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DE69025803D1 - Verwendung von Rapamycin, dessen Derivaten und Prodrugs zur Herstellung eines Arzneimittels zur Hemmung der Transplantatabstossung bei Säugetieren - Google Patents

Verwendung von Rapamycin, dessen Derivaten und Prodrugs zur Herstellung eines Arzneimittels zur Hemmung der Transplantatabstossung bei Säugetieren

Info

Publication number
DE69025803D1
DE69025803D1 DE69025803T DE69025803T DE69025803D1 DE 69025803 D1 DE69025803 D1 DE 69025803D1 DE 69025803 T DE69025803 T DE 69025803T DE 69025803 T DE69025803 T DE 69025803T DE 69025803 D1 DE69025803 D1 DE 69025803D1
Authority
DE
Germany
Prior art keywords
transplant rejection
rapamycin
inhibiting
prodrugs
mammals
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69025803T
Other languages
English (en)
Other versions
DE69025803T2 (de
Inventor
Roy Calne
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
CALNE
Original Assignee
CALNE
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=23425763&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE69025803(D1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by CALNE filed Critical CALNE
Application granted granted Critical
Publication of DE69025803D1 publication Critical patent/DE69025803D1/de
Publication of DE69025803T2 publication Critical patent/DE69025803T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52—Purines, e.g. adenine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
    • A61K38/13—Cyclosporins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Transplantation (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Materials For Medical Uses (AREA)
DE69025803T 1989-06-06 1990-06-05 Verwendung von Rapamycin, dessen Derivaten und Prodrugs zur Herstellung eines Arzneimittels zur Hemmung der Transplantatabstossung bei Säugetieren Expired - Lifetime DE69025803T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/362,354 US5100899A (en) 1989-06-06 1989-06-06 Methods of inhibiting transplant rejection in mammals using rapamycin and derivatives and prodrugs thereof

Publications (2)

Publication Number Publication Date
DE69025803D1 true DE69025803D1 (de) 1996-04-18
DE69025803T2 DE69025803T2 (de) 1996-07-25

Family

ID=23425763

Family Applications (2)

Application Number Title Priority Date Filing Date
DE2001199045 Active DE10199045I2 (de) 1989-06-06 1990-06-05 Verwendung von Rapamycin, dessen Derivaten und Prodrugs zur Herstellung eines Arzneimittels zur Hemmung der Transplantatabstossung bei S{ugetieren
DE69025803T Expired - Lifetime DE69025803T2 (de) 1989-06-06 1990-06-05 Verwendung von Rapamycin, dessen Derivaten und Prodrugs zur Herstellung eines Arzneimittels zur Hemmung der Transplantatabstossung bei Säugetieren

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DE2001199045 Active DE10199045I2 (de) 1989-06-06 1990-06-05 Verwendung von Rapamycin, dessen Derivaten und Prodrugs zur Herstellung eines Arzneimittels zur Hemmung der Transplantatabstossung bei S{ugetieren

Country Status (18)

Country Link
US (5) US5100899A (de)
EP (1) EP0401747B1 (de)
JP (1) JP2969150B2 (de)
KR (1) KR0160957B1 (de)
AT (1) ATE135215T1 (de)
AU (1) AU638253B2 (de)
CA (1) CA2018287C (de)
DE (2) DE10199045I2 (de)
DK (1) DK0401747T3 (de)
ES (1) ES2085299T3 (de)
GR (1) GR3019792T3 (de)
HK (1) HK1005704A1 (de)
HU (1) HU206974B (de)
IL (1) IL94634A (de)
LU (1) LU90831I2 (de)
MX (1) MX173183B (de)
NL (1) NL300056I2 (de)
SG (1) SG44632A1 (de)

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* Cited by examiner, † Cited by third party
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ATE135215T1 (de) 1996-03-15
EP0401747A2 (de) 1990-12-12
CA2018287A1 (en) 1990-12-06
DE10199045I1 (de) 2003-06-05
EP0401747A3 (de) 1991-07-03
US5212155A (en) 1993-05-18
DE69025803T2 (de) 1996-07-25
US5461058A (en) 1995-10-24
JPH0373158A (ja) 1991-03-28
CA2018287C (en) 2001-11-20
NL300056I1 (nl) 2001-12-01
AU638253B2 (en) 1993-06-24
AU5686590A (en) 1991-01-31
US5308847A (en) 1994-05-03
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HUT54047A (en) 1991-01-28
DK0401747T3 (da) 2004-03-08
NL300056I2 (nl) 2002-04-02
US5100899A (en) 1992-03-31
HU206974B (en) 1993-03-01
IL94634A0 (en) 1991-04-15
JP2969150B2 (ja) 1999-11-02
LU90831I2 (fr) 2001-11-12
KR910000169A (ko) 1991-01-29
KR0160957B1 (ko) 1998-12-01
MX173183B (es) 1994-02-07
IL94634A (en) 1996-03-31
ES2085299T3 (es) 1996-06-01
DE10199045I2 (de) 2006-07-13
SG44632A1 (en) 1997-12-19
US5403833A (en) 1995-04-04
EP0401747B1 (de) 1996-03-13
HU903487D0 (en) 1990-12-28
GR3019792T3 (en) 1996-07-31

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