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PE20191083A1 - Agonistas duales acilados de glp-1/glp-2 - Google Patents

Agonistas duales acilados de glp-1/glp-2

Info

Publication number
PE20191083A1
PE20191083A1 PE2019001207A PE2019001207A PE20191083A1 PE 20191083 A1 PE20191083 A1 PE 20191083A1 PE 2019001207 A PE2019001207 A PE 2019001207A PE 2019001207 A PE2019001207 A PE 2019001207A PE 20191083 A1 PE20191083 A1 PE 20191083A1
Authority
PE
Peru
Prior art keywords
glp
formula
psi
dual
accylated
Prior art date
Application number
PE2019001207A
Other languages
English (en)
Inventor
Larsen Bjarne Due
Jonathan Griffin
Lise Giehm
Alistair Vincent Gordon Edwards
Original Assignee
Zealand Pharma As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zealand Pharma As filed Critical Zealand Pharma As
Publication of PE20191083A1 publication Critical patent/PE20191083A1/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/26—Glucagons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A61K47/542—Carboxylic acids, e.g. a fatty acid or an amino acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/12—Antidiarrhoeals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/605—Glucagons

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Diabetes (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Endocrinology (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Epidemiology (AREA)
  • Emergency Medicine (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Toxicology (AREA)
  • Immunology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Se refiere a un agonista dual de GLP-1/GLP-2 (peptido similar al glucagon tipos 1 y 2 humano) representado por la formula: R1-X -U-R2, en la que: R1 es hidrogeno, acetilo, formilo, entre otros; R2 es NH2 u OH; X es un peptido de formula: H-X2-EG-X5-F-X7-X8-E-X10-X11-TIL-X15-X16-X17-A-X19-X20-X21-FI-X24-WL-X27-X28-X29-KIT-X33 (formula I), en la que: X2 es Aib o G; X5 y X7 son T o S; X8 es S, E o D; X10 es L, M, entre otros; X11 es A, N o S; X15 es D o E; X16 es G, E, entre otros; X17 es Q, E, entre otros; X19 es A, V o S; X20 es R, K o psi; X21 es D, L o E; X24 es A, N o S; X27 es I, Q, entre otros; X28 es Q, E, entre otros; X29 es H, Y, entre otros; X33 es D o E; U esta ausente o es una secuencia de 1 a 15 residuos seleccionados de K, k, E, A, T, I, L y psi. La molecula contiene solo un psi, en la que spsi es un residuo K, k, R, Orn, Dap o Dab en la que la cadena lateral esta conjugada a un sustituyente que tiene la formula Z1 o Z1-Z2, en la que Z1 es CH3-(CH2)10-22-(CO)- o HOOC-(CH2)10-22-(CO)-; Z2 es ZS1-, -ZS2-, entre otros; ZS1 es isoGlu, isoLys, entre otros; Z2 es -(Peg3)m; m es 1, 2 o 3 y en la que al menos uno de X5 y X7 es T. Tambien se refiere a una composicion que comprende al agonista dual. Dicho agonista es util para la profilaxis o el tratamiento del dano y la disfuncion intestinal, la regulacion del peso corporal y la profilaxis o el tratamiento de la disfuncion metabolica
PE2019001207A 2016-12-09 2017-12-11 Agonistas duales acilados de glp-1/glp-2 PE20191083A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DKPA201600757 2016-12-09
PCT/EP2017/082290 WO2018104561A1 (en) 2016-12-09 2017-12-11 Acylated glp-1/glp-2 dual agonists

Publications (1)

Publication Number Publication Date
PE20191083A1 true PE20191083A1 (es) 2019-08-20

Family

ID=61005766

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2019001207A PE20191083A1 (es) 2016-12-09 2017-12-11 Agonistas duales acilados de glp-1/glp-2

Country Status (19)

Country Link
US (4) US20190142904A1 (es)
EP (2) EP3551651B1 (es)
JP (2) JP6563614B1 (es)
KR (1) KR102502040B1 (es)
CN (2) CN117384274A (es)
AU (1) AU2017371516C1 (es)
BR (1) BR112019010624A2 (es)
CA (1) CA3043151A1 (es)
CL (1) CL2019001552A1 (es)
CO (1) CO2019005924A2 (es)
DK (1) DK3551651T3 (es)
ES (1) ES2979184T3 (es)
IL (1) IL266219B2 (es)
MX (1) MX2019006486A (es)
PE (1) PE20191083A1 (es)
RU (1) RU2753193C2 (es)
SG (2) SG10201911851VA (es)
WO (1) WO2018104561A1 (es)
ZA (1) ZA201902950B (es)

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CA3138716A1 (en) * 2019-06-14 2020-12-17 Zealand Pharma A/S Pharmaceutical parenteral composition of dual glp1/2 agonist
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JP2023531726A (ja) 2020-06-26 2023-07-25 キャリーオペ，インク． Ａｍｐｋアクチベーター
KR20230121824A (ko) 2020-12-16 2023-08-21 질랜드 파마 에이/에스 Glp-1/glp-2 이중 효능제의 약학적 조성물
KR20230121822A (ko) 2020-12-16 2023-08-21 질랜드 파마 에이/에스 Glp-1/glp-2 이중 효능제의 약학적 조성물
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WO2022175410A1 (en) 2021-02-18 2022-08-25 Zealand Pharma A/S Composition for treating short bowel syndrome
MX2024002600A (es) 2021-09-03 2024-03-22 Zealand Pharma As Regimen de dosificacion.
MX2024007447A (es) * 2021-12-17 2024-08-27 Bainan Biotech Aps Agonistas duales peptidicos del gipr y del glp-2r.
WO2023132609A1 (ko) * 2022-01-05 2023-07-13 주식회사 휴온스랩 지속형 지방산-펩타이드 유도체 및 이의 용도
CN116655772A (zh) * 2022-02-18 2023-08-29 成都奥达生物科技有限公司 一种长效的glp-1/glp-2双激动剂化合物
WO2024061919A1 (en) 2022-09-19 2024-03-28 Zealand Pharma A/S Combination therapy

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