DK169071B1 - Benzacetamidderivater, fremgangsmåder til deres fremstilling samt et farmaceutisk præparat indeholdende et sådant derivat - Google Patents
Benzacetamidderivater, fremgangsmåder til deres fremstilling samt et farmaceutisk præparat indeholdende et sådant derivat Download PDFInfo
- Publication number
- DK169071B1 DK169071B1 DK470087A DK470087A DK169071B1 DK 169071 B1 DK169071 B1 DK 169071B1 DK 470087 A DK470087 A DK 470087A DK 470087 A DK470087 A DK 470087A DK 169071 B1 DK169071 B1 DK 169071B1
- Authority
- DK
- Denmark
- Prior art keywords
- trans
- pyrrolidin
- methyl
- dichloro
- tetrahydronaphth
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/32—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
- C07D295/135—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/10—Antioedematous agents; Diuretics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C233/34—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups
- C07C233/41—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a ring other than a six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/23—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
- C07C323/39—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton at least one of the nitrogen atoms being part of any of the groups, X being a hetero atom, Y being any atom
- C07C323/40—Y being a hydrogen or a carbon atom
- C07C323/41—Y being a hydrogen or an acyclic carbon atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2602/00—Systems containing two condensed rings
- C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
- C07C2602/04—One of the condensed rings being a six-membered aromatic ring
- C07C2602/10—One of the condensed rings being a six-membered aromatic ring the other ring being six-membered, e.g. tetraline
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Neurology (AREA)
- Pain & Pain Management (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Polyesters Or Polycarbonates (AREA)
- Luminescent Compositions (AREA)
- Indole Compounds (AREA)
- Heterocyclic Compounds Containing Sulfur Atoms (AREA)
- Pyrane Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Pyrrole Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Lubricants (AREA)
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US90554386A | 1986-09-10 | 1986-09-10 | |
US90554386 | 1986-09-10 | ||
US7102887 | 1987-07-16 | ||
US07/071,028 US4876269A (en) | 1986-09-10 | 1987-07-16 | Benoz-fused cycloalkane trans-1,2-diamine derivatives |
Publications (3)
Publication Number | Publication Date |
---|---|
DK470087D0 DK470087D0 (da) | 1987-09-09 |
DK470087A DK470087A (da) | 1988-03-11 |
DK169071B1 true DK169071B1 (da) | 1994-08-08 |
Family
ID=26751758
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK470087A DK169071B1 (da) | 1986-09-10 | 1987-09-09 | Benzacetamidderivater, fremgangsmåder til deres fremstilling samt et farmaceutisk præparat indeholdende et sådant derivat |
Country Status (20)
Country | Link |
---|---|
US (1) | US4876269A (de) |
EP (1) | EP0260555B1 (de) |
JP (1) | JPH0819065B2 (de) |
KR (1) | KR960009421B1 (de) |
AT (1) | ATE75223T1 (de) |
AU (1) | AU607935B2 (de) |
CA (1) | CA1341024C (de) |
DE (1) | DE3778463D1 (de) |
DK (1) | DK169071B1 (de) |
ES (1) | ES2040721T3 (de) |
FI (1) | FI88298C (de) |
GR (1) | GR3004962T3 (de) |
HU (1) | HU198016B (de) |
IE (1) | IE60423B1 (de) |
IL (1) | IL83842A (de) |
MX (1) | MX170515B (de) |
NO (1) | NO172934C (de) |
NZ (1) | NZ221726A (de) |
PT (1) | PT85668B (de) |
SU (1) | SU1582984A3 (de) |
