CO6660484A2 - Análogos de glucagón - Google Patents
Análogos de glucagónInfo
- Publication number
- CO6660484A2 CO6660484A2 CO12232550A CO12232550A CO6660484A2 CO 6660484 A2 CO6660484 A2 CO 6660484A2 CO 12232550 A CO12232550 A CO 12232550A CO 12232550 A CO12232550 A CO 12232550A CO 6660484 A2 CO6660484 A2 CO 6660484A2
- Authority
- CO
- Colombia
- Prior art keywords
- methods
- glucagon analogues
- glucagon
- peptides
- glp
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/605—Glucagons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/26—Glucagons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Endocrinology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Epidemiology (AREA)
- Toxicology (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Cardiology (AREA)
- Diabetes (AREA)
- Heart & Thoracic Surgery (AREA)
- Immunology (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Child & Adolescent Psychology (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
La invención proporciona materiales y procedimientos para promover la pérdida de peso o evitar la ganancia de peso sin afectar al control glucémico. En particular, la invención proporciona péptidos de análogos al glucagón novedosos eficaces en dichos procedimientos. Los péptidos pueden mediar su efecto mediante un incremento en la selectividad para el receptor de GLP-1 en comparación con el glucagón humano.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DKPA201000550 | 2010-06-23 | ||
US35862310P | 2010-06-25 | 2010-06-25 |
Publications (1)
Publication Number | Publication Date |
---|---|
CO6660484A2 true CO6660484A2 (es) | 2013-04-30 |
Family
ID=44630045
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CO12232550A CO6660484A2 (es) | 2010-06-23 | 2012-12-21 | Análogos de glucagón |
Country Status (22)
Country | Link |
---|---|
US (2) | US9403894B2 (es) |
EP (1) | EP2585481B1 (es) |
JP (1) | JP5937582B2 (es) |
KR (1) | KR20130086339A (es) |
CN (1) | CN103038250A (es) |
AP (1) | AP3286A (es) |
AR (1) | AR081975A1 (es) |
AU (1) | AU2011269427A1 (es) |
BR (1) | BR112012033227A2 (es) |
CA (1) | CA2802889A1 (es) |
CL (1) | CL2012003643A1 (es) |
CO (1) | CO6660484A2 (es) |
EA (1) | EA201291233A1 (es) |
EC (1) | ECSP12012351A (es) |
MX (1) | MX2012014774A (es) |
NZ (1) | NZ604033A (es) |
PE (1) | PE20130326A1 (es) |
SG (1) | SG186276A1 (es) |
TN (1) | TN2012000567A1 (es) |
TW (1) | TW201202265A (es) |
UY (1) | UY33462A (es) |
WO (1) | WO2011160630A2 (es) |
Families Citing this family (69)
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WO2006117565A2 (en) | 2005-05-04 | 2006-11-09 | Zealand Pharma A/S | Glucagon-like-peptide-2 (glp-2) analogues |
US8642727B2 (en) | 2006-11-08 | 2014-02-04 | Zealand Pharma A/S | Selective glucagon-like-peptide-2 (GLP-2) analogues |
AU2008365555B2 (en) | 2008-12-15 | 2016-01-14 | Zealand Pharma A/S | Glucagon analogues |
CN102292347A (zh) | 2008-12-15 | 2011-12-21 | 西兰制药公司 | 胰高血糖素类似物 |
BRPI0823379A2 (pt) | 2008-12-15 | 2015-07-14 | Zealand Pharma As | Análogos de glucagon |
DK2370462T3 (da) | 2008-12-15 | 2014-09-08 | Zealand Pharma As | Glucagon-analoger |
