CY1120080T1 - Φαρμακευτικη συνθεση περιεχουσα εναν αναστολεα hdac και εναν κυκλοπολυσακχαριτη - Google Patents
Φαρμακευτικη συνθεση περιεχουσα εναν αναστολεα hdac και εναν κυκλοπολυσακχαριτηInfo
- Publication number
- CY1120080T1 CY1120080T1 CY20181100336T CY181100336T CY1120080T1 CY 1120080 T1 CY1120080 T1 CY 1120080T1 CY 20181100336 T CY20181100336 T CY 20181100336T CY 181100336 T CY181100336 T CY 181100336T CY 1120080 T1 CY1120080 T1 CY 1120080T1
- Authority
- CY
- Cyprus
- Prior art keywords
- cyclopolysaccharide
- pharmaceutical composition
- composition contains
- hdac inhibitor
- contains hdac
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
- C07D235/16—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
- A61K47/40—Cyclodextrins; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
- A61K47/6949—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit inclusion complexes, e.g. clathrates, cavitates or fullerenes
- A61K47/6951—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit inclusion complexes, e.g. clathrates, cavitates or fullerenes using cyclodextrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Immunology (AREA)
- Inorganic Chemistry (AREA)
- Dermatology (AREA)
- Oncology (AREA)
- Hematology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Η παρούσα εφεύρεση κατευθύνεται σε φαρμακευτικές συνθέσεις οι οποίες περιέχουν: (α) έναν κυκλοπολυσακχαρίτη και (β) μια ένωση του Τύπου (I) ή το φαρμακευτικό αποδεκτό άλας αυτής: όπου τα Χ1, Χ2, Q, Ζ, και m ορίζονται στο παρόν. Επίσης αποκαλύπτεται μια μέθοδος για τη θεραπευτική αγωγή μιας νεοπλασματικής ασθένειας ή μιας άνοσης ασθένειας με αυτές τις συνθέσεις.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161536038P | 2011-09-18 | 2011-09-18 | |
| US201261602408P | 2012-02-23 | 2012-02-23 | |
| PCT/US2012/055277 WO2013040286A2 (en) | 2011-09-18 | 2012-09-14 | Pharmaceutical compositions |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CY1120080T1 true CY1120080T1 (el) | 2018-12-12 |
Family
ID=47883974
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CY20181100336T CY1120080T1 (el) | 2011-09-18 | 2018-03-26 | Φαρμακευτικη συνθεση περιεχουσα εναν αναστολεα hdac και εναν κυκλοπολυσακχαριτη |
Country Status (40)
| Country | Link |
|---|---|
| US (1) | US9376395B2 (el) |
| EP (2) | EP3318284B1 (el) |
| JP (2) | JP2014526512A (el) |
| KR (2) | KR20140078619A (el) |
| CN (1) | CN103826630B (el) |
| AP (1) | AP3656A (el) |
| AR (1) | AR087909A1 (el) |
| AU (1) | AU2012308453B2 (el) |
| BR (1) | BR112014006271B1 (el) |
| CA (1) | CA2847842C (el) |
| CL (1) | CL2014000645A1 (el) |
| CO (1) | CO6930367A2 (el) |
| CR (1) | CR20140134A (el) |
| CY (1) | CY1120080T1 (el) |
| DK (1) | DK2758052T3 (el) |
| DO (1) | DOP2014000048A (el) |
| EA (1) | EA028413B1 (el) |
| EC (1) | ECSP14013239A (el) |
| ES (2) | ES2662775T3 (el) |
| GT (1) | GT201400069A (el) |
| HK (2) | HK1199824A1 (el) |
| HR (1) | HRP20180690T1 (el) |
| HU (1) | HUE037575T2 (el) |
| IL (1) | IL230838A (el) |
| LT (1) | LT2758052T (el) |
| ME (1) | ME03088B (el) |
| MX (1) | MX346432B (el) |
| MY (1) | MY169495A (el) |
| NI (1) | NI201400022A (el) |
| NZ (1) | NZ621386A (el) |
| PE (1) | PE20141552A1 (el) |
| PL (1) | PL2758052T3 (el) |
| PT (1) | PT2758052T (el) |
| RS (1) | RS57063B1 (el) |
| SI (1) | SI2758052T1 (el) |
| TN (1) | TN2014000095A1 (el) |
| TW (1) | TWI583382B (el) |
| UA (1) | UA116333C2 (el) |
| WO (1) | WO2013040286A2 (el) |
| ZA (1) | ZA201401676B (el) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AR092790A1 (es) | 2012-02-01 | 2015-05-06 | Euro Celtique Sa | Derivados bencimidazolicos del acido hidroxamico |
| AU2013234955A1 (en) | 2012-03-23 | 2014-11-13 | Dennis Brown | Compositions and methods to improve the therapeutic benefit of indirubin and analogs thereof, including meisoindigo |