Families Citing this family (26)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5234944A (en) * | 1986-08-21 | 1993-08-10 | Roussel Uclaf | Novel indanes |
US6271395B1 (en) * | 1978-08-19 | 2001-08-07 | Hoechst Marion Roussol | Substituted with an N-methyl benzene-acetamide and 1-pyrrolidinyl |
FR2640625B2 (fr) * | 1986-08-21 | 1993-05-21 | Roussel Uclaf | Nouveaux composes optiquement actifs derives de l'indane, leur application comme medicaments et les compositions pharmaceutiques les renfermant |
EP0258096B1 (de) * | 1986-08-21 | 1992-09-09 | Roussel-Uclaf | Indanderivate, Verfahren zu ihrer Herstellung, ihre Verwendung als Arzneimittel, diese enthaltende pharmazeutische Zusammensetzungen und erhaltene Zwischenprodukte |
FR2608598B1 (fr) * | 1986-12-23 | 1989-04-14 | Roussel Uclaf | Nouveaux derives de l'indane, leur procede de preparation et les nouveaux intermediaires ainsi obtenus, leur application comme medicaments et les compositions les renfermant |
FR2627491B1 (fr) * | 1988-02-18 | 1992-01-24 | Roussel Uclaf | Nouveaux derives du benzocyclohexane et du benzocycloheptane ainsi que leurs sels, leur procede de preparation et les nouveaux intermediaires ainsi obtenus, leur application comme medicaments et les compositions les renfermant |
AU626949B2 (en) * | 1988-12-06 | 1992-08-13 | Warner-Lambert Company | 2-amino-4 or 5-methoxycyclohexyl amides useful as analgesics |
US5348971A (en) * | 1988-12-16 | 1994-09-20 | Roussel Uclaf | Indanes useful as analgesics |
DK626889A (da) * | 1988-12-16 | 1990-06-17 | Roussel Uclaf | Indanderivater, deres fremstilling samt laegemidler med indhold deraf |
US5239090A (en) * | 1989-02-01 | 1993-08-24 | Beecham Group P.L.C. | Certain optically active 3,4-dihydrobenzopyran-4-ols which are intermediates |
GB8902118D0 (en) * | 1989-02-01 | 1989-03-22 | Beecham Group Plc | Chemical process |
JP2931986B2 (ja) * | 1989-02-17 | 1999-08-09 | 武田薬品工業株式会社 | アラルキルアミン誘導体 |
US5063242A (en) * | 1989-04-21 | 1991-11-05 | Warner-Lambert Company | 7-((substituted)amino)-8-((substituted)carbonyl)-methylamino-1-oxaspiro[4,5]decanes as diuretics antiinflammatory, and cerebrovascular agents |
US4965278A (en) | 1989-04-21 | 1990-10-23 | Warner-Lambert Company | 7-(substituted)amino)-8-((substituted)carbonyl)-methylamino)-1-oxaspiro[4,5]decanes as diuretics antiiflammatory, and cerebrovascular agents |
US5545755A (en) * | 1989-05-31 | 1996-08-13 | The Upjohn Company | Therapeutically useful 2-aminotetralin derivatives |
WO1992006967A1 (en) * | 1990-10-12 | 1992-04-30 | The Upjohn Company | Therapeutically useful 2-aminotetralin derivatives |
ATE172712T1 (de) | 1989-05-31 | 1998-11-15 | Upjohn Co | Zns-wirksame 8-heterocyclyl-2-aminotetralin derivate |
US5130330A (en) * | 1990-01-31 | 1992-07-14 | G. D. Searle & Co. | Nitrogen-containing cyclohetero cycloalkylaminoaryl derivatives for cns disorders |
DK0530335T3 (da) * | 1991-03-15 | 1996-10-14 | Hoffmann La Roche | Disphosphonsyrederivater som mellemprodukter til fremstillingen af diphosphinligander |
US5317028A (en) * | 1992-09-08 | 1994-05-31 | Warner-Lambert Co. | 7-((substituted)amino)-8((substituted)carbonyl)-methylamino-1-oxaspiro(4,5)decanes useful in Parkinson's disease, dystonia, and other movement disorders |
US6239154B1 (en) | 1996-03-08 | 2001-05-29 | Adolor Corporation | Kappa agonist compounds pharmaceutical formulations and method of prevention and treatment of pruritus therewith |
US5646151A (en) * | 1996-03-08 | 1997-07-08 | Adolor Corporation | Kappa agonist compounds and pharmaceutical formulations thereof |
US5763445A (en) | 1996-03-08 | 1998-06-09 | Adolor Corporation | Kappa agonist compounds pharmaceutical formulations and method of prevention and treatment of pruritus therewith |
