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EA201000550A1 - Производные тиазола - Google Patents

Производные тиазола

Info

Publication number
EA201000550A1
EA201000550A1 EA201000550A EA201000550A EA201000550A1 EA 201000550 A1 EA201000550 A1 EA 201000550A1 EA 201000550 A EA201000550 A EA 201000550A EA 201000550 A EA201000550 A EA 201000550A EA 201000550 A1 EA201000550 A1 EA 201000550A1
Authority
EA
Eurasian Patent Office
Prior art keywords
tiazole
derivatives
tiazole derivatives
compounds
meanings
Prior art date
Application number
EA201000550A
Other languages
English (en)
Inventor
Кай Шиманн
Мелани Шультц
Андре Блаукат
Инго Кобер
Вольфганг Штэле
Original Assignee
Мерк Патент Гмбх
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Мерк Патент Гмбх filed Critical Мерк Патент Гмбх
Publication of EA201000550A1 publication Critical patent/EA201000550A1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Соединения формулы (I)в которой R, R, R, R, K, G, Е и W могут иметь значения, как указано в п.1 формулы изобретения. Указанные соединения используются для лечения опухолей.
EA201000550A 2007-10-05 2008-09-19 Производные тиазола EA201000550A1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102007047735A DE102007047735A1 (de) 2007-10-05 2007-10-05 Thiazolderivate
PCT/EP2008/007894 WO2009046842A2 (de) 2007-10-05 2008-09-19 Thialzolderivate zur behandlung von krebs

Publications (1)

Publication Number Publication Date
EA201000550A1 true EA201000550A1 (ru) 2010-10-29

Family

ID=40418145

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201000550A EA201000550A1 (ru) 2007-10-05 2008-09-19 Производные тиазола

Country Status (16)

Country Link
US (1) US8557824B2 (ru)
EP (1) EP2209777B1 (ru)
JP (2) JP2010540580A (ru)
KR (1) KR20100080836A (ru)
CN (1) CN101815714A (ru)
AR (1) AR068658A1 (ru)
AU (1) AU2008310068B2 (ru)
BR (1) BRPI0817579A2 (ru)
CA (1) CA2701525C (ru)
DE (1) DE102007047735A1 (ru)
EA (1) EA201000550A1 (ru)
ES (1) ES2548525T3 (ru)
IL (1) IL204563A (ru)
MX (1) MX2010003365A (ru)
WO (1) WO2009046842A2 (ru)
ZA (1) ZA201003123B (ru)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2121660B1 (en) * 2007-01-25 2014-12-31 E. I. Du Pont de Nemours and Company Fungicidal amides
DE102009049211A1 (de) * 2009-10-13 2011-04-28 Merck Patent Gmbh Sulfoxide
WO2012127885A1 (ja) 2011-03-18 2012-09-27 小野薬品工業株式会社 テトラヒドロカルボリン誘導体
WO2015077503A1 (en) 2013-11-22 2015-05-28 Pharmakea, Inc. Autotaxin inhibitor compounds
US9051320B1 (en) 2014-08-18 2015-06-09 Pharmakea, Inc. Methods for the treatment of metabolic disorders by a selective small molecule autotaxin inhibitor
GB201501870D0 (en) 2015-02-04 2015-03-18 Cancer Rec Tech Ltd Autotaxin inhibitors
GB201502020D0 (en) 2015-02-06 2015-03-25 Cancer Rec Tech Ltd Autotaxin inhibitory compounds
AU2016268250B2 (en) 2015-05-27 2020-08-27 Sabre Therapeutics Llc Autotaxin inhibitors and uses thereof
US10118904B2 (en) 2015-06-05 2018-11-06 Vertex Pharmaceuticals Incorporated Triazoles for the treatment of Demyelinating Diseases
WO2018106641A1 (en) 2016-12-06 2018-06-14 Vertex Pharmaceuticals Incorporated Pyrazoles for the treatment of demyelinating diseases
WO2018106643A1 (en) 2016-12-06 2018-06-14 Vertex Pharmaceuticals Incorporated Heterocyclic azoles for the treatment of demyelinating diseases
WO2018106646A1 (en) 2016-12-06 2018-06-14 Vertex Pharmaceuticals Incorporated Aminotriazoles for the treatment of demyelinating diseases
TW202110831A (zh) * 2019-06-04 2021-03-16 大陸商江蘇恆瑞醫藥股份有限公司 吡啶酮類衍生物、其製備方法及其在醫藥上的應用
AU2020311940A1 (en) 2019-07-11 2022-02-03 ESCAPE Bio, Inc. Indazoles and azaindazoles as LRRK2 inhibitors
CN113493453B (zh) * 2020-04-07 2023-06-16 江苏恒瑞医药股份有限公司 稠合芳香环类衍生物、其制备方法及其在医药上的应用