| CA2925546C (en) | 2012-10-29 | 2022-06-14 | The University Of North Carolina At Chapel Hill | Methods and compositions for treating mucosal tissue disorders |
| GB201409471D0 (en) * | 2014-05-28 | 2014-07-09 | Euro Celtique Sa | Pharmaceutical composition |
| GB201409488D0 (en) * | 2014-05-28 | 2014-07-09 | Euro Celtique Sa | Pharmaceutical composition |
| GB201409485D0 (en) * | 2014-05-28 | 2014-07-09 | Euro Celtique Sa | Pharmaceutical composition |
| CA2969790A1 (en) * | 2014-12-05 | 2016-06-09 | University of Modena and Reggio Emilia | Combinations of histone deacetylase inhibitors and bendamustine |
| WO2017067474A1 (zh) * | 2015-10-20 | 2017-04-27 | 杭州民生药物研究院有限公司 | 一种药物组合物及其制备方法 |
| UA123785C2 (uk) | 2016-03-28 | 2021-06-02 | Інсайт Корпорейшн | Сполуки піролотриазину як інгібітори tam |
| CA3040155C (en) | 2016-10-11 | 2024-01-16 | Euro-Celtique S.A. | Compound for use in the treatment of hodgkin lymphoma |
| GB201709406D0 (en) | 2017-06-13 | 2017-07-26 | Euro-Cletique S A | Compounds for treating TNBC |
| GB201709403D0 (en) | 2017-06-13 | 2017-07-26 | Euro Celtique Sa | Compounds for treating sarcoma |
| GB201709402D0 (en) | 2017-06-13 | 2017-07-26 | Euro Celtique Sa | Compounds for treating t-pll |
| GB201709405D0 (en) * | 2017-06-13 | 2017-07-26 | Euro Celtique Sa | Compounds for treating ovarian cancer |
| JP6770986B2 (ja) | 2018-03-06 | 2020-10-21 | 日本電産モビリティ株式会社 | 誘導性負荷制御装置 |
| SG11202013163TA (en) | 2018-06-29 | 2021-01-28 | Incyte Corp | Formulations of an axl/mer inhibitor |
| WO2020128912A1 (en) * | 2018-12-18 | 2020-06-25 | Mundipharma International Corporation Limited | Compounds for treating lymphoma or a t-cell malignant disease |
Family Cites Families (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US645A (en) | 1838-03-17 | Back for poeges and fetrnages | ||
| DE34727C (de) | Ch. H. TH. HAVEMANN in Paris, 16 rue Bleue | Verfahren zur direkten Gewinnung metallischen Bleis | ||
| US5376A (en) | 1847-11-20 | Improvement in bog-cutters | ||
| US4522811A (en) | 1982-07-08 | 1985-06-11 | Syntex (U.S.A.) Inc. | Serial injection of muramyldipeptides and liposomes enhances the anti-infective activity of muramyldipeptides |
| US6407079B1 (en) | 1985-07-03 | 2002-06-18 | Janssen Pharmaceutica N.V. | Pharmaceutical compositions containing drugs which are instable or sparingly soluble in water and methods for their preparation |
| US5376645A (en) | 1990-01-23 | 1994-12-27 | University Of Kansas | Derivatives of cyclodextrins exhibiting enhanced aqueous solubility and the use thereof |
| KR0166088B1 (ko) | 1990-01-23 | 1999-01-15 | . | 수용해도가 증가된 시클로덱스트린 유도체 및 이의 용도 |
| GB9126209D0 (en) | 1991-12-10 | 1992-02-12 | Orion Yhtymae Oy | Drug formulations for parenteral use |
| US5602112A (en) * | 1992-06-19 | 1997-02-11 | Supergen, Inc. | Pharmaceutical formulation |
| US5874418A (en) | 1997-05-05 | 1999-02-23 | Cydex, Inc. | Sulfoalkyl ether cyclodextrin based solid pharmaceutical formulations and their use |
| US6046177A (en) | 1997-05-05 | 2000-04-04 | Cydex, Inc. | Sulfoalkyl ether cyclodextrin based controlled release solid pharmaceutical formulations |
| WO1998056422A1 (en) | 1997-06-13 | 1998-12-17 | The University Of Kansas | Polar drug or prodrug compositions with extended shelf-life storage and a method of making thereof |
| AU2004215624B2 (en) * | 2003-02-25 | 2011-06-02 | Topotarget Uk Limited | Hydroxamic acid compounds comprising a bicyclic heteroaryl group as HDAC inhibitors |
| CN101189003B (zh) * | 2005-05-13 | 2012-02-08 | 托波塔吉特英国有限公司 | Hdac抑制剂的药物制剂 |
| WO2008067027A2 (en) * | 2006-10-20 | 2008-06-05 | Icos Corporation | Compositions of chkl inhibitors and cyclodextrin |
| US8987468B2 (en) * | 2008-02-04 | 2015-03-24 | The Translational Genomics Research Institute | Compounds, pharmaceutical compositions and methods of use of hydroxamic acid derivatives |