UA104766C2 (uk) | 2009-07-13 | 2014-03-11 | Зіленд Фарма А/С | Ацильовані аналоги глюкагону |
UY33462A (es) | 2010-06-23 | 2012-01-31 | Zealand Pharma As | Analogos de glucagon |
MA34383B1 (fr) | 2010-06-24 | 2013-07-03 | Zealand Pharma As | Analogues de glucagon |
EP2665487A1 (en) * | 2011-01-20 | 2013-11-27 | Zealand Pharma A/S | Combination of acylated glucagon analogues with insulin analogues |
AR088161A1 (es) | 2011-09-23 | 2014-05-14 | Novo Nordisk As | Analogos de glucagon |
EA201490982A1 (ru) * | 2011-12-23 | 2015-01-30 | Зилэнд Фарма А/С | Аналоги глюкагона |
TR201815338T4 (tr) | 2012-05-03 | 2018-11-21 | Zealand Pharma As | Gıp-glp-1 dual agonist bileşikleri ve yöntemler. |
JP6298044B2 (ja) | 2012-05-03 | 2018-03-20 | ジーランド ファーマ アクティーゼルスカブ | グルカゴン様ペプチド−2(glp−2)類似体 |
SG11201407860PA (en) | 2012-06-14 | 2014-12-30 | Sanofi Sa | Exendin-4 peptide analogues |
AR091866A1 (es) | 2012-07-23 | 2015-03-04 | Zealand Pharma As | Analogos del glucagon |
EP2895506A1 (en) | 2012-09-17 | 2015-07-22 | Imperial Innovations Limited | Peptide analogues of glucagon and glp1 |
TWI608013B (zh) * | 2012-09-17 | 2017-12-11 | 西蘭製藥公司 | 升糖素類似物 |
GB2505941A (en) * | 2012-09-17 | 2014-03-19 | Imp Innovations Ltd | Peptide analogues of glucagon for the treatment of obesity and diabetes |
UA116217C2 (uk) | 2012-10-09 | 2018-02-26 | Санофі | Пептидна сполука як подвійний агоніст рецепторів glp1-1 та глюкагону |
PL2934568T3 (pl) | 2012-12-21 | 2018-03-30 | Sanofi | Agonista podwójny GLP1/GIP lub potrójny GLP1/GIP/glukagon |
DK2976325T3 (en) | 2013-03-21 | 2017-06-06 | Sanofi Aventis Deutschland | SYNTHESIS OF PEPTIDE PRODUCTS CONTAINING CYCLIC IMID |
ES2623979T3 (es) | 2013-03-21 | 2017-07-12 | Sanofi-Aventis Deutschland Gmbh | Síntesis de productos peptídicos que contienen hidantoína |
AR095986A1 (es) | 2013-04-03 | 2015-11-25 | Sanofi Sa | Proteínas modificadas que regulan glucosa en sangre con perfil alterado de actividad farmacológica y preparación de las mismas |
BR112015025464A2 (pt) | 2013-04-18 | 2017-10-10 | Novo Nordisk As | coagonistas do receptor de glp-1/glucagon estáveis, prolongados para uso médico |
US9988429B2 (en) | 2013-10-17 | 2018-06-05 | Zealand Pharma A/S | Glucagon analogues |
BR112016008115B1 (pt) * | 2013-10-17 | 2024-03-12 | Boehringer Ingelheim International Gmbh | Análogos de glucagon acilados |
EA035466B9 (ru) * | 2013-11-06 | 2020-08-17 | Зилэнд Фарма А/С | Соединения и способы на основе двойного агониста гип и гпп-1 |
CN105829339B (zh) | 2013-11-06 | 2021-03-12 | 西兰制药公司 | 胰高血糖素-glp-1-gip三重激动剂化合物 |
WO2015086728A1 (en) | 2013-12-13 | 2015-06-18 | Sanofi | Exendin-4 peptide analogues as dual glp-1/gip receptor agonists |
TW201609797A (zh) | 2013-12-13 | 2016-03-16 | 賽諾菲公司 | 雙重glp-1/升糖素受體促效劑 |
EP3080155A1 (en) | 2013-12-13 | 2016-10-19 | Sanofi | Exendin-4 peptide analogues as dual glp-1/glucagon receptor agonists |
EP3080152A1 (en) | 2013-12-13 | 2016-10-19 | Sanofi | Non-acylated exendin-4 peptide analogues |
TW201609799A (zh) | 2013-12-13 | 2016-03-16 | 賽諾菲公司 | 雙重glp-1/gip受體促效劑 |
TW201625670A (zh) | 2014-04-07 | 2016-07-16 | 賽諾菲公司 | 衍生自exendin-4之雙重glp-1/升糖素受體促效劑 |
