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CY1118156T1 - Ενωσεις αντιστροφης αμιδης ως αναστολεις δεακετυλασης πρωτεϊνων και μεθοδοι χρησης αυτων - Google Patents

Ενωσεις αντιστροφης αμιδης ως αναστολεις δεακετυλασης πρωτεϊνων και μεθοδοι χρησης αυτων

Info

Publication number
CY1118156T1
CY1118156T1 CY20161101080T CY161101080T CY1118156T1 CY 1118156 T1 CY1118156 T1 CY 1118156T1 CY 20161101080 T CY20161101080 T CY 20161101080T CY 161101080 T CY161101080 T CY 161101080T CY 1118156 T1 CY1118156 T1 CY 1118156T1
Authority
CY
Cyprus
Prior art keywords
compounds
inhibitors
methods
protein determination
amide
Prior art date
Application number
CY20161101080T
Other languages
English (en)
Inventor
Duzer John H Van
Ralph Mazitschek
Walter Ogier
James Elliott Bradner
Guoxiang Huang
Dejian Xie
Nan Yu
Original Assignee
Acetylon Pharmaceuticals, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Acetylon Pharmaceuticals, Inc. filed Critical Acetylon Pharmaceuticals, Inc.
Publication of CY1118156T1 publication Critical patent/CY1118156T1/el

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    • A61K31/164—Amides, e.g. hydroxamic acids of a carboxylic acid with an aminoalcohol, e.g. ceramides
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
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Abstract

Η παρούσα εφεύρεση αναφέρεται σε καινοτόμες ενώσεις «αντίστροφης αμίδης» που περιέχουν μια ψευδαργυρική ομάδα χηλίωσης, και στην χρήση τέτοιων ενώσεων για την αναστολή του HDAC6 και στην θεραπευτική αντιμετώπιση διαφόρων ασθενειών, διαταραχών ή καταστάσεων που σχετίζονται με το HDAC6.
CY20161101080T 2010-01-22 2016-10-26 Ενωσεις αντιστροφης αμιδης ως αναστολεις δεακετυλασης πρωτεϊνων και μεθοδοι χρησης αυτων CY1118156T1 (el)

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