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ES2028801T3 - Procedimiento para la obtencion de cicloalcano (1.2-b)indolsulfonamidas. - Google Patents

Procedimiento para la obtencion de cicloalcano (1.2-b)indolsulfonamidas.

Info

Publication number
ES2028801T3
ES2028801T3 ES198787101901T ES87101901T ES2028801T3 ES 2028801 T3 ES2028801 T3 ES 2028801T3 ES 198787101901 T ES198787101901 T ES 198787101901T ES 87101901 T ES87101901 T ES 87101901T ES 2028801 T3 ES2028801 T3 ES 2028801T3
Authority
ES
Spain
Prior art keywords
indolsulfonamides
cycloalcano
procedure
obtaining
indoles
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES198787101901T
Other languages
English (en)
Inventor
Horst Dr. Boshagen
Ulrich Dr. Rosentreter
Folker Dr. Lieb
Hermann Dr. Oediger
Friedel Dr. Seuter
Elisabeth Dr. Perzborn
Volker-Bernd Dr. Fiedler
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer AG
Original Assignee
Bayer AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer AG filed Critical Bayer AG
Application granted granted Critical
Publication of ES2028801T3 publication Critical patent/ES2028801T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/12—Radicals substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/80—[b, c]- or [b, d]-condensed
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/80—[b, c]- or [b, d]-condensed
    • C07D209/82—Carbazoles; Hydrogenated carbazoles
    • C07D209/86—Carbazoles; Hydrogenated carbazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the ring system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/80—[b, c]- or [b, d]-condensed
    • C07D209/82—Carbazoles; Hydrogenated carbazoles
    • C07D209/88—Carbazoles; Hydrogenated carbazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Indole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

NUEVAS CIALOALCANO[1,2-B]INDOL-SULFONAMIDAS O BIEN SUS SALES, QUE PUEDEN OBTENERSE POR TRANSFORMACION DE [BENZOL-SULFONAMIDOALQUIL]CICLOALCANO[1,2-B] INDOLES CON ARILONITRILO, SUBSIGUIENTE SAPONIFICACION Y SI ES CASO HIDROGENACION Y TRANSFORMACION CON UNA BASE. LOS [BENZOLSULFONAMIDOALQUIL]CICLOALCANO [1,2-B]INDOLES SON PRODUCTOS INTERMEDIOS, QUE PUEDEN OBTENERSE A PARTIR DE LAS CORRESPONDIENTES FENILHIDRACINAS CON CICLOALQUILCETONAS. LAS CICLOALCANO[1,2-B]INDOL -SULFONAMIDAS O BIEN SUS SALES PUEDEN APLICARSE CON FINES TERAPEUTICOS.
ES198787101901T 1986-02-21 1987-02-11 Procedimiento para la obtencion de cicloalcano (1.2-b)indolsulfonamidas. Expired - Lifetime ES2028801T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE3605566 1986-02-21
DE19863631824 DE3631824A1 (de) 1986-02-21 1986-09-19 Cycloalkano(1.2-b)indol-sulfonamide

Publications (1)

Publication Number Publication Date
ES2028801T3 true ES2028801T3 (es) 1992-07-16

Family

ID=25841196

Family Applications (1)

Application Number Title Priority Date Filing Date
ES198787101901T Expired - Lifetime ES2028801T3 (es) 1986-02-21 1987-02-11 Procedimiento para la obtencion de cicloalcano (1.2-b)indolsulfonamidas.

Country Status (19)

Country Link
US (3) US4827032A (es)
EP (1) EP0242518B1 (es)
JP (1) JPH075552B2 (es)
KR (2) KR940007302B1 (es)
AU (1) AU595855B2 (es)
CA (1) CA1309414C (es)
CS (1) CS275837B6 (es)
DE (2) DE3631824A1 (es)
DK (1) DK167009B1 (es)
ES (1) ES2028801T3 (es)
FI (1) FI86544C (es)
GR (1) GR3001763T3 (es)
HU (1) HU198686B (es)
IE (1) IE59470B1 (es)
IL (1) IL81611A (es)
NO (1) NO171633C (es)
NZ (1) NZ219319A (es)
PH (1) PH24491A (es)
PT (1) PT84316B (es)