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5747469A (en) 1991-03-06 1998-05-05 Board Of Regents, The University Of Texas System Methods and compositions comprising DNA damaging agents and p53
JPH11513382A (ja) 1995-10-20 1999-11-16 ドクトル カルル トーマエ ゲゼルシャフト ミット ベシュレンクテル ハフツング ５員複素環化合物、これらの化合物を含む医薬品、それらの使用及びそれらの調製方法
GB9904387D0 (en) 1999-02-25 1999-04-21 Pharmacia & Upjohn Spa Antitumour synergistic composition
AU4972900A (en) 1999-04-08 2000-11-14 Arch Development Corporation Use of anti-vegf antibody to enhance radiation in cancer therapy
GB0230162D0 (en) 2002-12-24 2003-02-05 Metris Therapeutics Ltd Compounds useful in inhibiting angiogenesis
FR2856685B1 (fr) * 2003-06-25 2005-09-23 Merck Sante Sas Derives de thiazolylpiperidine, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent
EP1735622A2 (en) * 2004-04-13 2006-12-27 Arena Pharmaceuticals, Inc. Modulators of human g protein-coupled receptors for the treatment of hyperglycemia and related disorders
EP1637529A1 (en) 2004-09-20 2006-03-22 4Sc Ag Novel piperidin-4-yl-thiazole-carboxamide analogues as inhibitors of T-cell proliferation and uses thereof
US7601745B2 (en) * 2004-09-27 2009-10-13 4Sc Ag Heterocyclic NF-kB inhibitors
TW200738701A (en) * 2005-07-26 2007-10-16 Du Pont Fungicidal carboxamides
ATE430744T1 (de) 2005-08-18 2009-05-15 Hoffmann La Roche Thiazolylpiperidin-derivate nützlich als h3 rezeptor modulatoren
WO2007105448A1 (ja) 2006-02-28 2007-09-20 Idemitsu Kosan Co., Ltd. ナフタセン誘導体及びそれを用いた有機エレクトロルミネッセンス素子
EP1832586A1 (en) 2006-03-10 2007-09-12 Oridis Biomed Forschungs- und Entwicklungs GmbH Thiazole-piperidine derivatives in treatment of diseases of liver and the pancreas
WO2007104557A2 (en) 2006-03-15 2007-09-20 4Sc Ag Novel heterocyclic nf-kb inhibitors
EP1834954A1 (en) * 2006-03-15 2007-09-19 4Sc Ag Thiazoles as NF-kB Inhibitors (proteasome inhibitors)
US7638541B2 (en) * 2006-12-28 2009-12-29 Metabolex Inc. 5-ethyl-2-{4-[4-(4-tetrazol-1-yl-phenoxymethyl)-thiazol-2-yl]-piperidin-1-yl}-pyrimidine

Also Published As

Publication number Publication date
WO2009046842A3 (de) 2009-06-25
ES2548525T3 (es) 2015-10-19
WO2009046842A2 (de) 2009-04-16
AR068658A1 (es) 2009-11-25
US20100240676A1 (en) 2010-09-23
EP2209777A2 (de) 2010-07-28
MX2010003365A (es) 2010-04-30
ZA201003123B (en) 2011-04-28
IL204563A (en) 2017-03-30
BRPI0817579A2 (pt) 2015-04-07
AU2008310068A1 (en) 2009-04-16
DE102007047735A1 (de) 2009-04-09
CA2701525C (en) 2016-06-28
CA2701525A1 (en) 2009-04-16
CN101815714A (zh) 2010-08-25
KR20100080836A (ko) 2010-07-12
JP5843930B2 (ja) 2016-01-13
EP2209777B1 (de) 2015-07-29
IL204563A0 (en) 2010-11-30
US8557824B2 (en) 2013-10-15
JP2014240392A (ja) 2014-12-25
AU2008310068B2 (en) 2014-05-01
JP2010540580A (ja) 2010-12-24

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