DK1854800T3 - Tumorhæmmende derivater af ecteinascidin ET-743 - Google Patents

Tumorhæmmende derivater af ecteinascidin ET-743

Info

Publication number: DK1854800T3
Authority: DK; Denmark
Prior art keywords: substituted; unsubstituted; alkenyl; alkyl; alkynyl
Prior art date: 2001-07-17

Application number

DK07011446.7T

Other languages

English (en)

Inventor

Carmen Cuevas

Simon Munt

Valentin Martinez

Maria Flores

Pilar Gallego

Ignacio Manzanares

Original Assignee

Pharma Mar Sa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2001-07-17

Filing date

2002-07-17

Publication date

2012-10-01

2002-07-17 Application filed by Pharma Mar Sa filed Critical Pharma Mar Sa

2012-10-01 Application granted granted Critical

2012-10-01 Publication of DK1854800T3 publication Critical patent/DK1854800T3/da

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D515/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D515/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains four or more hetero rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Saccharide Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Plural Heterocyclic Compounds (AREA)
Hydrogenated Pyridines (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)

DK07011446.7T 2001-07-17 2002-07-17 Tumorhæmmende derivater af ecteinascidin ET-743 DK1854800T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GBGB0117402.8A GB0117402D0 (en)	2001-07-17	2001-07-17	New antitumoral derivatives of et-743
EP02747577A EP1406907B1 (en)	2001-07-17	2002-07-17	Antitumoral derivatives of et-743

Publications (1)

Publication Number	Publication Date
DK1854800T3 true DK1854800T3 (da)	2012-10-01

Family

ID=9918658

Family Applications (3)

Application Number	Title	Priority Date	Filing Date
DK02747577T DK1406907T3 (da)	2001-07-17	2002-07-17	Antitumorderivater af ET-743
DK07011446.7T DK1854800T3 (da)	2001-07-17	2002-07-17	Tumorhæmmende derivater af ecteinascidin ET-743
DK10180049.8T DK2298780T3 (da)	2001-07-17	2002-07-17	Tumorhæmmende derivater af Ecteinascidin ET-743

Family Applications Before (1)

Application Number	Title	Priority Date	Filing Date
DK02747577T DK1406907T3 (da)	2001-07-17	2002-07-17	Antitumorderivater af ET-743

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
DK10180049.8T DK2298780T3 (da)	2001-07-17	2002-07-17	Tumorhæmmende derivater af Ecteinascidin ET-743

Country Status (16)

Country	Link
US (2)	US7759345B2 (da)
EP (3)	EP2298780B1 (da)
JP (1)	JP4653950B2 (da)
AT (1)	ATE371661T1 (da)
AU (2)	AU2002317967C1 (da)
CA (1)	CA2453991C (da)
CY (2)	CY1107809T1 (da)
DE (1)	DE60222135T2 (da)
DK (3)	DK1406907T3 (da)
ES (3)	ES2291479T3 (da)
GB (1)	GB0117402D0 (da)
MX (1)	MXPA04000506A (da)
NO (2)	NO335262B1 (da)
PT (3)	PT1406907E (da)
SI (2)	SI1854800T1 (da)
WO (1)	WO2003008423A1 (da)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
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MXPA02011319A (es)	2000-05-15	2003-06-06	Pharma Mar Sa	Analogos antitumorales de ecteinascidina 743.
GB0202544D0 (en) *	2002-02-04	2002-03-20	Pharma Mar Sa	The synthesis of naturally occuring ecteinascidins and related compounds
EP1812114A2 (en) *	2004-09-29	2007-08-01	Pharma Mar S.A., Sociedad Unipersonal	Ecteinascidin compounds as anti-inflammatory agents
GB0521536D0 (en) *	2005-10-22	2005-11-30	Invibio Ltd	Fiducial marker
JP6037337B2 (ja)	2010-05-25	2016-12-07	ファルマ、マール、ソシエダード、アノニマＰｈａｒｍａＭｒｓ，Ｓ．Ａ．	エクチナサイジン化合物の製造のための合成方法
JOP20190254A1 (ar)	2017-04-27	2019-10-27	Pharma Mar Sa	مركبات مضادة للأورام
WO2024186263A1 (en) *	2023-03-07	2024-09-12	Axcynsis Therapeutics Pte. Ltd.	Antibody-drug conjugates comprising trabectedin and lurbinectedin derivatives