TW201625669A (zh) | 2014-04-07 | 2016-07-16 | 賽諾菲公司 | 衍生自艾塞那肽-4(Exendin-4)之肽類雙重GLP-1/升糖素受體促效劑 |
TW201625668A (zh) | 2014-04-07 | 2016-07-16 | 賽諾菲公司 | 作為胜肽性雙重glp-1/昇糖素受體激動劑之艾塞那肽-4衍生物 |
US10570184B2 (en) | 2014-06-04 | 2020-02-25 | Novo Nordisk A/S | GLP-1/glucagon receptor co-agonists for medical use |
US9932381B2 (en) | 2014-06-18 | 2018-04-03 | Sanofi | Exendin-4 derivatives as selective glucagon receptor agonists |
JP6898231B6 (ja) | 2014-10-29 | 2021-07-28 | ジーランド ファーマ アクティーゼルスカブ | Gipアゴニスト化合物及び方法 |
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KR101887577B1 (ko) | 2016-10-19 | 2018-09-10 | (주)케어젠 | 항비만 및 항당뇨 효능을 갖는 펩타이드 및 이의 용도 |
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KR102230363B1 (ko) * | 2017-08-16 | 2021-03-22 | 동아에스티 주식회사 | 아실화 옥신토모듈린 펩타이드 유사체 |
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EP3746449B1 (en) | 2018-02-02 | 2022-03-30 | Boehringer Ingelheim International GmbH | Pyrazole- and indazole-substituted oxadiazolopyridine derivatives for use as ghrelin o-acyl transferase (goat) inhibitors |
CR20200329A (es) | 2018-02-02 | 2020-09-04 | Boehringer Ingelheim Int | Derivados de triazolopirimidina para usar como inhibidores de ghrelin o-acil transferasa (goat) |
MX2020010715A (es) | 2018-04-10 | 2021-01-08 | Sanofi Aventis Deutschland | Sintesis de lixisenatida con taponamiento. |
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WO2009155257A1 (en) | 2008-06-17 | 2009-12-23 | Indiana University Research And Technology Corporation | Glucagon analogs exhibiting enhanced solubility and stability physiological ph buffers |
CN103641907A (zh) | 2008-06-17 | 2014-03-19 | 印第安纳大学研究及科技有限公司 | 胰高血糖素/glp-1受体共激动剂 |
PL219335B1 (pl) | 2008-07-04 | 2015-04-30 | Inst Biotechnologii I Antybiotyków | Pochodna insuliny lub jej farmaceutycznie dopuszczalna sól, jej zastosowanie oraz zawierająca ją kompozycja farmaceutyczna |
ES2552636T3 (es) | 2008-07-31 | 2015-12-01 | Case Western Reserve University | Insulina estabilizada por halógenos |
AU2008365555B2 (en) * | 2008-12-15 | 2016-01-14 | Zealand Pharma A/S | Glucagon analogues |
BRPI0823379A2 (pt) | 2008-12-15 | 2015-07-14 | Zealand Pharma As | Análogos de glucagon |
CN102292347A (zh) | 2008-12-15 | 2011-12-21 | 西兰制药公司 | 胰高血糖素类似物 |
DK2370462T3 (da) * | 2008-12-15 | 2014-09-08 | Zealand Pharma As | Glucagon-analoger |
CA2747490C (en) | 2008-12-19 | 2017-02-14 | Indiana University Research And Technology Corporation | Insulin analogs |
WO2010080609A1 (en) | 2008-12-19 | 2010-07-15 | Indiana University Research And Technology Corporation | Amide-based insulin prodrugs |
CN101519446A (zh) | 2009-03-31 | 2009-09-02 | 上海一就生物医药有限公司 | 一种重组人胰岛素及其类似物的制备方法 |
UA104766C2 (uk) | 2009-07-13 | 2014-03-11 | Зіленд Фарма А/С | Ацильовані аналоги глюкагону |
US20130157953A1 (en) * | 2010-01-20 | 2013-06-20 | Zealand Pharma A/S | Treatment of cardiac conditions |
UY33462A (es) | 2010-06-23 | 2012-01-31 | Zealand Pharma As | Analogos de glucagon |
MA34383B1 (fr) | 2010-06-24 | 2013-07-03 | Zealand Pharma As | Analogues de glucagon |
