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CY1110798T1 - Συνδυασμοι περιλαμβανοντες αντιμουσκαρινικους παραγοντες και αναστολεις pde4 - Google Patents

Συνδυασμοι περιλαμβανοντες αντιμουσκαρινικους παραγοντες και αναστολεις pde4

Info

Publication number
CY1110798T1
CY1110798T1 CY20101100844T CY101100844T CY1110798T1 CY 1110798 T1 CY1110798 T1 CY 1110798T1 CY 20101100844 T CY20101100844 T CY 20101100844T CY 101100844 T CY101100844 T CY 101100844T CY 1110798 T1 CY1110798 T1 CY 1110798T1
Authority
CY
Cyprus
Prior art keywords
antimuscarinating
agents
pde4 inhibitors
containers including
anion
Prior art date
Application number
CY20101100844T
Other languages
English (en)
Inventor
Escardo Jordi Gras
Calvo Jesus Llenas
Hamish Ryder
Diaz Pio Orviz
Original Assignee
Almirall, S.A.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=34956036&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CY1110798(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Almirall, S.A. filed Critical Almirall, S.A.
Publication of CY1110798T1 publication Critical patent/CY1110798T1/el

Links

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/138—Aryloxyalkylamines, e.g. propranolol, tamoxifen, phenoxybenzamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid 
    • A—HUMAN NECESSITIES
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    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/196—Carboxylic acids, e.g. valproic acid having an amino group the amino group being directly attached to a ring, e.g. anthranilic acid, mefenamic acid, diclofenac, chlorambucil
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    • A61K31/277—Nitriles; Isonitriles having a ring, e.g. verapamil
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
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    • A61K31/439—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring forming part of a bridged ring system, e.g. quinuclidine
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    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/46—8-Azabicyclo [3.2.1] octane; Derivatives thereof, e.g. atropine, cocaine
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    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
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    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
    • A—HUMAN NECESSITIES
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    • A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
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    • A61K31/655—Azo (—N=N—), diazo (=N2), azoxy (>N—O—N< or N(=O)—N<), azido (—N3) or diazoamino (—N=N—N<) compounds
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
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    • A61K9/00—Medicinal preparations characterised by special physical form
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    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/0075—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a dry powder inhaler [DPI], e.g. comprising micronized drug mixed with lactose carrier particles
    • A—HUMAN NECESSITIES
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    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pulmonology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Emergency Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Otolaryngology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Rheumatology (AREA)
  • Immunology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
  • Wrappers (AREA)

Abstract

Συνδυασμός ο οποίος περιλαμβάνει (a) έναν αναστολέα PDE4 και (b) έναν ανταγωνιστή των μουσκαρινικών υποδοχέων Μ3 ο οποίος είναι το (3R)-(2-υδροξυ-2,2-διθειεν-2-υλακετοξυ)-1-(3-φαινοξυπροπυλ)-1-αζωνιαδικυκλο[2.2.2]οκτάνιο, υπό τη μορφή ενός άλατος έχοντος ένα ανιόν Χ, το οποίο είναι ένα φαρμακευτικά αποδεκτό ανιόν ενός μονοσθενούς ή πολυσθενούς οξέως.
CY20101100844T 2004-05-31 2010-09-16 Συνδυασμοι περιλαμβανοντες αντιμουσκαρινικους παραγοντες και αναστολεις pde4 CY1110798T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
ES200401312A ES2257152B1 (es) 2004-05-31 2004-05-31 Combinaciones que comprenden agentes antimuscarinicos y agonistas beta-adrenergicos.
EP07019644A EP1891973B1 (en) 2004-05-31 2005-05-31 Combinations comprising antimuscarinic agents and PDE4 inhibitors

Publications (1)

Publication Number Publication Date
CY1110798T1 true CY1110798T1 (el) 2015-06-10

Family

ID=34956036

Family Applications (7)