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JPS59225189A (ja)	1983-06-03	1984-12-18	Shionogi & Co Ltd	キノナミン誘導体およびその製造法
JPS6084288A (ja)	1983-10-13	1985-05-13	Shionogi & Co Ltd	シアノキノナミンアセテ−ト類およびその製造法
EP0309477B1 (en)	1986-06-09	1991-11-06	The Board Of Trustees Of The University Of Illinois	Ecteinascidins 729, 743, 745, 759a, 759b and 770
US5149804A (en)	1990-11-30	1992-09-22	The Board Of Trustees Of The University Of Illinois	Ecteinascidins 736 and 722
US5256663A (en)	1986-06-09	1993-10-26	The Board Of Trustees Of The University Of Illinois	Compositions comprising ecteinascidins and a method of treating herpes simplex virus infections therewith
US5089273A (en)	1986-06-09	1992-02-18	Board Of Trustees Of The University Of Illinois	Ecteinascidins 729, 743, 745, 759A, 759B and 770
US5478932A (en)	1993-12-02	1995-12-26	The Board Of Trustees Of The University Of Illinois	Ecteinascidins
US20040059112A1 (en) *	1994-02-18	2004-03-25	Rinehart Kenneth L.	Ecteinascidins
US5721362A (en) *	1996-09-18	1998-02-24	President And Fellows Of Harvard College	Process for producing ecteinascidin compounds
US5985876A (en)	1997-04-15	1999-11-16	Univ Illinois	Nucleophile substituted ecteinascidins and N-oxide ecteinascidins
EP1067933B1 (en) *	1998-04-06	2007-08-15	The Board Of Trustees Of The University Of Illinois	Semi-synthetic ecteinascidins
DE69927014T2 (de)	1998-05-05	2006-06-14	Pharma Mar Sa	Kultivierung von sessilen meerestieren
WO1999058125A1 (en)	1998-05-11	1999-11-18	Pharma Mar, S.A.	Metabolites of ecteinascidin 743
US6124292A (en) *	1998-09-30	2000-09-26	President And Fellows Of Harvard College	Synthetic analogs of ecteinascidin-743
MY164077A (en) *	1999-05-13	2017-11-30	Pharma Mar Sa	Compositions and uses of et743 for treating cancer
MY130271A (en)	1999-05-14	2007-06-29	Pharma Mar Sa	Hemisynthetic method and new compounds
JP2003520801A (ja)	2000-01-19	2003-07-08	ザ・トラスティーズ・オブ・コランビア・ユニバーシティー・イン・ザ・シティー・オブ・ニューヨーク	サフラマイシン−エクテイナシジン系列の化合物、それらの使用及び合成
US6815544B2 (en)	2000-02-11	2004-11-09	President And Fellows Of Harvard College	Synthetic process for an intermediate for ecteinascidin and phthalascidin compounds
US6569859B1 (en)	2000-02-22	2003-05-27	President And Fellows Of Harvard College	Synthetic analogs of ecteinascidin-743
MXPA02010088A (es)	2000-04-12	2004-08-19	Pharma Mar Sa	Derivados de ecteinascidina antitumorales.
US7919493B2 (en) *	2000-04-12	2011-04-05	Pharma Mar, S.A.	Anititumoral ecteinascidin derivatives
MXPA02011319A (es) *	2000-05-15	2003-06-06	Pharma Mar Sa	Analogos antitumorales de ecteinascidina 743.
US7420051B2 (en) *	2000-05-15	2008-09-02	Pharma Mar, S.A.	Synthetic process for the manufacture of an ecteinaschidin compound
EP1365808B1 (en) *	2000-11-06	2011-01-19	Pharma Mar, S.A.	Compositions for antitumour treatment containing ecteinascidin 743
PL368458A1 (en) *	2001-10-19	2005-03-21	Pharmamar S.A.	Improved use of antitumoral compound in cancer therapy
GB0202544D0 (en) *	2002-02-04	2002-03-20	Pharma Mar Sa	The synthesis of naturally occuring ecteinascidins and related compounds
GB0218813D0 (en)	2002-08-13	2002-09-18	Pharma Mar Sa	DNA sequences from an endosymbiont and their uses
GB0229793D0 (en) *	2002-12-20	2003-01-29	Pharma Mar Sa	The gene cluster involved in safracin biosynthesis and its uses for genetic engineering
GB0312407D0 (en) *	2003-05-29	2003-07-02	Pharma Mar Sau	Treatment
GB0324201D0 (en) *	2003-10-15	2003-11-19	Pharma Mar Sau	Improved antitumoral combinations
EP1689404B9 (en)	2003-11-13	2009-04-22	Pharma Mar, S.A.U.	Combination of et-743 with 5-fluorouracil pro-drugs for the treatment of cancer
CN1897949A (zh) *	2003-11-14	2007-01-17	马尔药品公司	包含使用et－743和紫杉醇来治疗癌症的联合疗法
GB0326486D0 (en) *	2003-11-14	2003-12-17	Pharma Mar Sau	Combination treatment
EP1768671A2 (en) *	2004-07-09	2007-04-04	Pharma Mar, S.A.	Use of ecteinascidin in the treatment of cancer in patients with low level of brca1
EP1812114A2 (en) *	2004-09-29	2007-08-01	Pharma Mar S.A., Sociedad Unipersonal	Ecteinascidin compounds as anti-inflammatory agents
BRPI0518250A2 (pt) *	2004-10-26	2008-11-11	Pharma Mar Sa	tratamentos anticÂncer
EP1658848B1 (en) *	2004-10-29	2007-08-01	Pharma Mar S.A., Sociedad Unipersonal	Formulations comprising ecteinascidin and a disaccharide
GB0522082D0 (en) *	2005-10-31	2005-12-07	Pharma Mar Sa	Formulations
CA2630900A1 (en) *	2005-11-25	2007-05-31	University Of Medicine And Dentistry Of New Jersey	Use of parp-1 inhibitors
EP2023931A2 (en) *	2006-05-12	2009-02-18	Pharma Mar S.A.	Anticancer treatments with a combination of docetaxel and ecteinascidin
AU2008313634A1 (en)	2007-10-19	2009-04-23	Pharma Mar, S.A.	Prognostic molecular markers for ET-743 treatment
NZ589270A (en)	2008-05-16	2011-12-22	Pharma Mar Sa	Multiple myeloma treatments
NZ589269A (en)	2008-05-16	2013-03-28	Pharma Mar Sa	Combination therapy with an antitumor alkaloid

