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CY1107809T1 - Αντι-νεοπλασιακα παραγωγα του et-743 - Google Patents

Αντι-νεοπλασιακα παραγωγα του et-743

Info

Publication number
CY1107809T1
CY1107809T1 CY20071101494T CY071101494T CY1107809T1 CY 1107809 T1 CY1107809 T1 CY 1107809T1 CY 20071101494 T CY20071101494 T CY 20071101494T CY 071101494 T CY071101494 T CY 071101494T CY 1107809 T1 CY1107809 T1 CY 1107809T1
Authority
CY
Cyprus
Prior art keywords
substituted
unsubstituted
alkenyl
alkyl
alkynyl
Prior art date
Application number
CY20071101494T
Other languages
English (en)
Inventor
Valentin Martinez
Maria Flores
Pilar Gallego
Carmen Cuevas
Simon Munt
Ignacio Manzanares
Original Assignee
Pharma Mar S.A.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharma Mar S.A. filed Critical Pharma Mar S.A.
Publication of CY1107809T1 publication Critical patent/CY1107809T1/el

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D515/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D515/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains four or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Saccharide Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

Παρέχονται παράγωγα του Et-743 ή του Et-770 ή του Et-729. Τα παράγωγα είναι του γενικού τύπου (la) όπου οι ομάδες υποκαταστατών λαμβάνουν διάφορες επιτρεπόμενες σημασίες.
CY20071101494T 2001-07-17 2007-11-21 Αντι-νεοπλασιακα παραγωγα του et-743 CY1107809T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0117402.8A GB0117402D0 (en) 2001-07-17 2001-07-17 New antitumoral derivatives of et-743
EP02747577A EP1406907B1 (en) 2001-07-17 2002-07-17 Antitumoral derivatives of et-743

Publications (1)

Publication Number Publication Date
CY1107809T1 true CY1107809T1 (el) 2013-06-19

Family

ID=9918658

Family Applications (2)

Application Number Title Priority Date Filing Date
CY20071101494T CY1107809T1 (el) 2001-07-17 2007-11-21 Αντι-νεοπλασιακα παραγωγα του et-743
CY20121100864T CY1113359T1 (el) 2001-07-17 2012-09-20 Αντι-νεοπλασιακα παραγωγα του et-743

Family Applications After (1)

Application Number Title Priority Date Filing Date
CY20121100864T CY1113359T1 (el) 2001-07-17 2012-09-20 Αντι-νεοπλασιακα παραγωγα του et-743

Country Status (16)

Country Link
US (2) US7759345B2 (el)
EP (3) EP2298780B1 (el)
JP (1) JP4653950B2 (el)
AT (1) ATE371661T1 (el)
AU (2) AU2002317967C1 (el)
CA (1) CA2453991C (el)
CY (2) CY1107809T1 (el)
DE (1) DE60222135T2 (el)
DK (3) DK2298780T3 (el)
ES (3) ES2394772T3 (el)
GB (1) GB0117402D0 (el)
MX (1) MXPA04000506A (el)
NO (2) NO335262B1 (el)
PT (3) PT1854800E (el)
SI (2) SI1854800T1 (el)
WO (1) WO2003008423A1 (el)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MXPA02011319A (es) * 2000-05-15 2003-06-06 Pharma Mar Sa Analogos antitumorales de ecteinascidina 743.
GB0202544D0 (en) * 2002-02-04 2002-03-20 Pharma Mar Sa The synthesis of naturally occuring ecteinascidins and related compounds
WO2006035244A2 (en) * 2004-09-29 2006-04-06 Pharma Mar S.A., Sociedad Unipersonal Ecteinascidin compounds as anti -inflammatory agents
GB0521536D0 (en) * 2005-10-22 2005-11-30 Invibio Ltd Fiducial marker
CN103038240A (zh) 2010-05-25 2013-04-10 法马马有限公司 制备海鞘素化合物的合成方法
JOP20190254A1 (ar) 2017-04-27 2019-10-27 Pharma Mar Sa مركبات مضادة للأورام
WO2024186263A1 (en) * 2023-03-07 2024-09-12 Axcynsis Therapeutics Pte. Ltd. Antibody-drug conjugates comprising trabectedin and lurbinectedin derivatives

