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MXPA04000506A - Nuevos derivados de et-743 antitumorales. - Google Patents

Nuevos derivados de et-743 antitumorales.

Info

Publication number
MXPA04000506A
MXPA04000506A MXPA04000506A MXPA04000506A MXPA04000506A MX PA04000506 A MXPA04000506 A MX PA04000506A MX PA04000506 A MXPA04000506 A MX PA04000506A MX PA04000506 A MXPA04000506 A MX PA04000506A MX PA04000506 A MXPA04000506 A MX PA04000506A
Authority
MX
Mexico
Prior art keywords
derivatives
new antitumoral
antitumoral derivatives
new
general formula
Prior art date
Application number
MXPA04000506A
Other languages
English (en)
Inventor
Gallego Pilar
Original Assignee
Pharma Mar Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharma Mar Sa filed Critical Pharma Mar Sa
Publication of MXPA04000506A publication Critical patent/MXPA04000506A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D515/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D515/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains four or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Hydrogenated Pyridines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Se proporcionan derivados de Et-743 o Et-770 o Et-729. Los derivados son de la formula general (la), en donde los grupos substituyentes toman varios significados permitidos. (ver formula).
MXPA04000506A 2001-07-17 2002-07-17 Nuevos derivados de et-743 antitumorales. MXPA04000506A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0117402.8A GB0117402D0 (en) 2001-07-17 2001-07-17 New antitumoral derivatives of et-743
PCT/GB2002/003288 WO2003008423A1 (en) 2001-07-17 2002-07-17 New antitumoral derivatives of et-743

Publications (1)

Publication Number Publication Date
MXPA04000506A true MXPA04000506A (es) 2004-07-23

Family

ID=9918658

Family Applications (1)

Application Number Title Priority Date Filing Date
MXPA04000506A MXPA04000506A (es) 2001-07-17 2002-07-17 Nuevos derivados de et-743 antitumorales.

Country Status (16)

Country Link
US (2) US7759345B2 (es)
EP (3) EP1406907B1 (es)
JP (1) JP4653950B2 (es)
AT (1) ATE371661T1 (es)
AU (2) AU2002317967C1 (es)
CA (1) CA2453991C (es)
CY (2) CY1107809T1 (es)
DE (1) DE60222135T2 (es)
DK (3) DK1406907T3 (es)
ES (3) ES2389671T3 (es)
GB (1) GB0117402D0 (es)
MX (1) MXPA04000506A (es)
NO (2) NO335262B1 (es)
PT (3) PT2298780E (es)
SI (2) SI2298780T1 (es)
WO (1) WO2003008423A1 (es)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MXPA02011319A (es) 2000-05-15 2003-06-06 Pharma Mar Sa Analogos antitumorales de ecteinascidina 743.
GB0202544D0 (en) * 2002-02-04 2002-03-20 Pharma Mar Sa The synthesis of naturally occuring ecteinascidins and related compounds
CA2583464A1 (en) * 2004-09-29 2006-04-06 Pharma Mar S.A., Sociedad Unipersonal Ecteinascidin compounds as anti -inflammatory agents
GB0521536D0 (en) * 2005-10-22 2005-11-30 Invibio Ltd Fiducial marker
CN103038240A (zh) 2010-05-25 2013-04-10 法马马有限公司 制备海鞘素化合物的合成方法
JOP20190254A1 (ar) 2017-04-27 2019-10-27 Pharma Mar Sa مركبات مضادة للأورام
WO2024186263A1 (en) * 2023-03-07 2024-09-12 Axcynsis Therapeutics Pte. Ltd. Antibody-drug conjugates comprising trabectedin and lurbinectedin derivatives