Families Citing this family (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3826371A1 (de) * 1988-08-03 1990-02-08 Bayer Ag Tetrahydro-1-benz-(c,d)-indolpropionsaeure-sulfonamide
DE3829455A1 (de) * 1988-08-31 1990-03-15 Boehringer Mannheim Gmbh Sulfonamidoalkyl-cyclohexan-verbindungen, verfahren zu ihrer herstellung sowie arzneimittel
US5070099A (en) * 1988-10-31 1991-12-03 E. R. Squibb & Sons, Inc. Arylthioalkylphenyl carboxylic acids, derivatives thereof, compositions containing same method of use
US4959383A (en) * 1988-10-31 1990-09-25 E. R. Squibb & Sons, Inc. Phenylsulfone alkenoic acids, derivatives thereof, compositions containing same and method of use
US5006542A (en) * 1988-10-31 1991-04-09 E. R. Squibb & Sons, Inc. Arylthioalkylphenyl carboxylic acids, derivatives thereof, compositions containing same and method of use
GB8924392D0 (en) * 1989-10-30 1989-12-20 Bayer Ag Substituted cycloalkano/b/dihydroindole-and-indolesulphonamides
GB9008108D0 (en) * 1990-04-10 1990-06-06 Bayer Ag Cycloalkano(b)dihydroindoles and-indolesulphonamides substituted by heterocycles
DE4027278A1 (de) * 1990-08-29 1992-03-05 Bayer Ag Heterocyclisch substituierte indolsulfonamide
US5827871A (en) * 1991-06-26 1998-10-27 Smithkline Beecham Plc Medicaments 1,2,3,4-tetrahydrocarbazoles and 5-HT1 agonist use thereof
DE4131346A1 (de) * 1991-09-20 1993-03-25 Bayer Ag Indolsulfonamid substituierte dihydropyridine, verfahren zu ihrer herstellung und ihre verwendung in arzneimitteln
EP0603432B1 (en) * 1992-12-18 1998-10-21 Smithkline Beecham Plc Tetrahydrocarbazole derivatives for the manufacture of a medicament for the treatment of a disease where a 5-HT1-like agonist is indicated
DE19507751A1 (de) * 1995-03-06 1996-09-12 Bayer Ag Verfahren zur Herstellung von substituierten 1,2,3,4-Tetrahydrocarbazolen
US5708187A (en) * 1996-06-27 1998-01-13 Eli Lilly And Company 6-substituted-1,2,3,4-tetrahydro-9H-carbazoles and 7-substituted-10H-cyclohepta 7,6-B!indoles: New 5-HT1F agonists
DE19757983A1 (de) * 1997-12-24 1999-07-01 Bayer Yakuhin Ltd Thermodynamisch stabile Form von (r)-3[[(4-Fluorophenyl)sulfonyl]amino]-1,2,3,4-tetrahydro-9H-carbazol-0-propansäure (Ramatroban)
WO2007019675A1 (en) * 2005-08-12 2007-02-22 Merck Frosst Canada Ltd. Indole derivatives as crth2 receptor antagonists
US7662831B2 (en) * 2006-07-27 2010-02-16 Wyeth Llc Tetracyclic indoles as potassium channel modulators
US7601856B2 (en) * 2006-07-27 2009-10-13 Wyeth Benzofurans as potassium ion channel modulators
MX2009001105A (es) 2006-08-07 2009-02-10 Actelion Pharmaceuticals Ltd Derivados del acido (3-amino-1,2,3,4-tetrahidro-9h-carbazol-9-il)- acetico.
GB0624087D0 (en) * 2006-12-01 2007-01-10 Selamine Ltd Ramipril combination salt
GB0624090D0 (en) * 2006-12-01 2007-01-10 Selamine Ltd Ramipril amine salts
GB0624084D0 (en) * 2006-12-01 2007-01-10 Selamine Ltd Ramipril amino acid salts
EP2107907B1 (en) * 2006-12-20 2012-02-01 Cardoz AB Combination of pemirolast and ramatroban for use in the treatment of inflammatory disorders
WO2008087371A1 (en) * 2007-01-16 2008-07-24 Cardoz Ab New combination for use in the treatment of inflammatory disorders
WO2009007674A2 (en) * 2007-07-11 2009-01-15 Cardoz Ab Combination for use in the treatment of atherosclerosis comprising a mast cell inhibitor and ramatroban or seratrodast
US8501959B2 (en) * 2008-06-24 2013-08-06 Panmira Pharmaceuticals, Llc Cycloalkane[B]indole antagonists of prostaglandin D2 receptors
CA2728311A1 (en) 2008-07-15 2010-01-21 F. Hoffmann-La Roche Ag Aminotetrahydroindazoloacetic acids
JP2012508715A (ja) 2008-11-17 2012-04-12 エフ．ホフマン−ラ ロシュ アーゲー ナフチル酢酸
NZ591914A (en) 2008-11-17 2013-04-26 Hoffmann La Roche Naphthylacetic acids
JP5373104B2 (ja) 2008-11-17 2013-12-18 エフ．ホフマン−ラ ロシュ アーゲー Ｃｒｔｈ２アンタゴニスト又は部分アゴニストとして使用されるナフチル酢酸
MY183111A (en) 2010-03-22 2021-02-15 Idorsia Pharmaceuticals Ltd 3-(heteroaryl-amino)-1,2,3,4-tetrahydro-9h-carbazole derivatives and their use as prostaglandin d2 receptor modulators
SG193902A1 (en) 2011-04-14 2013-11-29 Actelion Pharmaceuticals Ltd 7-(heteroaryl-amino)-6,7,8,9-tetrahydropyrido[1,2-a]indol acetic acid derivatives and their use as prostaglandin d2 receptor modulators
US8470884B2 (en) 2011-11-09 2013-06-25 Hoffmann-La Roche Inc. Alkenyl naphthylacetic acids
RS57867B1 (sr) 2014-03-17 2018-12-31 Idorsia Pharmaceuticals Ltd Derivati azaindol sirćetne kiseline i njihova upotreba kao modulatora receptora prostaglandina d2
AU2015233046A1 (en) 2014-03-18 2016-11-03 Idorsia Pharmaceuticals Ltd Azaindole acetic acid derivatives and their use as prostaglandin D2 receptor modulators
EP3256121B1 (en) 2015-02-13 2024-08-07 INSERM - Institut National de la Santé et de la Recherche Médicale Ptgdr-1 and/or ptgdr-2 antagonists for preventing and/or treating systemic lupus erythematosus
CN108026093B (zh) 2015-09-15 2021-11-16 爱杜西亚药品有限公司 结晶形式