WO1999003459A1 (en) * | 1997-07-14 | 1999-01-28 | Adolor Corporation | Kappa agonist anti-pruritic pharmaceutical formulations and method of treating pruritus therewith |
US5760023A (en) * | 1997-07-14 | 1998-06-02 | Adolor Corporation | Kappa agonist anti-pruritic pharmaceutical formulations and method of treating pruritus therewith |
WO2024040266A2 (en) * | 2022-08-19 | 2024-02-22 | Mitokinin, Inc. | Disubstituted benzoimidazole and indole analogs as modulators of pink1 |
Family Cites Families (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4145435A (en) * | 1976-11-12 | 1979-03-20 | The Upjohn Company | 2-aminocycloaliphatic amide compounds |
US4098904A (en) * | 1976-11-12 | 1978-07-04 | The Upjohn Company | Analgesic n-(2-aminocycloaliphatic)benzamides |
US4212878A (en) * | 1978-01-26 | 1980-07-15 | The Upjohn Company | Phenylacetamide derivative analgesics |
CA1109080A (en) * | 1978-05-30 | 1981-09-15 | Hideo Kato | Indanamine derivatives |
US4359476A (en) * | 1981-04-09 | 1982-11-16 | The Upjohn Company | Adjacently substituted cycloalkane-amide analgesics |
US4466977A (en) * | 1981-04-09 | 1984-08-21 | The Upjohn Company | N-[2-Amino(oxy- or thia- group-substituted-cycloaliphatic)]benzeneacetamides and -benzamide analgesics |
US4460600A (en) * | 1981-04-09 | 1984-07-17 | The Upjohn Company | Adjacently substituted ketal derivatives of cycloalkane-amide analgesics |
GB2096607B (en) * | 1981-04-09 | 1985-02-27 | Upjohn Co | Aminocycloalkyl amides |
US4360531A (en) * | 1981-04-09 | 1982-11-23 | The Upjohn Company | Substituted cycloalkanes |
US4438130A (en) * | 1981-11-12 | 1984-03-20 | The Upjohn Company | Analgesic 1-oxa-, aza- and thia-spirocyclic compounds |
US4560767A (en) * | 1983-06-17 | 1985-12-24 | The Upjohn Company | N-(2-amino-cycloalkenyl)benzeneacetamide and -benzamide analgesics and tritiated kappa agonists therefrom |
US4656182A (en) * | 1983-12-06 | 1987-04-07 | Warner-Lambert Company | Substituted trans-1,2-diaminocyclohexyl amide compounds |
US4632935A (en) * | 1984-05-30 | 1986-12-30 | The Upjohn Company | Omega-(hydroxy-, ether and ester)-alkyl-2-amino-cycloalkyl- and cycloalkenyl amides as analgesics |
EP0258096B1 (de) * | 1986-08-21 | 1992-09-09 | Roussel-Uclaf | Indanderivate, Verfahren zu ihrer Herstellung, ihre Verwendung als Arzneimittel, diese enthaltende pharmazeutische Zusammensetzungen und erhaltene Zwischenprodukte |
-
1987
- 1987-07-16 US US07/071,028 patent/US4876269A/en not_active Expired - Lifetime
- 1987-09-05 ES ES87113010T patent/ES2040721T3/es not_active Expired - Lifetime
- 1987-09-05 DE DE8787113010T patent/DE3778463D1/de not_active Expired - Lifetime
- 1987-09-05 AT AT87113010T patent/ATE75223T1/de not_active IP Right Cessation
- 1987-09-05 EP EP87113010A patent/EP0260555B1/de not_active Expired - Lifetime
- 1987-09-08 NZ NZ221726A patent/NZ221726A/en unknown
- 1987-09-08 CA CA000546354A patent/CA1341024C/en not_active Expired - Fee Related
- 1987-09-09 IE IE240687A patent/IE60423B1/en not_active IP Right Cessation
- 1987-09-09 IL IL83842A patent/IL83842A/xx unknown
- 1987-09-09 NO NO87873762A patent/NO172934C/no unknown
- 1987-09-09 DK DK470087A patent/DK169071B1/da not_active IP Right Cessation
- 1987-09-09 FI FI873896A patent/FI88298C/fi not_active IP Right Cessation
- 1987-09-09 SU SU874203411A patent/SU1582984A3/ru active
- 1987-09-09 JP JP62224204A patent/JPH0819065B2/ja not_active Expired - Lifetime
- 1987-09-09 PT PT85668A patent/PT85668B/pt not_active IP Right Cessation
- 1987-09-09 HU HU874018A patent/HU198016B/hu not_active IP Right Cessation