Application Number Title Priority Date Filing Date
CY20091100290T CY1108885T1 (el) 2004-05-31 2009-03-16 Συνδυασμοι περιλαμβανοντες αντιμουσκαρινους παραγοντες και κορτικοστεροειδη
CY20091100315T CY1108902T1 (el) 2004-05-31 2009-03-20 Συνδυασμοι περιλαμβανοντες αντιμουσκαρινικους παραγοντες και β-αδρενεργικους συναγωνιστες
CY20091100602T CY1109139T1 (el) 2004-05-31 2009-06-09 Συνδυασμοι που περιλαμβανουν αντιμουσκαρινικους παραγοντες και βητα-αδρενεργικους αγωνιστες
CY20101100311T CY1109938T1 (el) 2004-05-31 2010-04-06 Συνδυασμοι που περιλαμβανουν αντιμουσκαρινικους παραγοντες και κορτικοστεροειδη
CY20101100844T CY1110798T1 (el) 2004-05-31 2010-09-16 Συνδυασμοι περιλαμβανοντες αντιμουσκαρινικους παραγοντες και αναστολεις pde4
CY20141100869T CY1115669T1 (el) 2004-05-31 2014-10-22 Συνδυασμοι που περιλαμβανουν αντιμουσκαρινικους παραγοντες και βητα-αδρενεργικους αγωνιστες
CY2015006C CY2015006I1 (el) 2004-05-31 2015-03-03 Συνδυασμοι που περιλαμβανουν αντιμουσκαρινικους παραγοντες και βητα-αδρενεργικους αγωνιστες

Family Applications Before (4)

Application Number Title Priority Date Filing Date
CY20091100290T CY1108885T1 (el) 2004-05-31 2009-03-16 Συνδυασμοι περιλαμβανοντες αντιμουσκαρινους παραγοντες και κορτικοστεροειδη
CY20091100315T CY1108902T1 (el) 2004-05-31 2009-03-20 Συνδυασμοι περιλαμβανοντες αντιμουσκαρινικους παραγοντες και β-αδρενεργικους συναγωνιστες
CY20091100602T CY1109139T1 (el) 2004-05-31 2009-06-09 Συνδυασμοι που περιλαμβανουν αντιμουσκαρινικους παραγοντες και βητα-αδρενεργικους αγωνιστες
CY20101100311T CY1109938T1 (el) 2004-05-31 2010-04-06 Συνδυασμοι που περιλαμβανουν αντιμουσκαρινικους παραγοντες και κορτικοστεροειδη

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CY20141100869T CY1115669T1 (el) 2004-05-31 2014-10-22 Συνδυασμοι που περιλαμβανουν αντιμουσκαρινικους παραγοντες και βητα-αδρενεργικους αγωνιστες
CY2015006C CY2015006I1 (el) 2004-05-31 2015-03-03 Συνδυασμοι που περιλαμβανουν αντιμουσκαρινικους παραγοντες και βητα-αδρενεργικους αγωνιστες

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US (41) US20080051378A1 (el)
EP (14) EP2002845A3 (el)
JP (8) JP4928258B2 (el)
KR (3) KR101256417B1 (el)
CN (8) CN102085373A (el)
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BE (1) BE1016608A5 (el)
BR (6) BRPI0511667A (el)
CA (3) CA2569077C (el)
CH (1) CH696962A5 (el)
CL (1) CL2011000607A1 (el)
CY (7) CY1108885T1 (el)
DE (3) DE602005011803D1 (el)
DK (5) DK1765404T3 (el)
EC (6) ECSP067036A (el)
ES (7) ES2257152B1 (el)
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IL (3) IL179687A (el)
IT (1) ITMI20051021A1 (el)
LT (1) LTC1763368I2 (el)
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NZ (3) NZ551667A (el)
PE (3) PE20081650A1 (el)
PL (6) PL1763368T5 (el)
PT (4) PT2292267E (el)
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RU (4) RU2373935C2 (el)
SI (5) SI2292267T1 (el)
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UY (1) UY28933A1 (el)
WO (3) WO2005115466A1 (el)
ZA (6) ZA200600261B (el)

Families Citing this family (55)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
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