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EA201071249A1 - Режимы дозирования антипрогестинов - Google Patents

Режимы дозирования антипрогестинов

Info

Publication number
EA201071249A1
EA201071249A1 EA201071249A EA201071249A EA201071249A1 EA 201071249 A1 EA201071249 A1 EA 201071249A1 EA 201071249 A EA201071249 A EA 201071249A EA 201071249 A EA201071249 A EA 201071249A EA 201071249 A1 EA201071249 A1 EA 201071249A1
Authority
EA
Eurasian Patent Office
Prior art keywords
estrogen
antiprogestines
endometriosis
treatment
present
Prior art date
Application number
EA201071249A
Other languages
English (en)
Inventor
Джозеф С. Подольски
Original Assignee
Репрос Терапьютикс Инк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Репрос Терапьютикс Инк. filed Critical Репрос Терапьютикс Инк.
Publication of EA201071249A1 publication Critical patent/EA201071249A1/ru

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2059—Starch, including chemically or physically modified derivatives; Amylose; Amylopectin; Dextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2086—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/04—Drugs for genital or sexual disorders; Contraceptives for inducing labour or abortion; Uterotonics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/30—Oestrogens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/32—Antioestrogens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/36—Antigestagens

Landscapes

  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Endocrinology (AREA)
  • Diabetes (AREA)
  • Reproductive Health (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pregnancy & Childbirth (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Steroid Compounds (AREA)

Abstract

Настоящее изобретение относится к способам введения композиций, включающих в себя антагониста рецепторов прогестерона, для применения при лечении эстроген-зависимых состояний. Изобретение также указывает на методы лечения болей, связанных с эндометриозом. Композиции могут вводиться женщинам, больным эндометриозом, а также женщинам, проходящим лечение эстрогеном и/или селективными модуляторами рецепторов эстрогена (СМРЭ). В некоторых вариантах осуществления настоящее изобретение представляет метод для подавления эндометриального разрастания.
EA201071249A 2008-04-28 2009-04-27 Режимы дозирования антипрогестинов EA201071249A1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US4847208P 2008-04-28 2008-04-28
PCT/US2009/041826 WO2009134718A1 (en) 2008-04-28 2009-04-27 Pregesteron antagonists such as cdb-4124 in the treatment of endometriosis, uterine fibroids, dysmenorrhea, breast cancer etc

Publications (1)

Publication Number Publication Date
EA201071249A1 true EA201071249A1 (ru) 2011-08-30

Family

ID=40751037

Family Applications (3)

Application Number Title Priority Date Filing Date
EA201071249A EA201071249A1 (ru) 2008-04-28 2009-04-27 Режимы дозирования антипрогестинов
EA201401347A EA032646B1 (ru) 2008-04-28 2009-04-27 Режимы дозирования антипрогестинов
EA201990835A EA201990835A3 (ru) 2008-04-28 2009-04-27 Режимы дозирования антипрогестинов

Family Applications After (2)

Application Number Title Priority Date Filing Date
EA201401347A EA032646B1 (ru) 2008-04-28 2009-04-27 Режимы дозирования антипрогестинов
EA201990835A EA201990835A3 (ru) 2008-04-28 2009-04-27 Режимы дозирования антипрогестинов

Country Status (24)

Country Link
US (2) US8426394B2 (ru)
EP (1) EP2293797B1 (ru)
JP (1) JP5791499B2 (ru)
KR (2) KR20130059442A (ru)
CN (2) CN102014923A (ru)
AR (1) AR071516A1 (ru)
AU (1) AU2009241355B2 (ru)
BR (1) BRPI0911563A2 (ru)
CA (1) CA2722753C (ru)
CL (1) CL2009001010A1 (ru)
DK (1) DK2293797T3 (ru)
EA (3) EA201071249A1 (ru)
ES (1) ES2561810T3 (ru)
IL (1) IL208844A0 (ru)
ME (1) ME01123B (ru)
MX (1) MX2010011272A (ru)
MY (1) MY161059A (ru)
NI (1) NI201000183A (ru)
NZ (1) NZ589533A (ru)
SG (1) SG10201408483QA (ru)
TW (1) TWI477276B (ru)
UA (1) UA102849C2 (ru)
WO (1) WO2009134718A1 (ru)
ZA (1) ZA201007529B (ru)

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Also Published As

Publication number Publication date
ME01123B (me) 2013-03-20
WO2009134718A1 (en) 2009-11-05
SG10201408483QA (en) 2015-02-27
ZA201007529B (en) 2011-07-27
EP2293797A1 (en) 2011-03-16
KR20130059442A (ko) 2013-06-05
WO2009134718A8 (en) 2010-09-23
TWI477276B (zh) 2015-03-21
AU2009241355A1 (en) 2009-11-05
CN102014923A (zh) 2011-04-13
US8735381B2 (en) 2014-05-27
MY161059A (en) 2017-04-14
IL208844A0 (en) 2011-01-31
MX2010011272A (es) 2010-12-21
US20110046098A1 (en) 2011-02-24
CA2722753A1 (en) 2009-11-05
JP2011518845A (ja) 2011-06-30
NI201000183A (es) 2012-06-06
AU2009241355B2 (en) 2013-11-14
US20130289008A1 (en) 2013-10-31
EA032646B1 (ru) 2019-06-28
EA201401347A1 (ru) 2015-07-30
BRPI0911563A2 (pt) 2016-07-12
NZ589533A (en) 2012-06-29
AR071516A1 (es) 2010-06-23
UA102849C2 (ru) 2013-08-27
CL2009001010A1 (es) 2009-06-19
US8426394B2 (en) 2013-04-23
KR20110014162A (ko) 2011-02-10
EA201990835A3 (ru) 2019-12-30
EP2293797B1 (en) 2015-11-11
CN105616427A (zh) 2016-06-01
ES2561810T3 (es) 2016-03-01
EA201990835A2 (ru) 2019-08-30
JP5791499B2 (ja) 2015-10-07
DK2293797T3 (en) 2016-01-11
CA2722753C (en) 2018-07-03
TW200950786A (en) 2009-12-16

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