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EA201070422A1 - Производные оксадиазола - Google Patents

Производные оксадиазола

Info

Publication number
EA201070422A1
EA201070422A1 EA201070422A EA201070422A EA201070422A1 EA 201070422 A1 EA201070422 A1 EA 201070422A1 EA 201070422 A EA201070422 A EA 201070422A EA 201070422 A EA201070422 A EA 201070422A EA 201070422 A1 EA201070422 A1 EA 201070422A1
Authority
EA
Eurasian Patent Office
Prior art keywords
oxadiazol derivatives
oxadiazol
derivatives
compounds
formula
Prior art date
Application number
EA201070422A
Other languages
English (en)
Inventor
Анна Кваттропани
Сирил Монтань
Вольфганг Зауэр
Стефано Крозиньяни
Аньес Бомбрэн
Матильд Мюзерелль
Жером Дорбэ
Дельфин Марэн
Жером Гонзалес
Патрик Жербер
Original Assignee
Мерк Сероно С.А.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Мерк Сероно С.А. filed Critical Мерк Сероно С.А.
Publication of EA201070422A1 publication Critical patent/EA201070422A1/ru

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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/30—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D263/32—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
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    • C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings

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  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Diabetes (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Pulmonology (AREA)
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  • Biomedical Technology (AREA)
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  • Urology & Nephrology (AREA)
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  • Hospice & Palliative Care (AREA)
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  • Cardiology (AREA)
  • Obesity (AREA)
  • Heart & Thoracic Surgery (AREA)
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Abstract

Изобретение относится к соединениям формулы Iгде R, R, R, R, W, Q и S являются такими, как определено в п.1. Соединения могут быть использованы, например, при лечении аутоиммунных заболеваний, таких как рассеянный склероз.
EA201070422A 2007-10-04 2008-10-01 Производные оксадиазола EA201070422A1 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP07117921 2007-10-04
US99825407P 2007-10-09 2007-10-09
PCT/EP2008/063180 WO2009043889A2 (en) 2007-10-04 2008-10-01 Oxadiazole derivatives

Publications (1)

Publication Number Publication Date
EA201070422A1 true EA201070422A1 (ru) 2010-12-30

Family

ID=38984441

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201070422A EA201070422A1 (ru) 2007-10-04 2008-10-01 Производные оксадиазола

Country Status (15)

Country Link
US (1) US8202865B2 (ru)
EP (1) EP2193125B1 (ru)
JP (2) JP6144450B2 (ru)
KR (1) KR20100075608A (ru)
CN (1) CN101970420B (ru)
AR (1) AR068731A1 (ru)
AU (1) AU2008306885B2 (ru)
BR (1) BRPI0818457A2 (ru)
CA (1) CA2696863C (ru)
EA (1) EA201070422A1 (ru)
ES (1) ES2622423T3 (ru)
IL (1) IL204521A0 (ru)
MX (1) MX2010003612A (ru)
WO (1) WO2009043889A2 (ru)
ZA (2) ZA201001121B (ru)

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ES2450750T3 (es) 2007-03-16 2014-03-25 Actelion Pharmaceuticals Ltd. Derivados de amino-piridina como agonistas del receptor S1P1/EDG1
EP2193126B1 (en) 2007-10-04 2015-06-24 Merck Serono S.A. Oxadiazole diaryl compounds
EP2250165B1 (en) * 2007-12-21 2018-07-25 Merck Serono S.A. Triazole oxadiazoles derivatives
ES2389469T3 (es) 2008-03-07 2012-10-26 Actelion Pharmaceuticals Ltd. Derivados novedosos de aminometilbeceno
WO2010085582A1 (en) 2009-01-23 2010-07-29 Bristol-Myers Squibb Company Substituted oxadiazole derivatives as s1p agonists in the treatment of autoimmune and inflammatory diseases
CN102361867A (zh) 2009-01-23 2012-02-22 百时美施贵宝公司 在治疗自身免疫疾病和炎性疾病中作为s1p激动剂的取代的噁二唑衍生物
CN102361868A (zh) 2009-01-23 2012-02-22 百时美施贵宝公司 作为1-磷酸-鞘氨醇激动剂的吡唑-1，2，4-噁二唑衍生物
EP2241558A1 (en) * 2009-04-03 2010-10-20 Merck Serono SA Oxadiazole derivatives
GB0911130D0 (en) * 2009-06-26 2009-08-12 Glaxo Group Ltd Novel compounds
JP2012530728A (ja) * 2009-06-26 2012-12-06 グラクソ グループ リミテッド スフィンゴシン１−リン酸受容体アゴニストとして用いられる５員ヘテロアリール誘導体
AU2010272219B2 (en) 2009-07-16 2015-02-26 Idorsia Pharmaceuticals Ltd Pyridin-4-yl derivatives
US8399451B2 (en) 2009-08-07 2013-03-19 Bristol-Myers Squibb Company Heterocyclic compounds
EP2592071B1 (en) 2009-10-29 2019-09-18 Bristol-Myers Squibb Company Tricyclic heterocyclic compounds
WO2011054530A1 (en) 2009-11-05 2011-05-12 Fibrostatin, S.L. Gpbp inhibition using q2 peptidomimetics
JP2013522240A (ja) * 2010-03-17 2013-06-13 グラクソ グループ リミテッド スフィンゴシン１−リン酸１（ｓ１ｐ１）受容体作用薬として用いるためのピリミジン誘導体
ES2548683T3 (es) 2010-04-23 2015-10-20 Bristol-Myers Squibb Company Amidas del ácido 4-(5-isoxazolil o 5-pirrazolil-1,2,4-oxadiazol-3-il)-mandélico como agonistas de receptor de esfingosina-1-fosfato 1
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