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1415322A (fr) * 1963-12-09 1965-10-22 Eastman Kodak Co Nouveaux composés de 3-sulfamidocyclobutanone et de 3-sulfamidocyclobutanol
US3642816A (en) * 1967-08-10 1972-02-15 Sterling Drug Inc 3-acetamido-1 2 3 4-tetrahydrocarbazole
JPS4713658Y1 (es) * 1969-12-18 1972-05-18
CH586678A5 (es) * 1970-05-25 1977-04-15 Hoffmann La Roche
DE2226702A1 (de) * 1972-05-25 1973-12-13 Schering Ag Neue mittel zur behandlung des diabetes mellitus
JPS5186117A (en) * 1975-01-27 1976-07-28 Tanabe Seiyaku Co Johoseibiryushiseizainoseiho
US4235901A (en) * 1978-05-08 1980-11-25 American Home Products Corporation 1-Hydroxyalkanamine pyrano(3,4-b)indole compositions and use thereof

Also Published As

Publication number Publication date
PT84316A (en) 1987-03-01
KR890001982A (ko) 1989-04-07
IL81611A (en) 1991-03-10
CA1309414C (en) 1992-10-27
NO171633C (no) 1993-04-14
KR960001914B1 (en) 1996-02-06
KR940007302B1 (ko) 1994-08-12
CS8701093A2 (en) 1990-11-14
DK87187D0 (da) 1987-02-20
GR3001763T3 (en) 1992-11-23
FI870693A0 (fi) 1987-02-19
PT84316B (pt) 1989-09-14
PH24491A (en) 1990-07-18
DK167009B1 (da) 1993-08-16
FI86544B (fi) 1992-05-29
IE59470B1 (en) 1994-03-09
AU595855B2 (en) 1990-04-12
US4904797A (en) 1990-02-27
DK87187A (da) 1987-08-22
KR870007885A (ko) 1987-09-22
DE3769191D1 (de) 1991-05-16
NO870437L (no) 1987-08-24
EP0242518B1 (de) 1991-04-10
CS275837B6 (en) 1992-03-18
EP0242518A1 (de) 1987-10-28
FI86544C (fi) 1992-09-10
NO870437D0 (no) 1987-02-04
FI870693A (fi) 1987-08-22
HU198686B (en) 1989-11-28
NZ219319A (en) 1990-12-21
IE870439L (en) 1987-08-21
AU6880887A (en) 1987-08-27
DE3631824A1 (de) 1988-03-31
US4827032A (en) 1989-05-02
JPH0592954A (ja) 1993-04-16
US4965258A (en) 1990-10-23
HUT44493A (en) 1988-03-28
JPH075552B2 (ja) 1995-01-25
NO171633B (no) 1993-01-04

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