Family Cites Families (43)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS59225189A (ja) 1983-06-03 1984-12-18 Shionogi & Co Ltd キノナミン誘導体およびその製造法
JPS6084288A (ja) 1983-10-13 1985-05-13 Shionogi & Co Ltd シアノキノナミンアセテ−ト類およびその製造法
US5089273A (en) 1986-06-09 1992-02-18 Board Of Trustees Of The University Of Illinois Ecteinascidins 729, 743, 745, 759A, 759B and 770
US5149804A (en) * 1990-11-30 1992-09-22 The Board Of Trustees Of The University Of Illinois Ecteinascidins 736 and 722
WO1987007610A2 (en) * 1986-06-09 1987-12-17 University Of Illinois Ecteinascidins 729, 743, 745, 759a, 759b and 770
US5256663A (en) 1986-06-09 1993-10-26 The Board Of Trustees Of The University Of Illinois Compositions comprising ecteinascidins and a method of treating herpes simplex virus infections therewith
US5478932A (en) * 1993-12-02 1995-12-26 The Board Of Trustees Of The University Of Illinois Ecteinascidins
US20040059112A1 (en) * 1994-02-18 2004-03-25 Rinehart Kenneth L. Ecteinascidins
US5721362A (en) 1996-09-18 1998-02-24 President And Fellows Of Harvard College Process for producing ecteinascidin compounds
US5985876A (en) * 1997-04-15 1999-11-16 Univ Illinois Nucleophile substituted ecteinascidins and N-oxide ecteinascidins
IL138856A0 (en) * 1998-04-06 2001-10-31 Univ Illinois Semi-synthetic ecteinascidins
AU759494B2 (en) * 1998-05-05 2003-04-17 Pharma Mar S.A. Culture of sessile marine animals
JP4583598B2 (ja) * 1998-05-11 2010-11-17 ファルマ・マール・ソシエダード・アノニマ エクテイナシジン７４３の代謝産物
US6124292A (en) * 1998-09-30 2000-09-26 President And Fellows Of Harvard College Synthetic analogs of ecteinascidin-743
MY164077A (en) * 1999-05-13 2017-11-30 Pharma Mar Sa Compositions and uses of et743 for treating cancer
AR035842A1 (es) * 1999-05-14 2004-07-21 Pharma Mar Sa Metodo de hemisintesis para la formacion de compuestos intermediarios y derivados y de estructuras relacionadas con la ecteinascidina y de tetrahidroisoquinolinfenoles y compuestos intermediarios de aplicacion en dicho metodo
US6686470B2 (en) * 2000-01-19 2004-02-03 The Trustees Of Columbia University In The City Of New York Compounds of the saframycin-ecteinascidin series, uses, and synthesis thereof
US6815544B2 (en) * 2000-02-11 2004-11-09 President And Fellows Of Harvard College Synthetic process for an intermediate for ecteinascidin and phthalascidin compounds
US6569859B1 (en) * 2000-02-22 2003-05-27 President And Fellows Of Harvard College Synthetic analogs of ecteinascidin-743
US7919493B2 (en) * 2000-04-12 2011-04-05 Pharma Mar, S.A. Anititumoral ecteinascidin derivatives
BRPI0110024B8 (pt) 2000-04-12 2021-05-25 Pharma Mar Sa derivados de ecteinascidina antitumorais, composição farmacêutica que os compreende e uso dos mesmos
MXPA02011319A (es) * 2000-05-15 2003-06-06 Pharma Mar Sa Analogos antitumorales de ecteinascidina 743.
US7420051B2 (en) * 2000-05-15 2008-09-02 Pharma Mar, S.A. Synthetic process for the manufacture of an ecteinaschidin compound
ATE495793T1 (de) * 2000-11-06 2011-02-15 Pharma Mar Sa Antitumorzusammensetzungen welche ecteinascidin 743 enthalten
CA2462502A1 (en) * 2001-10-19 2003-05-15 Pharma Mar, S.A. Improved use of antitumoral compound in cancer therapy
GB0202544D0 (en) * 2002-02-04 2002-03-20 Pharma Mar Sa The synthesis of naturally occuring ecteinascidins and related compounds
GB0218813D0 (en) * 2002-08-13 2002-09-18 Pharma Mar Sa DNA sequences from an endosymbiont and their uses
GB0229793D0 (en) * 2002-12-20 2003-01-29 Pharma Mar Sa The gene cluster involved in safracin biosynthesis and its uses for genetic engineering
GB0312407D0 (en) * 2003-05-29 2003-07-02 Pharma Mar Sau Treatment
GB0324201D0 (en) * 2003-10-15 2003-11-19 Pharma Mar Sau Improved antitumoral combinations
DK1689404T3 (da) * 2003-11-13 2009-01-26 Pharma Mar Sau Kombination af et-743 med 5-fluoracil-prodrugs til behandling af cancer
GB0326486D0 (en) * 2003-11-14 2003-12-17 Pharma Mar Sau Combination treatment
EP1691809A1 (en) * 2003-11-14 2006-08-23 Pharma Mar, S.A. Combination therapy comprising the use of et-743 and paclitaxel for treating cancer
NZ552607A (en) * 2004-07-09 2009-07-31 Pharma Mar Sa Prognostic molecular markers
WO2006035244A2 (en) * 2004-09-29 2006-04-06 Pharma Mar S.A., Sociedad Unipersonal Ecteinascidin compounds as anti -inflammatory agents
UA87877C2 (en) * 2004-10-26 2009-08-25 Фарма Мар С.А., Сосьедад Униперсональ Pegylated liposomal doxorubicin in combination with ecteinescidin 743
ATE368461T1 (de) * 2004-10-29 2007-08-15 Pharma Mar Sa Zusammensetzungen enthaltend ecteinascidin und einen disaccharide
GB0522082D0 (en) * 2005-10-31 2005-12-07 Pharma Mar Sa Formulations
AU2006318226A1 (en) * 2005-11-25 2007-05-31 Pharma Mar, S.A. Sociedad Unipersonal Use of PARP-1 inhibitors
AU2007249281A1 (en) * 2006-05-12 2007-11-22 Pharma Mar, S.A. Anticancer treatments with a combination of docetaxel and ecteinascidin
CA2703026A1 (en) 2007-10-19 2009-04-23 Rafael Rosell Costa Prognostic molecular markers for et-743 treatment
RU2010151602A (ru) 2008-05-16 2012-06-27 Фарма Мар, С.А. (Es) Комбинированная терапия с помощью рм00104 и другого противоопухолевого средства
EP2303274A1 (en) 2008-05-16 2011-04-06 Pharma Mar S.A. Multiple myeloma treatments