Family Cites Families (43)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS59225189A (ja) 1983-06-03 1984-12-18 Shionogi & Co Ltd キノナミン誘導体およびその製造法
JPS6084288A (ja) 1983-10-13 1985-05-13 Shionogi & Co Ltd シアノキノナミンアセテ−ト類およびその製造法
US5149804A (en) * 1990-11-30 1992-09-22 The Board Of Trustees Of The University Of Illinois Ecteinascidins 736 and 722
US5089273A (en) 1986-06-09 1992-02-18 Board Of Trustees Of The University Of Illinois Ecteinascidins 729, 743, 745, 759A, 759B and 770
US5256663A (en) 1986-06-09 1993-10-26 The Board Of Trustees Of The University Of Illinois Compositions comprising ecteinascidins and a method of treating herpes simplex virus infections therewith
ATE69234T1 (de) * 1986-06-09 1991-11-15 Univ Illinois Ekteinascidine 729, 743, 745, 759a, 759b and 770.
US5478932A (en) 1993-12-02 1995-12-26 The Board Of Trustees Of The University Of Illinois Ecteinascidins
US20040059112A1 (en) * 1994-02-18 2004-03-25 Rinehart Kenneth L. Ecteinascidins
US5721362A (en) * 1996-09-18 1998-02-24 President And Fellows Of Harvard College Process for producing ecteinascidin compounds
US5985876A (en) 1997-04-15 1999-11-16 Univ Illinois Nucleophile substituted ecteinascidins and N-oxide ecteinascidins
KR100603219B1 (ko) 1998-04-06 2006-07-20 더 보오드 오브 트러스티스 오브 더 유니버시티 오브 일리노이즈 반합성 엑테이나시딘
EP1076486B1 (en) 1998-05-05 2005-08-31 Pharma Mar, S.A. Culture of sessile marine animals
KR100643092B1 (ko) 1998-05-11 2006-11-10 파르마 마르, 에스.에이. 엑테인아시딘 743의 대사산물
US6124292A (en) * 1998-09-30 2000-09-26 President And Fellows Of Harvard College Synthetic analogs of ecteinascidin-743
MY164077A (en) * 1999-05-13 2017-11-30 Pharma Mar Sa Compositions and uses of et743 for treating cancer
AR035842A1 (es) 1999-05-14 2004-07-21 Pharma Mar Sa Metodo de hemisintesis para la formacion de compuestos intermediarios y derivados y de estructuras relacionadas con la ecteinascidina y de tetrahidroisoquinolinfenoles y compuestos intermediarios de aplicacion en dicho metodo
CA2397597A1 (en) 2000-01-19 2001-07-26 The Trustees Of Columbia University In The City Of New York Compounds of the saframycin-ecteinascidin series, uses, and synthesis thereof
US6815544B2 (en) 2000-02-11 2004-11-09 President And Fellows Of Harvard College Synthetic process for an intermediate for ecteinascidin and phthalascidin compounds
US6569859B1 (en) 2000-02-22 2003-05-27 President And Fellows Of Harvard College Synthetic analogs of ecteinascidin-743
US7919493B2 (en) * 2000-04-12 2011-04-05 Pharma Mar, S.A. Anititumoral ecteinascidin derivatives
WO2001077115A1 (en) 2000-04-12 2001-10-18 Pharma Mar, S.A. Antitumoral ecteinascidin derivatives
US7420051B2 (en) * 2000-05-15 2008-09-02 Pharma Mar, S.A. Synthetic process for the manufacture of an ecteinaschidin compound
MXPA02011319A (es) 2000-05-15 2003-06-06 Pharma Mar Sa Analogos antitumorales de ecteinascidina 743.
CN100374162C (zh) * 2000-11-06 2008-03-12 法马马有限公司 海鞘素－743在制备用于治疗肿瘤的药剂中的应用
CA2462502A1 (en) * 2001-10-19 2003-05-15 Pharma Mar, S.A. Improved use of antitumoral compound in cancer therapy
GB0202544D0 (en) * 2002-02-04 2002-03-20 Pharma Mar Sa The synthesis of naturally occuring ecteinascidins and related compounds
GB0218813D0 (en) 2002-08-13 2002-09-18 Pharma Mar Sa DNA sequences from an endosymbiont and their uses
GB0229793D0 (en) * 2002-12-20 2003-01-29 Pharma Mar Sa The gene cluster involved in safracin biosynthesis and its uses for genetic engineering
GB0312407D0 (en) * 2003-05-29 2003-07-02 Pharma Mar Sau Treatment
GB0324201D0 (en) * 2003-10-15 2003-11-19 Pharma Mar Sau Improved antitumoral combinations
PL1689404T3 (pl) 2003-11-13 2009-02-27 Pharma Mar Sau Połączenie ET-743 z pro lekami 5-fluorouracylu do leczenia raka
GB0326486D0 (en) * 2003-11-14 2003-12-17 Pharma Mar Sau Combination treatment
EP1691809A1 (en) * 2003-11-14 2006-08-23 Pharma Mar, S.A. Combination therapy comprising the use of et-743 and paclitaxel for treating cancer
US20080293725A1 (en) * 2004-07-09 2008-11-27 Rafael Rosell Costa Prognostic Molecular Markers
CA2583464A1 (en) * 2004-09-29 2006-04-06 Pharma Mar S.A., Sociedad Unipersonal Ecteinascidin compounds as anti -inflammatory agents
UA87877C2 (en) * 2004-10-26 2009-08-25 Фарма Мар С.А., Сосьедад Униперсональ Pegylated liposomal doxorubicin in combination with ecteinescidin 743
DK1658848T3 (da) * 2004-10-29 2007-11-26 Pharma Mar Sa Formuleringer omfattende ecteinascidin og et disaccharid
GB0522082D0 (en) * 2005-10-31 2005-12-07 Pharma Mar Sa Formulations
DE602006020335D1 (de) * 2005-11-25 2011-04-07 Pharma Mar Sa Verwendung von parp-1-hemmern
US20100009906A1 (en) * 2006-05-12 2010-01-14 Pharma Mar, S.A. Anticancer Treatments
JP2011500046A (ja) 2007-10-19 2011-01-06 ファルマ・マール・ソシエダード・アノニマ Ｅｔ−７４３治療のための予後分子マーカー
CA2724325A1 (en) 2008-05-16 2009-11-19 Pharma Mar, S.A. Combination therapy with an antitumor alkaloid
RU2519750C2 (ru) 2008-05-16 2014-06-20 Фарма Мар, С.А. Способы лечения множественной миеломы

