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ES2159491B1 - Base cristalina de citalopram - Google Patents

Base cristalina de citalopram

Info

Publication number
ES2159491B1
ES2159491B1 ES200100548A ES200100548A ES2159491B1 ES 2159491 B1 ES2159491 B1 ES 2159491B1 ES 200100548 A ES200100548 A ES 200100548A ES 200100548 A ES200100548 A ES 200100548A ES 2159491 B1 ES2159491 B1 ES 2159491B1
Authority
ES
Spain
Prior art keywords
citalopram
crystal base
salts
base
formulations
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
ES200100548A
Other languages
English (en)
Other versions
ES2159491A1 (es
Inventor
Hans Petersen
Klaus Peter Boegesoe
Per Holm
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
H Lundbeck AS
Original Assignee
H Lundbeck AS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=8159320&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ES2159491(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by H Lundbeck AS filed Critical H Lundbeck AS
Publication of ES2159491A1 publication Critical patent/ES2159491A1/es
Application granted granted Critical
Publication of ES2159491B1 publication Critical patent/ES2159491B1/es
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/87—Benzo [c] furans; Hydrogenated benzo [c] furans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A61K31/343—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
  • Laminated Bodies (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Silicates, Zeolites, And Molecular Sieves (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Manufacture Of Macromolecular Shaped Articles (AREA)

Abstract

Base cristalina de citalopram, 1-[3-dimetilamino)propil]-1-(4- fluoro-fenil)-1,3-dihidro-5-isobenzofurano-carbonitrilo, un bien conocido fármaco antidepresivo, formulaciones de dicha fase, un procedimiento para la preparación de sales purificadas de citalopram, tales como el hidrobromuro, por uso de la base, las sales obtenidas por dicho procedimiento y formulaciones que contienen dichas sales.
ES200100548A 2000-03-13 2001-03-09 Base cristalina de citalopram Expired - Fee Related ES2159491B1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DKPA200000402 2000-03-13
DKPCT/DK00/00183 2000-04-13

Publications (2)

Publication Number Publication Date
ES2159491A1 ES2159491A1 (es) 2001-10-01
ES2159491B1 true ES2159491B1 (es) 2002-05-01

Family

ID=8159320

Family Applications (3)

Application Number Title Priority Date Filing Date
ES01909568T Expired - Lifetime ES2173054T3 (es) 2000-03-13 2001-02-28 Base cristalina de citalopram.
ES02009350T Expired - Lifetime ES2180471T3 (es) 2000-03-13 2001-02-28 Base cristalina de citalopram y su sal hidrocloruro o hidrobromuro.
ES200100548A Expired - Fee Related ES2159491B1 (es) 2000-03-13 2001-03-09 Base cristalina de citalopram

Family Applications Before (2)

Application Number Title Priority Date Filing Date
ES01909568T Expired - Lifetime ES2173054T3 (es) 2000-03-13 2001-02-28 Base cristalina de citalopram.
ES02009350T Expired - Lifetime ES2180471T3 (es) 2000-03-13 2001-02-28 Base cristalina de citalopram y su sal hidrocloruro o hidrobromuro.

Country Status (42)

