es) | 2006-11-16 |
| EP1064275B1 (en) | 2002-11-06 |
| AU2861299A (en) | 1999-09-20 |
| ES2182493T3 (es) | 2003-03-01 |
| NO991045D0 (no) | 1999-03-03 |
| CN1292786A (zh) | 2001-04-25 |
| CN1232030A (zh) | 1999-10-20 |
| IL138119A (en) | 2004-05-12 |
| WO1999045003A1 (en) | 1999-09-10 |
| NO20004357D0 (no) | 2000-09-01 |
| ATE227280T1 (de) | 2002-11-15 |
| NO20004357L (no) | 2000-11-06 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FC2A | Withdrawal, rejection or dismissal of laid open patent application |