2001
- 2001-07-17 GB GBGB0117402.8A patent/GB0117402D0/en not_active Ceased
2002
- 2002-07-17 AT AT02747577T patent/ATE371661T1/de active
- 2002-07-17 PT PT02747577T patent/PT1406907E/pt unknown
- 2002-07-17 SI SI200231003T patent/SI1854800T1/sl unknown
- 2002-07-17 ES ES02747577T patent/ES2291479T3/es not_active Expired - Lifetime
- 2002-07-17 ES ES10180049T patent/ES2394772T3/es not_active Expired - Lifetime
- 2002-07-17 DE DE60222135T patent/DE60222135T2/de not_active Expired - Lifetime
- 2002-07-17 DK DK02747577T patent/DK1406907T3/da active
- 2002-07-17 MX MXPA04000506A patent/MXPA04000506A/es active IP Right Grant
- 2002-07-17 DK DK07011446.7T patent/DK1854800T3/da active
- 2002-07-17 EP EP10180049A patent/EP2298780B1/en not_active Expired - Lifetime
- 2002-07-17 DK DK10180049.8T patent/DK2298780T3/da active
- 2002-07-17 ES ES07011446T patent/ES2389671T3/es not_active Expired - Lifetime
- 2002-07-17 PT PT101800498T patent/PT2298780E/pt unknown
- 2002-07-17 PT PT07011446T patent/PT1854800E/pt unknown
- 2002-07-17 JP JP2003513982A patent/JP4653950B2/ja not_active Expired - Lifetime
- 2002-07-17 AU AU2002317967A patent/AU2002317967C1/en not_active Expired
- 2002-07-17 CA CA2453991A patent/CA2453991C/en not_active Expired - Lifetime
- 2002-07-17 SI SI200231015T patent/SI2298780T1/sl unknown
- 2002-07-17 EP EP07011446A patent/EP1854800B1/en not_active Expired - Lifetime
- 2002-07-17 WO PCT/GB2002/003288 patent/WO2003008423A1/en active IP Right Grant
- 2002-07-17 EP EP02747577A patent/EP1406907B1/en not_active Expired - Lifetime
- 2002-07-17 US US10/484,060 patent/US7759345B2/en active Active
2004
- 2004-01-16 NO NO20040189A patent/NO335262B1/no not_active IP Right Cessation
2007
- 2007-11-21 CY CY20071101494T patent/CY1107809T1/el unknown
2008
- 2008-08-20 AU AU2008207381A patent/AU2008207381B2/en not_active Expired
2010
- 2010-04-06 US US12/755,218 patent/US8076337B2/en not_active Expired - Fee Related
2012
- 2012-09-20 CY CY20121100864T patent/CY1113359T1/el unknown
2014
- 2014-06-06 NO NO20140711A patent/NO340213B1/no not_active IP Right Cessation