Also Published As

Publication number Publication date
SI2298780T1 (sl) 2013-01-31
ES2291479T3 (es) 2008-03-01
US7759345B2 (en) 2010-07-20
DE60222135D1 (de) 2007-10-11
EP1854800A1 (en) 2007-11-14
JP2004536132A (ja) 2004-12-02
DK2298780T3 (da) 2013-01-07
DE60222135T2 (de) 2008-05-21
JP4653950B2 (ja) 2011-03-16
CA2453991C (en) 2011-12-20
EP1406907A1 (en) 2004-04-14
DK1854800T3 (da) 2012-10-01
EP2298780B1 (en) 2012-09-12
SI1854800T1 (sl) 2012-11-30
US20100197695A1 (en) 2010-08-05
US20060106021A1 (en) 2006-05-18
DK1406907T3 (da) 2008-02-04
ES2394772T3 (es) 2013-02-05
PT2298780E (pt) 2012-12-17
AU2008207381B2 (en) 2011-07-14
GB0117402D0 (en) 2001-09-05
CA2453991A1 (en) 2003-01-30
NO20040189L (no) 2004-03-16
ES2389671T3 (es) 2012-10-30
NO20140711L (no) 2004-03-16
PT1406907E (pt) 2007-12-10
WO2003008423A1 (en) 2003-01-30
NO335262B1 (no) 2014-10-27
AU2002317967C1 (en) 2009-01-22
CY1107809T1 (el) 2013-06-19
EP1854800B1 (en) 2012-06-27
NO340213B1 (no) 2017-03-20
AU2002317967B2 (en) 2008-06-05
AU2008207381A1 (en) 2008-09-11
US8076337B2 (en) 2011-12-13
EP1406907B1 (en) 2007-08-29
EP2298780A1 (en) 2011-03-23
CY1113359T1 (el) 2016-06-22
ATE371661T1 (de) 2007-09-15
PT1854800E (pt) 2012-09-25

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