Country Link
US (7) US20010031784A1 (es)
EP (2) EP1169314B2 (es)
JP (1) JP2003527383A (es)
KR (1) KR20020080486A (es)
CN (2) CN1258530C (es)
AR (1) AR029811A1 (es)
AT (3) ATE250050T1 (es)
AU (2) AU746664B2 (es)
BE (1) BE1013210A3 (es)
BG (1) BG107065A (es)
BR (1) BR0109373A (es)
CA (2) CA2411732A1 (es)
CH (2) CH691477A5 (es)
CZ (1) CZ292077B6 (es)
DE (7) DE20007303U1 (es)
DK (3) DK173903B1 (es)
EA (1) EA200200972A1 (es)
ES (3) ES2173054T3 (es)
FI (2) FI20010156A0 (es)
FR (1) FR2806086B1 (es)
GB (2) GB2357762B (es)
GR (1) GR1003796B (es)
HK (1) HK1054750A1 (es)
HR (1) HRP20020756A2 (es)
HU (3) HU0001581D0 (es)
IE (1) IES20010109A2 (es)
IL (2) IL158072A0 (es)
IS (1) IS5841A (es)
IT (2) IT1319645B1 (es)
MX (1) MXPA02008793A (es)
NL (2) NL1016435C1 (es)
NO (2) NO312031B1 (es)
PL (1) PL360158A1 (es)
PT (2) PT1227088E (es)
SE (2) SE517136C2 (es)
SI (2) SI1227088T1 (es)
SK (1) SK285528B6 (es)
TR (1) TR200202185T2 (es)
UA (1) UA74360C2 (es)
WO (1) WO2001068627A1 (es)
YU (1) YU68802A (es)
ZA (1) ZA200207148B (es)