Also Published As

Publication number	Publication date
DE60222135T2 (de)	2008-05-21
AU2002317967B2 (en)	2008-06-05
WO2003008423A1 (en)	2003-01-30
DK2298780T3 (da)	2013-01-07
CY1113359T1 (el)	2016-06-22
JP4653950B2 (ja)	2011-03-16
ES2291479T3 (es)	2008-03-01
US8076337B2 (en)	2011-12-13
AU2002317967C1 (en)	2009-01-22
EP1854800B1 (en)	2012-06-27
US7759345B2 (en)	2010-07-20
PT1854800E (pt)	2012-09-25
NO335262B1 (no)	2014-10-27
EP2298780B1 (en)	2012-09-12
EP1406907B1 (en)	2007-08-29
PT2298780E (pt)	2012-12-17
NO20040189L (no)	2004-03-16
NO20140711L (no)	2004-03-16
AU2008207381B2 (en)	2011-07-14
DK1406907T3 (da)	2008-02-04
CY1107809T1 (el)	2013-06-19
JP2004536132A (ja)	2004-12-02
NO340213B1 (no)	2017-03-20
PT1406907E (pt)	2007-12-10
CA2453991A1 (en)	2003-01-30
EP2298780A1 (en)	2011-03-23
ATE371661T1 (de)	2007-09-15
SI1854800T1 (sl)	2012-11-30
CA2453991C (en)	2011-12-20
US20060106021A1 (en)	2006-05-18
ES2389671T3 (es)	2012-10-30
DE60222135D1 (de)	2007-10-11
EP1854800A1 (en)	2007-11-14
AU2008207381A1 (en)	2008-09-11
GB0117402D0 (en)	2001-09-05
ES2394772T3 (es)	2013-02-05
SI2298780T1 (sl)	2013-01-31
EP1406907A1 (en)	2004-04-14
MXPA04000506A (es)	2004-07-23
US20100197695A1 (en)	2010-08-05

Publication	Publication Date	Title
CY1113359T1 (el)	2016-06-22	Αντι-νεοπλασιακα παραγωγα του et-743
MXPA04001240A (es)	2004-06-03	Analogos antitumorales.
DK1117297T3 (da)	2006-01-09	Syntetiske analoger af ecteinascidin-743
DE60033857D1 (de)	2007-04-19	Derivate des N-((Chinolinyl)oxy)-phenyl)-Harnstoffs und des N-((Chinazolinyl)oxy)-phenyl)-Harnstoffs mit Antitumor Aktivität
PT1280809E (pt)	2005-11-30	Derivados antitumorais de ecteinascidina
TW325473B (en)	1998-01-21	Azoamine derivative having methylene or substituted methylene on the amino ring
FI965020A0 (fi)	1996-12-13	Uusia yhdisteitä, menetelmiä niiden valmistamiseksi ja kasvaintenvastaisia aineita
NO972666D0 (no)	1997-06-10	Anilinderivater med nitrogenmonoksyd-synteseinhiberende aktivitet
DE60027131D1 (de)	2006-05-18	Inhibitoren für asparagin-proteasen
ATE232528T1 (de)	2003-02-15	Pyrimidinylpyrazolderivate
IE811580L (en)	1982-01-16	Herbicidal compounds
ATE550332T1 (de)	2012-04-15	4-imidazolin-2-onverbindungen als p38-map- kinaseinhibitors
HUP0200144A2 (hu)	2002-05-29	Eljárás peszticid hatású 5-amino-1-aril-3-cianopirazol-származékok előállítására és az új köztitermékek
TR200201600T2 (tr)	2002-10-21	Yer-alıma tabi tutulan, yeni, dallı 3-amino-1-fenil-1H-[1,2,4]triazol amino türevleri, bunların hazırlanması için prosesler ve bunları içeren farmasötik kompozisyonlar.
WO2004046151A3 (en)	2004-08-12	Porphyrin derivatives
GB0116966D0 (en)	2001-09-05	Anittumoral compounds
TW200637859A (en)	2006-11-01	Phenyl methanone derivatives
DK1532139T3 (da)	2007-10-15	Totalsyntese af myriaporoner