| CA2735899A1 (en) * | 2008-09-25 | 2010-04-01 | Cephalon, Inc. | Liquid formulations of bendamustine |
| ME02254B (me) * | 2009-01-23 | 2015-12-31 | Euro Celtique Sa | Derivati hidroksamske kiseline |
| US8436032B2 (en) * | 2009-02-25 | 2013-05-07 | Supratek Pharma Inc. | Bendamustine cyclopolysaccharide compositions |
| CN101928234B (zh) * | 2010-01-15 | 2012-12-12 | 北京欧凯纳斯科技有限公司 | 6/7-（杂）芳基-n-羟基己/庚酰胺化合物及其制备方法 |
| JO3659B1 (ar) * | 2010-06-02 | 2020-08-27 | Astellas Deutschland Gmbh | أشكال جرعات بينداموستين عن طريق الفم وإستخداماته العلاجية |
| CN102993102B (zh) * | 2011-09-16 | 2016-08-24 | 杭州民生药业有限公司 | [1-甲基-2-(7’-庚异羟肟酸基)-5-n，n-二(2’-氯乙基)]-1h-苯并咪唑的合成方法 |
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2012
- 2012-09-14 JP JP2014530810A patent/JP2014526512A/ja active Pending
- 2012-09-14 PT PT128314176T patent/PT2758052T/pt unknown
- 2012-09-14 WO PCT/US2012/055277 patent/WO2013040286A2/en active Application Filing
- 2012-09-14 ME MEP-2018-92A patent/ME03088B/me unknown
- 2012-09-14 MX MX2014003283A patent/MX346432B/es active IP Right Grant
- 2012-09-14 MY MYPI2014000622A patent/MY169495A/en unknown
- 2012-09-14 KR KR20147006534A patent/KR20140078619A/ko active Application Filing
- 2012-09-14 ES ES12831417.6T patent/ES2662775T3/es active Active
- 2012-09-14 EP EP17208980.7A patent/EP3318284B1/en active Active
- 2012-09-14 NZ NZ621386A patent/NZ621386A/en unknown
- 2012-09-14 CN CN201280044834.1A patent/CN103826630B/zh active Active
- 2012-09-14 AP AP2014007498A patent/AP3656A/xx active
- 2012-09-14 EA EA201490650A patent/EA028413B1/ru unknown
- 2012-09-14 US US14/345,562 patent/US9376395B2/en active Active
- 2012-09-14 DK DK12831417.6T patent/DK2758052T3/en active
- 2012-09-14 RS RS20180387A patent/RS57063B1/sr unknown
- 2012-09-14 KR KR1020197027187A patent/KR102048079B1/ko active IP Right Grant
- 2012-09-14 EP EP12831417.6A patent/EP2758052B9/en active Active
- 2012-09-14 BR BR112014006271-4A patent/BR112014006271B1/pt active IP Right Grant
- 2012-09-14 SI SI201231266T patent/SI2758052T1/en unknown
- 2012-09-14 ES ES17208980T patent/ES2911427T3/es active Active
- 2012-09-14 UA UAA201404114A patent/UA116333C2/uk unknown
- 2012-09-14 HU HUE12831417A patent/HUE037575T2/hu unknown
- 2012-09-14 LT LTEP12831417.6T patent/LT2758052T/lt unknown
- 2012-09-14 PE PE2014000365A patent/PE20141552A1/es active IP Right Grant
- 2012-09-14 CA CA2847842A patent/CA2847842C/en active Active
- 2012-09-14 AU AU2012308453A patent/AU2012308453B2/en active Active
- 2012-09-14 PL PL12831417T patent/PL2758052T3/pl unknown
- 2012-09-17 AR ARP120103432 patent/AR087909A1/es not_active Application Discontinuation
- 2012-09-17 TW TW101133961A patent/TWI583382B/zh active
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2014
- 2014-02-06 IL IL230838A patent/IL230838A/en active IP Right Grant
- 2014-03-04 DO DO2014000048A patent/DOP2014000048A/es unknown
- 2014-03-06 TN TNP2014000095A patent/TN2014000095A1/en unknown
- 2014-03-06 ZA ZA2014/01676A patent/ZA201401676B/en unknown
- 2014-03-13 EC ECSP14013239 patent/ECSP14013239A/es unknown
- 2014-03-17 CL CL2014000645A patent/CL2014000645A1/es unknown
- 2014-03-17 NI NI201400022A patent/NI201400022A/es unknown
- 2014-03-24 CR CR20140134A patent/CR20140134A/es unknown
- 2014-04-11 CO CO14079713A patent/CO6930367A2/es unknown
- 2014-04-14 GT GT201400069A patent/GT201400069A/es unknown
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2015
- 2015-01-12 HK HK15100300.8A patent/HK1199824A1/xx unknown
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2017
- 2017-12-14 JP JP2017239611A patent/JP6557318B2/ja active Active
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2018
- 2018-03-26 CY CY20181100336T patent/CY1120080T1/el unknown
- 2018-05-03 HR HRP20180690TT patent/HRP20180690T1/hr unknown
- 2018-10-09 HK HK18112837.2A patent/HK1253692A1/zh unknown
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