Families Citing this family (61)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3798940B2 (ja) 1999-04-14 2006-07-19 ハー・ルンドベック・アクチエゼルスカベット シタロプラムの製造方法
AR021155A1 (es) * 1999-07-08 2002-06-12 Lundbeck & Co As H Tratamiento de desordenes neuroticos
US8328829B2 (en) 1999-08-19 2012-12-11 Covidien Lp High capacity debulking catheter with razor edge cutting window
US7713279B2 (en) 2000-12-20 2010-05-11 Fox Hollow Technologies, Inc. Method and devices for cutting tissue
US7887556B2 (en) 2000-12-20 2011-02-15 Fox Hollow Technologies, Inc. Debulking catheters and methods
US6299622B1 (en) 1999-08-19 2001-10-09 Fox Hollow Technologies, Inc. Atherectomy catheter with aligned imager
US7708749B2 (en) 2000-12-20 2010-05-04 Fox Hollow Technologies, Inc. Debulking catheters and methods
IES20010157A2 (en) 2000-03-03 2002-03-06 Lundbeck & Co As H Method for the preparation of citalopram
GB2357762B (en) * 2000-03-13 2002-01-30 Lundbeck & Co As H Crystalline base of citalopram
IES20010206A2 (en) 2000-03-13 2002-03-06 Lundbeck & Co As H Method for the preparation of citalopram
US6977306B2 (en) 2000-05-02 2005-12-20 Sumitomo Chemical Company, Limited Citalopram hydrobromide crystal and method for crystallization thereof
AR032455A1 (es) 2000-05-12 2003-11-12 Lundbeck & Co As H Metodo para la preparacion de citalopram, un intermediario empleado en el metodo, un metodo para la preparacion del intermediario empleado en el metodo y composicion farmaceutica antidepresiva
GB2376233B (en) * 2000-08-10 2003-09-10 Lundbeck & Co As H Crystals of a pharmaceutically acceptable salt of citalopram wherein the median size of the crystals is at least 40 microns
IES20010693A2 (en) * 2000-08-10 2002-07-10 Lundbeck & Co As H Pharmaceutical composition containing citalopram
JP4080874B2 (ja) 2000-12-20 2008-04-23 フォックス ハロウ テクノロジーズ，インコーポレイティド 減嵩カテーテル
KR100439329B1 (ko) * 2000-12-22 2004-07-07 하. 룬트벡 아크티에 셀스카브 순수한 시탈로프람의 제조방법
AU2001100195B4 (en) * 2001-01-05 2001-12-20 H Lundbeck As Pharmaceutical composition containing citalopram.
GB0105627D0 (en) * 2001-03-07 2001-04-25 Cipla Ltd Preparation of phthalanes
CN1509169A (zh) * 2001-05-01 2004-06-30 H��¡�±������޹�˾ 对映体纯艾司西酞普兰的用途
WO2003011278A1 (en) 2001-07-31 2003-02-13 H. Lundbeck A/S Crystalline composition containing escitalopram
WO2003057132A2 (en) * 2002-01-07 2003-07-17 Sun Pharmaceutical Industries Limited Process for the preparation of 1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)- 1,3-dihydro-5-isobenzofuran carbonitrile
GB2387844B (en) * 2002-02-27 2005-05-11 Matrix Lab Ltd Separation of impurities from a crude mixture of citalopram
GB0204607D0 (en) * 2002-02-27 2002-04-10 Matrix Lab Ltd Process
GB2386119A (en) * 2002-02-27 2003-09-10 Cipla Ltd Purification of citalopram
GB2385848A (en) * 2002-02-27 2003-09-03 Cipla Ltd Citalopram salts
GB2386118A (en) * 2002-02-27 2003-09-10 Cipla Ltd Citalopram
EP1346989A1 (en) * 2002-03-21 2003-09-24 Jubilant Organosys Limited Improved process for the preparation of citalopram and its hydrobromide
GB0206708D0 (en) * 2002-03-21 2002-05-01 Cipla Ltd Pharmaceutical salts
US6812355B2 (en) 2002-10-22 2004-11-02 Sekhsaria Chemicals Limited Process for the manufacture of citalopram hydrobromide from 5-bromophthalide
US20050154052A1 (en) * 2003-03-24 2005-07-14 Hetero Drugs Limited Novel crystalline forms of (s)-citalopram oxalate
