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EE200200412A - 3-aminokinasoliin-2,4-dioon kui antibakteriaalne agens - Google Patents

3-aminokinasoliin-2,4-dioon kui antibakteriaalne agens

Info

Publication number
EE200200412A
EE200200412A EEP200200412A EEP200200412A EE200200412A EE 200200412 A EE200200412 A EE 200200412A EE P200200412 A EEP200200412 A EE P200200412A EE P200200412 A EEP200200412 A EE P200200412A EE 200200412 A EE200200412 A EE 200200412A
Authority
EE
Estonia
Prior art keywords
aminoquinazoline
dione
antibacterial agent
antibacterial
agent
Prior art date
Application number
EEP200200412A
Other languages
English (en)
Estonian (et)
Inventor
Daniel Hollis Showalter Howard
Bird Paul
Lee Ellsworth Edmund
Quoc Nguyen Dai
Peter Sanchez Joseph
Singh Rajeshwar
Andrew Stier Michael
Phong Tran Tuan
Morgan Watson Brian
Yip Judy
Original Assignee
Warner-Lambert Company
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Warner-Lambert Company filed Critical Warner-Lambert Company
Publication of EE200200412A publication Critical patent/EE200200412A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/95—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in positions 2 and 4
    • C07D239/96—Two oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/10—Spiro-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Communicable Diseases (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Virology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Paper (AREA)
EEP200200412A 2000-01-24 2000-12-12 3-aminokinasoliin-2,4-dioon kui antibakteriaalne agens EE200200412A (et)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US17825200P 2000-01-24 2000-01-24
US24126700P 2000-10-18 2000-10-18
PCT/US2000/033656 WO2001053273A1 (en) 2000-01-24 2000-12-12 3-aminoquinazolin-2,4-dione antibacterial agents

Publications (1)

Publication Number Publication Date
EE200200412A true EE200200412A (et) 2003-10-15

Family

ID=26874138

Family Applications (1)

Application Number Title Priority Date Filing Date
EEP200200412A EE200200412A (et) 2000-01-24 2000-12-12 3-aminokinasoliin-2,4-dioon kui antibakteriaalne agens

Country Status (38)

Country Link
US (2) US7094780B1 (pt)
EP (1) EP1255739B1 (pt)
JP (1) JP4811978B2 (pt)
KR (1) KR20020067701A (pt)
CN (1) CN1425008A (pt)
AP (1) AP2002002603A0 (pt)
AR (1) AR030186A1 (pt)
AT (1) ATE398110T1 (pt)
AU (1) AU783078B2 (pt)
BG (1) BG107023A (pt)
BR (1) BR0017010A (pt)
CA (1) CA2393802C (pt)
CO (1) CO5320600A1 (pt)
CR (1) CR6709A (pt)
DE (1) DE60039194D1 (pt)
EA (1) EA005585B1 (pt)
EE (1) EE200200412A (pt)
ES (1) ES2304992T3 (pt)
GE (1) GEP20053429B (pt)
HK (1) HK1054237A1 (pt)
HN (1) HN2001000009A (pt)
HR (1) HRP20020696A2 (pt)
HU (1) HUP0204101A3 (pt)
IL (1) IL150393A0 (pt)
IS (1) IS6448A (pt)
MA (1) MA26866A1 (pt)
MX (1) MXPA02005989A (pt)
NO (1) NO20023516L (pt)
OA (1) OA12316A (pt)
PA (1) PA8510101A1 (pt)
PE (1) PE20011060A1 (pt)
PL (1) PL356837A1 (pt)
SK (1) SK10572002A3 (pt)
SV (1) SV2001000288A (pt)
TN (1) TNSN01011A1 (pt)
UY (1) UY26551A1 (pt)
WO (1) WO2001053273A1 (pt)
YU (1) YU55902A (pt)