Also Published As

Publication number Publication date
DE60222135T2 (de) 2008-05-21
DK1854800T3 (da) 2012-10-01
NO20040189L (no) 2004-03-16
CA2453991C (en) 2011-12-20
MXPA04000506A (es) 2004-07-23
ATE371661T1 (de) 2007-09-15
SI2298780T1 (sl) 2013-01-31
DK1406907T3 (da) 2008-02-04
WO2003008423A1 (en) 2003-01-30
ES2389671T3 (es) 2012-10-30
EP1406907B1 (en) 2007-08-29
JP4653950B2 (ja) 2011-03-16
ES2291479T3 (es) 2008-03-01
DK2298780T3 (da) 2013-01-07
US20100197695A1 (en) 2010-08-05
CA2453991A1 (en) 2003-01-30
AU2002317967B2 (en) 2008-06-05
DE60222135D1 (de) 2007-10-11
CY1113359T1 (el) 2016-06-22
US8076337B2 (en) 2011-12-13
EP1854800A1 (en) 2007-11-14
US7759345B2 (en) 2010-07-20
EP2298780B1 (en) 2012-09-12
AU2008207381A1 (en) 2008-09-11
PT2298780E (pt) 2012-12-17
AU2002317967C1 (en) 2009-01-22
JP2004536132A (ja) 2004-12-02
EP2298780A1 (en) 2011-03-23
EP1854800B1 (en) 2012-06-27
PT1854800E (pt) 2012-09-25
EP1406907A1 (en) 2004-04-14
NO335262B1 (no) 2014-10-27
AU2008207381B2 (en) 2011-07-14
SI1854800T1 (sl) 2012-11-30
NO20140711L (no) 2004-03-16
GB0117402D0 (en) 2001-09-05
US20060106021A1 (en) 2006-05-18
PT1406907E (pt) 2007-12-10
NO340213B1 (no) 2017-03-20
ES2394772T3 (es) 2013-02-05

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