AU2003238676A1 (en) * 2003-04-21 2004-11-19 Podile Khadgapathi An improved process for the preparation of citalopram hydrobromide
US8246640B2 (en) 2003-04-22 2012-08-21 Tyco Healthcare Group Lp Methods and devices for cutting tissue at a vascular location
US7019153B2 (en) 2003-06-10 2006-03-28 Sun Pharmaceutical Industries Limited Process for hydrogenolysis of [1-(3-dimethylamino)propyl)]-1-(4-fluorophenyl)-1,3-dihydro-5-halo-isobenzofuran acetamido-3-substituted-3-cephem-4-carboxylic acid
GB0317475D0 (en) 2003-07-25 2003-08-27 Meditab Specialities Pvt Ltd Product
JP4025735B2 (ja) * 2003-08-21 2007-12-26 ローム アンド ハース カンパニー 水性系を処理する方法
GB0320312D0 (en) 2003-08-29 2003-10-01 Novartis Ag Purification process
CN100569765C (zh) * 2003-12-19 2009-12-16 杭州民生药业集团有限公司 西酞普兰中间体晶体碱
ITTO20050301A1 (it) * 2005-05-05 2006-11-06 Errekappa Euroterapici Spa Formulazioni liquide orali contenenti citalopram
EP1901714A2 (en) * 2005-05-20 2008-03-26 Aurobindo Pharma Limited Pharmaceutical dosage forms comprising escitalopram in form of granules
TWI358407B (en) * 2005-06-22 2012-02-21 Lundbeck & Co As H Crystalline base of escitalopram and orodispersibl
US7834201B2 (en) 2005-06-22 2010-11-16 H. Lundbeck A/S Crystalline base of escitalopram and orodispersible tablets comprising escitalopram base
EP2474308A1 (en) 2005-06-27 2012-07-11 Valeant International (Barbados) SRL Pharmaceutical formulations containing bupropion hydrobromide
US20070276419A1 (en) 2006-05-26 2007-11-29 Fox Hollow Technologies, Inc. Methods and devices for rotating an active element and an energy emitter on a catheter
US8784440B2 (en) 2008-02-25 2014-07-22 Covidien Lp Methods and devices for cutting tissue
CA2739665C (en) 2008-10-13 2018-01-02 Tyco Healthcare Group Lp Devices and methods for manipulating a catheter shaft
JP5579830B2 (ja) 2009-04-29 2014-08-27 コヴィディエン リミテッド パートナーシップ 組織を切断および研磨する方法および装置
JP5281195B2 (ja) 2009-05-14 2013-09-04 コヴィディエン リミテッド パートナーシップ 簡単に清掃され得るアテレクトミー用カテーテルおよび使用の方法
WO2011068932A1 (en) 2009-12-02 2011-06-09 Fox Hollow Technologies, Inc. Methods and devices for cutting tissue
EP2509519B1 (en) 2009-12-11 2019-08-07 Covidien LP Material removal device having improved material capture efficiency
EP2579791B1 (en) 2010-06-14 2014-04-23 Covidien LP Material removal device
EP2632352B1 (en) 2010-10-28 2017-04-12 Covidien LP Material removal device
CA2817213C (en) 2010-11-11 2016-06-14 Covidien Lp Flexible debulking catheters with imaging and methods of use and manufacture
JP5806407B2 (ja) 2011-09-01 2015-11-10 コヴィディエン リミテッド パートナーシップ 螺旋駆動軸を有するカテーテルおよび製造方法
US9579157B2 (en) 2012-09-13 2017-02-28 Covidien Lp Cleaning device for medical instrument and method of use
US9943329B2 (en) 2012-11-08 2018-04-17 Covidien Lp Tissue-removing catheter with rotatable cutter
WO2015200702A1 (en) 2014-06-27 2015-12-30 Covidien Lp Cleaning device for catheter and catheter including the same
US10314667B2 (en) 2015-03-25 2019-06-11 Covidien Lp Cleaning device for cleaning medical instrument
US10292721B2 (en) 2015-07-20 2019-05-21 Covidien Lp Tissue-removing catheter including movable distal tip
US10314664B2 (en) 2015-10-07 2019-06-11 Covidien Lp Tissue-removing catheter and tissue-removing element with depth stop
BR112022000992A2 (pt) 2019-07-19 2022-06-14 Arx Llc Regimes de tratamento de dexmedetomidina não sedantes
US11806334B1 (en) 2023-01-12 2023-11-07 Bioxcel Therapeutics, Inc. Non-sedating dexmedetomidine treatment regimens