- 1987-09-10 KR KR87010028A patent/KR960009421B1/ko not_active IP Right Cessation
- 1987-09-10 MX MX008173A patent/MX170515B/es unknown
- 1987-09-10 AU AU78224/87A patent/AU607935B2/en not_active Ceased
-
1992
- 1992-06-18 GR GR920401296T patent/GR3004962T3/el unknown
Also Published As
Publication number | Publication date |
---|---|
FI88298C (fi) | 1993-04-26 |
JPH0819065B2 (ja) | 1996-02-28 |
DK470087A (da) | 1988-03-11 |
EP0260555A1 (de) | 1988-03-23 |
NO873762D0 (no) | 1987-09-09 |
EP0260555B1 (de) | 1992-04-22 |
KR960009421B1 (en) | 1996-07-19 |
IL83842A (en) | 1991-06-30 |
HUT47076A (en) | 1989-01-30 |
GR3004962T3 (de) | 1993-04-28 |
CA1341024C (en) | 2000-06-13 |
KR880003906A (ko) | 1988-05-31 |
MX170515B (es) | 1993-08-27 |
JPS63146852A (ja) | 1988-06-18 |
ATE75223T1 (de) | 1992-05-15 |
FI873896A0 (fi) | 1987-09-09 |
US4876269A (en) | 1989-10-24 |
IE872406L (en) | 1988-03-10 |
IE60423B1 (en) | 1994-07-13 |
NO873762L (no) | 1988-03-11 |
IL83842A0 (en) | 1988-02-29 |
DE3778463D1 (de) | 1992-05-27 |
HU198016B (en) | 1989-07-28 |
ES2040721T3 (es) | 1993-11-01 |
NO172934B (no) | 1993-06-21 |
SU1582984A3 (ru) | 1990-07-30 |
NZ221726A (en) | 1990-04-26 |
DK470087D0 (da) | 1987-09-09 |
AU607935B2 (en) | 1991-03-21 |
PT85668A (en) | 1987-10-01 |
FI88298B (fi) | 1993-01-15 |
PT85668B (pt) | 1990-05-31 |
NO172934C (no) | 1993-09-29 |
AU7822487A (en) | 1988-03-17 |
FI873896A (fi) | 1988-03-11 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
DK169071B1 (da) | Benzacetamidderivater, fremgangsmåder til deres fremstilling samt et farmaceutisk præparat indeholdende et sådant derivat | |
CA2051399C (en) | Therapeutically useful 2-aminotetralin derivatives | |
US5545755A (en) | Therapeutically useful 2-aminotetralin derivatives | |
EP0712387B1 (de) | 2-aminoindane als selektive dopamin-d3-liganden | |
KR100815772B1 (ko) | 신규 고리상 아미드 유도체 | |
KR970005323B1 (ko) | 치료용으로 유용한 테트랄린 유도체 | |
EP1025096B1 (de) | Substituierte chromanderivate | |
CS258150B2 (en) | Method of arylcyclobutylalkylamines production | |
AU644081B2 (en) | Novel 8-substituted-2-aminotetralines | |
CZ285850B6 (cs) | 2-Aminoindany jako selektivní dopaminové D3 ligandy | |
Pierson et al. | Design and synthesis of propranolol analogs as serotonergic agents | |
KR100213531B1 (ko) | 헥사히드로아제핀 유도체, 그것들의 제법과 그것들을 함유하는 약학 조성물 | |
HU206077B (en) | Process for producing new naphthylalkyl- and indanylalkylamines and pharmaceutical compositions comprising such compounds | |
CA1049530A (en) | Diphenylpropylamines | |
LV11030B (en) | Novel morpholinol compounds, their preparation and use | |
KOJIMA et al. | Syntheses of (±)-2-[(inden-7-yloxy) methyl] morpholine hydrochloride (YM-08054, indeloxazine hydrochloride) and its derivatives with potential cerebral-activating and antidepressive properties | |
US4929627A (en) | Benzo-fused cycloalkane and oxa- and thia-, cycloalkane trans-1,2-diamine derivatives | |
AU778674B2 (en) | New morpholinobenzamide salts | |
IE63769B1 (en) | Aryloxypropanolaminotetralins a process for their preparation and pharmaceutical compositions containing them | |
US5043350A (en) | Benzo-fused cycloalkane and oxa- and thia-, cycloalkane trans-1,2-diamine derivatives | |
CA1341011C (en) | Benzo-fused cycloalkane and oxa- and thia-, cycloalkane trans-1,2-diamine derivatives | |
NZ230628A (en) | Ring-substituted alkylene amine derivatives, preparatory intermediates and pharmaceutical compositions |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
B1 | Patent granted (law 1993) | ||
PBP | Patent lapsed |
Country of ref document: DK |