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EP1395585B1 (en) 2001-05-30 2006-01-04 Warner-Lambert Company LLC Antibacterial agents
CA2446963A1 (en) * 2001-06-19 2002-12-27 Warner-Lambert Company Llc Quinazolinediones as antibacterial agents
US6900224B2 (en) * 2002-07-31 2005-05-31 The Procter & Gamble Company Antimicrobial quinolones, their compositions and uses
CA2538420A1 (en) * 2003-09-12 2005-03-24 Warner-Lambert Company Llc Quinolone antibacterial agents
WO2005026153A1 (en) * 2003-09-12 2005-03-24 Warner-Lambert Company Llc Quinazoline-2, 4-diones as antibacterial agents
MXPA06005550A (es) * 2003-11-18 2006-08-17 Warner Lambert Co Agentes antibacterianos.
WO2006019965A2 (en) * 2004-07-16 2006-02-23 Takeda San Diego, Inc. Dipeptidyl peptidase inhibitors
GB0416730D0 (en) 2004-07-27 2004-09-01 Novartis Ag Organic compounds
ES2332529T3 (es) * 2005-01-26 2010-02-08 F. Hoffmann-La Roche Ag Derivados de fenil-metanona y su empleo como inhibidores del transportador 1 de glicina.
GB0507298D0 (en) * 2005-04-11 2005-05-18 Novartis Ag Organic compounds
US7977346B2 (en) 2006-01-17 2011-07-12 Guoqing Paul Chen Spiro compounds and methods of use
MY148393A (en) 2006-03-28 2013-04-15 Taigen Biotechnology Co Ltd Malate salts, and polymorphs of (3s, 5s)-7-[3-amino-5-methyl-piperidinyl]-1-cyclopropyl-1,4-dihydro-8-methoxy-4-oxo-3-quinolinecarboxylic acid
WO2007110835A2 (en) 2006-03-28 2007-10-04 The Procter & Gamble Company A coupling process for preparing quinolone intermediates
US20080139574A1 (en) 2006-11-30 2008-06-12 Cadila Healthcare Limited Novel quinoline derivatives
WO2009096667A2 (ko) * 2008-01-30 2009-08-06 Shin Poong Pharmaceutical Co., Ltd. 신규한 퀴나졸린-2,4-디온 유도체 및 이를 함유하는 뇌신경질환 예방 및 치료용 의약 조성물
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WO2012088266A2 (en) 2010-12-22 2012-06-28 Incyte Corporation Substituted imidazopyridazines and benzimidazoles as inhibitors of fgfr3
AR085806A1 (es) 2011-03-15 2013-10-30 Trius Therapeutics Inc Inhibidores triciclicos de girasa
WO2013091539A1 (zh) * 2011-12-21 2013-06-27 江苏恒瑞医药股份有限公司 吡咯并六元杂芳环类衍生物、其制备方法及其在医药上的应用
PT3176170T (pt) 2012-06-13 2019-02-05 Incyte Holdings Corp Compostos tricíclicos substituídos como inibidores de fgfr
WO2014026125A1 (en) 2012-08-10 2014-02-13 Incyte Corporation Pyrazine derivatives as fgfr inhibitors
US10865216B2 (en) 2012-09-12 2020-12-15 Merck Sharp & Dohme Corp. Tricyclic Gyrase inhibitors
US9266892B2 (en) 2012-12-19 2016-02-23 Incyte Holdings Corporation Fused pyrazoles as FGFR inhibitors
KR102469849B1 (ko) 2013-04-19 2022-11-23 인사이트 홀딩스 코포레이션 Fgfr 저해제로서 이환식 헤테로사이클
US10851105B2 (en) 2014-10-22 2020-12-01 Incyte Corporation Bicyclic heterocycles as FGFR4 inhibitors
US9580423B2 (en) 2015-02-20 2017-02-28 Incyte Corporation Bicyclic heterocycles as FGFR4 inhibitors
MA41551A (fr) 2015-02-20 2017-12-26 Incyte Corp Hétérocycles bicycliques utilisés en tant qu'inhibiteurs de fgfr4
SG11201706287PA (en) 2015-02-20 2017-09-28 Incyte Corp Bicyclic heterocycles as fgfr inhibitors
CN108530448A (zh) * 2017-03-02 2018-09-14 浙江司太立制药股份有限公司 含有碱性氮杂螺环片段的苯并噻嗪-4-酮类化合物及其制备方法
AR111960A1 (es) 2017-05-26 2019-09-04 Incyte Corp Formas cristalinas de un inhibidor de fgfr y procesos para su preparación
PE20210920A1 (es) 2018-05-04 2021-05-19 Incyte Corp Formas solidas de un inhibidor de fgfr y procesos para prepararlas
CN112566912A (zh) 2018-05-04 2021-03-26 因赛特公司 Fgfr抑制剂的盐
CN111620866A (zh) * 2019-02-27 2020-09-04 南京药石科技股份有限公司 一种顺式-7,7-二氟-六氢-1H 吡咯并[3,4-c]吡啶衍生物及其制备方法
WO2020185532A1 (en) 2019-03-08 2020-09-17 Incyte Corporation Methods of treating cancer with an fgfr inhibitor
US11591329B2 (en) 2019-07-09 2023-02-28 Incyte Corporation Bicyclic heterocycles as FGFR inhibitors
US12122767B2 (en) 2019-10-01 2024-10-22 Incyte Corporation Bicyclic heterocycles as FGFR inhibitors
TW202128685A (zh) 2019-10-14 2021-08-01 美商英塞特公司 作為ｆｇｆｒ抑制劑之雙環雜環
US11566028B2 (en) 2019-10-16 2023-01-31 Incyte Corporation Bicyclic heterocycles as FGFR inhibitors
EP4069696A1 (en) 2019-12-04 2022-10-12 Incyte Corporation Tricyclic heterocycles as fgfr inhibitors
MX2022006691A (es) 2019-12-04 2022-09-19 Incyte Corp Derivados de un inhibidor de receptores del factor de crecimiento de fibroblastos (fgfr).
WO2021146424A1 (en) 2020-01-15 2021-07-22 Incyte Corporation Bicyclic heterocycles as fgfr inhibitors
CN111499513B (zh) * 2020-04-24 2023-03-14 上海毕得医药科技股份有限公司 一种2,3,4,5-四溴苯甲酸酯的合成方法
JP2024513575A (ja) 2021-04-12 2024-03-26 インサイト・コーポレイション Ｆｇｆｒ阻害剤及びネクチン－４標的化剤を含む併用療法
TW202313611A (zh) 2021-06-09 2023-04-01 美商英塞特公司 作為ｆｇｆｒ抑制劑之三環雜環