EP2665487A1 (en) | 2011-01-20 | 2013-11-27 | Zealand Pharma A/S | Combination of acylated glucagon analogues with insulin analogues |
EA201490982A1 (ru) | 2011-12-23 | 2015-01-30 | Зилэнд Фарма А/С | Аналоги глюкагона |
TWI608013B (zh) | 2012-09-17 | 2017-12-11 | 西蘭製藥公司 | 升糖素類似物 |
BR112016008115B1 (pt) | 2013-10-17 | 2024-03-12 | Boehringer Ingelheim International Gmbh | Análogos de glucagon acilados |
US9988429B2 (en) | 2013-10-17 | 2018-06-05 | Zealand Pharma A/S | Glucagon analogues |
-
2011
- 2011-06-22 UY UY0001033462A patent/UY33462A/es not_active Application Discontinuation
- 2011-06-22 AR ARP110102166A patent/AR081975A1/es unknown
- 2011-06-23 JP JP2013515697A patent/JP5937582B2/ja not_active Expired - Fee Related
- 2011-06-23 CN CN2011800305150A patent/CN103038250A/zh active Pending
- 2011-06-23 NZ NZ604033A patent/NZ604033A/en not_active IP Right Cessation
- 2011-06-23 KR KR1020137000529A patent/KR20130086339A/ko not_active Application Discontinuation
- 2011-06-23 TW TW100122081A patent/TW201202265A/zh unknown
- 2011-06-23 CA CA2802889A patent/CA2802889A1/en not_active Abandoned
- 2011-06-23 PE PE2012002434A patent/PE20130326A1/es not_active Application Discontinuation
- 2011-06-23 AP AP2013006669A patent/AP3286A/xx active
- 2011-06-23 SG SG2012090890A patent/SG186276A1/en unknown
- 2011-06-23 WO PCT/DK2011/000067 patent/WO2011160630A2/en active Application Filing
- 2011-06-23 US US13/702,841 patent/US9403894B2/en not_active Expired - Fee Related
- 2011-06-23 BR BR112012033227A patent/BR112012033227A2/pt not_active IP Right Cessation
- 2011-06-23 EA EA201291233A patent/EA201291233A1/ru unknown
- 2011-06-23 AU AU2011269427A patent/AU2011269427A1/en not_active Abandoned
- 2011-06-23 EP EP11741513.3A patent/EP2585481B1/en active Active
- 2011-06-23 MX MX2012014774A patent/MX2012014774A/es not_active Application Discontinuation
-
2012
- 2012-11-30 TN TNP2012000567A patent/TN2012000567A1/en unknown
- 2012-12-20 EC ECSP12012351 patent/ECSP12012351A/es unknown
- 2012-12-21 CO CO12232550A patent/CO6660484A2/es unknown
- 2012-12-21 CL CL2012003643A patent/CL2012003643A1/es unknown
-
2016
- 2016-06-27 US US15/194,025 patent/US20160304576A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
EP2585481B1 (en) | 2015-08-19 |
SG186276A1 (en) | 2013-01-30 |
JP5937582B2 (ja) | 2016-06-22 |
MX2012014774A (es) | 2013-01-29 |
JP2013534919A (ja) | 2013-09-09 |
UY33462A (es) | 2012-01-31 |
ECSP12012351A (es) | 2013-01-31 |
US20130157935A1 (en) | 2013-06-20 |
CN103038250A (zh) | 2013-04-10 |
US20160304576A1 (en) | 2016-10-20 |
TW201202265A (en) | 2012-01-16 |
NZ604033A (en) | 2014-12-24 |
US9403894B2 (en) | 2016-08-02 |
BR112012033227A2 (pt) | 2017-06-20 |
TN2012000567A1 (en) | 2014-04-01 |
EP2585481A2 (en) | 2013-05-01 |
CL2012003643A1 (es) | 2013-08-02 |
AR081975A1 (es) | 2012-10-31 |
KR20130086339A (ko) | 2013-08-01 |
EA201291233A1 (ru) | 2013-07-30 |
AP2013006669A0 (en) | 2013-01-31 |
AP3286A (en) | 2015-05-31 |
WO2011160630A3 (en) | 2012-02-16 |
WO2011160630A2 (en) | 2011-12-29 |
AU2011269427A1 (en) | 2012-12-20 |
CA2802889A1 (en) | 2011-12-29 |
PE20130326A1 (es) | 2013-03-17 |
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