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CZ291440B6 (cs) * 1997-07-08 2003-03-12 H. Lundbeck A/S Způsob výroby citalopramu
UA62985C2 (en) * 1997-11-10 2004-01-15 Lunnbeck As H A method for the preparation of citalopram
BR9714925A (pt) * 1997-11-11 2003-07-22 Lundbeck & Co As H Método para preparação de citalopran, composto e composição farmacêutica antidepressiva
ATE230738T1 (de) 1998-10-20 2003-01-15 Lundbeck & Co As H Verfahren zur herstellung von citalopram
JP3798940B2 (ja) 1999-04-14 2006-07-19 ハー・ルンドベック・アクチエゼルスカベット シタロプラムの製造方法
ITMI991579A1 (it) 1999-06-25 2001-01-15 Lundbeck & Co As H Metodo per la preparazione di citalopram
ITMI991581A1 (it) * 1999-06-25 2001-01-15 Lundbeck & Co As H Metodo per la preparazione di citalopram
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Also Published As

Publication number Publication date
US20030078442A1 (en) 2003-04-24
DK173903B1 (da) 2002-02-11
AR029811A1 (es) 2003-07-16
EP1227088B1 (en) 2003-09-17
NO20010619D0 (no) 2001-02-06
NL1017413C1 (nl) 2001-09-13
EP1169314A1 (en) 2002-01-09
US20050165244A1 (en) 2005-07-28
SE526022C2 (sv) 2005-06-14
ATE223396T1 (de) 2002-09-15
IL147339A0 (en) 2002-08-14
CZ292077B6 (cs) 2003-07-16
CN1680350A (zh) 2005-10-12
NO20010619L (no) 2001-09-14
BE1013210A3 (fr) 2001-10-02
CZ2001808A3 (cs) 2002-01-16
NO312031B1 (no) 2002-03-04
HUP0100531A2 (hu) 2002-01-28
SE517136C2 (sv) 2002-04-16
ES2180471T3 (es) 2004-05-01
NO315851B1 (no) 2003-11-03
WO2001068627A1 (en) 2001-09-20
EA200200972A1 (ru) 2003-02-27
HU0100450D0 (en) 2001-04-28
PL360158A1 (en) 2004-09-06
DE10108042A1 (de) 2001-10-18
EP1227088A1 (en) 2002-07-31
SE0200730D0 (sv) 2002-03-12
YU68802A (sh) 2005-11-28
BG107065A (bg) 2003-05-30
AT4364U1 (de) 2001-06-25
CA2360287C (en) 2003-09-09
FI20010225A0 (fi) 2001-02-07
AU746664B2 (en) 2002-05-02
GB2357762A (en) 2001-07-04
DE60100786D1 (de) 2003-10-23
SI1169314T2 (sl) 2011-08-31
US20040167210A1 (en) 2004-08-26
FI20010156A0 (fi) 2001-01-25
SK13132002A3 (sk) 2003-01-09
IL158072A0 (en) 2004-03-28
FR2806086A1 (fr) 2001-09-14
NO20020356D0 (no) 2002-01-23
CN1258530C (zh) 2006-06-07
DK1227088T3 (da) 2003-12-22
US20060247451A1 (en) 2006-11-02
SE0103046D0 (sv) 2001-09-14
ZA200207148B (en) 2003-04-23
NL1016435C1 (nl) 2000-11-06
ATE250050T1 (de) 2003-10-15
US20040132808A1 (en) 2004-07-08
DE20121240U1 (de) 2002-07-04
CN1429220A (zh) 2003-07-09
SE0200730L (sv) 2002-08-29
SI1227088T1 (en) 2003-12-31
SE0103046L (sv) 2001-11-14
JP2003527383A (ja) 2003-09-16
EP1169314B2 (en) 2011-06-01
HK1054750A1 (en) 2003-12-12
DE60100022T2 (de) 2003-03-06
DE60100022D1 (de) 2002-10-10
PT1227088E (pt) 2003-12-31
ES2173054T1 (es) 2002-10-16
GR1003796B (el) 2002-02-08
IT1319645B1 (it) 2003-10-23
PT1169314E (pt) 2002-11-29
ITMI20002425A1 (it) 2002-05-09
TR200202185T2 (tr) 2002-12-23
NO20020356L (no) 2001-09-14
FI20010225A (fi) 2001-09-14
BR0109373A (pt) 2002-12-24
ES2159491A1 (es) 2001-10-01
HUP0100531A3 (en) 2004-04-28
DE60100786T2 (de) 2004-07-15
IS5841A (is) 2001-09-14
AU2001100197B4 (en) 2001-12-06
ES2173054T3 (es) 2002-12-16
KR20020080486A (ko) 2002-10-23
HU0100531D0 (en) 2001-03-28
CA2360287A1 (en) 2001-09-20
AU3725201A (en) 2001-09-13
AU2001100197A4 (en) 2001-09-20
ES2180471T1 (es) 2003-02-16
CH691477A5 (de) 2001-07-31
US20010031784A1 (en) 2001-10-18
IES20010109A2 (en) 2002-02-20
GB0102797D0 (en) 2001-03-21
DE20007303U1 (de) 2000-07-27
HU0001581D0 (en) 2000-06-28
SK285528B6 (sk) 2007-03-01
GB2357762B (en) 2002-01-30
ITMI20010406A1 (it) 2002-08-28
DE1227088T1 (de) 2003-02-06
DK1169314T3 (da) 2002-10-14
SI1169314T1 (en) 2002-12-31
UA74360C2 (uk) 2005-12-15
US20050165092A1 (en) 2005-07-28
DE60100022T3 (de) 2011-11-17
GB0105982D0 (en) 2001-05-02
EP1169314B1 (en) 2002-09-04
CA2411732A1 (en) 2001-09-20
DE10164687B4 (de) 2006-04-27
MXPA02008793A (es) 2003-02-12
IL147339A (en) 2004-09-27
CH691537A5 (de) 2001-08-15
FI109022B (fi) 2002-05-15
HRP20020756A2 (en) 2004-12-31
FR2806086B1 (fr) 2003-05-09

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