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Also Published As

Publication number Publication date
EA005585B1 (ru) 2005-04-28
NO20023516D0 (no) 2002-07-23
CO5320600A1 (es) 2003-09-30
ES2304992T3 (es) 2008-11-01
BG107023A (en) 2003-04-30
CN1425008A (zh) 2003-06-18
DE60039194D1 (de) 2008-07-24
IL150393A0 (en) 2002-12-01
ATE398110T1 (de) 2008-07-15
KR20020067701A (ko) 2002-08-23
HRP20020696A2 (en) 2003-12-31
WO2001053273A1 (en) 2001-07-26
HN2001000009A (es) 2001-06-13
YU55902A (sh) 2006-01-16
MA26866A1 (fr) 2004-12-20
CA2393802C (en) 2011-04-19
HUP0204101A3 (en) 2004-05-28
AU2089901A (en) 2001-07-31
PA8510101A1 (es) 2003-06-30
SV2001000288A (es) 2001-11-30
JP4811978B2 (ja) 2011-11-09
MXPA02005989A (es) 2002-10-23
EP1255739A1 (en) 2002-11-13
US20060183762A1 (en) 2006-08-17
IS6448A (is) 2002-06-27
TNSN01011A1 (en) 2005-11-10
NO20023516L (no) 2002-07-23
PE20011060A1 (es) 2001-10-12
UY26551A1 (es) 2001-04-30
CA2393802A1 (en) 2001-07-26
BR0017010A (pt) 2002-11-05
US20060287308A1 (en) 2006-12-21
SK10572002A3 (sk) 2003-10-07
US7582627B2 (en) 2009-09-01
OA12316A (en) 2006-05-15
EA200200661A1 (ru) 2003-02-27
AP2002002603A0 (en) 2002-09-30
AR030186A1 (es) 2003-08-13
AU783078B2 (en) 2005-09-22
CR6709A (es) 2003-11-25
US7094780B1 (en) 2006-08-22
EP1255739B1 (en) 2008-06-11
HUP0204101A2 (hu) 2003-04-28
GEP20053429B (en) 2005-01-25
PL356837A1 (en) 2004-07-12
JP2003520277A (ja) 2003-07-02
HK1054237A1 (zh) 2003-11-21

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